Yann Moalic
@drym.bsky.social
Genomicist with a keen interest in hyperthermophilic Archaea
Reposted by Yann Moalic
New preprint from my lab (with Arya Kaul, @fernpizza.bsky.social, and @brinda.eu), in which we explore new genes hitchhiking on the beneficial deletion that fused them together, and find them in the LTEE, M. Tb/bovis, and across the bacterial tree of life
Novel genes arise from genomic deletions across the bacterial tree of life https://www.biorxiv.org/content/10.64898/2026.01.05.697752v1
January 6, 2026 at 4:12 PM
New preprint from my lab (with Arya Kaul, @fernpizza.bsky.social, and @brinda.eu), in which we explore new genes hitchhiking on the beneficial deletion that fused them together, and find them in the LTEE, M. Tb/bovis, and across the bacterial tree of life
Reposted by Yann Moalic
Now published in Nature Biotechnology:
go.nature.com/44P7nSm
If you missed it, the TL;DR is in my April thread below
go.nature.com/44P7nSm
If you missed it, the TL;DR is in my April thread below
January 6, 2026 at 9:38 AM
Now published in Nature Biotechnology:
go.nature.com/44P7nSm
If you missed it, the TL;DR is in my April thread below
go.nature.com/44P7nSm
If you missed it, the TL;DR is in my April thread below
Reposted by Yann Moalic
A cool genetic system to study site-pecific replication fork collapse and repair from the brilliant @winterhalterlab.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Rescuing the bacterial replisome at a nick requires recombinational repair and helicase reloading - Nature Communications
DNA damage can lead to cell death. Here, the authors show that a simple cut on either strand of DNA can inactivate bacterial chromosome replication. Surprisingly, only a core set of recombination prot...
www.nature.com
December 30, 2025 at 10:49 AM
A cool genetic system to study site-pecific replication fork collapse and repair from the brilliant @winterhalterlab.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Yann Moalic
Out today in @cp-cell.bsky.social! We studied how environmental stresses like high-fat diets today can prime tumorigenesis months to years in the future (1/n)
December 22, 2025 at 4:35 PM
Out today in @cp-cell.bsky.social! We studied how environmental stresses like high-fat diets today can prime tumorigenesis months to years in the future (1/n)
Reposted by Yann Moalic
FYI: New online! Detecting transcription factor binding sites with PADIT-seq
Detecting transcription factor binding sites with PADIT-seq
Nature Reviews Genetics, Published online: 01 December 2025; doi:10.1038/s41576-025-00924-0In this Tools of the Trade article, Shubham Khetan presents PADIT-seq (protein affinity to DNA by in vitro transcription and RNA sequencing), which enables the reliable identification of low-affinity DNA binding sites for transcription factors.
www.nature.com
December 22, 2025 at 2:13 PM
FYI: New online! Detecting transcription factor binding sites with PADIT-seq
Reposted by Yann Moalic
1. As we recently joined BlueSky, we want to repost this story for all newcomers!
We sat down with @radler92.bsky.social to get more insight into the unique videos from his recent preprint on Promethearchaeota (formerly Asgard archaea).
doi.org/10.1101/2025...
(Videos and info below)
We sat down with @radler92.bsky.social to get more insight into the unique videos from his recent preprint on Promethearchaeota (formerly Asgard archaea).
doi.org/10.1101/2025...
(Videos and info below)
Dynamic protrusions mediate unique crawling motility in Asgard Archaea (Promethearchaeota)
Crawling motility is a hallmark of eukaryotic cells and requires a dynamic actin cytoskeleton, regulated adhesion, and spatially organized signalling pathways1–3. Asgard archaea (phylum Promethearchae...
doi.org
December 18, 2025 at 2:08 PM
1. As we recently joined BlueSky, we want to repost this story for all newcomers!
We sat down with @radler92.bsky.social to get more insight into the unique videos from his recent preprint on Promethearchaeota (formerly Asgard archaea).
doi.org/10.1101/2025...
(Videos and info below)
We sat down with @radler92.bsky.social to get more insight into the unique videos from his recent preprint on Promethearchaeota (formerly Asgard archaea).
doi.org/10.1101/2025...
(Videos and info below)
Reposted by Yann Moalic
So you think your mammalian plasmids have nothing to fear from cloning and propagation in E.coli?
Quantitative profiling of millions of nucleotides by Tom Copeman will prove you wrong! Supervised with the amazing @proftomellis.bsky.social and AZ, now on BioRxiv:
doi.org/10.64898/202...
Quantitative profiling of millions of nucleotides by Tom Copeman will prove you wrong! Supervised with the amazing @proftomellis.bsky.social and AZ, now on BioRxiv:
doi.org/10.64898/202...
Quantitative profiling of millions of nucleotides reveals sequence-encoded interactions that govern plasmid propagation
Plasmids are central to modern biotechnology, especially therapeutic development, yet their propagation in Escherichia coli remains difficult to predict. Although expression-induced burden is well und...
doi.org
December 17, 2025 at 8:19 AM
So you think your mammalian plasmids have nothing to fear from cloning and propagation in E.coli?
Quantitative profiling of millions of nucleotides by Tom Copeman will prove you wrong! Supervised with the amazing @proftomellis.bsky.social and AZ, now on BioRxiv:
doi.org/10.64898/202...
Quantitative profiling of millions of nucleotides by Tom Copeman will prove you wrong! Supervised with the amazing @proftomellis.bsky.social and AZ, now on BioRxiv:
doi.org/10.64898/202...
Reposted by Yann Moalic
Are you a long-time fan of Archaea, an extremophile-phile, or are you simply curious?
Either way, we have good news.
We’re delighted to announce the 2026 EMBO Workshop on Archaea, 6–10 July.
Sign up: meetings.embo.org/event/26-arc...
We look forward to seeing you in Cambridge, UK.
Please repost!
Either way, we have good news.
We’re delighted to announce the 2026 EMBO Workshop on Archaea, 6–10 July.
Sign up: meetings.embo.org/event/26-arc...
We look forward to seeing you in Cambridge, UK.
Please repost!
Molecular Biology of Archaea: Life Through the Prism of Archaea
In 1977, Woese and colleagues revealed Archaea as a distinct domain of life. Building on this insight, the discovery of Asgard archaea has strengthened the view that many hallmarks of eukaryotic cell…
meetings.embo.org
December 16, 2025 at 12:00 PM
Are you a long-time fan of Archaea, an extremophile-phile, or are you simply curious?
Either way, we have good news.
We’re delighted to announce the 2026 EMBO Workshop on Archaea, 6–10 July.
Sign up: meetings.embo.org/event/26-arc...
We look forward to seeing you in Cambridge, UK.
Please repost!
Either way, we have good news.
We’re delighted to announce the 2026 EMBO Workshop on Archaea, 6–10 July.
Sign up: meetings.embo.org/event/26-arc...
We look forward to seeing you in Cambridge, UK.
Please repost!
Reposted by Yann Moalic
🚨 What if evolution is the ”law”… and networks are the machines that do the work?
In this paper (just published) I try to formalize how living systems are non-equilibrium, information-processing, adaptive matter. With a great biological flavor! 🧪🌐🌍🧬🦠
👉 iopscience.iop.org/article/10.1...
🧵 1/
In this paper (just published) I try to formalize how living systems are non-equilibrium, information-processing, adaptive matter. With a great biological flavor! 🧪🌐🌍🧬🦠
👉 iopscience.iop.org/article/10.1...
🧵 1/
December 16, 2025 at 9:04 AM
🚨 What if evolution is the ”law”… and networks are the machines that do the work?
In this paper (just published) I try to formalize how living systems are non-equilibrium, information-processing, adaptive matter. With a great biological flavor! 🧪🌐🌍🧬🦠
👉 iopscience.iop.org/article/10.1...
🧵 1/
In this paper (just published) I try to formalize how living systems are non-equilibrium, information-processing, adaptive matter. With a great biological flavor! 🧪🌐🌍🧬🦠
👉 iopscience.iop.org/article/10.1...
🧵 1/
Reposted by Yann Moalic
The scikit-bio paper in online in Nature Methods! Many thanks to our collaborators, community contributors and reviewers! We couldn’t have done it without you. www.nature.com/articles/s41... #Bioinformatics #OpenSource
Scikit-bio: a fundamental Python library for biological omic data analysis - Nature Methods
Nature Methods - Scikit-bio: a fundamental Python library for biological omic data analysis
www.nature.com
December 11, 2025 at 5:57 PM
The scikit-bio paper in online in Nature Methods! Many thanks to our collaborators, community contributors and reviewers! We couldn’t have done it without you. www.nature.com/articles/s41... #Bioinformatics #OpenSource
Validate User
academic.oup.com
December 6, 2025 at 12:04 PM
Reposted by Yann Moalic
Now published. Thank you very much to our collaborative team, and very supportive editors and reviewers!!!
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
Versatile NTP recognition and domain fusions expand the functional repertoire of the ParB-CTPase fold beyond chromosome segregation | PNAS
Nucleotide triphosphate (NTP)-dependent molecular switches regulate essential cellular
processes by cycling between active and inactive states thro...
www.pnas.org
December 4, 2025 at 7:23 PM
Now published. Thank you very much to our collaborative team, and very supportive editors and reviewers!!!
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
Our study on ribonucleotides incorporation the genomes of Haloferax volcanii and Thermococcus barophilus is new published in #NAR #ribonucleasesH
academic.oup.com/nar/article/...
academic.oup.com/nar/article/...
Validate User
academic.oup.com
November 22, 2025 at 11:01 AM
Our study on ribonucleotides incorporation the genomes of Haloferax volcanii and Thermococcus barophilus is new published in #NAR #ribonucleasesH
academic.oup.com/nar/article/...
academic.oup.com/nar/article/...
Reposted by Yann Moalic
Nature research paper: Ribonucleotide incorporation into mitochondrial DNA drives inflammation
go.nature.com/3KBRg2W
go.nature.com/3KBRg2W
Ribonucleotide incorporation into mitochondrial DNA drives inflammation - Nature
Imbalanced nucleotide metabolism leads to age- and mtDNA-dependent inflammatory responses and senescence-associated secretory phenotype in senescence.
go.nature.com
September 25, 2025 at 9:13 AM
Nature research paper: Ribonucleotide incorporation into mitochondrial DNA drives inflammation
go.nature.com/3KBRg2W
go.nature.com/3KBRg2W
Reposted by Yann Moalic
A high-resolution genome mapping technique now enables detailed study of transposons, offering new insights into genetic evolution, disease mechanisms, and potential agricultural advancements. doi.org/hbb5vk
Unlocking the genome's hidden half with new DNA sequencing technology
Cornell researchers have found that a new DNA sequencing technology can be used to study how transposons move within and bind to the genome.
phys.org
November 21, 2025 at 6:23 PM
A high-resolution genome mapping technique now enables detailed study of transposons, offering new insights into genetic evolution, disease mechanisms, and potential agricultural advancements. doi.org/hbb5vk
Reposted by Yann Moalic
How do cells activate or silence genes? Read about the #LaskerAward winners who devised ingenious experimental methods, leveraged offbeat model organisms, & capitalized on underappreciated observations to understand how organisms carefully control gene activity.
#LaskerLaureate 🧪
#LaskerLaureate 🧪
How Genes Express Themselves - Lasker Foundation
Robert Roeder was starting to worry in early 1969. A graduate student at the University of Washington, he’d been working long hours in the lab and filling notebook after notebook with data, but he…
ow.ly
November 18, 2025 at 5:17 PM
How do cells activate or silence genes? Read about the #LaskerAward winners who devised ingenious experimental methods, leveraged offbeat model organisms, & capitalized on underappreciated observations to understand how organisms carefully control gene activity.
#LaskerLaureate 🧪
#LaskerLaureate 🧪
Reposted by Yann Moalic
Academia is plagued by not-fit-for-purpose metrics that are then used ranking individuals and institutions
Will we ever move away from these? - there is a lot of talk but not a great deal of action?
The comment ⬇️ is a refreshing look at the problem.
www.nature.com/articles/d41...
Will we ever move away from these? - there is a lot of talk but not a great deal of action?
The comment ⬇️ is a refreshing look at the problem.
www.nature.com/articles/d41...
To reform universities, first tackle global rankings
Universities are in thrall to a rankings system that prioritizes narrow aspects of academic life. Three changes would give institutions the freedom to explore fresh ways of working.
www.nature.com
November 17, 2025 at 10:15 AM
Academia is plagued by not-fit-for-purpose metrics that are then used ranking individuals and institutions
Will we ever move away from these? - there is a lot of talk but not a great deal of action?
The comment ⬇️ is a refreshing look at the problem.
www.nature.com/articles/d41...
Will we ever move away from these? - there is a lot of talk but not a great deal of action?
The comment ⬇️ is a refreshing look at the problem.
www.nature.com/articles/d41...
Ignota Labs
www.ignotalabs.ai
November 11, 2025 at 5:30 PM
The Thermococcales as a model system: historical perspectives and emerging tools | Journal of Bacteriology journals.asm.org/doi/10.1128/...
The Thermococcales as a model system: historical perspectives and emerging tools | Journal of Bacteriology
The exploration of life in extreme environments gained prominence with Thomas Brock’s
“Life at High Temperatures” (1), and his subsequent isolation of Thermus aquaticus with Hudson Freeze in 1969 (2) ...
journals.asm.org
November 5, 2025 at 8:06 PM
The Thermococcales as a model system: historical perspectives and emerging tools | Journal of Bacteriology journals.asm.org/doi/10.1128/...