Great to have Dr David Sünderhauf visit Oxford over the past couple of days!
A really nice talk on competition between plasmids carrying CRISPR-Cas and Toxin-antitoxin systems. Theory, experiments and bioinformatics all in one project!
@davvi36.bsky.social @biology.ox.ac.uk
A really nice talk on competition between plasmids carrying CRISPR-Cas and Toxin-antitoxin systems. Theory, experiments and bioinformatics all in one project!
@davvi36.bsky.social @biology.ox.ac.uk
November 7, 2025 at 4:22 PM
Great to have Dr David Sünderhauf visit Oxford over the past couple of days!
A really nice talk on competition between plasmids carrying CRISPR-Cas and Toxin-antitoxin systems. Theory, experiments and bioinformatics all in one project!
@davvi36.bsky.social @biology.ox.ac.uk
A really nice talk on competition between plasmids carrying CRISPR-Cas and Toxin-antitoxin systems. Theory, experiments and bioinformatics all in one project!
@davvi36.bsky.social @biology.ox.ac.uk
Our new methods paper led by AWI colleagues with the support of #OmicronCr. CRISPR-Cas for single-cell diatom microbiome research. @isme-microbes.bsky.social
@norwichmicro.bsky.social @ueaenv.bsky.social
academic.oup.com/ismecommun/a...
@norwichmicro.bsky.social @ueaenv.bsky.social
academic.oup.com/ismecommun/a...
Genotype and culture condition effects on single-cell diatom microbiomes: enhanced detection of low-abundance taxa with CRISPR-Cas9
Abstract. Primary production in aquatic systems is governed by interactions between microalgae and their associated bacteria. Most of our knowledge about a
academic.oup.com
October 31, 2025 at 8:08 AM
Our new methods paper led by AWI colleagues with the support of #OmicronCr. CRISPR-Cas for single-cell diatom microbiome research. @isme-microbes.bsky.social
@norwichmicro.bsky.social @ueaenv.bsky.social
academic.oup.com/ismecommun/a...
@norwichmicro.bsky.social @ueaenv.bsky.social
academic.oup.com/ismecommun/a...
🧬 Wie steuern Zellen das Leben – und wie verändert CRISPR/Cas die Forschung?
Am 19. November 2025 lädt CIBSS Lehrer*innen der Oberstufe zur Fortbildung an die Uni Freiburg ein.
👉 Anmeldung: kurzlinks.de/ds9u
#CIBSS #CRISPR #Zellkommunikation #Lehrerfortbildung #Wissenschaft #Freiburg
Am 19. November 2025 lädt CIBSS Lehrer*innen der Oberstufe zur Fortbildung an die Uni Freiburg ein.
👉 Anmeldung: kurzlinks.de/ds9u
#CIBSS #CRISPR #Zellkommunikation #Lehrerfortbildung #Wissenschaft #Freiburg
October 30, 2025 at 1:53 PM
🧬 Wie steuern Zellen das Leben – und wie verändert CRISPR/Cas die Forschung?
Am 19. November 2025 lädt CIBSS Lehrer*innen der Oberstufe zur Fortbildung an die Uni Freiburg ein.
👉 Anmeldung: kurzlinks.de/ds9u
#CIBSS #CRISPR #Zellkommunikation #Lehrerfortbildung #Wissenschaft #Freiburg
Am 19. November 2025 lädt CIBSS Lehrer*innen der Oberstufe zur Fortbildung an die Uni Freiburg ein.
👉 Anmeldung: kurzlinks.de/ds9u
#CIBSS #CRISPR #Zellkommunikation #Lehrerfortbildung #Wissenschaft #Freiburg
Mithilfe der Crispr/Cas-Technologie können Forschende das Erbgut präzise editieren, um Erbkrankheiten zu therapieren. Dafür müssen sie jedoch ungewollte Schnitte im Genom frühzeitig erkennen. Pioneer Fellow Lilly van de Venn entwickelt solche Prüfverfahren. ethz.ch/de/news-und-...
Ein ETH-Spin-off will die Genschere in die Klinik bringen
Mithilfe der Crispr/Cas-Technologie können Forschende das Erbgut präzise editieren, um Erbkrankheiten zu therapieren. Dafür müssen sie jedoch ungewollte Schnitte im Genom frühzeitig erkennen. Pioneer ...
ethz.ch
October 27, 2025 at 10:08 AM
Mithilfe der Crispr/Cas-Technologie können Forschende das Erbgut präzise editieren, um Erbkrankheiten zu therapieren. Dafür müssen sie jedoch ungewollte Schnitte im Genom frühzeitig erkennen. Pioneer Fellow Lilly van de Venn entwickelt solche Prüfverfahren. ethz.ch/de/news-und-...
🧬 New insights into the diversity of #CRISPR–Cas systems!
#Metagenomic analyses uncovered 4,112 Cas12 proteins and 6 novel subtypes.
🤖 #AI-based Cas12fam annotates 18 domains.
🌿 Cas12 subtypes show habitat-specific enrichment.
🔗 doi.org/10.1002/imo2...
#microbiome #metagenomics #bioinformatics
#Metagenomic analyses uncovered 4,112 Cas12 proteins and 6 novel subtypes.
🤖 #AI-based Cas12fam annotates 18 domains.
🌿 Cas12 subtypes show habitat-specific enrichment.
🔗 doi.org/10.1002/imo2...
#microbiome #metagenomics #bioinformatics
Metagenomic mining reveals novel Cas12 subtypes and their evolutionary diversification
We identified 4112 Cas12 Proteins and 6 new Cas12 subtypes, revealed their significant diversity in N-terminal regions, repeat sequences, and sequences motifs. We developed an AI-driven algorithm, Ca...
onlinelibrary.wiley.com
October 21, 2025 at 2:25 PM
🧬 New insights into the diversity of #CRISPR–Cas systems!
#Metagenomic analyses uncovered 4,112 Cas12 proteins and 6 novel subtypes.
🤖 #AI-based Cas12fam annotates 18 domains.
🌿 Cas12 subtypes show habitat-specific enrichment.
🔗 doi.org/10.1002/imo2...
#microbiome #metagenomics #bioinformatics
#Metagenomic analyses uncovered 4,112 Cas12 proteins and 6 novel subtypes.
🤖 #AI-based Cas12fam annotates 18 domains.
🌿 Cas12 subtypes show habitat-specific enrichment.
🔗 doi.org/10.1002/imo2...
#microbiome #metagenomics #bioinformatics
It’s #WorldCRISPRday! To celebrate, revisit this #JBiolChem review: www.jbc.org/article/S002....
Tina Liu and @jenniferdoudna.bsky.social explore how Class 1 CRISPR-Cas systems are expanding possibilities for DNA/RNA editing, gene expression control and nucleic acid detection.
Tina Liu and @jenniferdoudna.bsky.social explore how Class 1 CRISPR-Cas systems are expanding possibilities for DNA/RNA editing, gene expression control and nucleic acid detection.
October 21, 2025 at 2:58 AM
It’s #WorldCRISPRday! To celebrate, revisit this #JBiolChem review: www.jbc.org/article/S002....
Tina Liu and @jenniferdoudna.bsky.social explore how Class 1 CRISPR-Cas systems are expanding possibilities for DNA/RNA editing, gene expression control and nucleic acid detection.
Tina Liu and @jenniferdoudna.bsky.social explore how Class 1 CRISPR-Cas systems are expanding possibilities for DNA/RNA editing, gene expression control and nucleic acid detection.
Functional RNA splitting drove the evolutionary emergence of type V CRISPR-Cas systems from transposons - ScienceDirect https://www.sciencedirect.com/science/article/pii/S0092867425010359?dgcid=rss_sd_all
Functional RNA splitting drove the evolutionary emergence of type V CRISPR-Cas systems from transposons
Transposon-encoded TnpB nucleases gave rise to type V CRISPR-Cas12 effectors through multiple independent domestication events. These systems use diff…
www.sciencedirect.com
October 1, 2025 at 12:06 AM
Functional RNA splitting drove the evolutionary emergence of type V CRISPR-Cas systems from transposons - ScienceDirect https://www.sciencedirect.com/science/article/pii/S0092867425010359?dgcid=rss_sd_all
Avance científico: eliminación del VIH en células humanas in vitro mediante edición genética CRISPR-Cas12b killbait.com/es/avance-ci... #ciencia #vih #crispr-cas #edicióngenética
Avance científico: eliminación del VIH en células humanas in vitro mediante edición genética CRISPR-Cas12b
Un grupo de investigadores del Amsterdam UMC ha conseguido, por primera vez, eliminar completamente el VIH en células T humanas cultivadas en laboratorio mediante la tecnología de edición genética…
killbait.com
September 30, 2025 at 8:38 PM
Avance científico: eliminación del VIH en células humanas in vitro mediante edición genética CRISPR-Cas12b killbait.com/es/avance-ci... #ciencia #vih #crispr-cas #edicióngenética
A functional RNA splitting mechanism has been identified as the key molecular innovation driving the origin of type V CRISPR-Cas systems, clarifying their evolutionary pathway and potential for genome editing. doi.org/g95bcj
Scientists reveal functional RNA splitting mechanism behind origin of type V CRISPR systems
CRISPR-Cas systems are adaptive immune systems found in prokaryotes that defend against invading nucleic acids through CRISPR RNA-guided cleavage.
phys.org
September 29, 2025 at 3:00 PM
A functional RNA splitting mechanism has been identified as the key molecular innovation driving the origin of type V CRISPR-Cas systems, clarifying their evolutionary pathway and potential for genome editing. doi.org/g95bcj
Congratulations @e-charpentier.bsky.social from @maxplanckpress.de, 🇩🇪, recipient of the IUBMB Jubilee Award Lecture for her outstanding contributions in the discovery of the CRISPR-Cas9 technology, CRISPR therapeutics and ERS Genomics and for developing the CRISPR-Cas genome editing technology
September 19, 2025 at 12:53 PM
Congratulations @e-charpentier.bsky.social from @maxplanckpress.de, 🇩🇪, recipient of the IUBMB Jubilee Award Lecture for her outstanding contributions in the discovery of the CRISPR-Cas9 technology, CRISPR therapeutics and ERS Genomics and for developing the CRISPR-Cas genome editing technology
New tool alert! 🚀 MCAAT uses de Bruijn graphs to detect #CRISPR arrays in #metagenomes, capturing data lost in assemblies. A step forward in uncovering the hidden diversity of CRISPR-Cas systems. By Talibli & Voß
buff.ly/QMX9yIe
buff.ly/QMX9yIe
September 18, 2025 at 8:01 AM
New tool alert! 🚀 MCAAT uses de Bruijn graphs to detect #CRISPR arrays in #metagenomes, capturing data lost in assemblies. A step forward in uncovering the hidden diversity of CRISPR-Cas systems. By Talibli & Voß
buff.ly/QMX9yIe
buff.ly/QMX9yIe
All systems go: CRISPR crosstalk for enhanced immunity
Barrangou Previews papers led by @peterfineran.bsky.social & Meeske demonstrating CRISPR-Cas systems have unprecedented level of cooperative crosstalk between different subtypes, enabling primed spacer acquisition
www.cell.com/cell-host-mi...
Barrangou Previews papers led by @peterfineran.bsky.social & Meeske demonstrating CRISPR-Cas systems have unprecedented level of cooperative crosstalk between different subtypes, enabling primed spacer acquisition
www.cell.com/cell-host-mi...
All systems go: CRISPR crosstalk for enhanced immunity
In this issue of Cell Host & Microbe, companion manuscripts from Margolis & Meeske
and Smith & Fineran demonstrate that CRISPR-Cas systems have an unprecedented level
of cooperative crosstalk between ...
www.cell.com
September 15, 2025 at 4:23 PM
All systems go: CRISPR crosstalk for enhanced immunity
Barrangou Previews papers led by @peterfineran.bsky.social & Meeske demonstrating CRISPR-Cas systems have unprecedented level of cooperative crosstalk between different subtypes, enabling primed spacer acquisition
www.cell.com/cell-host-mi...
Barrangou Previews papers led by @peterfineran.bsky.social & Meeske demonstrating CRISPR-Cas systems have unprecedented level of cooperative crosstalk between different subtypes, enabling primed spacer acquisition
www.cell.com/cell-host-mi...
Brauchen wir unbedingt:
„Mit einem eigenen Verfahren, Crispr/Cas 12a, gelang es Pairwise, im braunen Senf (Brassica juncea) die Gene abzuschalten, die für die Bildung der scharfen Senföle verantwortlich sind. Dadurch würden die nährstoffreicheren Senfblätter so mild schmecken wie grüner Salat, ….“
„Mit einem eigenen Verfahren, Crispr/Cas 12a, gelang es Pairwise, im braunen Senf (Brassica juncea) die Gene abzuschalten, die für die Bildung der scharfen Senföle verantwortlich sind. Dadurch würden die nährstoffreicheren Senfblätter so mild schmecken wie grüner Salat, ….“
Viel Lifestyle, aber kaum Marktwert: viele der mit der neuen Gentechnik entwickelten Produkte floppen......
www.keine-gentechnik.de/nachricht/34...
www.keine-gentechnik.de/nachricht/34...
So schnell welkt Crispr-Salat
Im letzten Jahr hatte die US-Firma Pairwise mit viel Tamtam ihren gentechnisch entbitterten Salat aus Senfblättern auf den Markt gebracht. Jetzt will sie diesen Teil ihres Geschäfts wieder loswerden u...
www.keine-gentechnik.de
March 26, 2024 at 7:22 AM
Brauchen wir unbedingt:
„Mit einem eigenen Verfahren, Crispr/Cas 12a, gelang es Pairwise, im braunen Senf (Brassica juncea) die Gene abzuschalten, die für die Bildung der scharfen Senföle verantwortlich sind. Dadurch würden die nährstoffreicheren Senfblätter so mild schmecken wie grüner Salat, ….“
„Mit einem eigenen Verfahren, Crispr/Cas 12a, gelang es Pairwise, im braunen Senf (Brassica juncea) die Gene abzuschalten, die für die Bildung der scharfen Senföle verantwortlich sind. Dadurch würden die nährstoffreicheren Senfblätter so mild schmecken wie grüner Salat, ….“
Knippen in het DNA om erfelijke ziektes te genezen: ‘De mogelijkheden van de Crispr-Cas techniek zijn eindeloos’
Knippen in het DNA om erfelijke ziektes te genezen: ‘De mogelijkheden van de Crispr-Cas techniek zijn eindeloos’
Tien patiënten zijn met behulp van de experimentele gentechniek Crispr-Cas voorgoed genezen van een erfelijke zwellingsziekte. Ook hemofilie en sik...
www.trouw.nl
February 2, 2024 at 4:46 PM
Knippen in het DNA om erfelijke ziektes te genezen: ‘De mogelijkheden van de Crispr-Cas techniek zijn eindeloos’
CRISPR et Cas: le système immunitaire des bactéries contre les virus phages #DiderOdyssée
December 9, 2024 at 8:08 AM
CRISPR et Cas: le système immunitaire des bactéries contre les virus phages #DiderOdyssée
We present the full story of the PPTOP vs DgiS1 phage battle using Acinetobacter baumannii bacteria as the battleground. PPTOP is a phage-plasmid that, among other weapons, carries a CRISPR-Cas I-Fa system specialized in targeting DgiS1.
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Biological warfare between two bacterial viruses in a defense archipelago sheds light on the spread of CRISPR-Cas systems
Rubio et al. describe an archipelago of anti-phage systems in the opportunistic pathogenic bacterium A. baumannii. This is the battleground of two phages fighting for integration. One of them inserts a CRISPR-Cas system that prevents the other from integrating, and the other could escape by mutations avoiding the CRISPR-Cas system.
www.cell.com
December 14, 2024 at 6:15 PM
We present the full story of the PPTOP vs DgiS1 phage battle using Acinetobacter baumannii bacteria as the battleground. PPTOP is a phage-plasmid that, among other weapons, carries a CRISPR-Cas I-Fa system specialized in targeting DgiS1.
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Cat1 forms filament networks to degrade NAD+ during the type III CRISPR-Cas antiviral response @science.org
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
April 10, 2025 at 7:16 PM
Cat1 forms filament networks to degrade NAD+ during the type III CRISPR-Cas antiviral response @science.org
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
CRISPR-Cas is how bacteria/archaea defend against invasive elements & is 'updated' via spacer acquisition after exposure, akin to 'immunity'. Here authors show that this happens slowly in the gut microbiota & identify a notably widespread array in Bifidobacterium longum
www.cell.com/cell-genomic...
www.cell.com/cell-genomic...
CRISPR-Cas spacer acquisition is a rare event in human gut microbiome
An-Ni Zhang et al. quantify spacer acquisition rates in human gut microbial species,
showing that spacer acquisition is rare. This finding challenges the use of CRISPR
arrays for predicting host-phage...
www.cell.com
January 15, 2025 at 3:52 AM
CRISPR-Cas is how bacteria/archaea defend against invasive elements & is 'updated' via spacer acquisition after exposure, akin to 'immunity'. Here authors show that this happens slowly in the gut microbiota & identify a notably widespread array in Bifidobacterium longum
www.cell.com/cell-genomic...
www.cell.com/cell-genomic...
SNIPR Biome strengthens IP portfolio with a patent granted for a novel #CRISPR-Cas system! Read more in the press release below.
February 24, 2025 at 10:14 AM
SNIPR Biome strengthens IP portfolio with a patent granted for a novel #CRISPR-Cas system! Read more in the press release below.
For readers interested in CRISPR-based therapies, this recent review covers chemical engineering of CRISPR–Cas systems for therapeutic applications
www.nature.com/articles/s41...
rdcu.be/epryC
www.nature.com/articles/s41...
rdcu.be/epryC
June 4, 2025 at 2:32 PM
For readers interested in CRISPR-based therapies, this recent review covers chemical engineering of CRISPR–Cas systems for therapeutic applications
www.nature.com/articles/s41...
rdcu.be/epryC
www.nature.com/articles/s41...
rdcu.be/epryC
## 유전자 변형 작물 연구: CRISPR-Cas 시스템 기반의 병해충 저항성 벼 품종 개발 및 최적화 (2026년 상용화 목표)
**1. 서론: CRISPR-Cas 기술을 활용한 벼 병해충 저항성 증진의 필요성** 벼는 세계 식량 안보에 매우 중요한 작물이며, 식량 생산의 20%를 차지한다. 병해충은 벼 생산량 감소의 주요 원인으로, 심각한 경제적 손실을 초래한다. 전통적인 병해충 방제 방법은 살충제의 과도한 사용으로 이어져 환경 오염과 인체 건강에 위험을 초래할 수 있다. CRISPR-Cas (Clustered…
**1. 서론: CRISPR-Cas 기술을 활용한 벼 병해충 저항성 증진의 필요성** 벼는 세계 식량 안보에 매우 중요한 작물이며, 식량 생산의 20%를 차지한다. 병해충은 벼 생산량 감소의 주요 원인으로, 심각한 경제적 손실을 초래한다. 전통적인 병해충 방제 방법은 살충제의 과도한 사용으로 이어져 환경 오염과 인체 건강에 위험을 초래할 수 있다. CRISPR-Cas (Clustered…
## 유전자 변형 작물 연구: CRISPR-Cas 시스템 기반의 병해충 저항성 벼 품종 개발 및 최적화 (2026년 상용화 목표)
**1. 서론: CRISPR-Cas 기술을 활용한 벼 병해충 저항성 증진의 필요성** 벼는 세계 식량 안보에 매우 중요한 작물이며, 식량 생산의 20%를 차지한다. 병해충은 벼 생산량 감소의 주요 원인으로, 심각한 경제적 손실을 초래한다. 전통적인 병해충 방제 방법은 살충제의 과도한 사용으로 이어져 환경 오염과 인체 건강에 위험을 초래할 수 있다. CRISPR-Cas (Clustered Regularly Interspaced Short Palindromic Repeats-Cas) 기술은 유전자 편집 기술의 혁신적인 발전을 가져왔으며, 유전자 변형 작물 (GMO) 개발에 획기적인 기회를 제공한다.
freederia.com
April 23, 2025 at 5:30 AM
## 유전자 변형 작물 연구: CRISPR-Cas 시스템 기반의 병해충 저항성 벼 품종 개발 및 최적화 (2026년 상용화 목표)
**1. 서론: CRISPR-Cas 기술을 활용한 벼 병해충 저항성 증진의 필요성** 벼는 세계 식량 안보에 매우 중요한 작물이며, 식량 생산의 20%를 차지한다. 병해충은 벼 생산량 감소의 주요 원인으로, 심각한 경제적 손실을 초래한다. 전통적인 병해충 방제 방법은 살충제의 과도한 사용으로 이어져 환경 오염과 인체 건강에 위험을 초래할 수 있다. CRISPR-Cas (Clustered…
**1. 서론: CRISPR-Cas 기술을 활용한 벼 병해충 저항성 증진의 필요성** 벼는 세계 식량 안보에 매우 중요한 작물이며, 식량 생산의 20%를 차지한다. 병해충은 벼 생산량 감소의 주요 원인으로, 심각한 경제적 손실을 초래한다. 전통적인 병해충 방제 방법은 살충제의 과도한 사용으로 이어져 환경 오염과 인체 건강에 위험을 초래할 수 있다. CRISPR-Cas (Clustered…
Did you know? Recent research highlights how CRISPR-Cas systems are revolutionizing molecular biology by enabling precise gene editing and diagnostics. Could these tools soon cure genetic diseases or revolutionize personalized medicine?
August 18, 2025 at 1:57 PM
Did you know? Recent research highlights how CRISPR-Cas systems are revolutionizing molecular biology by enabling precise gene editing and diagnostics. Could these tools soon cure genetic diseases or revolutionize personalized medicine?
Upcoming PhD defense seminar! Charles Lenihan of the Bailey Lab will present “Structural Snapshots of a Thermophilic CRISPR-Cas Effector Recognizing Target DNA”
🗓️Thursday, September 25
⏰Noon ET
📍 W4030
🔗Open to the BMB community via Zoom - DM for link by Monday, September 22
🗓️Thursday, September 25
⏰Noon ET
📍 W4030
🔗Open to the BMB community via Zoom - DM for link by Monday, September 22
September 15, 2025 at 2:55 PM
Upcoming PhD defense seminar! Charles Lenihan of the Bailey Lab will present “Structural Snapshots of a Thermophilic CRISPR-Cas Effector Recognizing Target DNA”
🗓️Thursday, September 25
⏰Noon ET
📍 W4030
🔗Open to the BMB community via Zoom - DM for link by Monday, September 22
🗓️Thursday, September 25
⏰Noon ET
📍 W4030
🔗Open to the BMB community via Zoom - DM for link by Monday, September 22
New photo of UPOBioinfo Group 2025-2026 - Bacteriophages and their relationship with CRISPR-Cas and other defense systems in bacteria.
Looking forward to a year of fascinating stories about bacteria and phages!
Looking forward to a year of fascinating stories about bacteria and phages!
September 25, 2025 at 2:42 PM
New photo of UPOBioinfo Group 2025-2026 - Bacteriophages and their relationship with CRISPR-Cas and other defense systems in bacteria.
Looking forward to a year of fascinating stories about bacteria and phages!
Looking forward to a year of fascinating stories about bacteria and phages!