Yann Moalic
@drym.bsky.social
Genomicist with a keen interest in hyperthermophilic Archaea
Reposted by Yann Moalic
Academia is plagued by not-fit-for-purpose metrics that are then used ranking individuals and institutions
Will we ever move away from these? - there is a lot of talk but not a great deal of action?
The comment ⬇️ is a refreshing look at the problem.
www.nature.com/articles/d41...
Will we ever move away from these? - there is a lot of talk but not a great deal of action?
The comment ⬇️ is a refreshing look at the problem.
www.nature.com/articles/d41...
To reform universities, first tackle global rankings
Universities are in thrall to a rankings system that prioritizes narrow aspects of academic life. Three changes would give institutions the freedom to explore fresh ways of working.
www.nature.com
November 17, 2025 at 10:15 AM
Academia is plagued by not-fit-for-purpose metrics that are then used ranking individuals and institutions
Will we ever move away from these? - there is a lot of talk but not a great deal of action?
The comment ⬇️ is a refreshing look at the problem.
www.nature.com/articles/d41...
Will we ever move away from these? - there is a lot of talk but not a great deal of action?
The comment ⬇️ is a refreshing look at the problem.
www.nature.com/articles/d41...
Ignota Labs
www.ignotalabs.ai
November 11, 2025 at 5:30 PM
The Thermococcales as a model system: historical perspectives and emerging tools | Journal of Bacteriology journals.asm.org/doi/10.1128/...
The Thermococcales as a model system: historical perspectives and emerging tools | Journal of Bacteriology
The exploration of life in extreme environments gained prominence with Thomas Brock’s
“Life at High Temperatures” (1), and his subsequent isolation of Thermus aquaticus with Hudson Freeze in 1969 (2) ...
journals.asm.org
November 5, 2025 at 8:06 PM
The Thermococcales as a model system: historical perspectives and emerging tools | Journal of Bacteriology journals.asm.org/doi/10.1128/...
Methanobrevibacter smithii: Trends in Microbiology www.cell.com/trends/micro...
Methanobrevibacter smithii
Methanobrevibacter smithii is one of the most prevalent and worldwide distributed
archaea in the human gut. M. smithii is a strict anaerobe that obtains its energy
through methanogenesis. In culture, ...
www.cell.com
November 3, 2025 at 9:41 PM
Methanobrevibacter smithii: Trends in Microbiology www.cell.com/trends/micro...
Reposted by Yann Moalic
AI is not just another research tool; it is redefining what research is, how it is done and what counts as an original contribution
go.nature.com/47Uh6sf
go.nature.com/47Uh6sf
PhD training needs a reboot in an AI world
As machines get better at data analysis and writing tasks, doctoral training must evolve to make the most of artificial-intelligence outputs.
go.nature.com
November 3, 2025 at 5:46 PM
AI is not just another research tool; it is redefining what research is, how it is done and what counts as an original contribution
go.nature.com/47Uh6sf
go.nature.com/47Uh6sf
Reposted by Yann Moalic
Artificial intelligence has enabled the complete mapping of Phage G, the largest cultivated bacteriophage, providing a new model for studying megaphages and potential antimicrobial applications. doi.org/g98g28
Phage G genome: AI analysis maps out world's largest cultivated bacteria-killing virus
Through cutting-edge methods and advanced artificial intelligence analysis, UNC Charlotte researchers leading a multidisciplinary team across four universities have successfully resolved the entire genome of "Phage G," the largest bacterial virus (aka bacteriophages or phages) ever cultivated in a physical lab environment.
phys.org
October 29, 2025 at 7:07 PM
Artificial intelligence has enabled the complete mapping of Phage G, the largest cultivated bacteriophage, providing a new model for studying megaphages and potential antimicrobial applications. doi.org/g98g28
Reposted by Yann Moalic
Big pharma seduced by transcription factors again. What has changed? www.nature.com/articles/s41...
Big pharma seduced by transcription factors again. What has changed? - Nature Biotechnology
Long considered undruggable, transcription factors have finally become fair game for a clutch of innovative biotechs who are combining biological insights with innovative chemistry to bring into play ...
www.nature.com
October 29, 2025 at 6:54 PM
Big pharma seduced by transcription factors again. What has changed? www.nature.com/articles/s41...
Reposted by Yann Moalic
Cross-species “xenotransplants”, as the well-worn joke goes, are the future—and always will be. But that punchline is starting to sound out of touch econ.st/4qvPMIf
Illustration: Allie Sullberg
Illustration: Allie Sullberg
October 28, 2025 at 8:30 PM
Cross-species “xenotransplants”, as the well-worn joke goes, are the future—and always will be. But that punchline is starting to sound out of touch econ.st/4qvPMIf
Illustration: Allie Sullberg
Illustration: Allie Sullberg
Reposted by Yann Moalic
One transcript, two functions: the emerging roles of dual-function RNAs
microLIFE review by @lizmarialuke.bsky.social and Kai Papenfort at @uni-jena.de
academic.oup.com/microlife/ad...
microLIFE review by @lizmarialuke.bsky.social and Kai Papenfort at @uni-jena.de
academic.oup.com/microlife/ad...
One transcript, two functions: the emerging roles of dual-function RNAs
Abstract. Bacteria use small regulatory RNAs (sRNAs) and small proteins to change gene expression and modulate cellular processes in response to changing e
academic.oup.com
October 27, 2025 at 6:15 PM
One transcript, two functions: the emerging roles of dual-function RNAs
microLIFE review by @lizmarialuke.bsky.social and Kai Papenfort at @uni-jena.de
academic.oup.com/microlife/ad...
microLIFE review by @lizmarialuke.bsky.social and Kai Papenfort at @uni-jena.de
academic.oup.com/microlife/ad...
Reposted by Yann Moalic
q.e.d Science
Critical Thinking AI for constructive criticism and science evaluation
qedscience.com
October 15, 2025 at 12:22 PM
Reposted by Yann Moalic
Check out our paper on intricate nested interactions between viruses and virus satellites of haloarchaea and their nanosized DPANN symbionts. Excellent collaboration with @deemteam.bsky.social, @anagtz.bsky.social and Michail Yakimov
Free access link: rdcu.be/eLtCH
🧵 by @yifanzhou.bsky.social 👇
Free access link: rdcu.be/eLtCH
🧵 by @yifanzhou.bsky.social 👇
Our work on viruses and virus satellites of haloarchaea and their DPANN symbionts is out today in Nature Microbiology!
@mkrupovic.bsky.social @deemteam.bsky.social @anagtz.bsky.social
www.nature.com/articles/s41...
@mkrupovic.bsky.social @deemteam.bsky.social @anagtz.bsky.social
www.nature.com/articles/s41...
Viruses and virus satellites of haloarchaea and their nanosized DPANN symbionts reveal intricate nested interactions - Nature Microbiology
An exploration of the viromes of haloarchaea and their ultra-small DPANN symbionts reveals plasmid-derived satellites of viruses from both archaeal groups, highlighting the complexity of nested symbio...
www.nature.com
October 17, 2025 at 10:28 AM
Check out our paper on intricate nested interactions between viruses and virus satellites of haloarchaea and their nanosized DPANN symbionts. Excellent collaboration with @deemteam.bsky.social, @anagtz.bsky.social and Michail Yakimov
Free access link: rdcu.be/eLtCH
🧵 by @yifanzhou.bsky.social 👇
Free access link: rdcu.be/eLtCH
🧵 by @yifanzhou.bsky.social 👇
Reposted by Yann Moalic
Controlled environment agriculture enables year-round indoor crop production with higher yields and reduced resource use, offering a resilient supplement to traditional farming amid increasing climate challenges. doi.org/g95j6g
From space science to dinner plates: Reimagining the future of farming indoors
Extreme weather events, from heavy rainfall to heat waves and droughts, are increasingly threatening crop yields globally, so new solutions are needed for agriculture.
phys.org
October 1, 2025 at 6:18 PM
Controlled environment agriculture enables year-round indoor crop production with higher yields and reduced resource use, offering a resilient supplement to traditional farming amid increasing climate challenges. doi.org/g95j6g
Reposted by Yann Moalic
(p)ppGpp-dependent activation of gene expression during nutrient limitation
#mBio from Jonathan Dworkin
journals.asm.org/doi/10.1128/...
#mBio from Jonathan Dworkin
journals.asm.org/doi/10.1128/...
(p)ppGpp-dependent activation of gene expression during nutrient limitation | mBio
Bacteria often experience nutrient limitation and, in response, attenuate energetically costly metabolic processes like protein synthesis. At the same time, however, they stimulate the expression of a subset of proteins that facilitate survival under ...
journals.asm.org
August 19, 2025 at 1:29 PM
(p)ppGpp-dependent activation of gene expression during nutrient limitation
#mBio from Jonathan Dworkin
journals.asm.org/doi/10.1128/...
#mBio from Jonathan Dworkin
journals.asm.org/doi/10.1128/...
Language models reveal a complex sequence basis for adaptive convergent evolution of protein functions | PNAS www.pnas.org/doi/10.1073/...
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
www.pnas.org
September 30, 2025 at 5:40 PM
Language models reveal a complex sequence basis for adaptive convergent evolution of protein functions | PNAS www.pnas.org/doi/10.1073/...
Reposted by Yann Moalic
🥳Excited to share our latest collaborative work using whole-cell models and #AI to design genomes!🦠🧬 What a time to be alive! Project led by Ioana Gherman, with Kieren Sharma, Joshua Rees-Garbutt, Claire Grierson, Lucia Marucci, Wei Pang & Zahraa Abdallah #synbio authors.elsevier.com/sd/article/S...
September 24, 2025 at 5:25 PM
🥳Excited to share our latest collaborative work using whole-cell models and #AI to design genomes!🦠🧬 What a time to be alive! Project led by Ioana Gherman, with Kieren Sharma, Joshua Rees-Garbutt, Claire Grierson, Lucia Marucci, Wei Pang & Zahraa Abdallah #synbio authors.elsevier.com/sd/article/S...
Reposted by Yann Moalic
Phenomenal. In my 10 year update of A Brief History, I make the point that in the first edition, not one disease had been successfully treated using gene therapy. Today that number is at least 7.
September 24, 2025 at 12:23 PM
Phenomenal. In my 10 year update of A Brief History, I make the point that in the first edition, not one disease had been successfully treated using gene therapy. Today that number is at least 7.