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Brain Case
@braincase.bsky.social
50 followers 50 following 180 posts
Specializes in neuroscience, focusing on virus vector research and translational research.Follow us on www.ebraincase.com
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Brain Case @braincase.bsky.social · Sep 26
🎉 LIVE at CNS 2025 Xi’an!
Visit Booth T9 to play our fun game, win exclusive Brain Case gifts 🐱✨, and grab the 2025 Neuroscience Frontier Handbook!

📅 Sept 25–28 | Xi’an International Convention & Exhibition Center
www.ebraincase.com/news/corpora...

#CNS2025 #CNSXiAn #Neuroscience #BrainScience
braincase.bsky.social
🚀 Gene Delivery Tools for Brain Endothelial Cells 🧠
AAV systems like AAV-BR1, AAV-BI30, and rAAV-miniBEND are transforming gene editing and disease modeling for brain endothelial cells, driving breakthroughs in neurovascular research.
🔗 www.ebraincase.com/support/lite...

#GeneDelivery #AAVVectors
The Most Comprehensive Collection of Gene Delivery Tools for Brain Endothelial Cells
Learn about the AAV-BR1, AAV-BI30, AAV-X1 series, and rAAV-miniBEND systems for gene delivery, editing, and precise disease modeling in neurovascular research. These cutting-edge tools are paving the ...
www.ebraincase.com
February 4, 2026 at 6:26 AM
braincase.bsky.social
🧠🫧 Company article sharing
This study identifies a non-spinal bladder–brain vagal pathway that transmits inflammatory signals and maintains bladder homeostasis, revealed by viral tracing , DREADD-fMRI and Immunohistochemistry.

🔗 www.ebraincase.com/support/cust...

#Neuroscience
#BladderBrainAxis
Literature Insight | Neuroscience Bulletin | Fuqiang Xu, Pengjie Wen, and Jie Wang Reveal a Non-spinal Bladder–Brain Vagal Neural Pathway
This study identifies a non-spinal bladder–brain vagal pathway that transmits inflammatory signals and maintains bladder homeostasis, revealed by viral tracing , DREADD-fMRI and Immunohistochemistry.
www.ebraincase.com
January 30, 2026 at 8:32 AM
braincase.bsky.social
🧬 #AAV vs. #Lentivirus: How do you choose the right #genedelivery vector?

This article shows their key differences, ideal use cases, and examples to help you decide which #vector fits your project best.

🔗 www.ebraincase.com/support/lite...

#GeneDelivery #ViralVectors #GeneTherapy #Neuroscience
AAV vs. Lentivirus: Key Differences and Applications of Two Masterpieces in Gene Delivery
A comprehensive comparison of AAV and lentiviral vectors, covering gene delivery mechanisms, packaging capacity, immunogenicity, and in vivo vs in vitro applications, with case studies from gene thera...
www.ebraincase.com
January 28, 2026 at 9:09 AM
braincase.bsky.social
🧠👃 Customer article sharing | How does the brain respond to the smell of spoiled food?
2-methylbutyric acid (2MBA) activates aPir^Glu neurons, routing signals to:
➡️ MD → retching-like behavior
➡️ NAc → aversion
🔗 www.ebraincase.com/support/cust...

#Neuroscience #Olfaction #NeuralCircuits
Customer Article | Nature Communications | Teams led by Zhi Zhang, Xia Zhu, and Wei Wang at USTC reveal how the nose–brain axis regulates behavioral responses to rancid odors
A Nature Communications study reveals a dual nose–brain axis in mice, showing how spoiled food odors activate distinct neural circuits to drive retching-like behavior and aversion.
www.ebraincase.com
January 20, 2026 at 6:41 AM
braincase.bsky.social
💥Brain Case Biotech – Most Popular Product Series | Episode 1
1️⃣ Red-shifted Ca2+indicator（SomaFRCaMPi&Red-shifted K+ indicator(RGEPO1/2)
2️⃣ GRAB Neurotransmitter Sensors
3️⃣ Ultra-stable Monomeric Red Fluorescent Protein
4️⃣ rAAV-miniBEND System for Brain Vasculature
📍 www.ebraincase.com/news/corpora...
January 16, 2026 at 6:29 AM
braincase.bsky.social
Client Article Sharing | Molecular Psychiatry 🎉✨
Zhejiang University Team Reveals That Gut Microbiota Contribute to the Pathology of Bipolar Depression by Regulating Synaptic Plasticity and Dopamine Transmission in the VTA–mPFC Pathway.
👉 www.ebraincase.com/support/cust...

#BD #Neuroscience
Client Article | Molecular Psychiatry | Zhejiang University Team Reveals That Gut Microbiota Contribute to the Pathology of Bipolar Depression by Regulating Synaptic Plasticity and Dopamine Transmissi...
Gut microbiota from bipolar disorder patients disrupts the VTA–mPFC dopamine pathway, impairing synaptic plasticity and inducing depression-like behaviors.
www.ebraincase.com
January 8, 2026 at 9:10 AM
braincase.bsky.social
🐱✨ Dr. Bu Goodies Showcase | Episode 4

Meet the next little companions in our Dr. Bu themed goodies showcase — the BuBu notebook, fridge magnets, and Lidong keychain 💙💚
www.ebraincase.com

#DrBu
#BuBu
#BrainCaseBiotech
#BrandCulture
#ScienceMascot
#LabLife
#BiotechCommunity
#BuBuShowcase
December 25, 2025 at 8:18 AM
braincase.bsky.social
🐱✨ Dr. Bu Goodies Showcase | Episode 3

Meet the next cozy companions in our Dr. Bu themed goodies showcase — the BuBu mug & glass cup, along with a canvas bag and eye mask 💙💚

www.ebraincase.com

#DrBu
#BuBu
#BrainCaseBiotech
#BrandCulture
#ScienceMascot
#LabLife
#BiotechCommunity
#BuBuShowcase
December 25, 2025 at 8:12 AM
braincase.bsky.social
🐱✨ Dr. Bu Goodies Showcase | Episode 2

Meet the next essentials in our Dr. Bu themed goodies showcase — the BuBu phone stand & stickers, mouse pad, and mini timer 💙💚

BuBu is always by your side in the lab. 🐾
Stay tuned for more Dr. Bu surprises!
www.ebraincase.com

#BrandCulture
#ScienceMascot
December 25, 2025 at 1:07 AM
braincase.bsky.social
🐱✨ Dr. Bu Goodies Showcase | Episode 1
Meet the first stars of our Dr. Bu themed goodies showcase —
the BuBu plush toy and pillow 💙💚

This is just the beginning.🧬
Welcome to BuBu’s world — stay tuned for more Dr. Bu surprises! 🐾
www.ebraincase.com

#BrainCaseBiotech
#BrandCulture
#ScienceMascot
December 23, 2025 at 1:22 AM
braincase.bsky.social
🐱🧬 Meet Dr. Bu!

Say hello to Dr. Bu — the official mascot of Brain Case Biotech 💙💚
Also known as BuBu, I’m your friendly lab cat, born from every case worth exploring.

Cute in the lab, serious about science.🔬✨

Nice to meet you! 🐾
www.ebraincase.com

#BrainCaseBiotech
#mascot
#LabCat
#Neuroscience
December 19, 2025 at 1:22 AM
braincase.bsky.social
🎄2025 Research Impact Snapshot✨
🧬From vector design to in vivo validation, we support neuroscience research across the full early research pipeline.
🔗 www.ebraincase.com

We’re grateful to be part of this journey—and look forward to advancing science together in the year ahead.
#Neuroscience #Virus
December 18, 2025 at 2:11 AM
braincase.bsky.social
🧠Client Article | #Neuron🎉
A new study reveals a tumor–metabolite–neuron axis in pancreatic #cancer. Tumor-derived SAM and METTL14-mediated m⁶A modification drive LPBN neural hyperexcitability and pain–depression comorbidity
🧪 #ViralTools used in this work from us
www.ebraincase.com/support/cust...
Client Article | Neuron | Prof. Jingdun Xie’s Team at Sun Yat-sen University Decodes PDAC Comorbidity: How the Tumor–Metabolism–Neuron Axis Drives Pain and Depression
This study reveals how tumor-derived SAM and METTL14-driven m⁶A modification rewire LPBN neural circuits to drive pain–depression comorbidity in PDAC.
www.ebraincase.com
December 16, 2025 at 3:29 AM
braincase.bsky.social
🎥 New Explainer Video: How to Choose the Right Green Calcium Imaging Tool?
From GCaMP6 to jGCaMP7, jGCaMP8, and the latest soma-targeted RiboL1-jGCaMP8—this video breaks down AP sensitivity, kinetics, brightness, and the best applications for each indicator.
👉 youtu.be/Y2Nu0yJrN0g?...

#Neuroscience
🎥 New Explainer Video: How to Choose the Right Green Calcium Imaging Tool?
YouTube video by Brain Case 布林凯斯
youtu.be
December 12, 2025 at 6:29 AM
braincase.bsky.social
📡🤩Ultimate GCaMP Comparison⚡
GCaMP6 → jGCaMP7 → jGCaMP8 → RiboL1-jGCaMP8
We benchmark sensitivity, kinetics, soma targeting & RO-injection brightness to identify the best GECIs for each experimental need.
www.ebraincase.com/support/lite...

#GCaMP #GECI #Neuroscience #CalciumImaging #NeuralActivity
How to Choose the Right Green Calcium Imaging Tool? From GCaMP6 to jGCaMP8 — This Guide Explains Everything You Need!
A complete guide comparing GCaMP6, jGCaMP7, jGCaMP8 and RiboL1-jGCaMP8, covering sensitivity, kinetics, soma targeting and RO-injection brightness performance.
www.ebraincase.com
December 11, 2025 at 7:26 AM
braincase.bsky.social
Tissue clearing unlocks organ-scale, single-cell 3D imaging without sectioning. Learn key clearing methods and applications in neural and immune circuit mapping. Brain Case Biotech provides reliable, end-to-end clearing services. 👉 www.ebraincase.com/support/lite...

#Neuroscience #TissueClearing
In-Depth Interpretation | Tissue Clearing Technologies: A 3D Imaging Tool for Neuroscience
Learn how hydrophobic, hydrophilic, and hydrogel-based tissue clearing enable organ-scale 3D imaging, transforming neural circuit mapping and disease research.
www.ebraincase.com
December 9, 2025 at 2:18 AM
braincase.bsky.social
✨AAV Critical Quality Attributes (CQAs) Explained🤩
AAV quality drives gene therapy safety & efficacy. This review breaks down the 5 key CQAs—identity, titer & potency, purity, impurities, and safety.

Read More👉: www.ebraincase.com/support/lite...

#GeneTherapy #AAV #Biotech #ViralVector #CQA
In-Depth Analysis of Critical Quality Attributes (CQAs) for AAV
Explore the critical quality attributes (CQA) of AAV vectors, including identity, potency, purity, impurities, and safety, for safe and effective gene therapy.
www.ebraincase.com
December 5, 2025 at 8:38 AM
braincase.bsky.social
Red–green lactate sensors (R-iLACCO1.2 + eLACCO2.1) enable real-time, no-blind-spot imaging of intracellular production, organelle shuttling,and extracellular release.A powerful tool for studying neuroenergetics, ANLS, and tumor metabolism
👉 www.ebraincase.com/support/lite...

#Neuroscience #sensor
Literature Interpretation | “Red–Green Sensors” Enable Seamless, Full-Spectrum Visualization of L-Lactate Metabolic Dynamics
A breakthrough red–green dual-sensor system enables high-resolution, minimally invasive in vivo imaging of L-lactate dynamics in awake mice, revealing metabolic–neuronal coupling.
www.ebraincase.com
December 3, 2025 at 2:04 AM
braincase.bsky.social
⚡Literature Review | Breakthrough! R-eLACCO2.1 enables awake-mouse cortical imaging, capturing extracellular L-lactate dynamics and neuronal activity simultaneously.

🔗 Original: www.nature.com/articles/s41...
👉 Insights: www.ebraincase.com/support/lite...

#ReLACCO #LactateSensor #LactateImaging
A red fluorescent genetically encoded biosensor for in vivo imaging of extracellular l-lactate dynamics - Nature Communications
l-lactate is a key metabolite supporting neuronal activity, but methods to monitor l-lactate dynamics alongside neuronal activity in vivo have been limited. Here, authors report R-eLACCO2.1, a red flu...
www.nature.com
December 1, 2025 at 7:01 AM
braincase.bsky.social
🧬Customer Research !
How do rodents choose their insect prey? A new study reveals that linoleic acid (LA) attracts mice while (Z)-9-tricosene triggers avoidance, regulated by the VTA–mOT dopaminergic pathway. D1 neurons drive attraction, and D2 mediate aversion
🔗 www.ebraincase.com/support/cust...
Customer Research Highlight | PNAS | Yunfeng Zhang, Yiqun Yu, and Minghong Ma Teams Reveal How the VTA–mOT Dopaminergic Pathway Regulates Odor-Guided Insect Predation in Mice
A PNAS study reveals how linoleic acid and (Z)-9-tricosene, detected via the main olfactory system, interact with the VTA–mOT dopaminergic pathway to regulate rodent insect predation.
www.ebraincase.com
November 28, 2025 at 1:39 AM
braincase.bsky.social
🧬 AAV not expressing?
🔍 Weak fluorescence?
Here’s your step-by-step guide to fixing the most common AAV pitfalls—from titer and serotype to detection and sample processing.
www.ebraincase.com/support/lite...

#AAV #AAVVector #ViralVectors #GeneDelivery #GeneExpression #NeuroscienceResearch
Cracking the AAV Expression Problem: No Signal? Weak Fluorescence? Here’s Your Step-by-Step Fix from Virus to Detection
Learn how to solve AAV expression loss and weak fluorescence with step-by-step optimization of vector design, viral titer, injection dose, timing, detection, and sample processing.
www.ebraincase.com
November 25, 2025 at 8:23 AM
braincase.bsky.social
🧠Year-End Research Sale 2025 is live | Nov 24–Dec 7
🧬 AAV In-Stock:
1→20% OFF
3→30% OFF
5→40% OFF
🧪Combo Pack $589: 6×20 µL viral vectors (1 new)
🎁Mystery Box $199
🧫Neurotropic Virus Series: 20% OFF
🔬Custom Packaging: Up to 40% OFF
View full promo list & details www.ebraincase.com/news/corpora...
🧠 Year-End Research Sale 2025 : A Unified Thanksgiving–Black Friday–Cyber Monday Promotion✨
Holiday research sale featuring AAVs, PRV/HSV/RV/VSV tools, combo packs, mystery boxes, and custom virus packaging discounts. Nov 24–Dec 7.
www.ebraincase.com
November 24, 2025 at 2:06 AM
braincase.bsky.social
🧠 ear-End Research Sale 2025 is live|Nov 24–Dec 7
🧬AAV In-Stock: 1→20% OFF
3 →30% OFF
5 →40% OFF
🧪Combo Pack $589: 6×20 µL viral vectors (1 new)
🎁Mystery Box $199
🧫Neurotropic Virus Series: 20% OFF
🔬Custom Packaging: Up to 40% OFF
View full promo list & details: www.ebraincase.com/news/corpora...
🧠 Year-End Research Sale 2025 : A Unified Thanksgiving–Black Friday–Cyber Monday Promotion✨
Holiday research sale featuring AAVs, PRV/HSV/RV/VSV tools, combo packs, mystery boxes, and custom virus packaging discounts. Nov 24–Dec 7.
www.ebraincase.com
November 24, 2025 at 2:04 AM
braincase.bsky.social
🧬Tongji University developed thoracic spinal cord organoids (enTsOrg) using iPSCs, LDH, and Matrigel, enabling motor function recovery in an SCI mouse model. Brain Case Biotech is honored to have provided the viral vector tools.
www.ebraincase.com/support/cust...
#Neuroscience #Organoids #BrainCase
November 20, 2025 at 8:32 AM
braincase.bsky.social
🧬 Literature Highlight
eLACCO2.1 and R-iLACCO enable high-sensitivity, dual-color monitoring of extracellular and intracellular L-lactate in neurons, astrocytes, glioblastoma, and live mice—advancing neural and tumor metabolism research.

🔗👉 www.ebraincase.com/support/lite...

#Neuroscience #Lactate
Literature Highlight | “Red–Green Sensors” Enable Full-Field, Dynamic Visualization of L-Lactate Metabolism
These probes enable spectrally and spatially multiplexed imaging of extracellular and intracellular L-lactate in cultured cells (e.g., HeLa cells, neurons), brain slices, and live mice.
www.ebraincase.com
November 17, 2025 at 7:11 AM