Miranda et al. used optogenetics in conjunction with hormone secretion measurements, electrophysiology, and cytoplasmic free Ca2+ concentration imaging to interrogate the relative roles of paracrine and electrical control of β-cells by δ-cells. 🧪
#PancSky
doi.org/10.2337/db25...
#PancSky
doi.org/10.2337/db25...
October 31, 2025 at 6:12 AM
Miranda et al. used optogenetics in conjunction with hormone secretion measurements, electrophysiology, and cytoplasmic free Ca2+ concentration imaging to interrogate the relative roles of paracrine and electrical control of β-cells by δ-cells. 🧪
#PancSky
doi.org/10.2337/db25...
#PancSky
doi.org/10.2337/db25...
Using all-optical “read-write” experiments—two-photon calcium imaging combined with two-photon optogenetics—we recorded and manipulated cortical neurons in mice navigating novel and familiar environments.
October 24, 2025 at 3:40 AM
Using all-optical “read-write” experiments—two-photon calcium imaging combined with two-photon optogenetics—we recorded and manipulated cortical neurons in mice navigating novel and familiar environments.
It was fun writing this essay, about bottom-up neuroscience and how we might simulate entire brains, using data collected via new technologies (expansion microscopy, optogenetics, whole brain voltage imaging, and more), with @kordinglab.bsky.social!
Applying new tools to entire brains, starting with C. elegans, offers the opportunity to uncover how molecules work together to generate neural physiology, and how neurons generate behavior, write @kordinglab.bsky.social and @eboyden3.bsky.social.
#neuroskyence
bit.ly/48EzEO8
#neuroskyence
bit.ly/48EzEO8
Whole-brain, bottom-up neuroscience: The time for it is now
Applying new tools to entire brains, starting with C. elegans, offers the opportunity to uncover how molecules work together to generate neural physiology and how neurons work together to generate…
bit.ly
October 21, 2025 at 12:38 AM
It was fun writing this essay, about bottom-up neuroscience and how we might simulate entire brains, using data collected via new technologies (expansion microscopy, optogenetics, whole brain voltage imaging, and more), with @kordinglab.bsky.social!
Insights from optogenetics in conjunction with hormone secretion measurements, electrophysiology, and cytoplasmic free Ca2+ concentration ([Ca2+]i) imaging to interrogate the relative roles of paracrine and electrical control of β-cells by δ-cells. diabetesjournals.org/diabetes/art...?
δ-Cells Control a Subset of β-Cells in Mouse Pancreatic Islets
Somatostatin is a powerful inhibitor of insulin secretion and β-cell electrical activity, but the effects are weak in intact islets, possibly because of hi
diabetesjournals.org
October 17, 2025 at 10:35 AM
Insights from optogenetics in conjunction with hormone secretion measurements, electrophysiology, and cytoplasmic free Ca2+ concentration ([Ca2+]i) imaging to interrogate the relative roles of paracrine and electrical control of β-cells by δ-cells. diabetesjournals.org/diabetes/art...?
Optogenetics and time-resolved cryo–electron tomography captures hippocampal synaptic vesicle “kiss-shrink-run” exocytosis
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
@science.org
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
@science.org
October 16, 2025 at 8:13 PM
Optogenetics and time-resolved cryo–electron tomography captures hippocampal synaptic vesicle “kiss-shrink-run” exocytosis
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
@science.org
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
@science.org
In 2016, the first Opto GRC was created to bring together scientists pushing the boundaries of optogenetics research 🧠🌟
Join us to celebrate 10 incredible years of collaboration and discovery—applications for #OptoGRC2026 are now open!
Apply now: www.grc.org/optogenetic-...
Join us to celebrate 10 incredible years of collaboration and discovery—applications for #OptoGRC2026 are now open!
Apply now: www.grc.org/optogenetic-...
October 10, 2025 at 7:19 PM
In 2016, the first Opto GRC was created to bring together scientists pushing the boundaries of optogenetics research 🧠🌟
Join us to celebrate 10 incredible years of collaboration and discovery—applications for #OptoGRC2026 are now open!
Apply now: www.grc.org/optogenetic-...
Join us to celebrate 10 incredible years of collaboration and discovery—applications for #OptoGRC2026 are now open!
Apply now: www.grc.org/optogenetic-...
called it
October 9, 2025 at 11:55 AM
called it
Who Will Win the Nobel Prize? Scientists Make Their Predictions
Will this year’s Nobel Prizes go to GLP-1 research, optogenetics, or something else? Researchers picked their favorites to win the prize.
Written byThe Scientist
www.the-scientist.com/who-will-win.... 🧪
Will this year’s Nobel Prizes go to GLP-1 research, optogenetics, or something else? Researchers picked their favorites to win the prize.
Written byThe Scientist
www.the-scientist.com/who-will-win.... 🧪
Who Will Win the Nobel Prize? Scientists Make Their Predictions
Will this year’s Nobel Prizes go to GLP-1 research, optogenetics, or something else? Researchers picked their favorites to win the prize.
www.the-scientist.com
September 30, 2025 at 10:43 PM
Who Will Win the Nobel Prize? Scientists Make Their Predictions
Will this year’s Nobel Prizes go to GLP-1 research, optogenetics, or something else? Researchers picked their favorites to win the prize.
Written byThe Scientist
www.the-scientist.com/who-will-win.... 🧪
Will this year’s Nobel Prizes go to GLP-1 research, optogenetics, or something else? Researchers picked their favorites to win the prize.
Written byThe Scientist
www.the-scientist.com/who-will-win.... 🧪
Very happy for this to finally be published! We developed new machine learning methods for scalable mapping of synaptic connectivity using holographic optogenetics and compressed sensing.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A pair of papers on using holographic optogenetics and compressed sensing for connectomics:
Rapid learning of neural circuitry from holographic ensemble stimulation enabled by model-based compressed sensing
www.nature.com/articles/s41...
Rapid learning of neural circuitry from holographic ensemble stimulation enabled by model-based compressed sensing
www.nature.com/articles/s41...
Rapid learning of neural circuitry from holographic ensemble stimulation enabled by model-based compressed sensing - Nature Neuroscience
The authors develop a new computational system for high-throughput mapping of synaptic connectivity using two-photon holographic optogenetics and intracellular recordings.
www.nature.com
September 29, 2025 at 7:26 PM
Very happy for this to finally be published! We developed new machine learning methods for scalable mapping of synaptic connectivity using holographic optogenetics and compressed sensing.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
We only had a very minor contribution to this story with Alexis, but definitly worth a reading for those interested by patterning, precision and refinment. Nice combining of quantitative live imaging, modeling and optogenetics to dissect vein patterning dynamics
www.cell.com/developmenta...
www.cell.com/developmenta...
Signaling-dependent refinement of cell fate choice during tissue remodeling in Drosophila pupal wings
Herszterg et al. show that during morphogenesis of the Drosophila pupal wing, a wave
of Notch signaling activity updates cell fates to ensure robust and precise patterning
of wing veins.
www.cell.com
September 19, 2025 at 8:35 AM
We only had a very minor contribution to this story with Alexis, but definitly worth a reading for those interested by patterning, precision and refinment. Nice combining of quantitative live imaging, modeling and optogenetics to dissect vein patterning dynamics
www.cell.com/developmenta...
www.cell.com/developmenta...
A pair of papers on using holographic optogenetics and compressed sensing for connectomics:
Rapid learning of neural circuitry from holographic ensemble stimulation enabled by model-based compressed sensing
www.nature.com/articles/s41...
Rapid learning of neural circuitry from holographic ensemble stimulation enabled by model-based compressed sensing
www.nature.com/articles/s41...
Rapid learning of neural circuitry from holographic ensemble stimulation enabled by model-based compressed sensing - Nature Neuroscience
The authors develop a new computational system for high-throughput mapping of synaptic connectivity using two-photon holographic optogenetics and intracellular recordings.
www.nature.com
September 19, 2025 at 4:15 AM
A pair of papers on using holographic optogenetics and compressed sensing for connectomics:
Rapid learning of neural circuitry from holographic ensemble stimulation enabled by model-based compressed sensing
www.nature.com/articles/s41...
Rapid learning of neural circuitry from holographic ensemble stimulation enabled by model-based compressed sensing
www.nature.com/articles/s41...
Very cool study by @oyiz.bsky.social using optogenetics to shed light on how oxytocin signaling regulates vocalization to maintain maternal bonds (with nice write-up by @bellonec.bsky.social, “Cries into ties” indeed) 🧪
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Cries into ties
Oxytocin neurons in mouse pups regulate vocalization to maintain maternal bonds
www.science.org
September 12, 2025 at 2:07 PM
Very cool study by @oyiz.bsky.social using optogenetics to shed light on how oxytocin signaling regulates vocalization to maintain maternal bonds (with nice write-up by @bellonec.bsky.social, “Cries into ties” indeed) 🧪
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
🚨New preprint alert🚨
We used closed-loop optogenetics to causally test the importance of inhibitory spike timing in network function and found that manipulating PV+ cell theta phase locking in the dentate gyrus can shift seizure susceptibility (both ways!)
We used closed-loop optogenetics to causally test the importance of inhibitory spike timing in network function and found that manipulating PV+ cell theta phase locking in the dentate gyrus can shift seizure susceptibility (both ways!)
September 11, 2025 at 5:07 PM
🚨New preprint alert🚨
We used closed-loop optogenetics to causally test the importance of inhibitory spike timing in network function and found that manipulating PV+ cell theta phase locking in the dentate gyrus can shift seizure susceptibility (both ways!)
We used closed-loop optogenetics to causally test the importance of inhibitory spike timing in network function and found that manipulating PV+ cell theta phase locking in the dentate gyrus can shift seizure susceptibility (both ways!)
Woah! RT @virginiahughes #sfn11 stories: rat model of #autism (http://bit.ly/uYeSCA) + optogenetics in monkeys! (http://bit.ly/v1LR3x)
Researchers debut SHANK2 mouse, SHANK3 rat
Mice lacking the autism risk gene SHANK2 show social defi...
bit.ly
December 2, 2024 at 3:32 PM
Woah! RT @virginiahughes #sfn11 stories: rat model of #autism (http://bit.ly/uYeSCA) + optogenetics in monkeys! (http://bit.ly/v1LR3x)
#Throwback to the "Türen auf mit der Maus" event in October 2024. The group of @wachtenlab.bsky.social invited 15 young students and their parents to experience fun #experiments involving light and microscopy #optogenetics💡
Check out the new reel on our Instagram account (Link in bio)!
Check out the new reel on our Instagram account (Link in bio)!
March 6, 2025 at 10:35 AM
#Throwback to the "Türen auf mit der Maus" event in October 2024. The group of @wachtenlab.bsky.social invited 15 young students and their parents to experience fun #experiments involving light and microscopy #optogenetics💡
Check out the new reel on our Instagram account (Link in bio)!
Check out the new reel on our Instagram account (Link in bio)!
Check out our Biohybrid feature in the New Scientist! #Science #BCI #Neuroscience #optogenetics
www.newscientist.com/article/2458...
www.newscientist.com/article/2458...
Implant made with living neurons connects to mouse brains
In a unique demonstration of brain implants that incorporate living cells, the devices were able to connect with the brains of live mice
www.newscientist.com
December 6, 2024 at 5:26 AM
Check out our Biohybrid feature in the New Scientist! #Science #BCI #Neuroscience #optogenetics
www.newscientist.com/article/2458...
www.newscientist.com/article/2458...
Hot off the press from the Tye Lab!! Deciphering memory function with optogenetics. http://europepmc.org/abstract/med/24484707 #EuropePMC
Europe PMC
Europe PMC is an archive of life sciences journal literat...
europepmc.org
December 26, 2024 at 4:21 AM
Hot off the press from the Tye Lab!! Deciphering memory function with optogenetics. http://europepmc.org/abstract/med/24484707 #EuropePMC
Program member Dr Tyler Browne @tjbrowne.bsky.social presenting "Using optogenetics to investigate projection neuron local axon collateral branches within the dorsal horn of the spinal cord" in the Data blitz session at the 4th Optogenetics Australia meeting in Sydney this morning.
February 6, 2025 at 12:08 AM
Program member Dr Tyler Browne @tjbrowne.bsky.social presenting "Using optogenetics to investigate projection neuron local axon collateral branches within the dorsal horn of the spinal cord" in the Data blitz session at the 4th Optogenetics Australia meeting in Sydney this morning.
It is not a matter of replacing FMRI with a better method. We should use each method for what they are good for, in terms of spatial, temporal resolution and applicability to humans or animals (eg focused deep ultrasound and optogenetics).
August 26, 2024 at 12:54 PM
It is not a matter of replacing FMRI with a better method. We should use each method for what they are good for, in terms of spatial, temporal resolution and applicability to humans or animals (eg focused deep ultrasound and optogenetics).
Would you be terribly surprised to learn that this person hangs out in the Jordan Peterson subreddit?
May 16, 2024 at 5:10 PM
Would you be terribly surprised to learn that this person hangs out in the Jordan Peterson subreddit?
Key point: Optogenetics induced excessive neural excitation of the hypothalamus projecting toward the mediodorsal thalamus and prelimbic cortex.
onlinelibrary.wiley.com/doi/full/10....
#epilepsy #ILAE #ablationbasedepilepsysurgery #EEGanalysis #epilepticencephalopathy #epilepticnetwork
onlinelibrary.wiley.com/doi/full/10....
#epilepsy #ILAE #ablationbasedepilepsysurgery #EEGanalysis #epilepticencephalopathy #epilepticnetwork
March 25, 2025 at 5:13 PM
Key point: Optogenetics induced excessive neural excitation of the hypothalamus projecting toward the mediodorsal thalamus and prelimbic cortex.
onlinelibrary.wiley.com/doi/full/10....
#epilepsy #ILAE #ablationbasedepilepsysurgery #EEGanalysis #epilepticencephalopathy #epilepticnetwork
onlinelibrary.wiley.com/doi/full/10....
#epilepsy #ILAE #ablationbasedepilepsysurgery #EEGanalysis #epilepticencephalopathy #epilepticnetwork
Can light precisely control behavior? 🧠✨
With OptoXRs, researchers showed that activating specific intracellular pathways can drive reward-related actions in mice.
🔗 www.nature.com/articles/nat...
📍 www.ebraincase.com/support/lite...
#OptoXRs #Optogenetics #Neurobiology
With OptoXRs, researchers showed that activating specific intracellular pathways can drive reward-related actions in mice.
🔗 www.nature.com/articles/nat...
📍 www.ebraincase.com/support/lite...
#OptoXRs #Optogenetics #Neurobiology
Literature Interpretation | Nature | OptoXRs: Light-controlled tools for cellular signaling and precise regulation mammalian behavior
optoXRs provides a new method with both specificity and temporal precision for investigating the causal role of biochemical signals in mammalian behavior.
www.ebraincase.com
September 3, 2025 at 3:15 AM
Can light precisely control behavior? 🧠✨
With OptoXRs, researchers showed that activating specific intracellular pathways can drive reward-related actions in mice.
🔗 www.nature.com/articles/nat...
📍 www.ebraincase.com/support/lite...
#OptoXRs #Optogenetics #Neurobiology
With OptoXRs, researchers showed that activating specific intracellular pathways can drive reward-related actions in mice.
🔗 www.nature.com/articles/nat...
📍 www.ebraincase.com/support/lite...
#OptoXRs #Optogenetics #Neurobiology
@ikadow.bsky.social rocking the stage with her keynote lecture at the Optogenetics Meeting near Göttingen. Amazing work on dopamine and metabolic states in the fly with state of the art tools.
October 9, 2025 at 7:54 PM
@ikadow.bsky.social rocking the stage with her keynote lecture at the Optogenetics Meeting near Göttingen. Amazing work on dopamine and metabolic states in the fly with state of the art tools.
Optogenetics illuminates the neural circuit regulating swimming behavior in the marine annelid P dumerilii #EuroEvoDevo @matosches
November 21, 2024 at 5:10 PM
Optogenetics illuminates the neural circuit regulating swimming behavior in the marine annelid P dumerilii #EuroEvoDevo @matosches
December 26, 2024 at 7:40 PM