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Epilepsia Journal
@epilepsiajournal.bsky.social
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Epilepsia® – A Journal of the ILAE
Epilepsia® is the world's leading journal of original scientific research and commentary in epileptology. Impact Factor: 6.6. Epilepsia® publishes original articles on all aspects of epilepsy, clinical and experimental. T
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epilepsiajournal.bsky.social
New in Epilepsia – November 8, 2025
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#epilepsy #epilepsia #ILAE #EpilepsyResearch #NewInEpilepsy #JustPublished #LatestResearch
November 10, 2025 at 3:50 PM
epilepsiajournal.bsky.social
We evaluated the efficacy and safety of adjunctive cenobamate (100, 200, and 400 mg/day) in Asian patients with uncontrolled focal seizures.
doi.org/10.1111/epi....
#epilepsy #ILAE #epilepsia #antiseizuremedication #focalepilepsy #phase3 #refractory
A randomized, double‐blind, placebo‐controlled, multicenter study to evaluate the efficacy and safety of adjunctive cenobamate in Asian patients with focal seizures
A randomized, double-blind, placebo-controlled, multicenter study to evaluate the efficacy and safety of adjunctive cenobamate in Asian patients with focal seizures.
doi.org
November 10, 2025 at 3:48 PM
epilepsiajournal.bsky.social
Pilocarpine-induced SE elevates the respiratory rate and ventilation.
doi.org/10.1111/epi....
#epilepsy #ILAE #epilepsia #apnea #cholinergicactivation #EEG #plethysmography #seizureinducedmortality
November 7, 2025 at 3:30 PM
epilepsiajournal.bsky.social
Absence seizures in monogenic epilepsies often show early onset, atypical features, drug-resistance, and poor developmental outcomes.
doi.org/10.1111/epi....

#epilepsy #ILAE #epilepsia #atypicalabsence #epilepsyclassification #monogenic #neurodevelopment #nextgenerationsequencing
November 7, 2025 at 3:29 PM
epilepsiajournal.bsky.social
The effects of astrocyte Gq-coupled Designer Receptors Exclusively Activated by Designer Drugs modulation were investigated in a mouse model of temporal lobe epilepsy.
doi.org/10.1111/epi....

#epilepsy #ILAE #epilepsia #astrocytes #chemogeneticmodulation #DREADDs #metabolomics #temporallobe
November 7, 2025 at 3:28 PM
epilepsiajournal.bsky.social
De novo missense variants in BAIAP2 identified in six patients with severe DEEs, featuring refractory epilepsy, developmental delays, and intellectual disability.
doi.org/10.1111/epi....

#epilepsy #ILAE #epilepsia #BAIAP2 #IRSp53 #DEE #intellectualdisability #wholeexomesequencing
November 6, 2025 at 5:08 PM
epilepsiajournal.bsky.social
Cluster analysis reveals distinct profiles based on age at onset, symptoms, cognitive level, presence of developmental and epileptic encephalopathy, disease mechanism, and treatment response.
doi.org/10.1111/epi....

#epilepsy #ILAE #epilepsia #geneticepilepsy #pediatric #pediatricmovementdisorders
November 6, 2025 at 5:07 PM
epilepsiajournal.bsky.social
AI models integrating magnetic resonance imaging, clinical, and antiseizure medication (ASM) data predicted seizure freedom in newly diagnosed epilepsy.
doi.org/10.1111/epi....

#epilepsy #ILAE #epilepsia #antiseizuremedication #artificialintelligence #brainMRI #epilepsyimaging #machinelearning #AI
November 5, 2025 at 2:55 PM
epilepsiajournal.bsky.social
We developed and validated three natural language processing (NLP) methods to identify patients with epilepsy from clinical notes.
doi.org/10.1111/epi....

#epilepsy #ILAE #epilepsia #Automatedphenotyping #electronichealthrecord #naturallanguageprocessing #NLP #Pretrainedlanguagemodel
November 5, 2025 at 2:54 PM
epilepsiajournal.bsky.social
The main goal of treatment in developmental and epileptic encephalopathy with spike–wave activation in sleep (D)EE-SWAS is to prevent or minimize cognitive impairment.
doi.org/10.1111/epi....

#epilepsy #ILAE #epilepsia #DEESWAS #clobazam #cognition #corticosteroid #ESES
November 4, 2025 at 5:51 PM
epilepsiajournal.bsky.social
Letter to the Editor

Building bridges: One man's mission to bring hope to life with epilepsy
doi.org/10.1111/epi....

#epilepsy #ILAE #Epilepsia #communityengagementspecialist #qualityimprovement #epilepsymonitoringunit
Building bridges: One man's mission to bring hope to life with epilepsy
Click on the article title to read more.
doi.org
November 4, 2025 at 5:51 PM
epilepsiajournal.bsky.social
New in Epilepsia Open – November 1, 2025
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#epilepsy #epilepsiaopen #ILAE #EpilepsyResearch #NewInEpilepsy #JustPublished #LatestResearch
November 3, 2025 at 7:31 PM
epilepsiajournal.bsky.social
Bexicaserin, a highly selective 5HT2C receptor superagonist, is an investigational molecule in clinical development that has progressed to phase 3 for the treatment of seizures associated with DEEs.
doi.org/10.1111/epi....
#epilepsy #ILAE #Epilepsia #bexicaserin #DEE #seizures #serotonin
November 3, 2025 at 7:30 PM
epilepsiajournal.bsky.social
7T magnetic resonance imaging (MRI) detected epileptogenic lesions in 15% of 3T MRI-negative patients with drug-resistant epilepsy.
doi.org/10.1111/epi....

#Epilepsy #ILAE #epilepsia #7T #epilepsysurgery #epileptogeniclesion #UHFMRI
October 28, 2025 at 5:43 PM
epilepsiajournal.bsky.social
We utilized open-source tools to analyze interictal biomarkers: high-frequency oscillations and phase–amplitude coupling.
doi.org/10.1111/epi....

#Epilepsy #ILAE #epilepsia #drugresistantepilepsy #intracranialEEG #modulationindex #neuromodulation
October 28, 2025 at 5:42 PM
epilepsiajournal.bsky.social
New in Epilepsia – October 25, 2025
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#epilepsy #epilepsia #ILAE #EpilepsyResearch #NewInEpilepsy #JustPublished #LatestResearch
October 27, 2025 at 7:35 PM
epilepsiajournal.bsky.social
This scoping review systematically discusses these etiologies and their interactions, guided by a bibliometric analysis using VOSviewer software.
doi.org/10.1111/epi....

#Epilepsy #ILAE #epilepsia #causality #mesialtemporalsclerosis #systematicreview #temporallobeepilepsy
October 27, 2025 at 7:34 PM
epilepsiajournal.bsky.social
We highlight the dual imperative of driving forward innovations in neurotechnologies while prioritizing patient safety.
doi.org/10.1111/epi.... Open Access

#epilepsy #ilae #epilepsia #normalizationofdeviance #neuromodulation #drugresistantepilepsy #safety #ethics
October 23, 2025 at 2:26 PM
epilepsiajournal.bsky.social
We conducted a translation and back-translation methodology to obtain a Spanish version of the Epilepsy Surgery Satisfaction Questionnaire-19 (ESP-ESSQ_19).
doi.org/10.1111/epi....

#epilepsy #ilae #epilepsia #drugresistantepilepsy #epilepsysurgery #patientsatisfaction #qualityoflife
October 23, 2025 at 2:26 PM
epilepsiajournal.bsky.social
In 325 patients with autism spectrum disorder (ASD) and epilepsy, the proportion of seizure freedom after resection and neuromodulation were 54% and 33.5%, respectively.
doi.org/10.1111/epi....

#epilepsy #ilae #epilepsia #autism #corpuscallosotomy #LITT #neuromodulation #resectivesurgery #VNS
October 22, 2025 at 7:21 PM
epilepsiajournal.bsky.social
In general, local GMV differences were positively associated with epileptogenic zone (EZ) contacts in the whole cohort and MRI-positive patients, but not in MRI-negative patients.
doi.org/10.1111/epi....

#epilepsy #ilae #epilepsia #biomarker #graymattervolume #MRI #stereoEEG #voxelbasedmorphometry
October 22, 2025 at 7:20 PM
epilepsiajournal.bsky.social
NP-NPY was able to increase resistance against induced seizures in two models of SCN1A-derived epilepsy.
doi.org/10.1111/epi....

#epilepsy #ilae #epilepsia #Dravetsyndrome #nanoparticle #neuropeptideY #SCN1A
October 21, 2025 at 4:31 PM
epilepsiajournal.bsky.social
Classifying by ILAE syndrome and etiology helps predict long-term outcomes in childhood onset epilepsy.
doi.org/10.1111/epi....

#epilepsy #ILAE #epilepsia #childhoodepilepsy #clinicallyvalidatedepilepsy #NorwegianCohortStudy #seizurefreedom
October 21, 2025 at 4:30 PM
epilepsiajournal.bsky.social
New in Epilepsia – October 18, 2025
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#epilepsy #epilepsia #ILAE #EpilepsyResearch #NewInEpilepsy #JustPublished #LatestResearch
October 20, 2025 at 6:23 PM
epilepsiajournal.bsky.social
We show that a minimally invasive unilateral subcutaneous 24/7 EEG device can reliably detect convulsive and most (90%) absence seizures in patients with difficult idiopathic generalized #epilepsy.
doi.org/10.1111/epi....

#ILAE #epilepsia #drugrefractoryIGE #subcutaneousEEG #videoEEGmonitoring
October 20, 2025 at 6:22 PM