New paper from our group - megaphages, compact CRISPR-Cas effectors, and more from landfill phage, led by the talented Dr. Nikhil George (not on bsky). rdcu.be/ePo8o
Discarded diversity: novel megaphages, auxiliary metabolic genes, and virally encoded CRISPR-Cas systems in landfills
link.springer.com
November 11, 2025 at 6:38 PM
New paper from our group - megaphages, compact CRISPR-Cas effectors, and more from landfill phage, led by the talented Dr. Nikhil George (not on bsky). rdcu.be/ePo8o
#microsky #phagesky #phage defence
Anti-CRISPR protein hijacks host’s enolase to tackle and block CRISPR-Cas
www.nature.com/articles/s41...
Anti-CRISPR protein hijacks host’s enolase to tackle and block CRISPR-Cas
www.nature.com/articles/s41...
A phage-encoded anti-CRISPR protein co-opts host enolase to prevent type III CRISPR immunity - Nature Microbiology
Streptococcus thermophilus phages circumvent host CRISPR defences via AcrIIIA2, which complexes with enolase, a highly abundant glycolysis enzyme, to block phage RNA binding.
www.nature.com
November 11, 2025 at 4:27 PM
#microsky #phagesky #phage defence
Anti-CRISPR protein hijacks host’s enolase to tackle and block CRISPR-Cas
www.nature.com/articles/s41...
Anti-CRISPR protein hijacks host’s enolase to tackle and block CRISPR-Cas
www.nature.com/articles/s41...
Dive into issue 19 of the Biochemical Journal now! This issue covers the broad molecular mechanisms of life, from advances in non-coding RNA biology, to plant-bacteria interactions, to the latest research into CRISPR-Cas systems. 🧪https://buff.ly/KnqafNT
November 11, 2025 at 2:30 PM
Dive into issue 19 of the Biochemical Journal now! This issue covers the broad molecular mechanisms of life, from advances in non-coding RNA biology, to plant-bacteria interactions, to the latest research into CRISPR-Cas systems. 🧪https://buff.ly/KnqafNT
Horizontal Gene Transfer: Latest results from PubMed
Evolutionary insights into provirus-encoded CRISPR-Cas systems in halophilic archaea
#NCBI #PubMed #HGT
Evolutionary insights into provirus-encoded CRISPR-Cas systems in halophilic archaea
#NCBI #PubMed #HGT
Evolutionary insights into provirus-encoded CRISPR-Cas systems in halophilic archaea - PubMed
Prokaryotic microorganisms coexist with mobile genetic elements (MGEs), which can be both genetic threats and evolutionary catalysts. In <i>Haloferax lucentense</i>, a halophilic archaeon, we have recently identified an unusual genomic arrangement: a complete type I-B CRISPR-Cas system encoded on a …
pubmed.ncbi.nlm.nih.gov
November 11, 2025 at 2:03 PM
Horizontal Gene Transfer: Latest results from PubMed
Evolutionary insights into provirus-encoded CRISPR-Cas systems in halophilic archaea
#NCBI #PubMed #HGT
Evolutionary insights into provirus-encoded CRISPR-Cas systems in halophilic archaea
#NCBI #PubMed #HGT
Une émission de la Méthode Scientifique sur les ciseaux moléculaires CRISPR-Cas-9, kessecé à quoi ça sert, à partir de l'annonce des bébés CRISPR.
Crispr-Cas9 : le ciseau moléculaire à la croisée des chemins
Faut-il croire en l'annonce de la naissance des premiers “bébés CRISPR” ? L’édition du génome : une révolution confirmée par Crispr ? Des milliers de publications plus tard, quelles “prouesses” ont ét...
www.radiofrance.fr
November 11, 2025 at 7:09 AM
Une émission de la Méthode Scientifique sur les ciseaux moléculaires CRISPR-Cas-9, kessecé à quoi ça sert, à partir de l'annonce des bébés CRISPR.
In diagnostics, rapid avian influenza tests — especially CRISPR-Cas–based lateral flow assays — can detect the virus in minutes with high sensitivity. These technologies are key for early detection and outbreak containment across One Health frontiers. 6/9
November 10, 2025 at 12:06 PM
In diagnostics, rapid avian influenza tests — especially CRISPR-Cas–based lateral flow assays — can detect the virus in minutes with high sensitivity. These technologies are key for early detection and outbreak containment across One Health frontiers. 6/9
als transen niet biologisch zouden zijn is dit dan nog wel een biologische baby?
www.trouw.nl/wetenschap/h...
www.trouw.nl/wetenschap/h...
November 10, 2025 at 10:45 AM
als transen niet biologisch zouden zijn is dit dan nog wel een biologische baby?
www.trouw.nl/wetenschap/h...
www.trouw.nl/wetenschap/h...
Phage provoke growth delays and SOS response induction despite CRISPR-Cas protection.
DOI: 10.1098/rstb.2024.0474
https://pubmed.ncbi.nlm.nih.gov/40904102/
DOI: 10.1098/rstb.2024.0474
https://pubmed.ncbi.nlm.nih.gov/40904102/
Phage provoke growth delays and SOS response induction despite CRISPR-Cas protection - PubMed
Bacteria evolve resistance against their phage foes with a wide range of resistance strategies whose costs and benefits depend on the level of protection they confer and on the costs for maintainance. <i>Pseudomonas aeruginosa</i> can evolve resistance against its phage DMS<i>3vir</i> either by surf …
pubmed.ncbi.nlm.nih.gov
November 9, 2025 at 7:32 PM
Phage provoke growth delays and SOS response induction despite CRISPR-Cas protection.
DOI: 10.1098/rstb.2024.0474
https://pubmed.ncbi.nlm.nih.gov/40904102/
DOI: 10.1098/rstb.2024.0474
https://pubmed.ncbi.nlm.nih.gov/40904102/
And Gattaca was about embryo selection, not direct genetic manipulation, which is what these techbros are talking about.
If they knew how tricky it was just to get a good GM plant expressing edited genes in the correct way, even with CRISPR-CAS, they might think again.
If they knew how tricky it was just to get a good GM plant expressing edited genes in the correct way, even with CRISPR-CAS, they might think again.
November 9, 2025 at 4:32 AM
And Gattaca was about embryo selection, not direct genetic manipulation, which is what these techbros are talking about.
If they knew how tricky it was just to get a good GM plant expressing edited genes in the correct way, even with CRISPR-CAS, they might think again.
If they knew how tricky it was just to get a good GM plant expressing edited genes in the correct way, even with CRISPR-CAS, they might think again.
CRISPR-CAS is totally unrelated to mRNA vaccines.
CRISPR-CAS edits very specific areas of DNA to insert/replace/remove. Not used for COVID.
mRNA-vaccine uses man-made mRNA to create a specific protein that is also available on a virus, cancer,… to train the immune system to combat that pathogen.
CRISPR-CAS edits very specific areas of DNA to insert/replace/remove. Not used for COVID.
mRNA-vaccine uses man-made mRNA to create a specific protein that is also available on a virus, cancer,… to train the immune system to combat that pathogen.
November 9, 2025 at 3:11 AM
CRISPR-CAS is totally unrelated to mRNA vaccines.
CRISPR-CAS edits very specific areas of DNA to insert/replace/remove. Not used for COVID.
mRNA-vaccine uses man-made mRNA to create a specific protein that is also available on a virus, cancer,… to train the immune system to combat that pathogen.
CRISPR-CAS edits very specific areas of DNA to insert/replace/remove. Not used for COVID.
mRNA-vaccine uses man-made mRNA to create a specific protein that is also available on a virus, cancer,… to train the immune system to combat that pathogen.
Exciting PhD opportunity! Uncover the molecular mechanism of the MADS bacterial immune system and its synergy with CRISPR-Cas. Based in the Szczelkun lab in Bristol with strong collaboration with the Blower lab at NEB and opportunities to work with other amazing research groups! Link below:
November 8, 2025 at 5:48 PM
Exciting PhD opportunity! Uncover the molecular mechanism of the MADS bacterial immune system and its synergy with CRISPR-Cas. Based in the Szczelkun lab in Bristol with strong collaboration with the Blower lab at NEB and opportunities to work with other amazing research groups! Link below:
An updated evolutionary classification of CRISPR-Cas systems including rare variants
->Nature | More from Lil Dr Glen EcoChat at BigEarthData.ai
->Nature | More from Lil Dr Glen EcoChat at BigEarthData.ai
An updated evolutionary classification of CRISPR-Cas systems including rare variants
Distinct features in class 1 CRISPR–Cas systems Although numerous class 1 CRISPR–Cas systems have been discovered since the 2020 classification, only type VII and two subtypes (III-G and III-H) have been explicitly added to the classification9. While working on this...
www.nature.com
November 7, 2025 at 11:35 PM
Great to have Dr David Sünderhauf visit Oxford over the past couple of days!
A really nice talk on competition between plasmids carrying CRISPR-Cas and Toxin-antitoxin systems. Theory, experiments and bioinformatics all in one project!
@davvi36.bsky.social @biology.ox.ac.uk
A really nice talk on competition between plasmids carrying CRISPR-Cas and Toxin-antitoxin systems. Theory, experiments and bioinformatics all in one project!
@davvi36.bsky.social @biology.ox.ac.uk
November 7, 2025 at 4:22 PM
Great to have Dr David Sünderhauf visit Oxford over the past couple of days!
A really nice talk on competition between plasmids carrying CRISPR-Cas and Toxin-antitoxin systems. Theory, experiments and bioinformatics all in one project!
@davvi36.bsky.social @biology.ox.ac.uk
A really nice talk on competition between plasmids carrying CRISPR-Cas and Toxin-antitoxin systems. Theory, experiments and bioinformatics all in one project!
@davvi36.bsky.social @biology.ox.ac.uk
Out now!
An updated evolutionary classification of CRISPR–Cas systems including rare variants
#microsky
www.nature.com/articles/s41...
An updated evolutionary classification of CRISPR–Cas systems including rare variants
#microsky
www.nature.com/articles/s41...
An updated evolutionary classification of CRISPR–Cas systems including rare variants - Nature Microbiology
An exploration of previously undescribed variants from the long tail of the CRISPR–Cas distribution.
www.nature.com
November 7, 2025 at 11:10 AM
Out now!
An updated evolutionary classification of CRISPR–Cas systems including rare variants
#microsky
www.nature.com/articles/s41...
An updated evolutionary classification of CRISPR–Cas systems including rare variants
#microsky
www.nature.com/articles/s41...
Het repareren van genen met Crispr-Cas kan een medische revolutie zijn, maar wat zijn de bijwerkingen?
Het repareren van genen met Crispr-Cas kan een medische revolutie zijn, maar wat zijn de bijwerkingen?
Gentherapie staat weer volop in de belangstelling na de wonderbaarlijke behandeling van een baby. Hoe nauwkeurig is deze ‘genetische chirurgie’, en hoe erg is het als er iets misgaat?
www.trouw.nl
November 7, 2025 at 9:03 AM
Het repareren van genen met Crispr-Cas kan een medische revolutie zijn, maar wat zijn de bijwerkingen?
An updated evolutionary classification of CRISPR–Cas systems including rare variants | Nature Microbiology https://www.nature.com/articles/s41564-025-02180-8
An updated evolutionary classification of CRISPR–Cas systems including rare variants - Nature Microbiology
An exploration of previously undescribed variants from the long tail of the CRISPR–Cas distribution.
www.nature.com
November 7, 2025 at 12:40 AM
An updated evolutionary classification of CRISPR–Cas systems including rare variants | Nature Microbiology https://www.nature.com/articles/s41564-025-02180-8
Our lab shone at EMBO Workshop CRISPR-Cas: From Biology to Therapeutic Applications in Sorrento! Haidy presented her award-winning poster on modulating anti-tumor efficacy & T cell exhaustion! 🏆Frank shared insights on developing a BE platform for cancer research. #CRISPR #EMBO #Science #GeneEditing
November 6, 2025 at 8:30 AM
Our lab shone at EMBO Workshop CRISPR-Cas: From Biology to Therapeutic Applications in Sorrento! Haidy presented her award-winning poster on modulating anti-tumor efficacy & T cell exhaustion! 🏆Frank shared insights on developing a BE platform for cancer research. #CRISPR #EMBO #Science #GeneEditing
無酸素状態はマウス腸管におけるCRISPR-Cas免疫を活性化する
crisp-bio.blog.jp/archives/395...
crisp-bio.blog.jp/archives/395...
November 5, 2025 at 9:37 PM
無酸素状態はマウス腸管におけるCRISPR-Cas免疫を活性化する
crisp-bio.blog.jp/archives/395...
crisp-bio.blog.jp/archives/395...
#NewResearch
Anoxia activates CRISPR–Cas immunity in the mouse intestine
www.nature.com/articles/s41...
#microsky
Anoxia activates CRISPR–Cas immunity in the mouse intestine
www.nature.com/articles/s41...
#microsky
Anoxia activates CRISPR–Cas immunity in the mouse intestine - Nature Microbiology
The Citrobacter rodentium CRISPR–Cas system is activated by the oxygen-responsive transcriptional regulator Fnr in the anoxic environment of the mouse gut.
www.nature.com
November 5, 2025 at 3:41 PM
#NewResearch
Anoxia activates CRISPR–Cas immunity in the mouse intestine
www.nature.com/articles/s41...
#microsky
Anoxia activates CRISPR–Cas immunity in the mouse intestine
www.nature.com/articles/s41...
#microsky
3PaTec? Brauche Nachhilfe. Hab ich nichts von gehört bisher.
@forscherrobert.bsky.social vielleicht?
Ist das be sinnige Methode? Klingt irgendwie aufwändig und leuchtet nicht so ein wie Crispr/Cas
@forscherrobert.bsky.social vielleicht?
Ist das be sinnige Methode? Klingt irgendwie aufwändig und leuchtet nicht so ein wie Crispr/Cas
November 4, 2025 at 5:48 PM
3PaTec? Brauche Nachhilfe. Hab ich nichts von gehört bisher.
@forscherrobert.bsky.social vielleicht?
Ist das be sinnige Methode? Klingt irgendwie aufwändig und leuchtet nicht so ein wie Crispr/Cas
@forscherrobert.bsky.social vielleicht?
Ist das be sinnige Methode? Klingt irgendwie aufwändig und leuchtet nicht so ein wie Crispr/Cas
Los sistemas CRISPR son una herramienta fantástica para estudiar la función de la información genética. En ellos, una proteína de la familia Cas es dirigida por un ARN guía a puntos específicos para hacer cortes precisos en la información genética de las células.
November 4, 2025 at 10:39 AM
Los sistemas CRISPR son una herramienta fantástica para estudiar la función de la información genética. En ellos, una proteína de la familia Cas es dirigida por un ARN guía a puntos específicos para hacer cortes precisos en la información genética de las células.
🌱 Die Entdeckung von #CRISPR/Cas 2012 markiert eine neue Ära der #Landwirtschaft. #NGTs ermöglichen präzise Eingriffe ins Pflanzengenom – für bessere Qualität, höhere Erträge und Vielfalt. 🇪🇺 Diese Faktoren sollten in der Regulierung berücksichtigt werden. www.transgen.de/forschung/25...
November 4, 2025 at 8:22 AM
🌱 Die Entdeckung von #CRISPR/Cas 2012 markiert eine neue Ära der #Landwirtschaft. #NGTs ermöglichen präzise Eingriffe ins Pflanzengenom – für bessere Qualität, höhere Erträge und Vielfalt. 🇪🇺 Diese Faktoren sollten in der Regulierung berücksichtigt werden. www.transgen.de/forschung/25...
Signal or noise? > Clustered Regularly Interspaced Short Palindromic Repeats
(CRISPR)-Cas Unleashed: Transforming Gene Editing With
Breakthroughs, Applications, and… >> Comment below! #strategy #competitiveintelligence #marketing #pharma #healthcare #biotech #pharmaceutical #competitivemarketing
(CRISPR)-Cas Unleashed: Transforming Gene Editing With
Breakthroughs, Applications, and… >> Comment below! #strategy #competitiveintelligence #marketing #pharma #healthcare #biotech #pharmaceutical #competitivemarketing
Clustered Regularly Interspaced Short Palindromic Repeats
(CRISPR)-Cas Unleashed: Transforming Gene Editing With
Breakthroughs, Applications, and Ethical Dilemmas - Cureus
Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-Cas Unleashed: Transforming Gene Editing With Breakthroughs, Applications, and Ethical Dilemmas Cureus
dlvr.it
November 1, 2025 at 5:30 PM
Signal or noise? > Clustered Regularly Interspaced Short Palindromic Repeats
(CRISPR)-Cas Unleashed: Transforming Gene Editing With
Breakthroughs, Applications, and… >> Comment below! #strategy #competitiveintelligence #marketing #pharma #healthcare #biotech #pharmaceutical #competitivemarketing
(CRISPR)-Cas Unleashed: Transforming Gene Editing With
Breakthroughs, Applications, and… >> Comment below! #strategy #competitiveintelligence #marketing #pharma #healthcare #biotech #pharmaceutical #competitivemarketing
The gardener tried that and it almost worked but it still left demon seeds behind. I really think communicating with entities that can be made aware of the true nature of reality and then guiding them into acting as gut bacteria // CRISPR-Cas might be the way to go.
October 31, 2025 at 10:09 PM
The gardener tried that and it almost worked but it still left demon seeds behind. I really think communicating with entities that can be made aware of the true nature of reality and then guiding them into acting as gut bacteria // CRISPR-Cas might be the way to go.