@vinceconticello.bsky.social
Reposted
De novo design of protein nanoparticles with integrated functional motifs pubmed.ncbi.nlm.nih.gov/41509406/ #cryoem
January 10, 2026 at 7:40 PM
De novo design of protein nanoparticles with integrated functional motifs pubmed.ncbi.nlm.nih.gov/41509406/ #cryoem
Reposted
Another fruitful collaboration with the Otzen group 🦠🧫🧬
We looked for curli and Fap operons across the bacterial tree of life (GTDB v226), and found that while Fap operon synteny and FapC repeat numbers are remarkably conserved, the opposite is true for curli operons and csgA!
We looked for curli and Fap operons across the bacterial tree of life (GTDB v226), and found that while Fap operon synteny and FapC repeat numbers are remarkably conserved, the opposite is true for curli operons and csgA!
December 7, 2025 at 9:17 AM
Another fruitful collaboration with the Otzen group 🦠🧫🧬
We looked for curli and Fap operons across the bacterial tree of life (GTDB v226), and found that while Fap operon synteny and FapC repeat numbers are remarkably conserved, the opposite is true for curli operons and csgA!
We looked for curli and Fap operons across the bacterial tree of life (GTDB v226), and found that while Fap operon synteny and FapC repeat numbers are remarkably conserved, the opposite is true for curli operons and csgA!
New manuscript alert. Turns out that calcium ion coordination may be a more common mechanism than we initially expected to trigger polymerization of extracellular filaments. @mikesleutel.bsky.social @vikramalva.bsky.social
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
From fibril to framework: P. abyssi AbpX illuminates a calcium-responsive family of microbial biomatrix proteins that form thermostable hydrogels
Evolutionary pressure on microbial communities propagating under extreme environmental conditions often results in unique structural adaptations to promote cell survival. Here, we report an investigat...
www.biorxiv.org
January 5, 2026 at 3:02 PM
New manuscript alert. Turns out that calcium ion coordination may be a more common mechanism than we initially expected to trigger polymerization of extracellular filaments. @mikesleutel.bsky.social @vikramalva.bsky.social
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Reposted
Distinct flagellins differentially fine tune biofilm initiation via flagellar stator-associated proteins www.biorxiv.org/content/10.64898/2025.12.30.697036v1 #cryoem
December 31, 2025 at 12:46 PM
Distinct flagellins differentially fine tune biofilm initiation via flagellar stator-associated proteins www.biorxiv.org/content/10.64898/2025.12.30.697036v1 #cryoem
Reposted
Alpha-synuclein fibril structures cluster into distinct classes pubmed.ncbi.nlm.nih.gov/41404791/ #cryoem
December 19, 2025 at 12:36 AM
Alpha-synuclein fibril structures cluster into distinct classes pubmed.ncbi.nlm.nih.gov/41404791/ #cryoem
Reposted
Capsid flexibility during Ty1 virus-like particle assembly www.biorxiv.org/content/10.64898/2025.12.17.694965v1 #cryoem
December 19, 2025 at 8:10 AM
Capsid flexibility during Ty1 virus-like particle assembly www.biorxiv.org/content/10.64898/2025.12.17.694965v1 #cryoem
Reposted
Happy to share that our work on HLp, a bacterial histone from Leptospira perolatii, is now published in Nature Communications 🎉
In this study, we show that HLp forms stable tetramers that wrap ~60 bp of DNA, revealing a distinct histone–DNA organization in bacteria.
www.nature.com/articles/s41...
In this study, we show that HLp forms stable tetramers that wrap ~60 bp of DNA, revealing a distinct histone–DNA organization in bacteria.
www.nature.com/articles/s41...
December 13, 2025 at 8:09 AM
Happy to share that our work on HLp, a bacterial histone from Leptospira perolatii, is now published in Nature Communications 🎉
In this study, we show that HLp forms stable tetramers that wrap ~60 bp of DNA, revealing a distinct histone–DNA organization in bacteria.
www.nature.com/articles/s41...
In this study, we show that HLp forms stable tetramers that wrap ~60 bp of DNA, revealing a distinct histone–DNA organization in bacteria.
www.nature.com/articles/s41...
Reposted
Type III secretion system effector evolved to be mechanically labile and initiate unfolding from the N-terminus. https://www.biorxiv.org/content/10.64898/2025.12.03.691928v1
December 4, 2025 at 10:46 AM
Type III secretion system effector evolved to be mechanically labile and initiate unfolding from the N-terminus. https://www.biorxiv.org/content/10.64898/2025.12.03.691928v1
Reposted
Check out our latest paper on mirusviruses, one of the most remarkable new groups of protist viruses - extremely diverse, carry lots of spliceosomal introns (including new homing introns) and are at the evolutionary crossroads between tailed phages and herpesviruses! www.nature.com/articles/s41...
Widespread and intron-rich mirusviruses are predicted to reproduce in nuclei of unicellular eukaryotes - Nature Microbiology
Environmental metagenomic explorations show that Mirusviricota lineages lack essential replication and transcription genes and contain spliceosomal introns, suggesting nuclear reproduction.
www.nature.com
November 28, 2025 at 4:43 PM
Check out our latest paper on mirusviruses, one of the most remarkable new groups of protist viruses - extremely diverse, carry lots of spliceosomal introns (including new homing introns) and are at the evolutionary crossroads between tailed phages and herpesviruses! www.nature.com/articles/s41...
Reposted
A Bundled Antiparallel Cytochrome Nanowire Structure Suggests Roles in Cell-Cell Electron Transfer and Biofilm Formation pubmed.ncbi.nlm.nih.gov/41279714/ #cryoem
November 25, 2025 at 6:58 PM
A Bundled Antiparallel Cytochrome Nanowire Structure Suggests Roles in Cell-Cell Electron Transfer and Biofilm Formation pubmed.ncbi.nlm.nih.gov/41279714/ #cryoem
Reposted
The Inaugural Flatiron Institute Cryo-EM Conformational Heterogeneity Challenge pubmed.ncbi.nlm.nih.gov/41280101/ #cryoem
November 25, 2025 at 2:16 PM
The Inaugural Flatiron Institute Cryo-EM Conformational Heterogeneity Challenge pubmed.ncbi.nlm.nih.gov/41280101/ #cryoem
Reposted
Latest work from the group looking at using our functionalised dipeptides for energy storage via a micellar analogue to MOST...
www.nature.com/articles/s42...
www.nature.com/articles/s42...
Functionalized azobenzenes for micellar solar thermal energy storage as a next-generation MOST system - Communications Chemistry
Molecular solar thermal energy storage (MOST) systems employ photoswitchable molecules that absorb sunlight and store energy through reversible isomerization, cyclization or other intramolecular rearr...
www.nature.com
November 25, 2025 at 9:04 AM
Latest work from the group looking at using our functionalised dipeptides for energy storage via a micellar analogue to MOST...
www.nature.com/articles/s42...
www.nature.com/articles/s42...
Reposted
How Sup35 monomer conformation and amyloid fibril polymorphism determine yeast strain phenotypes pubmed.ncbi.nlm.nih.gov/41282265/ #cryoem
November 25, 2025 at 10:31 AM
How Sup35 monomer conformation and amyloid fibril polymorphism determine yeast strain phenotypes pubmed.ncbi.nlm.nih.gov/41282265/ #cryoem
Assembly, architecture and functional roles of microbial surface layers
Review article published in @natrevmicro.nature.com with @bupbuse.bsky.social, Andriko von Kügelgen and @vikramalva.bsky.social.
S-layers are everywhere!
www.nature.com/articles/s41...
Review article published in @natrevmicro.nature.com with @bupbuse.bsky.social, Andriko von Kügelgen and @vikramalva.bsky.social.
S-layers are everywhere!
www.nature.com/articles/s41...
Assembly, architecture and functional roles of microbial surface layers - Nature Reviews Microbiology
Surface layers (S-layers) are ubiquitous protein assemblies that coat prokaryotic cells, with their functional roles increasingly coming into focus. In this Review, Isbilir and colleagues discuss rece...
www.nature.com
November 14, 2025 at 5:53 PM
Reposted
Structural insights into the atypical filament assembly of pyrin domain-containing IFI16 pubmed.ncbi.nlm.nih.gov/41193640/ #cryoem
November 6, 2025 at 8:43 PM
Structural insights into the atypical filament assembly of pyrin domain-containing IFI16 pubmed.ncbi.nlm.nih.gov/41193640/ #cryoem
Reposted
An Asgard archaeon with internal membrane compartments
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
November 7, 2025 at 10:44 AM
An Asgard archaeon with internal membrane compartments
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
Reposted
Structures of the sheathed flagellum reveal mechanisms of assembly and rotation in Vibrio cholerae pubmed.ncbi.nlm.nih.gov/41174224/ #cryoem
November 2, 2025 at 7:40 PM
Structures of the sheathed flagellum reveal mechanisms of assembly and rotation in Vibrio cholerae pubmed.ncbi.nlm.nih.gov/41174224/ #cryoem
Reposted
We are looking for a computational postdoc to work with us on new optimisation algorithms to make #RELION even better. Join our bubbly team at the @mrclmb.bsky.social in Cambridge, UK. 🤗 RTs appreciated.
mrc.tal.net/vx/appcentre...
mrc.tal.net/vx/appcentre...
Quick Check Needed
mrc.tal.net
October 29, 2025 at 9:17 AM
We are looking for a computational postdoc to work with us on new optimisation algorithms to make #RELION even better. Join our bubbly team at the @mrclmb.bsky.social in Cambridge, UK. 🤗 RTs appreciated.
mrc.tal.net/vx/appcentre...
mrc.tal.net/vx/appcentre...
Reposted
Separation of halide oxidation and substrate halogenation chemistries rationalizes site-selective vanadium dependent haloperoxidase catalysis www.biorxiv.org/content/10.1101/2025.10.24.684477v1 #cryoem
October 26, 2025 at 11:46 AM
Separation of halide oxidation and substrate halogenation chemistries rationalizes site-selective vanadium dependent haloperoxidase catalysis www.biorxiv.org/content/10.1101/2025.10.24.684477v1 #cryoem
Reposted
Impurities in amyloid studies: The power of automated model building within a cautionary tale for structural biologists pubmed.ncbi.nlm.nih.gov/41123416/ #cryoem
October 23, 2025 at 11:06 PM
Impurities in amyloid studies: The power of automated model building within a cautionary tale for structural biologists pubmed.ncbi.nlm.nih.gov/41123416/ #cryoem
Reposted
A nice N&V article by Mike Dyall-Smith on our recent paper
( www.nature.com/articles/s41... ):
www.nature.com/articles/s41...
( www.nature.com/articles/s41... ):
www.nature.com/articles/s41...
Archaeal symbioses all the way down - Nature Microbiology
Ethiopian salt lakes feature unique microbial communities with nesting layers of symbioses, where haloarchaea and their ultra-small archaeal symbionts are prey to viruses, which are in turn hijacked b...
www.nature.com
October 20, 2025 at 11:51 AM
A nice N&V article by Mike Dyall-Smith on our recent paper
( www.nature.com/articles/s41... ):
www.nature.com/articles/s41...
( www.nature.com/articles/s41... ):
www.nature.com/articles/s41...
Reposted
Seed structure and phosphorylation in the fuzzy coat impact tau seeding competency pubmed.ncbi.nlm.nih.gov/41107248/ #cryoem
October 18, 2025 at 3:24 PM
Seed structure and phosphorylation in the fuzzy coat impact tau seeding competency pubmed.ncbi.nlm.nih.gov/41107248/ #cryoem
Reposted
Donor strand complementation and calcium ion coordination drive the chaperone-free polymerization of archaeal cannulae pubmed.ncbi.nlm.nih.gov/41083437/ #cryoem
October 14, 2025 at 12:29 PM
Donor strand complementation and calcium ion coordination drive the chaperone-free polymerization of archaeal cannulae pubmed.ncbi.nlm.nih.gov/41083437/ #cryoem
Cannulae paper published in final form. Thanks to the many collaborators and to the reviewers. @jerryknowsnothing.bsky.social @mikesleutel.bsky.social @vikramalva.bsky.social
rdcu.be/eKVlI
rdcu.be/eKVlI
Client Challenge
rdcu.be
October 14, 2025 at 10:57 AM
Cannulae paper published in final form. Thanks to the many collaborators and to the reviewers. @jerryknowsnothing.bsky.social @mikesleutel.bsky.social @vikramalva.bsky.social
rdcu.be/eKVlI
rdcu.be/eKVlI