Completely chuffed about the idea of Crispr/Cas therapeutics.
February 18, 2026 at 3:31 PM
Completely chuffed about the idea of Crispr/Cas therapeutics.
Die CRISPR/Cas-Genschere
Die Grundlagen wurden 2012 von Emmanuelle Charpentier und Jennifer Doudna entwickelt,
Die Grundlagen wurden 2012 von Emmanuelle Charpentier und Jennifer Doudna entwickelt,
February 13, 2026 at 8:40 PM
Die CRISPR/Cas-Genschere
Die Grundlagen wurden 2012 von Emmanuelle Charpentier und Jennifer Doudna entwickelt,
Die Grundlagen wurden 2012 von Emmanuelle Charpentier und Jennifer Doudna entwickelt,
We call this mechanism "coercive assimilation," where plasmids create a selective pressure that penalizes immune systems like CRISPR-Cas and Restriction-Modification. (2/)
February 12, 2026 at 12:42 AM
We call this mechanism "coercive assimilation," where plasmids create a selective pressure that penalizes immune systems like CRISPR-Cas and Restriction-Modification. (2/)
Comparison of CRISPR-Cas-based knockdown of endogenous mRNA in sensory neurons https://www.biorxiv.org/content/10.64898/2026.02.06.704510v1
February 9, 2026 at 8:30 AM
Comparison of CRISPR-Cas-based knockdown of endogenous mRNA in sensory neurons https://www.biorxiv.org/content/10.64898/2026.02.06.704510v1
'The widespread prokaryotic immune systems, in particular restriction–modification, CRISPR–Cas and defensive toxin–antitoxin systems, are absent in eukaryotes, whereas relatively rare ones, such as Argonautes and antiviral STAND NTPases, became central to eukaryotic innate immunity'
The paradox of immune systems conservation between prokaryotes and eukaryotes - Nature Reviews Microbiology
The widespread prokaryotic immune systems, in particular restriction–modification, CRISPR–Cas and defensive toxin–antitoxin systems, are absent in eukaryotes, whereas relatively rare ones, such as Arg...
www.nature.com
February 8, 2026 at 10:22 AM
'The widespread prokaryotic immune systems, in particular restriction–modification, CRISPR–Cas and defensive toxin–antitoxin systems, are absent in eukaryotes, whereas relatively rare ones, such as Argonautes and antiviral STAND NTPases, became central to eukaryotic innate immunity'
Research Briefing: Reprogramming CRISPR–Cas enzymes for customized genome editing www.nature.com/articles/s41...
rdcu.be/e2nvh
rdcu.be/e2nvh
Reprogramming CRISPR–Cas enzymes for customized genome editing - Nature Biotechnology
We developed Protein2PAM, an evolution-informed protein language model that predicts protospacer-adjacent motif (PAM) specificity of CRISPR–Cas enzymes. Using in silico mutagenesis and model-guided ev...
www.nature.com
February 4, 2026 at 9:38 PM
Research Briefing: Reprogramming CRISPR–Cas enzymes for customized genome editing www.nature.com/articles/s41...
rdcu.be/e2nvh
rdcu.be/e2nvh
Customizing CRISPR–Cas PAM specificity with protein language models - @thisismadani.bsky.social go.nature.com/4a4G9Zy
Customizing CRISPR–Cas PAM specificity with protein language models - Nature Biotechnology
The protospacer-adjacent motif specificity of several Cas enzymes is customized using protein language models.
go.nature.com
February 2, 2026 at 4:07 PM
Customizing CRISPR–Cas PAM specificity with protein language models - @thisismadani.bsky.social go.nature.com/4a4G9Zy
Customizing CRISPR–Cas PAM specificity with protein language models
Paper: www.nature.com/articles/s41... (free: rdcu.be/e1YwG)
Code: github.com/Profluent-AI...
Web: protein2pam.profluent.bio
Paper: www.nature.com/articles/s41... (free: rdcu.be/e1YwG)
Code: github.com/Profluent-AI...
Web: protein2pam.profluent.bio
February 2, 2026 at 7:14 PM
Customizing CRISPR–Cas PAM specificity with protein language models
Paper: www.nature.com/articles/s41... (free: rdcu.be/e1YwG)
Code: github.com/Profluent-AI...
Web: protein2pam.profluent.bio
Paper: www.nature.com/articles/s41... (free: rdcu.be/e1YwG)
Code: github.com/Profluent-AI...
Web: protein2pam.profluent.bio
😮Impresionante: en una prueba de concepto en células in vitro removieron el cromosoma extra que causa el síndrome de Down con la tecnología CRISPR-CAS-9. Por supuesto, falta mucho para su aplicación en humanos, pero el ensayo abre un camino para tratar desórdenes genéticos👇
x.com/Rainmaker197...
x.com/Rainmaker197...
x.com
January 29, 2026 at 9:03 PM
😮Impresionante: en una prueba de concepto en células in vitro removieron el cromosoma extra que causa el síndrome de Down con la tecnología CRISPR-CAS-9. Por supuesto, falta mucho para su aplicación en humanos, pero el ensayo abre un camino para tratar desórdenes genéticos👇
x.com/Rainmaker197...
x.com/Rainmaker197...
De ENVI-commissie stemt in met een nieuw wettelijk kader voor nieuwe genomische technieken oftewel #NGT's. Dit betekent dat technieken zoals CRISPR-Cas (voor aanpassingen in het DNA van planten) binnen handbereik komen voor de EU-landbouw. 🧬🌱 #veredeling
Goedkeuring nieuwe gentechnieken voor de landbouw nabij
De ENVI-milieucommissie van het Europees Parlement heeft een akkoord gesloten over nieuwe genomische technieken (NGT's). Dit is een grote stap richting een definitief groen licht voor deze innovatieve...
www.nieuweoogst.nl
January 29, 2026 at 9:16 AM
De ENVI-commissie stemt in met een nieuw wettelijk kader voor nieuwe genomische technieken oftewel #NGT's. Dit betekent dat technieken zoals CRISPR-Cas (voor aanpassingen in het DNA van planten) binnen handbereik komen voor de EU-landbouw. 🧬🌱 #veredeling
How do the ancestors of CRISPR-Cas unwind DNA and how can this lead to better genome editing? With our collaboration between @doudna-lab.bsky.social x @jacobsenucla.bsky.social x Zev Bryant's lab x @savagecatsonly.bsky.social we've uncovered the secrets behind TnpB's dynamics!
www.biorxiv.org
January 15, 2026 at 6:55 AM
How do the ancestors of CRISPR-Cas unwind DNA and how can this lead to better genome editing? With our collaboration between @doudna-lab.bsky.social x @jacobsenucla.bsky.social x Zev Bryant's lab x @savagecatsonly.bsky.social we've uncovered the secrets behind TnpB's dynamics!
Novel compact CRISPR systems unlock easier delivery and more applications... epigenome editing anyone 👀
Very happy to be involved in work to rationally engineer enhanced Cme2 - an ultra-high fidelity & compact Cas, delivered in vivo in a single AAV (with gRNA)
www.biorxiv.org/content/10.6...
Very happy to be involved in work to rationally engineer enhanced Cme2 - an ultra-high fidelity & compact Cas, delivered in vivo in a single AAV (with gRNA)
www.biorxiv.org/content/10.6...
Iterative engineering of a compact Cas9 ortholog for in vivo gene editing via single AAV delivery
The development of compact and efficient CRISPR-Cas systems is crucial for biomedical and therapeutic genome editing, particularly in vivo applications based on viral delivery. Here, we performed a co...
www.biorxiv.org
January 13, 2026 at 2:45 PM
Novel compact CRISPR systems unlock easier delivery and more applications... epigenome editing anyone 👀
Very happy to be involved in work to rationally engineer enhanced Cme2 - an ultra-high fidelity & compact Cas, delivered in vivo in a single AAV (with gRNA)
www.biorxiv.org/content/10.6...
Very happy to be involved in work to rationally engineer enhanced Cme2 - an ultra-high fidelity & compact Cas, delivered in vivo in a single AAV (with gRNA)
www.biorxiv.org/content/10.6...
Lees ook ‘“Alles over #genvoedsel” en argumenten tégen #CRISPR-Cas gewas’
buizeradvies.nl/2018/09/22/w...
Organicseeds.nl mijnetenmijnkeuze.nl mechanischschoon.nl
#ecologischverantwoordelandbouw #duurzamevoedselzekerheid #residuenvrij #gezondvoedsel #GMOfree #gezondheid 7/X
buizeradvies.nl/2018/09/22/w...
Organicseeds.nl mijnetenmijnkeuze.nl mechanischschoon.nl
#ecologischverantwoordelandbouw #duurzamevoedselzekerheid #residuenvrij #gezondvoedsel #GMOfree #gezondheid 7/X
January 8, 2026 at 10:51 AM
Lees ook ‘“Alles over #genvoedsel” en argumenten tégen #CRISPR-Cas gewas’
buizeradvies.nl/2018/09/22/w...
Organicseeds.nl mijnetenmijnkeuze.nl mechanischschoon.nl
#ecologischverantwoordelandbouw #duurzamevoedselzekerheid #residuenvrij #gezondvoedsel #GMOfree #gezondheid 7/X
buizeradvies.nl/2018/09/22/w...
Organicseeds.nl mijnetenmijnkeuze.nl mechanischschoon.nl
#ecologischverantwoordelandbouw #duurzamevoedselzekerheid #residuenvrij #gezondvoedsel #GMOfree #gezondheid 7/X
The #CRISPR “gene scissors” have become an important basis for genome-editing technologies in many fields. 🧬✂️ A team from the #HIRI in Würzburg has now demonstrated that these CRISPR-Cas systems are even more versatile than previously thought. Read more: www.helmholtz-hiri.de/en/newsroom/...
Beyond gene scissors: New CRISPR mechanism discovered
Team from Würzburg, Braunschweig, and the US identifies Cas12a3 nuclease showing precise activity | Study just published in Nature
www.helmholtz-hiri.de
January 7, 2026 at 4:12 PM
The #CRISPR “gene scissors” have become an important basis for genome-editing technologies in many fields. 🧬✂️ A team from the #HIRI in Würzburg has now demonstrated that these CRISPR-Cas systems are even more versatile than previously thought. Read more: www.helmholtz-hiri.de/en/newsroom/...
Genome editing in brown algae! 🧬🪸🌿 Now out in Cell Reports Methods!
Excited to share this highly efficient, transgene-free CRISPR–Cas genome editing protocol for brown algae, requiring no cloning and no specialized equipment.
doi.org/10.1016/j.cr...
#CRISPR #BrownAlgae
@mpi-bio-fml.bsky.social
Excited to share this highly efficient, transgene-free CRISPR–Cas genome editing protocol for brown algae, requiring no cloning and no specialized equipment.
doi.org/10.1016/j.cr...
#CRISPR #BrownAlgae
@mpi-bio-fml.bsky.social
January 2, 2026 at 2:20 PM
Genome editing in brown algae! 🧬🪸🌿 Now out in Cell Reports Methods!
Excited to share this highly efficient, transgene-free CRISPR–Cas genome editing protocol for brown algae, requiring no cloning and no specialized equipment.
doi.org/10.1016/j.cr...
#CRISPR #BrownAlgae
@mpi-bio-fml.bsky.social
Excited to share this highly efficient, transgene-free CRISPR–Cas genome editing protocol for brown algae, requiring no cloning and no specialized equipment.
doi.org/10.1016/j.cr...
#CRISPR #BrownAlgae
@mpi-bio-fml.bsky.social
CRISPR-HAWK: Haplotype- and Variant-aware guide design toolkit for CRISPR-Cas www.biorxiv.org/content/10.6... 🧬🖥️🧪 github.com/pinellolab/C... (noncommercial)
December 29, 2025 at 5:00 PM
CRISPR-HAWK: Haplotype- and Variant-aware guide design toolkit for CRISPR-Cas www.biorxiv.org/content/10.6... 🧬🖥️🧪 github.com/pinellolab/C... (noncommercial)
19. Dezember 2025 – Die Mitgliedstaaten der Europäischen Union haben sich mit knapper Mehrheit auf eine Änderung der Gentechnik-Regeln in der Landwirtschaft geeinigt. Künftig sollen für bestimmte gentechnisch veränderte Kulturpflanzen weniger strenge Vorgaben gelten. #GMO #Gentechnik #Kulturpflanzen
December 30, 2025 at 12:30 AM
19. Dezember 2025 – Die Mitgliedstaaten der Europäischen Union haben sich mit knapper Mehrheit auf eine Änderung der Gentechnik-Regeln in der Landwirtschaft geeinigt. Künftig sollen für bestimmte gentechnisch veränderte Kulturpflanzen weniger strenge Vorgaben gelten. #GMO #Gentechnik #Kulturpflanzen
@peterfineran.bsky.social and colleagues develop Tn-seq for phages by leveraging anti-CRISPR (Acr) as a positive
selectable marker in the presence of CRISPR-Cas counter-selection, and identify essential genes in phage from non model orgs
www.biorxiv.org/content/10.6...
selectable marker in the presence of CRISPR-Cas counter-selection, and identify essential genes in phage from non model orgs
www.biorxiv.org/content/10.6...
December 20, 2025 at 11:34 PM
@peterfineran.bsky.social and colleagues develop Tn-seq for phages by leveraging anti-CRISPR (Acr) as a positive
selectable marker in the presence of CRISPR-Cas counter-selection, and identify essential genes in phage from non model orgs
www.biorxiv.org/content/10.6...
selectable marker in the presence of CRISPR-Cas counter-selection, and identify essential genes in phage from non model orgs
www.biorxiv.org/content/10.6...
SNIPR Biome strengthens IP portfolio with a patent granted for a novel #CRISPR-Cas system! Read more in the press release below.
February 24, 2025 at 10:14 AM
SNIPR Biome strengthens IP portfolio with a patent granted for a novel #CRISPR-Cas system! Read more in the press release below.
Cat1 forms filament networks to degrade NAD+ during the type III CRISPR-Cas antiviral response @science.org
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
April 10, 2025 at 7:16 PM
Cat1 forms filament networks to degrade NAD+ during the type III CRISPR-Cas antiviral response @science.org
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
CRISPR-Cas is how bacteria/archaea defend against invasive elements & is 'updated' via spacer acquisition after exposure, akin to 'immunity'. Here authors show that this happens slowly in the gut microbiota & identify a notably widespread array in Bifidobacterium longum
www.cell.com/cell-genomic...
www.cell.com/cell-genomic...
CRISPR-Cas spacer acquisition is a rare event in human gut microbiome
An-Ni Zhang et al. quantify spacer acquisition rates in human gut microbial species,
showing that spacer acquisition is rare. This finding challenges the use of CRISPR
arrays for predicting host-phage...
www.cell.com
January 15, 2025 at 3:52 AM
CRISPR-Cas is how bacteria/archaea defend against invasive elements & is 'updated' via spacer acquisition after exposure, akin to 'immunity'. Here authors show that this happens slowly in the gut microbiota & identify a notably widespread array in Bifidobacterium longum
www.cell.com/cell-genomic...
www.cell.com/cell-genomic...
## 유전자 변형 작물 연구: CRISPR-Cas 시스템 기반의 병해충 저항성 벼 품종 개발 및 최적화 (2026년 상용화 목표)
**1. 서론: CRISPR-Cas 기술을 활용한 벼 병해충 저항성 증진의 필요성** 벼는 세계 식량 안보에 매우 중요한 작물이며, 식량 생산의 20%를 차지한다. 병해충은 벼 생산량 감소의 주요 원인으로, 심각한 경제적 손실을 초래한다. 전통적인 병해충 방제 방법은 살충제의 과도한 사용으로 이어져 환경 오염과 인체 건강에 위험을 초래할 수 있다. CRISPR-Cas (Clustered…
**1. 서론: CRISPR-Cas 기술을 활용한 벼 병해충 저항성 증진의 필요성** 벼는 세계 식량 안보에 매우 중요한 작물이며, 식량 생산의 20%를 차지한다. 병해충은 벼 생산량 감소의 주요 원인으로, 심각한 경제적 손실을 초래한다. 전통적인 병해충 방제 방법은 살충제의 과도한 사용으로 이어져 환경 오염과 인체 건강에 위험을 초래할 수 있다. CRISPR-Cas (Clustered…
## 유전자 변형 작물 연구: CRISPR-Cas 시스템 기반의 병해충 저항성 벼 품종 개발 및 최적화 (2026년 상용화 목표)
**1. 서론: CRISPR-Cas 기술을 활용한 벼 병해충 저항성 증진의 필요성** 벼는 세계 식량 안보에 매우 중요한 작물이며, 식량 생산의 20%를 차지한다. 병해충은 벼 생산량 감소의 주요 원인으로, 심각한 경제적 손실을 초래한다. 전통적인 병해충 방제 방법은 살충제의 과도한 사용으로 이어져 환경 오염과 인체 건강에 위험을 초래할 수 있다. CRISPR-Cas (Clustered Regularly Interspaced Short Palindromic Repeats-Cas) 기술은 유전자 편집 기술의 혁신적인 발전을 가져왔으며, 유전자 변형 작물 (GMO) 개발에 획기적인 기회를 제공한다.
freederia.com
April 23, 2025 at 5:30 AM
## 유전자 변형 작물 연구: CRISPR-Cas 시스템 기반의 병해충 저항성 벼 품종 개발 및 최적화 (2026년 상용화 목표)
**1. 서론: CRISPR-Cas 기술을 활용한 벼 병해충 저항성 증진의 필요성** 벼는 세계 식량 안보에 매우 중요한 작물이며, 식량 생산의 20%를 차지한다. 병해충은 벼 생산량 감소의 주요 원인으로, 심각한 경제적 손실을 초래한다. 전통적인 병해충 방제 방법은 살충제의 과도한 사용으로 이어져 환경 오염과 인체 건강에 위험을 초래할 수 있다. CRISPR-Cas (Clustered…
**1. 서론: CRISPR-Cas 기술을 활용한 벼 병해충 저항성 증진의 필요성** 벼는 세계 식량 안보에 매우 중요한 작물이며, 식량 생산의 20%를 차지한다. 병해충은 벼 생산량 감소의 주요 원인으로, 심각한 경제적 손실을 초래한다. 전통적인 병해충 방제 방법은 살충제의 과도한 사용으로 이어져 환경 오염과 인체 건강에 위험을 초래할 수 있다. CRISPR-Cas (Clustered…
Knippen in het DNA om erfelijke ziektes te genezen: ‘De mogelijkheden van de Crispr-Cas techniek zijn eindeloos’
Knippen in het DNA om erfelijke ziektes te genezen: ‘De mogelijkheden van de Crispr-Cas techniek zijn eindeloos’
Tien patiënten zijn met behulp van de experimentele gentechniek Crispr-Cas voorgoed genezen van een erfelijke zwellingsziekte. Ook hemofilie en sik...
www.trouw.nl
February 2, 2024 at 4:46 PM
Knippen in het DNA om erfelijke ziektes te genezen: ‘De mogelijkheden van de Crispr-Cas techniek zijn eindeloos’
We present the full story of the PPTOP vs DgiS1 phage battle using Acinetobacter baumannii bacteria as the battleground. PPTOP is a phage-plasmid that, among other weapons, carries a CRISPR-Cas I-Fa system specialized in targeting DgiS1.
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Biological warfare between two bacterial viruses in a defense archipelago sheds light on the spread of CRISPR-Cas systems
Rubio et al. describe an archipelago of anti-phage systems in the opportunistic pathogenic bacterium A. baumannii. This is the battleground of two phages fighting for integration. One of them inserts a CRISPR-Cas system that prevents the other from integrating, and the other could escape by mutations avoiding the CRISPR-Cas system.
www.cell.com
December 14, 2024 at 6:15 PM
We present the full story of the PPTOP vs DgiS1 phage battle using Acinetobacter baumannii bacteria as the battleground. PPTOP is a phage-plasmid that, among other weapons, carries a CRISPR-Cas I-Fa system specialized in targeting DgiS1.
www.cell.com/cell-reports...
www.cell.com/cell-reports...
CRISPR et Cas: le système immunitaire des bactéries contre les virus phages #DiderOdyssée
December 9, 2024 at 8:08 AM
CRISPR et Cas: le système immunitaire des bactéries contre les virus phages #DiderOdyssée