Tim Spellman
@tspell.bsky.social
Neuroscientist, container of multitudes, sinner in the hands of an angry god
Reposted by Tim Spellman
It’s a real shame that folks with mental illness have to fight not only their symptoms but also concerted efforts to undermine their treatment. 😢
The @nytimes.com mag published a long piece entitled “rethinking adhd”. Here is a 🧵 highlighting its factual & logical errors
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The @nytimes.com mag published a long piece entitled “rethinking adhd”. Here is a 🧵 highlighting its factual & logical errors
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April 22, 2025 at 4:41 AM
It’s a real shame that folks with mental illness have to fight not only their symptoms but also concerted efforts to undermine their treatment. 😢
The @nytimes.com mag published a long piece entitled “rethinking adhd”. Here is a 🧵 highlighting its factual & logical errors
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The @nytimes.com mag published a long piece entitled “rethinking adhd”. Here is a 🧵 highlighting its factual & logical errors
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Reposted by Tim Spellman
A much-needed joint effort from five labs to see which behavioral effects of psilocybin in mice are reliable, and which may be spurious 🐁🍄
@theborislab.bsky.social @mazenkheirbek.bsky.social @indigenerd.bsky.social Vikaas Sohal and Stephan Lammel 👏
www.biorxiv.org/content/10.1...
@theborislab.bsky.social @mazenkheirbek.bsky.social @indigenerd.bsky.social Vikaas Sohal and Stephan Lammel 👏
www.biorxiv.org/content/10.1...
A multi-institutional investigation of psilocybin's effects on mouse behavior
Studies reporting novel therapeutic effects of psychedelic drugs are rapidly emerging. However, the reproducibility and reliability of these findings could remain uncertain for years. Here, we impleme...
www.biorxiv.org
April 9, 2025 at 7:11 PM
A much-needed joint effort from five labs to see which behavioral effects of psilocybin in mice are reliable, and which may be spurious 🐁🍄
@theborislab.bsky.social @mazenkheirbek.bsky.social @indigenerd.bsky.social Vikaas Sohal and Stephan Lammel 👏
www.biorxiv.org/content/10.1...
@theborislab.bsky.social @mazenkheirbek.bsky.social @indigenerd.bsky.social Vikaas Sohal and Stephan Lammel 👏
www.biorxiv.org/content/10.1...
Reposted by Tim Spellman
MyVivarium is an #opensource tool for animal colony management. It uses QR codes, IoT sensors, & allows for cloud-based tracking. Read about it in this week's post on OpenBehavior:
edspace.american.edu/openbehavior...
edspace.american.edu/openbehavior...
March 28, 2025 at 5:55 PM
MyVivarium is an #opensource tool for animal colony management. It uses QR codes, IoT sensors, & allows for cloud-based tracking. Read about it in this week's post on OpenBehavior:
edspace.american.edu/openbehavior...
edspace.american.edu/openbehavior...
Reposted by Tim Spellman
One of the NIMH PIs whose name is the termination list: Sooyhun Lee, whose lab just published this beautiful @nature.com paper (that has received too little press because comms at NIH are down). Read! Cite!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
March 6, 2025 at 7:04 PM
One of the NIMH PIs whose name is the termination list: Sooyhun Lee, whose lab just published this beautiful @nature.com paper (that has received too little press because comms at NIH are down). Read! Cite!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Tim Spellman
Check out FlexRig, an open-source platform for decision-making & cognitive flexibility studies. 🐁🧠 Olfactory, auditory, somatosensory cues, & more! Low-cost, fully customizable. #OpenSource #Neuroscience #ResearchTools @tspell.bsky.social
edspace.american.edu/openbehavior...
edspace.american.edu/openbehavior...
FlexRig
Visit the post for more.
edspace.american.edu
February 28, 2025 at 8:18 PM
Check out FlexRig, an open-source platform for decision-making & cognitive flexibility studies. 🐁🧠 Olfactory, auditory, somatosensory cues, & more! Low-cost, fully customizable. #OpenSource #Neuroscience #ResearchTools @tspell.bsky.social
edspace.american.edu/openbehavior...
edspace.american.edu/openbehavior...
Reposted by Tim Spellman
Special shout out this AM to NIH 🧪 grant mgmt specialists, POs, and SROs during this chaotic time - THANK YOU for caring for our grants and uploading scores/summary statements despite the unprecedented challenges you may be facing. You are science warriors and we APPRECIATE & SUPPORT YOU 🫶
February 17, 2025 at 3:44 PM
Special shout out this AM to NIH 🧪 grant mgmt specialists, POs, and SROs during this chaotic time - THANK YOU for caring for our grants and uploading scores/summary statements despite the unprecedented challenges you may be facing. You are science warriors and we APPRECIATE & SUPPORT YOU 🫶
Reposted by Tim Spellman
Can whole-brain imaging of cellular c-Fos signals be used to classify #psychedelics? 🧠🔬💊
Our study by @aboharbf.bsky.social and @pashadavoudian.bsky.social, developing an imaging and machine learning pipeline to test a panel of psychoactive drugs.
Paper here 👇
www.nature.com/articles/s41...
Our study by @aboharbf.bsky.social and @pashadavoudian.bsky.social, developing an imaging and machine learning pipeline to test a panel of psychoactive drugs.
Paper here 👇
www.nature.com/articles/s41...
Classification of psychedelics and psychoactive drugs based on brain-wide imaging of cellular c-Fos expression - Nature Communications
A challenge in psychiatric drug discovery is to predict the therapeutic potential of a novel compound. Here, the authors show that brain-wide imaging of immediate early gene expression can be used to ...
www.nature.com
February 13, 2025 at 3:51 PM
Can whole-brain imaging of cellular c-Fos signals be used to classify #psychedelics? 🧠🔬💊
Our study by @aboharbf.bsky.social and @pashadavoudian.bsky.social, developing an imaging and machine learning pipeline to test a panel of psychoactive drugs.
Paper here 👇
www.nature.com/articles/s41...
Our study by @aboharbf.bsky.social and @pashadavoudian.bsky.social, developing an imaging and machine learning pipeline to test a panel of psychoactive drugs.
Paper here 👇
www.nature.com/articles/s41...
This is excellent
Made some slides for scientists to talk about what's been happening & what we should do next. There are probably many people better qualified than me to talk about these issues. If that's you, please, please, please consider holding some virtual advocacy training sessions for researchers this week.
The War on Science (Feb 2025 teach-in draft)
The War on Science What’s happening? What can we do about it? An interactive teach-in for biomedical researchers Please share, modify, and repurpose this template presentation (with credit). Good luck...
docs.google.com
February 10, 2025 at 3:46 PM
This is excellent
Reposted by Tim Spellman
Made some slides for scientists to talk about what's been happening & what we should do next. There are probably many people better qualified than me to talk about these issues. If that's you, please, please, please consider holding some virtual advocacy training sessions for researchers this week.
The War on Science (Feb 2025 teach-in draft)
The War on Science What’s happening? What can we do about it? An interactive teach-in for biomedical researchers Please share, modify, and repurpose this template presentation (with credit). Good luck...
docs.google.com
February 10, 2025 at 6:30 AM
Made some slides for scientists to talk about what's been happening & what we should do next. There are probably many people better qualified than me to talk about these issues. If that's you, please, please, please consider holding some virtual advocacy training sessions for researchers this week.
Reposted by Tim Spellman
If you have been affected by the fires in LA, or are concerned about your ability to keep precious Drosophila strains going during the latest funding crisis, we will host your strains as a backup. Please email me.
Please amplify. If you are also able to host fly strains, add your name as well.
Please amplify. If you are also able to host fly strains, add your name as well.
January 28, 2025 at 9:45 PM
If you have been affected by the fires in LA, or are concerned about your ability to keep precious Drosophila strains going during the latest funding crisis, we will host your strains as a backup. Please email me.
Please amplify. If you are also able to host fly strains, add your name as well.
Please amplify. If you are also able to host fly strains, add your name as well.
Reposted by Tim Spellman
The author’s resolution is both obvious and endogenous
January 1, 2025 at 6:26 AM
The author’s resolution is both obvious and endogenous
Reposted by Tim Spellman
The Senate Committee on Health, Education, Labor, and Pensions, led by Senator Bill Cassidy (R-LA) - a gastroenterologist with an MD from LSU, just released a report entitled NIH IN THE 21st CENTURY: ENSURING TRANSPARENCY AND AMERICAN BIOMEDICAL LEADERSHIP. Since he is the ranking Republican,
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December 18, 2024 at 9:37 PM
The Senate Committee on Health, Education, Labor, and Pensions, led by Senator Bill Cassidy (R-LA) - a gastroenterologist with an MD from LSU, just released a report entitled NIH IN THE 21st CENTURY: ENSURING TRANSPARENCY AND AMERICAN BIOMEDICAL LEADERSHIP. Since he is the ranking Republican,
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Reposted by Tim Spellman
It does matter to continue to try to elicit shame to prevent the 'rhinoceros stampede' from 'destroying the habitat for democracy.'
_________________________________________
¹ Rhinocerization is Hungarian playwright Eugène Ionesco's term for losing your empathy and becoming a nationalist minion.
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¹ Rhinocerization is Hungarian playwright Eugène Ionesco's term for losing your empathy and becoming a nationalist minion.
November 30, 2024 at 1:02 PM
It does matter to continue to try to elicit shame to prevent the 'rhinoceros stampede' from 'destroying the habitat for democracy.'
_________________________________________
¹ Rhinocerization is Hungarian playwright Eugène Ionesco's term for losing your empathy and becoming a nationalist minion.
_________________________________________
¹ Rhinocerization is Hungarian playwright Eugène Ionesco's term for losing your empathy and becoming a nationalist minion.
Reposted by Tim Spellman
A wonderful paper from @tonyzador.bsky.social and colleagues: Encoding innate ability through a genomic bottleneck www.pnas.org/doi/10.1073/...
Encoding innate ability through a genomic bottleneck | PNAS
Animals are born with extensive innate behavioral capabilities, which arise from neural
circuits encoded in the genome. However, the information ca...
www.pnas.org
November 28, 2024 at 9:57 AM
A wonderful paper from @tonyzador.bsky.social and colleagues: Encoding innate ability through a genomic bottleneck www.pnas.org/doi/10.1073/...
Reposted by Tim Spellman
There are many nuances regarding the structural neural plasticity associated with antidepressant drugs. 💊🧠
We share our thoughts here in a Nature Reviews Neuroscience article, led by Clara Liao with co-authors from Conor Liston’s lab at Weill Cornell.
www.nature.com/articles/s41...
We share our thoughts here in a Nature Reviews Neuroscience article, led by Clara Liao with co-authors from Conor Liston’s lab at Weill Cornell.
www.nature.com/articles/s41...
November 19, 2024 at 1:23 PM
There are many nuances regarding the structural neural plasticity associated with antidepressant drugs. 💊🧠
We share our thoughts here in a Nature Reviews Neuroscience article, led by Clara Liao with co-authors from Conor Liston’s lab at Weill Cornell.
www.nature.com/articles/s41...
We share our thoughts here in a Nature Reviews Neuroscience article, led by Clara Liao with co-authors from Conor Liston’s lab at Weill Cornell.
www.nature.com/articles/s41...
Reposted by Tim Spellman
Did you see this coming? Abstract categorization in a so-called sensorimotor midbrain area.
Primate superior colliculus is causally engaged in abstract higher-order cognition
www.nature.com/articles/s41...
#neuroscience
Primate superior colliculus is causally engaged in abstract higher-order cognition
www.nature.com/articles/s41...
#neuroscience
Primate superior colliculus is causally engaged in abstract higher-order cognition - Nature Neuroscience
Neuronal recordings show that primate superior colliculus encodes learned abstract visual categories. The authors demonstrate that it plays a causal role in categorization behavior, independent of its...
www.nature.com
September 19, 2024 at 5:44 PM
Did you see this coming? Abstract categorization in a so-called sensorimotor midbrain area.
Primate superior colliculus is causally engaged in abstract higher-order cognition
www.nature.com/articles/s41...
#neuroscience
Primate superior colliculus is causally engaged in abstract higher-order cognition
www.nature.com/articles/s41...
#neuroscience
Reposted by Tim Spellman
“The posts that were removed were all actioned correctly,” says Joe Benarroch, head of business operations at X, adding that the posts violated the company’s “posting private information policy” for “outing the identity of an anonymous user.”
www.wired.com/story/elon-m...
www.wired.com/story/elon-m...
Elon Musk's X Is Suspending Accounts That Reveal a Neo-Nazi Cartoonist's Alleged Identity
Researchers and journalists have been blocked on X from sharing the alleged identity of the neo-Nazi cartoonist Stonetoss.
www.wired.com
March 20, 2024 at 2:21 PM
“The posts that were removed were all actioned correctly,” says Joe Benarroch, head of business operations at X, adding that the posts violated the company’s “posting private information policy” for “outing the identity of an anonymous user.”
www.wired.com/story/elon-m...
www.wired.com/story/elon-m...
Reposted by Tim Spellman
New Paper Alert! 🚨
"Testing methods of neural systems understanding" by me & David Bau is online now: https://www.sciencedirect.com/science/article/pii/S1389041723000906
We argue for an explicit test of the tools used to understand 'neural systems', i.e. brains and artificial neural networks.
"Testing methods of neural systems understanding" by me & David Bau is online now: https://www.sciencedirect.com/science/article/pii/S1389041723000906
We argue for an explicit test of the tools used to understand 'neural systems', i.e. brains and artificial neural networks.
August 10, 2023 at 1:15 AM
New Paper Alert! 🚨
"Testing methods of neural systems understanding" by me & David Bau is online now: https://www.sciencedirect.com/science/article/pii/S1389041723000906
We argue for an explicit test of the tools used to understand 'neural systems', i.e. brains and artificial neural networks.
"Testing methods of neural systems understanding" by me & David Bau is online now: https://www.sciencedirect.com/science/article/pii/S1389041723000906
We argue for an explicit test of the tools used to understand 'neural systems', i.e. brains and artificial neural networks.
Reposted by Tim Spellman
New wave research?
We’ve got some ‘splining to do!
〰 These oscillations are high-frequency: 130-160 Hz, at the peaks of theta rhythms in the retrosplenial cortex (part of the brain essential for successful navigation).
https://www.cell.com/cell-reports/fulltext/S2211-1247(22)00822-1
🧪
#neuroscience
We’ve got some ‘splining to do!
〰 These oscillations are high-frequency: 130-160 Hz, at the peaks of theta rhythms in the retrosplenial cortex (part of the brain essential for successful navigation).
https://www.cell.com/cell-reports/fulltext/S2211-1247(22)00822-1
🧪
#neuroscience
July 31, 2023 at 1:32 PM
New wave research?
We’ve got some ‘splining to do!
〰 These oscillations are high-frequency: 130-160 Hz, at the peaks of theta rhythms in the retrosplenial cortex (part of the brain essential for successful navigation).
https://www.cell.com/cell-reports/fulltext/S2211-1247(22)00822-1
🧪
#neuroscience
We’ve got some ‘splining to do!
〰 These oscillations are high-frequency: 130-160 Hz, at the peaks of theta rhythms in the retrosplenial cortex (part of the brain essential for successful navigation).
https://www.cell.com/cell-reports/fulltext/S2211-1247(22)00822-1
🧪
#neuroscience
Reposted by Tim Spellman
Reposted by Tim Spellman
hi #neuroskyence, I’m emma! 👋🧠
I work on brain-machine interfaces in industry, first at neuralink (I wrote most of the software for the pig and monkey demos!), and more recently as cofounder + software lead at science corp.
always looking for more neuro + bci friends, ❤️ if that’s you! 🧪
I work on brain-machine interfaces in industry, first at neuralink (I wrote most of the software for the pig and monkey demos!), and more recently as cofounder + software lead at science corp.
always looking for more neuro + bci friends, ❤️ if that’s you! 🧪
July 29, 2023 at 6:19 PM
hi #neuroskyence, I’m emma! 👋🧠
I work on brain-machine interfaces in industry, first at neuralink (I wrote most of the software for the pig and monkey demos!), and more recently as cofounder + software lead at science corp.
always looking for more neuro + bci friends, ❤️ if that’s you! 🧪
I work on brain-machine interfaces in industry, first at neuralink (I wrote most of the software for the pig and monkey demos!), and more recently as cofounder + software lead at science corp.
always looking for more neuro + bci friends, ❤️ if that’s you! 🧪
Reposted by Tim Spellman
"Use the pool water to flood the server room to delete the surveillance footage" is the most Sierra adventure game solution to a problem I've ever heard
July 28, 2023 at 2:13 AM
"Use the pool water to flood the server room to delete the surveillance footage" is the most Sierra adventure game solution to a problem I've ever heard