Jeff Leek
@jtleek.bsky.social
Dad/Coach
Chief Data Officer, Fred Hutch https://hutchdatascience.org/
Professor, Fred Hutch https://jtleek.com/
Founder, Synthesize Bio https://www.synthesize.bio/
Building things to help people.
Opinions & content are my own.
Chief Data Officer, Fred Hutch https://hutchdatascience.org/
Professor, Fred Hutch https://jtleek.com/
Founder, Synthesize Bio https://www.synthesize.bio/
Building things to help people.
Opinions & content are my own.
Reposted by Jeff Leek
Ad hoc, post hoc and intrinsic-hoc in bioinformatics www.nature.com/articles/s41... (read free: rdcu.be/eNGd3) 🧬🖥️🧪
October 31, 2025 at 3:55 PM
Ad hoc, post hoc and intrinsic-hoc in bioinformatics www.nature.com/articles/s41... (read free: rdcu.be/eNGd3) 🧬🖥️🧪
A cool story that connects the first data I ever analyzed to the work we are doing with Synthesize ! youtube.com/shorts/zN4_m...
The Experiments #Biology Can’t Run — Until Now. #AI #entrepreneur #technology #tech #geneexpression
YouTube video by Madrona
youtube.com
September 24, 2025 at 9:27 PM
A cool story that connects the first data I ever analyzed to the work we are doing with Synthesize ! youtube.com/shorts/zN4_m...
Generative genomics predicts future and impossible experiments! Read the new preprint from Synthesize Bio: www.biorxiv.org/content/10.1... and anyone can try our models on the cloud or in R/Python! product.synthesize.bio
September 16, 2025 at 4:05 PM
Generative genomics predicts future and impossible experiments! Read the new preprint from Synthesize Bio: www.biorxiv.org/content/10.1... and anyone can try our models on the cloud or in R/Python! product.synthesize.bio
Reposted by Jeff Leek
CAIA is breaking down research silos with federated learning. AI models learn from diverse data without moving it.
Read more: www.canceralliance.ai/blog/beyond-...
Congrats to @jtleek.bsky.social + CAIA for advancing secure, equitable cancer research.
#CancerAI #FederatedLearning #Biostatistics
Read more: www.canceralliance.ai/blog/beyond-...
Congrats to @jtleek.bsky.social + CAIA for advancing secure, equitable cancer research.
#CancerAI #FederatedLearning #Biostatistics
Research beyond silos - Cancer AI Alliance
The Cancer AI Alliance (CAIA) brings together top cancer centers and tech leaders to break down institutional silos. Using federated learning, they securely train AI models on diverse patient data, ac...
www.canceralliance.ai
September 15, 2025 at 6:08 PM
CAIA is breaking down research silos with federated learning. AI models learn from diverse data without moving it.
Read more: www.canceralliance.ai/blog/beyond-...
Congrats to @jtleek.bsky.social + CAIA for advancing secure, equitable cancer research.
#CancerAI #FederatedLearning #Biostatistics
Read more: www.canceralliance.ai/blog/beyond-...
Congrats to @jtleek.bsky.social + CAIA for advancing secure, equitable cancer research.
#CancerAI #FederatedLearning #Biostatistics
Reposted by Jeff Leek
Our pioneering partnership with leading cancer centers and tech companies has been recognized by TIME magazine’s #TIME100AI 2025 for groundbreaking work in artificial intelligence and cancer research!
Honored to see the Cancer AI Alliance included on TIME's list of the TIME100 AI of 2025! #TIME100AI.
CAIA has been a true team sport based on the shared commitment of all our Alliance members to accelerate cancer research and ultimately improve and save patient’s lives.
time.com/collections/...
CAIA has been a true team sport based on the shared commitment of all our Alliance members to accelerate cancer research and ultimately improve and save patient’s lives.
time.com/collections/...
September 2, 2025 at 2:59 PM
Our pioneering partnership with leading cancer centers and tech companies has been recognized by TIME magazine’s #TIME100AI 2025 for groundbreaking work in artificial intelligence and cancer research!
Honored to see the Cancer AI Alliance included on TIME's list of the TIME100 AI of 2025! #TIME100AI.
CAIA has been a true team sport based on the shared commitment of all our Alliance members to accelerate cancer research and ultimately improve and save patient’s lives.
time.com/collections/...
CAIA has been a true team sport based on the shared commitment of all our Alliance members to accelerate cancer research and ultimately improve and save patient’s lives.
time.com/collections/...
August 28, 2025 at 1:03 PM
Honored to see the Cancer AI Alliance included on TIME's list of the TIME100 AI of 2025! #TIME100AI.
CAIA has been a true team sport based on the shared commitment of all our Alliance members to accelerate cancer research and ultimately improve and save patient’s lives.
time.com/collections/...
CAIA has been a true team sport based on the shared commitment of all our Alliance members to accelerate cancer research and ultimately improve and save patient’s lives.
time.com/collections/...
Check out this great post explaining our approach to enabling AI model learning and reasoning across multiple-institutions while carefully protecting (and never transferring!) patient data! www.canceralliance.ai/blog/caia-fe...
How CAIA harnesses federated learning for secure collaboration - Cancer AI Alliance
How can we train AI models on the collective knowledge of the nation's top cancer centers without exposing sensitive patient information? CAIA’s solution is an AI training approach called federated ...
www.canceralliance.ai
August 27, 2025 at 6:56 PM
Check out this great post explaining our approach to enabling AI model learning and reasoning across multiple-institutions while carefully protecting (and never transferring!) patient data! www.canceralliance.ai/blog/caia-fe...
I was recently on a panel talking about Synthesize Bio and the future of AI in biotech! www.youtube.com/watch?v=AR5s...
The Future of Drug Discovery: AI, Data, and Design
YouTube video by Madrona
www.youtube.com
August 19, 2025 at 7:08 PM
I was recently on a panel talking about Synthesize Bio and the future of AI in biotech! www.youtube.com/watch?v=AR5s...
Reposted by Jeff Leek
Fred Hutch data scientists Carrie Wright and Elizabeth Humphries weigh in on OpenAI's first open-weight reasoning #AI, noting its potential for personalization in research applications while emphasizing thoughtful integration. Via @nature.com go.nature.com/4mFSoRb
@fredhutchbiostat.bsky.social
@fredhutchbiostat.bsky.social
OpenAI launches reasoning LLM that you can download and tweak
One version of the gpt-oss large language model can run on a laptop, and performs nearly as well as the company’s most powerful models.
go.nature.com
August 8, 2025 at 8:34 PM
Fred Hutch data scientists Carrie Wright and Elizabeth Humphries weigh in on OpenAI's first open-weight reasoning #AI, noting its potential for personalization in research applications while emphasizing thoughtful integration. Via @nature.com go.nature.com/4mFSoRb
@fredhutchbiostat.bsky.social
@fredhutchbiostat.bsky.social
Code from my first live R package demo talk in honor of Hadley at #jsm2025
gist.github.com/jtleek/8c927...
Steve Salerno, Awan Afiaz, and I have been developing the scorcher package to help you more easily fit deep learning models in R !
github.com/jtleek/scorc...
gist.github.com/jtleek/8c927...
Steve Salerno, Awan Afiaz, and I have been developing the scorcher package to help you more easily fit deep learning models in R !
github.com/jtleek/scorc...
August 7, 2025 at 1:59 PM
Code from my first live R package demo talk in honor of Hadley at #jsm2025
gist.github.com/jtleek/8c927...
Steve Salerno, Awan Afiaz, and I have been developing the scorcher package to help you more easily fit deep learning models in R !
github.com/jtleek/scorc...
gist.github.com/jtleek/8c927...
Steve Salerno, Awan Afiaz, and I have been developing the scorcher package to help you more easily fit deep learning models in R !
github.com/jtleek/scorc...
The highlight of my #jsm2025 talk was @hadley.nz roasting the panel with ChatGPT.😂
I also love that he talked about aspiring to kindness!
I also love that he talked about aspiring to kindness!
August 6, 2025 at 4:26 PM
The highlight of my #jsm2025 talk was @hadley.nz roasting the panel with ChatGPT.😂
I also love that he talked about aspiring to kindness!
I also love that he talked about aspiring to kindness!
We are about to be live talking about how cool @hadley.nz is in CC214 at 1030am ! Come hang out if you are at #jsm2025
✨ Wednesday at #JSM2025:
👉 @jtleek.bsky.social joins the panel honoring @hadley.nz and the power of the #tidyverse.
👉 Lucas Liu presents on cancer recurrence detection using deep learning + LLMs, outperforming traditional NLP.
#FredHutch #LLMs #CancerAI #StatGraphics #RStats #DataScience
👉 @jtleek.bsky.social joins the panel honoring @hadley.nz and the power of the #tidyverse.
👉 Lucas Liu presents on cancer recurrence detection using deep learning + LLMs, outperforming traditional NLP.
#FredHutch #LLMs #CancerAI #StatGraphics #RStats #DataScience
2025 Joint Statistical Meetings - Statistics, Data Science, and AI Enriching Society
The Joint Statistical Meetings (JSM) is the largest gathering of statisticians held in North America. Attended by more than 5,000 people, meeting activities include oral presentations, panel sessions,...
ww2.amstat.org
August 6, 2025 at 3:17 PM
We are about to be live talking about how cool @hadley.nz is in CC214 at 1030am ! Come hang out if you are at #jsm2025
My family and I are going to be running the 5k at Obliteride again this year! (we'll be biking as soon as the boys are old enough :)). We are raising funds for data science and AI efforts to find cancer cures at the Fred Hutch, consider donating if you are able! secure.fredhutch.org/site/TR/Obli...
Jeff Leek
Help Fred Hutch Cancer Center advance innovative research. Donate today!
secure.fredhutch.org
July 28, 2025 at 2:53 PM
My family and I are going to be running the 5k at Obliteride again this year! (we'll be biking as soon as the boys are old enough :)). We are raising funds for data science and AI efforts to find cancer cures at the Fred Hutch, consider donating if you are able! secure.fredhutch.org/site/TR/Obli...
Wild congratulations to one of the most incredible people I’ve ever worked with. @benlangmead.bsky.social I hope you are celebrating this very well deserved honor!!!
Congratulations to @benlangmead.bsky.social on his promotion to full professor! 🎉 Prof. Langmead is recognized across the computational and life sciences fields for his innovative methods helping to transform how biomedical researchers and other life scientists access and use DNA sequencing data. 🧬
July 22, 2025 at 11:35 PM
Wild congratulations to one of the most incredible people I’ve ever worked with. @benlangmead.bsky.social I hope you are celebrating this very well deserved honor!!!
These are not just grants. This is thousands of people who devoted their lives and careers - taking pay cuts, working long hours, living with uncertainty - all for the chance to try to make people's lives a bit better for you and your loved ones. This breaks my heart.
Cutting NIH or NSF funding sounds abstract. Seeing what research is actually being cut makes it real. Kudos to @nytimes.com for this piece:
www.nytimes.com/interactive/...
www.nytimes.com/interactive/...
Here Are the Nearly 2,500 Medical Research Grants Canceled or Delayed by Trump
Some cuts have been starkly visible, but the country’s medical grant-making machinery has also radically transformed outside the public eye.
www.nytimes.com
June 4, 2025 at 8:20 PM
These are not just grants. This is thousands of people who devoted their lives and careers - taking pay cuts, working long hours, living with uncertainty - all for the chance to try to make people's lives a bit better for you and your loved ones. This breaks my heart.
Reposted by Jeff Leek
Damn... I wonder why scientists wouldn't want to come to the US to compete at the highest levels for highly-restricted funding that then gets pulled surreptitiously for some imagined reason or no reason at all, all while being vilified by the federal government for their work? A mystery! 🤔
May 30, 2025 at 12:58 PM
Damn... I wonder why scientists wouldn't want to come to the US to compete at the highest levels for highly-restricted funding that then gets pulled surreptitiously for some imagined reason or no reason at all, all while being vilified by the federal government for their work? A mystery! 🤔
Reposted by Jeff Leek
Industry friends, now is the time for MUCH more speaking out on behalf of academic colleagues under duress. Here are core open source methods that many of your products doubtlessly depend on either directly or indirectly (see en.wikipedia.org/wiki/HMMER) being abruptly defunded. Make noise.
May 29, 2025 at 2:39 PM
Industry friends, now is the time for MUCH more speaking out on behalf of academic colleagues under duress. Here are core open source methods that many of your products doubtlessly depend on either directly or indirectly (see en.wikipedia.org/wiki/HMMER) being abruptly defunded. Make noise.
If you are around Seattle, see ya there :)
🤖 UW Statistics hosts Hutch’s own @jtleek.bsky.social this Friday:
“Building and Using AI Engines – What Do We Do When We’ve Machine Learned Everything?”
📅 May 30 • 🕒 3:30 PM PT • 📍 UW Statistics
🔗 stat.uw.edu/seminars/bui...
#Statistics #AI #MachineLearning #FredHutch #UWStats #DataScience
“Building and Using AI Engines – What Do We Do When We’ve Machine Learned Everything?”
📅 May 30 • 🕒 3:30 PM PT • 📍 UW Statistics
🔗 stat.uw.edu/seminars/bui...
#Statistics #AI #MachineLearning #FredHutch #UWStats #DataScience
bsky.app
May 28, 2025 at 6:20 PM
If you are around Seattle, see ya there :)
Reposted by Jeff Leek
Bright and early talk by @jtleek.bsky.social at the Princess Margaret Cancer Centre Grand Rounds on building and scaling AI engines in oncology.
May 22, 2025 at 12:11 PM
Bright and early talk by @jtleek.bsky.social at the Princess Margaret Cancer Centre Grand Rounds on building and scaling AI engines in oncology.
NOOOOOOOOOOOOOOOOOOOOOO
The final (more or less) episode of the Not So Standard Deviations podcast is out now. Thanks for listening! nssdeviations.com/190-indefini...
Not So Standard Deviations: 190 - Indefinite Leave
190 - Indefinite Leave After a very brief summary of the changing data science landscape, Hilary and Roger do not actually end the podcast but discuss taking an indefinite leave, leaving the do...
nssdeviations.com
May 19, 2025 at 8:23 PM
NOOOOOOOOOOOOOOOOOOOOOO
Reposted by Jeff Leek
Congratulations to the @jxtxfoundation.bsky.social scholarship winners for the 2025 Biology of Genomes conference @cshlnews.bsky.social! Learn more about their research and the scholarship program here: jxtxfoundation.org/news/2025-3-... #bog25
May 6, 2025 at 2:48 PM
Congratulations to the @jxtxfoundation.bsky.social scholarship winners for the 2025 Biology of Genomes conference @cshlnews.bsky.social! Learn more about their research and the scholarship program here: jxtxfoundation.org/news/2025-3-... #bog25
Synthesize Bio's platform is awesome as a teaching tool. In just a couple of minutes you can (a) find a dataset, (b) run a validated workflow like @mikelove.bsky.social's published EDA workflow, and (c) share with your friends:
app.synthesize.bio/notebooks/3a...
app.synthesize.bio/notebooks/3a...
May 2, 2025 at 5:34 PM
Synthesize Bio's platform is awesome as a teaching tool. In just a couple of minutes you can (a) find a dataset, (b) run a validated workflow like @mikelove.bsky.social's published EDA workflow, and (c) share with your friends:
app.synthesize.bio/notebooks/3a...
app.synthesize.bio/notebooks/3a...
Reposted by Jeff Leek
This alliance helps solve the key technical challenges that will enable us to securely use both #AI and massive computational power to find these breakthrough insights and save more lives. Congrats to the CAIA team on this well-deserved recognition! #oncsky
Congrats to the Cancer AI Alliance (CAIA) on being named @geekwire.com's Health Innovation of the Year! This Fred Hutch-led initiative unites experts to apply responsible #AI to cancer centers’ data, unlocking insights while ensuring data security. Learn more: www.canceralliance.ai
May 2, 2025 at 5:27 PM
An incredible honor and the momentum is building for the Cancer AI Alliance. We have been hard at work behind the scenes - expect more public from us soon! @brianmbot.bsky.social (pictured) and the broader CAIA team are amazing and it is fantastic to see their work rewarded.
Congrats to the Cancer AI Alliance (CAIA) on being named @geekwire.com's Health Innovation of the Year! This Fred Hutch-led initiative unites experts to apply responsible #AI to cancer centers’ data, unlocking insights while ensuring data security. Learn more: www.canceralliance.ai
May 2, 2025 at 5:32 PM
An incredible honor and the momentum is building for the Cancer AI Alliance. We have been hard at work behind the scenes - expect more public from us soon! @brianmbot.bsky.social (pictured) and the broader CAIA team are amazing and it is fantastic to see their work rewarded.
Reposted by Jeff Leek
We are in a period of remarkable progress in cancer research and care. It’s critical that we don’t let near-term pressures immobilize us and lose sight of our long-term plans. Thanks to Becker’s Hospital Review for inviting me to share what's at stake. www.beckershospitalreview.com/oncology/ami...
Amid federal funding uncertainty, cancer center leaders forge ahead - Becker's Hospital Review | Healthcare News & Analysis
Facing federal funding uncertainty, a looming workforce shortage and an increasingly aging patient population, cancer center leaders in the U.S. remain undeterred. Their focus remains, as it has for d...
www.beckershospitalreview.com
April 30, 2025 at 8:23 PM
We are in a period of remarkable progress in cancer research and care. It’s critical that we don’t let near-term pressures immobilize us and lose sight of our long-term plans. Thanks to Becker’s Hospital Review for inviting me to share what's at stake. www.beckershospitalreview.com/oncology/ami...