Lightnews — Scholar-powered news

Epilepsia Journal

@epilepsiajournal.bsky.social

New in Epilepsia – November 15, 2025
mailchi.mp/ilae/new-art...

Subscribe - eepurl.com/iLSrNc

#epilepsy #epilepsia #ILAE #EpilepsyResearch #NewInEpilepsy #JustPublished #LatestResearch

November 17, 2025 at 4:25 PM

Epilepsia Journal

@epilepsiajournal.bsky.social

Treating epilepsy with ASMs is thus akin to playing chess—a game in which strategic decisions must be made at each point in time and constantly reevaluated to beat the opponent.
doi.org/10.1111/epi....

#epilepsy #ILAE #epilepsia #antiseizuremedications #chessboardgame #strategicdecisions

November 17, 2025 at 4:24 PM

Epilepsia Journal

@epilepsiajournal.bsky.social

We observed an increased PVS volume fraction in the basal ganglia across all epilepsy types considered.
doi.org/10.1111/epi....

#epilepsy #ILAE #epilepsia #glymphaticsystem #MRI #perivascularspaces

November 13, 2025 at 6:55 PM

Epilepsia Journal

@epilepsiajournal.bsky.social

Lennox–Gastaut syndrome (LGS) management requires regular assessments and multidisciplinary care.
doi.org/10.1111/epi....

#epilepsy #ILAE #epilepsia #LennoxGastaut #multidisciplinarycare #patientadvocacy

November 13, 2025 at 6:53 PM

Epilepsia Journal

@epilepsiajournal.bsky.social

Letter to the Editor

Electroencephalographic signal dimension provides the necessary stability of measurements for the unbiased evaluation of ASMs, unlike seizure frequency: Overcoming drawbacks of seizure occurrence variability
doi.org/10.1111/epi....

#epilepsy #ILAE #epilepsia #seizure

November 12, 2025 at 4:02 PM

Epilepsia Journal

@epilepsiajournal.bsky.social

DRPLA patients with epilepsy have earlier onset and longer CAG repeats than those without epilepsy.
onlinelibrary.wiley.com/doi/10.1111/...

#epilepsy #ILAE #epilepsia #antiseizuremedication #dentatorubralpallidoluysianatrophy #progressivemyoclonicepilepsy #trinucleotiderepeatdisorders

Epilepsy in dentatorubral–pallidoluysian atrophy: A systematic review and meta‐analysis

Summary of key clinical and electrophysiological characteristics of DRPLA-related epilepsy from a systematic review and meta-analysis of 1,191 patients. DRPLA patients with epilepsy showed earlier di...

onlinelibrary.wiley.com

November 12, 2025 at 3:59 PM

Epilepsia Journal

@epilepsiajournal.bsky.social

Five de novo heterozygous SRCAP variants are identified in five patients with DEE, and six biallelic variants are identified in six patients with focal epilepsy.
doi.org/10.1111/epi....

#epilepsy #ILAE #epilepsia #SRCAP #denovovariants #DEE #geneticdependentquantity #genotypephenotypecorrelations

November 11, 2025 at 3:48 PM

Epilepsia Journal

@epilepsiajournal.bsky.social

LOF Slc35a2 in oligodendrocytes results in severe hypomyelination, a reduction of oligodendrocytes, and reactive gliosis.
doi.org/10.1111/epi....

#epilepsy #ILAE #epilepsia #hypomyelination #malformations #corticaldevelopment #MOGHE #Slc35a2

November 11, 2025 at 3:47 PM

Epilepsia Journal

@epilepsiajournal.bsky.social

New in Epilepsia – November 8, 2025
mailchi.mp/ilae/new-art...

Subscribe - eepurl.com/iLSrNc

#epilepsy #epilepsia #ILAE #EpilepsyResearch #NewInEpilepsy #JustPublished #LatestResearch

November 10, 2025 at 3:50 PM

Epilepsia Journal

@epilepsiajournal.bsky.social

We evaluated the efficacy and safety of adjunctive cenobamate (100, 200, and 400 mg/day) in Asian patients with uncontrolled focal seizures.
doi.org/10.1111/epi....
#epilepsy #ILAE #epilepsia #antiseizuremedication #focalepilepsy #phase3 #refractory

A randomized, double‐blind, placebo‐controlled, multicenter study to evaluate the efficacy and safety of adjunctive cenobamate in Asian patients with focal seizures

A randomized, double-blind, placebo-controlled, multicenter study to evaluate the efficacy and safety of adjunctive cenobamate in Asian patients with focal seizures.

doi.org

November 10, 2025 at 3:48 PM

Epilepsia Journal

@epilepsiajournal.bsky.social

Pilocarpine-induced SE elevates the respiratory rate and ventilation.
doi.org/10.1111/epi....
#epilepsy #ILAE #epilepsia #apnea #cholinergicactivation #EEG #plethysmography #seizureinducedmortality

November 7, 2025 at 3:30 PM

Epilepsia Journal

@epilepsiajournal.bsky.social

Absence seizures in monogenic epilepsies often show early onset, atypical features, drug-resistance, and poor developmental outcomes.
doi.org/10.1111/epi....

#epilepsy #ILAE #epilepsia #atypicalabsence #epilepsyclassification #monogenic #neurodevelopment #nextgenerationsequencing

November 7, 2025 at 3:29 PM

Epilepsia Journal

@epilepsiajournal.bsky.social

The effects of astrocyte Gq-coupled Designer Receptors Exclusively Activated by Designer Drugs modulation were investigated in a mouse model of temporal lobe epilepsy.
doi.org/10.1111/epi....

#epilepsy #ILAE #epilepsia #astrocytes #chemogeneticmodulation #DREADDs #metabolomics #temporallobe

November 7, 2025 at 3:28 PM

Epilepsia Journal

@epilepsiajournal.bsky.social

De novo missense variants in BAIAP2 identified in six patients with severe DEEs, featuring refractory epilepsy, developmental delays, and intellectual disability.
doi.org/10.1111/epi....

#epilepsy #ILAE #epilepsia #BAIAP2 #IRSp53 #DEE #intellectualdisability #wholeexomesequencing

November 6, 2025 at 5:08 PM

Epilepsia Journal

@epilepsiajournal.bsky.social

Cluster analysis reveals distinct profiles based on age at onset, symptoms, cognitive level, presence of developmental and epileptic encephalopathy, disease mechanism, and treatment response.
doi.org/10.1111/epi....

#epilepsy #ILAE #epilepsia #geneticepilepsy #pediatric #pediatricmovementdisorders

November 6, 2025 at 5:07 PM

Epilepsia Journal

@epilepsiajournal.bsky.social

AI models integrating magnetic resonance imaging, clinical, and antiseizure medication (ASM) data predicted seizure freedom in newly diagnosed epilepsy.
doi.org/10.1111/epi....

#epilepsy #ILAE #epilepsia #antiseizuremedication #artificialintelligence #brainMRI #epilepsyimaging #machinelearning #AI

November 5, 2025 at 2:55 PM

Epilepsia Journal

@epilepsiajournal.bsky.social

We developed and validated three natural language processing (NLP) methods to identify patients with epilepsy from clinical notes.
doi.org/10.1111/epi....

#epilepsy #ILAE #epilepsia #Automatedphenotyping #electronichealthrecord #naturallanguageprocessing #NLP #Pretrainedlanguagemodel

November 5, 2025 at 2:54 PM

Epilepsia Journal

@epilepsiajournal.bsky.social

The main goal of treatment in developmental and epileptic encephalopathy with spike–wave activation in sleep (D)EE-SWAS is to prevent or minimize cognitive impairment.
doi.org/10.1111/epi....

#epilepsy #ILAE #epilepsia #DEESWAS #clobazam #cognition #corticosteroid #ESES

November 4, 2025 at 5:51 PM

Epilepsia Journal

@epilepsiajournal.bsky.social

Letter to the Editor

Building bridges: One man's mission to bring hope to life with epilepsy
doi.org/10.1111/epi....

#epilepsy #ILAE #Epilepsia #communityengagementspecialist #qualityimprovement #epilepsymonitoringunit

Building bridges: One man's mission to bring hope to life with epilepsy

Click on the article title to read more.

doi.org

November 4, 2025 at 5:51 PM

Epilepsia Journal

@epilepsiajournal.bsky.social

New in Epilepsia Open – November 1, 2025
mailchi.mp/ilae/new-art...

Subscribe - eepurl.com/iLSrNc

#epilepsy #epilepsiaopen #ILAE #EpilepsyResearch #NewInEpilepsy #JustPublished #LatestResearch

November 3, 2025 at 7:31 PM

Epilepsia Journal

@epilepsiajournal.bsky.social

Bexicaserin, a highly selective 5HT2C receptor superagonist, is an investigational molecule in clinical development that has progressed to phase 3 for the treatment of seizures associated with DEEs.
doi.org/10.1111/epi....
#epilepsy #ILAE #Epilepsia #bexicaserin #DEE #seizures #serotonin

November 3, 2025 at 7:30 PM

Epilepsia Journal

@epilepsiajournal.bsky.social

7T magnetic resonance imaging (MRI) detected epileptogenic lesions in 15% of 3T MRI-negative patients with drug-resistant epilepsy.
doi.org/10.1111/epi....

#Epilepsy #ILAE #epilepsia #7T #epilepsysurgery #epileptogeniclesion #UHFMRI