Stephen Floor
@snf.bsky.social
Dad, partner, scientist, music lover. I am passionate about developing RNA technologies to impact human health.
ok I have a mystery. What is the food ingredient “inland sea water powder”?
November 9, 2025 at 3:43 AM
ok I have a mystery. What is the food ingredient “inland sea water powder”?
I am once again reminded that the loudest person in the room is not necessarily the smartest or most qualified
August 26, 2025 at 10:14 PM
I am once again reminded that the loudest person in the room is not necessarily the smartest or most qualified
Reader, we would not like a dictator in the “land of the free and home of the brave”
August 25, 2025 at 3:45 PM
Reader, we would not like a dictator in the “land of the free and home of the brave”
Reposted by Stephen Floor
Delighted to present our second paper of the year. This one explores the molecular mechanism of TTP, a key post-transcriptional regulator of AU-rich mRNAs. Work led and coordinated by @filippekovic.bsky.social, in collaboration with Perry Blackshear.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Multivalent interactions with CCR4–NOT and PABPC1 determine mRNA repression efficiency by tristetraprolin - Nature Communications
Deadenylation leads to mRNA decay, with PABPC1 protecting the poly(A) tail, while tristetraprolin and CCR4–NOT promote deadenylation. Here, the authors describe how these three proteins interact to re...
www.nature.com
August 13, 2025 at 5:32 PM
Delighted to present our second paper of the year. This one explores the molecular mechanism of TTP, a key post-transcriptional regulator of AU-rich mRNAs. Work led and coordinated by @filippekovic.bsky.social, in collaboration with Perry Blackshear.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
I remember when OS updates were like "we will protect your computer from viruses and make it faster" and now they lead with
July 31, 2025 at 8:56 PM
I remember when OS updates were like "we will protect your computer from viruses and make it faster" and now they lead with
Reposted by Stephen Floor
Paper 2 -- Translational co-regulation detected in mammalian cells www.nature.com/articles/s41...
A deeper explanation of the human story, scientific conclusions, and Github/Zenodo links to use the pre-trained models: www.linkedin.com/feed/update/...
A deeper explanation of the human story, scientific conclusions, and Github/Zenodo links to use the pre-trained models: www.linkedin.com/feed/update/...
Translation efficiency covariation identifies conserved coordination patterns across cell types - Nature Biotechnology
Matched ribosome profiling and RNA sequencing data quantify translation efficiency patterns across 140 human and mouse cell lines.
www.nature.com
July 25, 2025 at 1:37 PM
Paper 2 -- Translational co-regulation detected in mammalian cells www.nature.com/articles/s41...
A deeper explanation of the human story, scientific conclusions, and Github/Zenodo links to use the pre-trained models: www.linkedin.com/feed/update/...
A deeper explanation of the human story, scientific conclusions, and Github/Zenodo links to use the pre-trained models: www.linkedin.com/feed/update/...
Reposted by Stephen Floor
Very excited that our most significant work, a collaboration w/ Dr. Can Cenik at UT Austin on translational gene regulation, was finally published in Nature Biotechnology in a dual set of studies:
Paper 1 -- an AI model trained to predict translation rates from mRNA sequences: rdcu.be/exN1l
Paper 1 -- an AI model trained to predict translation rates from mRNA sequences: rdcu.be/exN1l
Predicting the translation efficiency of messenger RNA in mammalian cells
Nature Biotechnology - A deep convolutional neural network model predicts the influence of the full-length mRNA sequence on translation efficiency.
url.de.m.mimecastprotect.com
July 25, 2025 at 1:37 PM
Very excited that our most significant work, a collaboration w/ Dr. Can Cenik at UT Austin on translational gene regulation, was finally published in Nature Biotechnology in a dual set of studies:
Paper 1 -- an AI model trained to predict translation rates from mRNA sequences: rdcu.be/exN1l
Paper 1 -- an AI model trained to predict translation rates from mRNA sequences: rdcu.be/exN1l
Another example of spurious effects when you try to interpret RNA biology from DNA introduced into cells without confirming exactly what RNA processing is happening. Important and common confounder - great paper!
Our collaboration with Tony Mustoe's lab us out today. MPRA libraries and possible cryptic splicing in MPRA reporters, or reporters in general. The additional novelty here is that such events are controlled or influenced by AU-rich sequences.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
U-rich elements drive pervasive cryptic splicing in 3’ UTR massively parallel reporter assays - Nature Communications
Massively parallel reporter assays (MPRAs) are powerful technologies for measuring the impact of non-coding sequences on gene expression. Here, the authors demonstrate that MPRA reporters often underg...
www.nature.com
July 25, 2025 at 2:30 PM
Another example of spurious effects when you try to interpret RNA biology from DNA introduced into cells without confirming exactly what RNA processing is happening. Important and common confounder - great paper!
Reposted by Stephen Floor
“With these considerations, we expect to fund through the 4th percentile.”
There it is, in black and white, the destruction of cancer research in the US.
There it is, in black and white, the destruction of cancer research in the US.
Funding policy for 2025 from NCI. Was just released: 4 percentile…maybe!
www.cancer.gov/grants-train...
www.cancer.gov/grants-train...
Funding Policy - Research Grants
NCI funding policy for research project grant (RPG) awards reflects the funding goals of the institute, NIH, and HHS.
www.cancer.gov
July 23, 2025 at 10:21 PM
“With these considerations, we expect to fund through the 4th percentile.”
There it is, in black and white, the destruction of cancer research in the US.
There it is, in black and white, the destruction of cancer research in the US.
apropos of nothing, a strong rec for “The Tyranny of Merit”, in which Sandel notes a putative meritocracy “fosters a sense of entitlement among the successful while humiliating those who do not succeed, ultimately undermining the common good and social solidarity”
bookshop.org/p/books/the-...
bookshop.org/p/books/the-...
The Tyranny of Merit: Can We Find the Common Good?
Can We Find the Common Good?
bookshop.org
July 12, 2025 at 9:18 PM
apropos of nothing, a strong rec for “The Tyranny of Merit”, in which Sandel notes a putative meritocracy “fosters a sense of entitlement among the successful while humiliating those who do not succeed, ultimately undermining the common good and social solidarity”
bookshop.org/p/books/the-...
bookshop.org/p/books/the-...
this is an example of the so-called meritocracy that’s threatened by introspection on who gets into college and why
"Nearly half of white students admitted to Harvard between 2009 and 2014 were legacy students or Dean’s Interest List—a list of applicants whose relatives have donated to Harvard, the existence of which only became public knowledge in 2018"
75% of them would not have been admitted otherwise
75% of them would not have been admitted otherwise
July 12, 2025 at 9:05 PM
this is an example of the so-called meritocracy that’s threatened by introspection on who gets into college and why
great review on the myriad ways that genetic variation in mRNA untranslated regions can cause disease!
Ever craved a review that details the diverse mechanisms through which UTR variants have been show to cause rare disease??? Or maybe just curious?
Well this review, written by the amazing Dr @nechamawieder.bsky.social , is for you 🤓🧬🩺
Well this review, written by the amazing Dr @nechamawieder.bsky.social , is for you 🤓🧬🩺
Super excited to share our new review paper - The role of untranslated region variants in Mendelian disease!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
July 7, 2025 at 5:05 PM
great review on the myriad ways that genetic variation in mRNA untranslated regions can cause disease!
This July 4 I celebrate my country born by separation from a tyrannical king, with the principles that all people are created equal and that the government represents the will of the People, not a monarch. The unalienable rights of Life, Liberty, and the pursuit of Happiness. Let freedom ring!
America is beautiful, contradictory, unfinished. I am proud of our country even as we constantly strive to make it better, to protect and deepen our democracy, to fulfill its promise for each and every person who calls it home.
Happy Independence Day. No Kings in America.
Happy Independence Day. No Kings in America.
July 4, 2025 at 8:09 PM
This July 4 I celebrate my country born by separation from a tyrannical king, with the principles that all people are created equal and that the government represents the will of the People, not a monarch. The unalienable rights of Life, Liberty, and the pursuit of Happiness. Let freedom ring!
absolutely love this new tour of the cosmos using the Skyviewer app built using new images off the Vera Rubin telescope - gorgeous and great explanations skyviewer.app/tours
Astronomical Tours | Skyviewer
skyviewer.app
June 24, 2025 at 2:49 PM
absolutely love this new tour of the cosmos using the Skyviewer app built using new images off the Vera Rubin telescope - gorgeous and great explanations skyviewer.app/tours
whenever I need some sunshine I turn to cientotres 103.1 FM out of San José, Costa Rica
radios-de-costa-rica.com/1031-fm
radios-de-costa-rica.com/1031-fm
103.1 FM Cientotres en vivo, Costa Rica
103.1 FM es una emisora de radio de Costa Rica que emite en San José. Escucha gratis música dinámica para jóvenes del género rock y pop.
radios-de-costa-rica.com
June 18, 2025 at 4:13 PM
whenever I need some sunshine I turn to cientotres 103.1 FM out of San José, Costa Rica
radios-de-costa-rica.com/1031-fm
radios-de-costa-rica.com/1031-fm
Reposted by Stephen Floor
A federal judge on Monday declared the Trump administration’s move to cut hundreds of grants issued by the National Institutes of Health illegal, accusing the government of discrimination against minorities and L.G.B.T.Q. individuals. nyti.ms/4jSIjOG
Trump’s Cuts to N.I.H. Grants Are Illegal, Federal Judge Rules
The judge accused the Trump administration of discriminating against minorities and L.G.B.T.Q. people and ordered the government to restore much of the funding.
nyti.ms
June 16, 2025 at 9:02 PM
A federal judge on Monday declared the Trump administration’s move to cut hundreds of grants issued by the National Institutes of Health illegal, accusing the government of discrimination against minorities and L.G.B.T.Q. individuals. nyti.ms/4jSIjOG
Reposted by Stephen Floor
the story today is of a profoundly low energy military parade being met with millions of americans in nationwide protests denouncing the dictatorial pretensions of the president
June 15, 2025 at 1:11 AM
the story today is of a profoundly low energy military parade being met with millions of americans in nationwide protests denouncing the dictatorial pretensions of the president
Traveling for a soccer tournament and there’s a rally of maybe 500 people here in South Lake Tahoe today, too. Solidarity. No kings, no tyrants 🇺🇸
Dude's wanted a military parade for himself for years and he finally makes it happen and turnout is worse than at a medium sized city's farmers market on a rainy day while like 2% of the entire country went out to protest his bullshit
June 15, 2025 at 12:25 AM
Traveling for a soccer tournament and there’s a rally of maybe 500 people here in South Lake Tahoe today, too. Solidarity. No kings, no tyrants 🇺🇸
Racism and xenophobia is already turning the US into a backwater to avoid
June 13, 2025 at 11:03 PM
Racism and xenophobia is already turning the US into a backwater to avoid
people will literally die because of this
“Covid-19 deniers, skeptics and outright anti-vaccine individuals.” Meet the government's new vaccine advisors. Story by @sherylnyt.bsky.social Gift link: nyti.ms/4462vqO
RFK Jr. Announces Eight New Members of CDC Vaccine Advisory Panel
The health secretary promised not to pick “anti-vaxxers.” But some public health leaders accused him of breaking his word.
nyti.ms
June 12, 2025 at 1:41 AM
people will literally die because of this
"all the best" 💩🤡
June 10, 2025 at 4:45 PM
"all the best" 💩🤡
Reposted by Stephen Floor
I urge others to similarly support our patriots at NIH who use their training and talents to improve human health and position the US as the world’s leader in biomedical discovery, innovation and technology development 🙏
Stanford's professor and Bethesda Declaration signatory @carolynbertozzi.bskyverified.social notes that the declaration “represents the voices of the highly trained Americans at NIH who want to serve their country and steward the biomedical enterprise.” 🧪
www.science.org/content/arti...
www.science.org/content/arti...
NIH staff and biomedical community sound alarm about agency politicization, funding slowdown
In test of NIH director’s support of dissent, NIH staff sign Bethesda Declaration urging reversal of grant cuts and freezes
www.science.org
June 9, 2025 at 3:40 PM
I urge others to similarly support our patriots at NIH who use their training and talents to improve human health and position the US as the world’s leader in biomedical discovery, innovation and technology development 🙏
fully agree - the real question is: will Trump let the DOGEs out?
In full sincerity, now is the moment to emphasize that undoing the changes implemented by DOGE is good for America, and increasing investment into NASA, NSF, NIH and other agencies will keep Elon from profiting off taxpayers.
June 5, 2025 at 9:01 PM
fully agree - the real question is: will Trump let the DOGEs out?
Reposted by Stephen Floor
These are not just grants. This is thousands of people who devoted their lives and careers - taking pay cuts, working long hours, living with uncertainty - all for the chance to try to make people's lives a bit better for you and your loved ones. This breaks my heart.
Cutting NIH or NSF funding sounds abstract. Seeing what research is actually being cut makes it real. Kudos to @nytimes.com for this piece:
www.nytimes.com/interactive/...
www.nytimes.com/interactive/...
Here Are the Nearly 2,500 Medical Research Grants Canceled or Delayed by Trump
Some cuts have been starkly visible, but the country’s medical grant-making machinery has also radically transformed outside the public eye.
www.nytimes.com
June 4, 2025 at 8:20 PM
These are not just grants. This is thousands of people who devoted their lives and careers - taking pay cuts, working long hours, living with uncertainty - all for the chance to try to make people's lives a bit better for you and your loved ones. This breaks my heart.
local yay area man discusses choices, when to go (dumb), how to be sprinkled with game, and gouda + broccoli
Bay Area ambassador E-40 packs in three decades worth of hits at the Tiny Desk for Black Music Month.
E-40: Tiny Desk Concert
Bay Area ambassador E-40 packs in three decades worth of hits at the Tiny Desk for Black Music Month.
n.pr
June 2, 2025 at 7:41 PM
local yay area man discusses choices, when to go (dumb), how to be sprinkled with game, and gouda + broccoli