iMeta Science
LightNews LightNews
banner
imetascience.bsky.social
iMeta Science
@imetascience.bsky.social
100 followers 64 following 240 posts
A Wiley partner journal aims to promote metagenomics and bioinformatics by publishing research articles, reproducible methods, protocols, and reviews.
Posts Replies Media Videos
Pinned
imetascience.bsky.social
iMeta Science @imetascience.bsky.social · Mar 20
Tidyplots empowers life scientists with easy code‐based data visualization
onlinelibrary.wiley.com/doi/full/10....
#Bioinformatics #R #Rstudio #visualization
Tidyplots empowers life scientists with easy code‐based data visualization
Effective data visualization is vital for analyzing and communicating experimental results. However, most code-based plotting tools require substantial programming experience, posing a significant ba....
onlinelibrary.wiley.com
imetascience.bsky.social
Efficacy and biomarker analysis of neoadjuvant disitamab vedotin (RC48‐ADC) combined immunotherapy in patients with muscle‐invasive bladder cancer
onlinelibrary.wiley.com/doi/10.1002/...
December 30, 2025 at 2:36 AM
imetascience.bsky.social
💡 An Interpretable Machine Learning Model for Predicting 5-Year Survival in Breast Cancer Based on Integration of Proteomics and Clinical Data! onlinelibrary.wiley.com/doi/10.1002/...
An Interpretable Machine Learning Model for Predicting 5‐Year Survival in Breast Cancer Based on Integration of Proteomics and Clinical Data
This study first introduced Kolmogorov–Arnold Network (KAN) into the deep learning model for the integration of clinical and proteomics data in predicting 5-year survival in breast cancer. The optima...
onlinelibrary.wiley.com
December 26, 2025 at 11:02 AM
imetascience.bsky.social
How does time‐restricted feeding mitigate Alzheimer's disease‐associated cognitive impairments? The role of the B. pseudolongum‐propionic acid‐FFAR3 axis. onlinelibrary.wiley.com/doi/10.1002/...
December 25, 2025 at 10:55 AM
imetascience.bsky.social
Dynamics and Regulation of Maternal–Fetal Interface Macrophages: From Immune Tolerance to Pregnancy Outcomes
🧐How macrophage signaling transforms maternal-fetal health and therapeutic discovery？
onlinelibrary.wiley.com/doi/10.1002/...
Dynamics and Regulation of Maternal–Fetal Interface Macrophages: From Immune Tolerance to Pregnancy Outcomes
The maternal–fetal interface demands tolerance alongside antimicrobial defense. Plastic macrophages orchestrate inflammation resolution, tissue remodeling, and angiogenesis in normal gestation; compl...
onlinelibrary.wiley.com
December 24, 2025 at 12:40 PM
imetascience.bsky.social
Network perturbation analysis identifies new molecular subtypes of endometrial cancer
💫Three distinct subtypes show different clinical outcomes.
onlinelibrary.wiley.com/doi/10.1002/...
Network Perturbation Analysis Identifies Three Molecular Subtypes With Distinct Clinical Outcomes and Therapeutic Vulnerabilities in Endometrial Cancer
We performed network perturbation analysis on transcriptomic data from endometrial cancer patients across multiple cohorts and identified three molecular subtypes with distinct clinical outcomes. The...
onlinelibrary.wiley.com
December 23, 2025 at 12:39 PM
imetascience.bsky.social
⚡️Gut microbes and liver metabolism collaborate to fight fatty liver!
⚙️ Cetobacterium somerae converts arginine to putrescine, which the liver transforms into spermidine to reduce hepatic lipid accumulation.
onlinelibrary.wiley.com/doi/10.1002/...
Host‐driven hepatic conversion of gut microbiota‐derived putrescine to spermidine mediates mannose's protective effects against hepatic steatosis in zebrafish
Evidence for liver metabolism of gut-derived microbial compounds into beneficial secondary metabolites has been lacking. Here, we demonstrate that Cetobacterium somerae (C. somerae), enriched by mann....
onlinelibrary.wiley.com
December 22, 2025 at 10:43 AM
imetascience.bsky.social
💡 Microbiota-Gut-Brain Axis Multi-Organ Chip Construction and Applications in Drug Evaluation
onlinelibrary.wiley.com/doi/10.1002/...
Microbiota‐gut‐brain axis multi‐organ chip construction and applications in drug evaluation
Microbiota-gut-brain axis multiorgan chip and its applications in drug evaluation. The chip includes essential biological components such as gut microbiota, gut barrier, blood-brain barrier (BBB), an...
onlinelibrary.wiley.com
December 17, 2025 at 11:55 AM
imetascience.bsky.social
Wuda Granule Improves the Gastrointestinal Motility via Gut-Brain Axis in Beagle Dogs!
⚙️ Central Wuda Granule drives whole-gut motility.
#GutBrainAxis #TraditionalMedicine #Neurogastroenterology onlinelibrary.wiley.com/doi/10.1002/...
Wuda Granule Improves the Gastrointestinal Motility via Gut‐Brain Axis in Beagle Dogs
Stress sensors were implanted in the gastric body, sinus, duodenum, jejunum, and colon of beagle dogs to record gastrointestinal motility. Gastrointestinal contractile motility was assessed before an...
onlinelibrary.wiley.com
December 16, 2025 at 12:53 PM
imetascience.bsky.social
Integrated multi-omics reveals how potassium sorbate may trigger acute kidney injury.
⚙️ Network toxicology, machine learning & single-cell analysis identify APP as a central hub driving oxidative stress, inflammation & endothelial–immune crosstalk.
onlinelibrary.wiley.com/doi/10.1002/...
Potassium Sorbate Triggers Kidney Injury via Dysregulated Intercellular Communication: A Study Combining Network Toxicology, Machine Learning, Molecular Docking, and Single‐Cell RNA Sequencing
Amyloid precursor protein (APP)-mediated endothelial-immune cell crosstalk is a novel mechanism for potassium sorbate-induced renal injury. Multi-omics integration (network toxicology, machine learni....
onlinelibrary.wiley.com
December 15, 2025 at 12:22 PM
imetascience.bsky.social
⚡️Using MicrobTiSDA to infer interspecies interactions from microbiome time-series data.
🔎A tool for analyzing the dynamic patterns of microbial abundance over time.
The complete analysis process from data preprocessing to result visualization. onlinelibrary.wiley.com/doi/10.1002/...
MicrobTiSDA: A flexible R package for inferring interspecies interactions and abundance dynamics in microbiome time‐series data
MicrobTiSDA is a user-friendly and flexible R package specifically designed for longitudinal microbiome data analysis. By integrating process-oriented functional modules—including data input, data pr...
onlinelibrary.wiley.com
December 12, 2025 at 9:28 AM
imetascience.bsky.social
🦌🧬 Single-cell multi-omics reveals how deer antlers achieve centimeter-scale daily bone growth.
#SingleCell #BoneRegeneration #MultiOmics #DeerAntler
onlinelibrary.wiley.com/doi/10.1002/...
A vast stem‐progenitor cell pool, richly vascular system, and hybrid ossification drive the daily centimeter‐scale elongation of bony antlers
Bone growth and regeneration remain major clinical challenges. Deer antlers, the fastest-growing mammalian bone, regenerate via endochondral ossification and elongate up to 2 cm per day, far surpassi....
onlinelibrary.wiley.com
December 11, 2025 at 12:24 PM
imetascience.bsky.social
🧬Single-cell spatial transcriptomics reveals potential molecular mechanisms of Abelmoschus manihot (L.) medic in treating diabetic kidney disease
#scRNAseq #MolecularMechanisms #iMeta onlinelibrary.wiley.com/doi/10.1002/...
Single‐cell spatial transcriptomics reveals potential molecular mechanisms of Abelmoschus manihot (L.) medic in treating diabetic kidney disease
A clinical study reported that Abelmoschus manihot (L.) Medic (A. manihot), in the form of Huangkui capsule (HKC), combined with irbesartan (IRB) is an effective therapy for patients with diabetic ki...
onlinelibrary.wiley.com
December 10, 2025 at 12:09 PM
imetascience.bsky.social
⏳ PhyloSuite v2 makes molecular dating analysis easier !
Using PhyloSuite v2 for molecular phylogeny and tree‐based analyses
#Phylogenetics #MolecularDating #Bioinformatics onlinelibrary.wiley.com/doi/10.1002/...
PhyloSuite v2: The development of an all‐in‐one, efficient and visualization‐oriented suite for molecular dating analysis and other advanced features
This graphical abstract illustrates the integrated molecular dating workflow in PhyloSuite v2. The new Molecular Dating Suite unifies data configuration, analysis, and visualization into a single, st...
onlinelibrary.wiley.com
December 9, 2025 at 12:42 PM
imetascience.bsky.social
🚀iMeta has been cited over 14,000 times!
⚡️According to statistics from the Dimensions website, as of December 8, 2025, #iMeta has published 349 papers, which have been cited 14,366 times, with an average of 41.16 citations per paper, and it takes only two days to reach 100 citations.
December 8, 2025 at 11:17 AM
imetascience.bsky.social
💡 Toward a Medical Data Element Ecosystem (MDEE) for the digital health era!
🌏 Build a comprehensive medical data ecosystem framework that spans the entire data lifecycle and offers a new perspective for advancing practice in the field.
onlinelibrary.wiley.com/doi/10.1002/...
Medical Data as a Key Asset in the Digital Health Era: A Framework for Challenges and Strategies
By conducting case studies and comparative analysis from a global perspective, this study develops the practical framework of Medical Data Element Ecosystem (MDEE)—one that facilitates MDEE construct....
onlinelibrary.wiley.com
December 8, 2025 at 11:04 AM
imetascience.bsky.social
🧠 Copper exposure drives #neurotoxicity through a gut–brain metabolic axis!
🔥 It triggers #gut barrier damage and inflammation, leading to #neural injury.
💊 The #probiotic W. coagulans XY2 counteracts toxicity by targeting a multi-layered network.
onlinelibrary.wiley.com/doi/10.1002/...
Weizmannia coagulans XY2 Mitigates Copper Neurotoxicity via Gut–Brain Axis Modulation of Tryptophan Metabolism and Oxidative‐Inflammatory Crosstalk
Copper interferes with tryptophan metabolism and 5-HT levels by modulating intestinal flora. Intestinal barrier breakdown and inflammatory response trigger nerve damage under copper exposure. W. coag...
onlinelibrary.wiley.com
December 7, 2025 at 7:44 AM
imetascience.bsky.social
🫁Immune–transcriptomic profiling uncovers a four-gene model AUC 0.94 for lung cancer with pulmonary tuberculosis!
💡#MTB remodels #tumor #microenvironment via metabolic-immune crosstalk.
⚡First #immune-transcriptomic map of #lung cancer plus tuberculosis.
onlinelibrary.wiley.com/doi/10.1002/...
Immunometabolic Features and Key Biomarkers in Lung Cancer Complicated by Pulmonary Tuberculosis: Insights From Transcriptome and Clinical Cohort Analysis
Integrative analysis of LC-PTB patients pinpoints six biomarkers (ANK2, EPB42, CA1, HBB, HBD, MYL4) that reshape the immune microenvironment, offering new targets for diagnosis and treatment of lung ...
onlinelibrary.wiley.com
December 7, 2025 at 7:29 AM
imetascience.bsky.social
🫁🔥 HDM-activated #bronchial #fibroblasts emerge as key drivers of airway #inflammation in allergic #asthma!
⚙️ Bronchial fibroblasts are not only structural cells but also direct responders to #allergens.
onlinelibrary.wiley.com/doi/10.1002/...
Bronchial Fibroblasts Respond to House Dust Mite Challenge With Cytokine Secretion: Role in Allergic Airway Inflammation
Schematic of the early-stage characteristics of house dust mites-induced bronchial fibroblasts, which are characterized by suppressed extracellular matrix production alongside activated inflammatory ...
onlinelibrary.wiley.com
December 3, 2025 at 10:31 AM
imetascience.bsky.social
🧬 CRISPR screen uncovers C9ORF50 as a key regulator of #cancer immune evasion!
⚙️ Blocking this splicing factor triggers #dsRNA buildup, Type I IFN activation & strong T-cell recruitment.
onlinelibrary.wiley.com/doi/10.1002/...
Genome‐wide CRISPR screen reveals an uncharacterized spliceosome regulator as new candidate immunotherapy target
This study identifies the uncharacterized gene C9ORF50 as a novel regulator of immune evasion. Functioning as an intrinsically disordered protein, C9ORF50 drives liquid-liquid phase separation to fac...
onlinelibrary.wiley.com
December 3, 2025 at 9:18 AM
imetascience.bsky.social
Whole #microbiota transplantation restores gut homeostasis throughout the #gastrointestinal tract - Tang - iMeta - Wiley Online Library onlinelibrary.wiley.com/doi/10.1002/...
December 2, 2025 at 12:29 PM
imetascience.bsky.social
Gut–X axis - Lin - 2025 - iMeta - Wiley Online Library onlinelibrary.wiley.com/doi/full/10....
December 2, 2025 at 12:16 PM
imetascience.bsky.social
🧬 GSE-Seq — high-throughput single-entity sequencing via droplet microfluidics!
⚙️ Integrates #barcode generation, degradable hydrogel processing & long-read #sequencing — uncovering vast microbial “dark matter.”
🔗https://doi.org/10.1002/imt2.70087
November 14, 2025 at 8:07 AM
imetascience.bsky.social
🌸 Profiling 6423 Chinese women, this study uncovers a midlife shift in the #vaginal #microbiota—
⚖️ Decline of #Lactobacillus crispatus, rise of #Gardnerella vaginalis around age 40.
🧠 A new #microbiome balance score predicts reproductive health risks.
🔗 doi.org/10.1002/imt2...
Nationwide profiling of vaginal microbiota in Chinese women reveals age‐dependent shifts and predictive biomarkers for reproductive health
The vaginal microbiome is central to reproductive health, yet large-scale studies in East Asian populations remain scarce. Here, we characterized the vaginal microbiota of 6423 Chinese women of repro...
doi.org
October 30, 2025 at 3:24 PM
imetascience.bsky.social
🧬 CycloneSEQ #nanopore sequencing rapidly reconstructs multidrug-resistant bacterial genomes!
⚙️ 96.16% read accuracy, 99.98% assembly accuracy.
💡 Complete genomes with just 15× long reads or 5× hybrid data.
🔗 onlinelibrary.wiley.com/doi/10.1002/...
#Bioinformatics #BGI
October 30, 2025 at 3:20 PM
imetascience.bsky.social
🐭 #Lactiplantibacillus plantarum Hi188 promotes post-weaning growth in mice.
🧪 The #metabolite 5-HIAA activates hepatic #AhR, boosting IGF-1 production.
🧑‍💻 Metagenomic and host transcriptome data reveal that 5-HIAA is co-produced by the host–microbiota axis.
🔗 doi.org/10.1002/imo2...
#microbiome
Host–microbiota interaction drives 5‐hydroxyindole‐3‐acetic acid production to promote linear growth in infant mice
This study discovered that Lactiplantibacillus plantarum Hi188 promoted linear growth in postweaning mice. Transcriptomic analysis, untargeted metabolomics, and in vitro experiments showed that the e...
doi.org
October 30, 2025 at 3:06 PM