Sebastian Falk
@sebastianfalk.bsky.social
🏳️🌈 Assoc. Prof @Max Perutz Labs Vienna, Biochemist & Structural Biologist, #RNA & #protein, Tennis addict, 🐈❤️,all time skeptic 🤨
Reposted by Sebastian Falk
📢 Open Call! The Max Perutz Labs invite applications for a Full Professorship in Integrative Structure Biology with a focus on in situ structural biology using cryo-electron tomography (cryo-ET) and related methods. More details ➡️ tinyurl.com/brswbymu
October 31, 2025 at 9:24 AM
📢 Open Call! The Max Perutz Labs invite applications for a Full Professorship in Integrative Structure Biology with a focus on in situ structural biology using cryo-electron tomography (cryo-ET) and related methods. More details ➡️ tinyurl.com/brswbymu
Reposted by Sebastian Falk
When transposons jump, genomes diverge - even in cultured cells.
I am happy to share our new preprint: a chromosome-scale genome assembly for Drosophila OSC cells, one of the key model systems in the piRNA field, especially for nuclear piRNA biology. 🧬🧵 (1/12)
I am happy to share our new preprint: a chromosome-scale genome assembly for Drosophila OSC cells, one of the key model systems in the piRNA field, especially for nuclear piRNA biology. 🧬🧵 (1/12)
October 14, 2025 at 8:34 PM
When transposons jump, genomes diverge - even in cultured cells.
I am happy to share our new preprint: a chromosome-scale genome assembly for Drosophila OSC cells, one of the key model systems in the piRNA field, especially for nuclear piRNA biology. 🧬🧵 (1/12)
I am happy to share our new preprint: a chromosome-scale genome assembly for Drosophila OSC cells, one of the key model systems in the piRNA field, especially for nuclear piRNA biology. 🧬🧵 (1/12)
Reposted by Sebastian Falk
Professorship in plant genetics.
The Botanical Institute at Kiel University is advertising a W2 professorship. Great opportunity to do plant research in the north of Germany. See:
www.berufungen.uni-kiel.de/de/dateien/o...
The Botanical Institute at Kiel University is advertising a W2 professorship. Great opportunity to do plant research in the north of Germany. See:
www.berufungen.uni-kiel.de/de/dateien/o...
www.berufungen.uni-kiel.de
October 12, 2025 at 9:01 AM
Professorship in plant genetics.
The Botanical Institute at Kiel University is advertising a W2 professorship. Great opportunity to do plant research in the north of Germany. See:
www.berufungen.uni-kiel.de/de/dateien/o...
The Botanical Institute at Kiel University is advertising a W2 professorship. Great opportunity to do plant research in the north of Germany. See:
www.berufungen.uni-kiel.de/de/dateien/o...
Reposted by Sebastian Falk
PIWI clade Argonautes are essential for transposon silencing. Without them, animals are sterile due to massive transposon activity.
But how does piRNA-guided target interaction translate into silencing?
PhD student Júlia Portell Montserrat has an intriguing answer
www.cell.com/molecular-ce...
But how does piRNA-guided target interaction translate into silencing?
PhD student Júlia Portell Montserrat has an intriguing answer
www.cell.com/molecular-ce...
September 17, 2025 at 10:39 AM
PIWI clade Argonautes are essential for transposon silencing. Without them, animals are sterile due to massive transposon activity.
But how does piRNA-guided target interaction translate into silencing?
PhD student Júlia Portell Montserrat has an intriguing answer
www.cell.com/molecular-ce...
But how does piRNA-guided target interaction translate into silencing?
PhD student Júlia Portell Montserrat has an intriguing answer
www.cell.com/molecular-ce...
Reposted by Sebastian Falk
I am excited to announce that I will be moving to IMB Mainz next year! The Winter call for the IPP PhD program is now open; if you are interested in maternal #mRNA regulation and #translation in early vertebrate development, please apply! Deadline: 16 October.
More info: www.imb.de/students-pos...
More info: www.imb.de/students-pos...
Laura Lorenzo Orts
IMB Mainz
www.imb.de
September 15, 2025 at 12:13 PM
I am excited to announce that I will be moving to IMB Mainz next year! The Winter call for the IPP PhD program is now open; if you are interested in maternal #mRNA regulation and #translation in early vertebrate development, please apply! Deadline: 16 October.
More info: www.imb.de/students-pos...
More info: www.imb.de/students-pos...
Reposted by Sebastian Falk
Join us for the Austrian Cryo-EM Symposium Nov 11–12 at @istaresearch.bsky.social!
Top speakers, cutting-edge cryo-EM, and a chance to explore Vienna & the ISTA campus.
Register now 👉 cryoem-symposium.pages.ist.ac.at #cryoEM #teamtomo
Top speakers, cutting-edge cryo-EM, and a chance to explore Vienna & the ISTA campus.
Register now 👉 cryoem-symposium.pages.ist.ac.at #cryoEM #teamtomo
September 15, 2025 at 9:37 AM
Join us for the Austrian Cryo-EM Symposium Nov 11–12 at @istaresearch.bsky.social!
Top speakers, cutting-edge cryo-EM, and a chance to explore Vienna & the ISTA campus.
Register now 👉 cryoem-symposium.pages.ist.ac.at #cryoEM #teamtomo
Top speakers, cutting-edge cryo-EM, and a chance to explore Vienna & the ISTA campus.
Register now 👉 cryoem-symposium.pages.ist.ac.at #cryoEM #teamtomo
Reposted by Sebastian Falk
🎉 Congrats to @kgaurav.bsky.social, Lukas Stelzl & @reneketting.bsky.social (SFB1551) on their new Biophysical Journal paper! #MUT16 #PhaseSeparation #MutatorFoci #SmallRNA #GeneRegulation #Celegans #ProteinAssembly #RNAResearch #MultiscaleSimulations Great teamwork👏👏👏 www.cell.com/biophysj/ful....
Multi-scale Simulations of MUT-16 Scaffold Protein Phase Separation and Client Recognition
Phase separation of proteins plays a critical role in cellular organisation. How phase
separated protein condensates underpin biological function and how condensates achieve
specificity remain elusive...
www.cell.com
August 14, 2025 at 12:28 PM
🎉 Congrats to @kgaurav.bsky.social, Lukas Stelzl & @reneketting.bsky.social (SFB1551) on their new Biophysical Journal paper! #MUT16 #PhaseSeparation #MutatorFoci #SmallRNA #GeneRegulation #Celegans #ProteinAssembly #RNAResearch #MultiscaleSimulations Great teamwork👏👏👏 www.cell.com/biophysj/ful....
Reposted by Sebastian Falk
Happy to share the latest work on a bacterial protein that inhibits human mRNA decay machinery, in collaboration with @smlea.bsky.social #RNAsky
www.nature.com/articles/s41... Intracellular pathogen effector reprograms host gene expression by inhibiting mRNA decay | Nature Communications
www.nature.com/articles/s41... Intracellular pathogen effector reprograms host gene expression by inhibiting mRNA decay | Nature Communications
Intracellular pathogen effector reprograms host gene expression by inhibiting mRNA decay - Nature Communications
Intracellular pathogens hijack host gene expression to subvert cellular processes. Here, the authors show that Legionella pneumophila’s PieF effector inhibits the human CCR4-NOT deadenylation machiner...
www.nature.com
July 13, 2025 at 3:59 AM
Happy to share the latest work on a bacterial protein that inhibits human mRNA decay machinery, in collaboration with @smlea.bsky.social #RNAsky
www.nature.com/articles/s41... Intracellular pathogen effector reprograms host gene expression by inhibiting mRNA decay | Nature Communications
www.nature.com/articles/s41... Intracellular pathogen effector reprograms host gene expression by inhibiting mRNA decay | Nature Communications
Reposted by Sebastian Falk
This guy…..
NIH Director Jay Bhattacharya used sickle cell disease research as an example of something he would not call DEI and cut. It's being cut.
www.nbcwashington.com/news/local/n...
www.nbcwashington.com/news/local/n...
July 4, 2025 at 2:11 PM
This guy…..
Reposted by Sebastian Falk
Exciting and rare opportunity to join the @maxperutzlabs.bsky.social and the @viennabiocenter.bsky.social as a Full Professor!
www.nature.com/naturecareer...
www.nature.com/naturecareer...
Full Professorship in Molecular Mechanisms of Disease - Vienna BioCenter, Austria job with Max Perutz Labs, University of Vienna | 12841053
Join theMax Perutz Labs as Full Professor to unravel disease mechanisms—from metabolism and stress to RNA regulation, epigenetics, and immunity.
www.nature.com
July 2, 2025 at 7:19 AM
Exciting and rare opportunity to join the @maxperutzlabs.bsky.social and the @viennabiocenter.bsky.social as a Full Professor!
www.nature.com/naturecareer...
www.nature.com/naturecareer...
Congratulations Marco and team. Great to see it published 🎉
The work of brilliant PhD student @mariananatalin6.bsky.social is now out in @molsystbiol.org! We asked how nutrients shape compensatory evolution to DNA replication stress. We find changes in physiology and adaptation rates, yet core genetic adaptation remains robust! See her thread for details!👇
Excited to share the first paper of my PhD with @marcofumasoni.bsky.social , now published in @molsystbiol.org 🥳! We explored how nutrient levels influence adaptation to perturbed DNA replication. Here’s what we learned 🧵👇 www.embopress.org/doi/full/10....
June 26, 2025 at 7:35 PM
Congratulations Marco and team. Great to see it published 🎉
Reposted by Sebastian Falk
Reposted by Sebastian Falk
🚀 Group leaders Peter Schlögelhofer, Robert Konrat, and @sebastianfalk.bsky.social have secured @fwf-at.bsky.social projects, bringing in nearly €1.5 million. Their projects span mRNA processing, novel NMR methods, and chromosome architecture ➡️ tinyurl.com/3a6j3pw8
@univie.ac.at
@meduniwien.ac.at
@univie.ac.at
@meduniwien.ac.at
May 15, 2025 at 1:47 PM
🚀 Group leaders Peter Schlögelhofer, Robert Konrat, and @sebastianfalk.bsky.social have secured @fwf-at.bsky.social projects, bringing in nearly €1.5 million. Their projects span mRNA processing, novel NMR methods, and chromosome architecture ➡️ tinyurl.com/3a6j3pw8
@univie.ac.at
@meduniwien.ac.at
@univie.ac.at
@meduniwien.ac.at
Reposted by Sebastian Falk
If only funders saw the bigger picture… The obsession with medical research has come at a cost: plant biology has been sidelined, with countless discoveries stalled. Just look at Barbara McClintock, who discovered mobile genetic elements—only to be dismissed at the time of her groundbreaking work.
#EMBOClimateResilience
“The way in which our universities have divided up the sciences does not reflect the ways in which nature has divided up its problems”
@embo.org
@monicabettencourt.bsky.social
“The way in which our universities have divided up the sciences does not reflect the ways in which nature has divided up its problems”
@embo.org
@monicabettencourt.bsky.social
April 15, 2025 at 4:21 AM
If only funders saw the bigger picture… The obsession with medical research has come at a cost: plant biology has been sidelined, with countless discoveries stalled. Just look at Barbara McClintock, who discovered mobile genetic elements—only to be dismissed at the time of her groundbreaking work.
Reisen mit Deutschen Bahn; immer wieder ein Erlebnis, leider selten ein schoenes. ICE228 von Wien nach Wue; 5 h Fahrt und nur drei funktionierende Toiletten im ganzen Zug. Der Zug ist voll.. mehr als 20 minuten Anstehen fuer menschliche Beduerfnisse. @deutsche-bahn.bsky.social @bahn.bsky.social
April 14, 2025 at 9:55 AM
Reisen mit Deutschen Bahn; immer wieder ein Erlebnis, leider selten ein schoenes. ICE228 von Wien nach Wue; 5 h Fahrt und nur drei funktionierende Toiletten im ganzen Zug. Der Zug ist voll.. mehr als 20 minuten Anstehen fuer menschliche Beduerfnisse. @deutsche-bahn.bsky.social @bahn.bsky.social
Reposted by Sebastian Falk
Earnshaw, Goloborodko, Dekker & Mirny labs are excited to present our latest work, "Rules of engagement for condensins and cohesins guide mitotic chromosome formation" - now accepted!!
www.science.org/doi/10.1126/...
A short clip describing the key results:
www.youtube.com/watch?v=pmvO...
www.science.org/doi/10.1126/...
A short clip describing the key results:
www.youtube.com/watch?v=pmvO...
Rules of Engagement
YouTube video by Johan Gibcus
www.youtube.com
April 11, 2025 at 7:45 AM
Earnshaw, Goloborodko, Dekker & Mirny labs are excited to present our latest work, "Rules of engagement for condensins and cohesins guide mitotic chromosome formation" - now accepted!!
www.science.org/doi/10.1126/...
A short clip describing the key results:
www.youtube.com/watch?v=pmvO...
www.science.org/doi/10.1126/...
A short clip describing the key results:
www.youtube.com/watch?v=pmvO...
Reposted by Sebastian Falk
Why NIH/NIGMS funding of basic research matters with our latest work now out in @cp-cellreports.bsky.social sky.social. We solved a >30-year-old mystery of what transcription factor drives the Flamenco piRNA cluster required for female Drosophila fertility. /1
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Traffic Jam activates the Flamenco piRNA cluster locus and the Piwi pathway to ensure transposon silencing and Drosophila fertility
Rivera et al. discover Drosophila Flamenco piRNA cluster enhancers bound and activated
by the Traffic Jam transcription factor. Traffic Jam also binds many follicle cell
genes including activating mul...
www.cell.com
April 11, 2025 at 4:38 PM
Why NIH/NIGMS funding of basic research matters with our latest work now out in @cp-cellreports.bsky.social sky.social. We solved a >30-year-old mystery of what transcription factor drives the Flamenco piRNA cluster required for female Drosophila fertility. /1
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Reposted by Sebastian Falk
www.nature.com/naturecareer... UBC LSI Job!!
Assistant Professor (tenure track) – Chromatin, Epigenetics - Vancouver, British Columbia (CA) job with The University of British Columbia (UBC) | 12837841
Assistant Professor (tenure track) - Chromatin Regulation, Genetic Regulatory Mechanisms, Epigenetics, Epigenomics
www.nature.com
April 4, 2025 at 4:03 AM
www.nature.com/naturecareer... UBC LSI Job!!
Reposted by Sebastian Falk
🚨 Out now! The Leonard lab reveals in @pnas.org that phosphatases PHLPP1/2, once thought to dephosphorylate Akt and suppress tumors, are actually catalytically inactive. Instead, they have a non-catalytic role, reshaping our understanding of Akt regulation ➡️ tinyurl.com/hf28b3mu
@univie.ac.at
@univie.ac.at
April 2, 2025 at 6:55 AM
🚨 Out now! The Leonard lab reveals in @pnas.org that phosphatases PHLPP1/2, once thought to dephosphorylate Akt and suppress tumors, are actually catalytically inactive. Instead, they have a non-catalytic role, reshaping our understanding of Akt regulation ➡️ tinyurl.com/hf28b3mu
@univie.ac.at
@univie.ac.at
Reposted by Sebastian Falk
Reposted by Sebastian Falk
This is Yale Professor Timothy Snyder, who studies authoritarians and tyranny, with a warning.
He and another Yale professor, Jason Stanley, who studies similar topics at Yale, are moving to Canadian universities, a result of the political and academic climate here.
He and another Yale professor, Jason Stanley, who studies similar topics at Yale, are moving to Canadian universities, a result of the political and academic climate here.
March 26, 2025 at 2:09 AM
This is Yale Professor Timothy Snyder, who studies authoritarians and tyranny, with a warning.
He and another Yale professor, Jason Stanley, who studies similar topics at Yale, are moving to Canadian universities, a result of the political and academic climate here.
He and another Yale professor, Jason Stanley, who studies similar topics at Yale, are moving to Canadian universities, a result of the political and academic climate here.
Reposted by Sebastian Falk
Our paper on prediction of phase-separation propensities of disordered proteins from sequence is now published:
www.pnas.org/doi/10.1073/...
The paper has been substantially updated compared to the preprint including new experimental data and using the neural network to finetune CALVADOS. 1/n
www.pnas.org/doi/10.1073/...
The paper has been substantially updated compared to the preprint including new experimental data and using the neural network to finetune CALVADOS. 1/n
March 25, 2025 at 5:54 PM
Our paper on prediction of phase-separation propensities of disordered proteins from sequence is now published:
www.pnas.org/doi/10.1073/...
The paper has been substantially updated compared to the preprint including new experimental data and using the neural network to finetune CALVADOS. 1/n
www.pnas.org/doi/10.1073/...
The paper has been substantially updated compared to the preprint including new experimental data and using the neural network to finetune CALVADOS. 1/n
Reposted by Sebastian Falk
📯📯📯 10 days left to apply for the International Master MemBioMed "From Membrane Biology to Neuroscience & Experimental Medicine". Scholarships available for selected students to acquire intensive training in analysing the complex behavior of biomembranes and exploiting their therapeutic potential 👇👇
🚨🚨 We are proud to launch MemBioMed, a new international Master program offering interdisciplinary training in biomembrane research at 3 sites: Université de Côte d'Azur 🇫🇷 Università di Genova 🇮🇹 & Osnabrück University 🇩🇪. We offer 15 scholarships & encourage talented students to apply by April 6th ♻️🙏
March 25, 2025 at 11:18 PM
📯📯📯 10 days left to apply for the International Master MemBioMed "From Membrane Biology to Neuroscience & Experimental Medicine". Scholarships available for selected students to acquire intensive training in analysing the complex behavior of biomembranes and exploiting their therapeutic potential 👇👇
Reposted by Sebastian Falk
Super excited to share our latest work on deciphering the #Ubiquitin Code
“𝗨𝗯𝗶𝗥𝗘𝗔𝗗 𝗱𝗲𝗰𝗶𝗽𝗵𝗲𝗿𝘀 𝗽𝗿𝗼𝘁𝗲𝗮𝘀𝗼𝗺𝗮𝗹 𝗱𝗲𝗴𝗿𝗮𝗱𝗮𝘁𝗶𝗼𝗻 𝗰𝗼𝗱𝗲 𝗼𝗳 𝗵𝗼𝗺𝗼𝘁𝘆𝗽𝗶𝗰 𝗮𝗻𝗱 𝗯𝗿𝗮𝗻𝗰𝗵𝗲𝗱 𝗞48 𝗮𝗻𝗱 𝗞63 𝘂𝗯𝗶𝗾𝘂𝗶𝘁𝗶𝗻 𝗰𝗵𝗮𝗶𝗻𝘀”
@cp-molcell.bsky.social
1/8
www.cell.com/molecular-ce...
“𝗨𝗯𝗶𝗥𝗘𝗔𝗗 𝗱𝗲𝗰𝗶𝗽𝗵𝗲𝗿𝘀 𝗽𝗿𝗼𝘁𝗲𝗮𝘀𝗼𝗺𝗮𝗹 𝗱𝗲𝗴𝗿𝗮𝗱𝗮𝘁𝗶𝗼𝗻 𝗰𝗼𝗱𝗲 𝗼𝗳 𝗵𝗼𝗺𝗼𝘁𝘆𝗽𝗶𝗰 𝗮𝗻𝗱 𝗯𝗿𝗮𝗻𝗰𝗵𝗲𝗱 𝗞48 𝗮𝗻𝗱 𝗞63 𝘂𝗯𝗶𝗾𝘂𝗶𝘁𝗶𝗻 𝗰𝗵𝗮𝗶𝗻𝘀”
@cp-molcell.bsky.social
1/8
www.cell.com/molecular-ce...
UbiREAD deciphers proteasomal degradation code of homotypic and branched K48 and K63 ubiquitin chains
Ubiquitin chains determine the fates of their modified proteins, including proteasomal
degradation. Kiss et al. present UbiREAD, a technology to monitor cellular degradation
and deubiquitination at hi...
www.cell.com
March 24, 2025 at 2:54 PM
Super excited to share our latest work on deciphering the #Ubiquitin Code
“𝗨𝗯𝗶𝗥𝗘𝗔𝗗 𝗱𝗲𝗰𝗶𝗽𝗵𝗲𝗿𝘀 𝗽𝗿𝗼𝘁𝗲𝗮𝘀𝗼𝗺𝗮𝗹 𝗱𝗲𝗴𝗿𝗮𝗱𝗮𝘁𝗶𝗼𝗻 𝗰𝗼𝗱𝗲 𝗼𝗳 𝗵𝗼𝗺𝗼𝘁𝘆𝗽𝗶𝗰 𝗮𝗻𝗱 𝗯𝗿𝗮𝗻𝗰𝗵𝗲𝗱 𝗞48 𝗮𝗻𝗱 𝗞63 𝘂𝗯𝗶𝗾𝘂𝗶𝘁𝗶𝗻 𝗰𝗵𝗮𝗶𝗻𝘀”
@cp-molcell.bsky.social
1/8
www.cell.com/molecular-ce...
“𝗨𝗯𝗶𝗥𝗘𝗔𝗗 𝗱𝗲𝗰𝗶𝗽𝗵𝗲𝗿𝘀 𝗽𝗿𝗼𝘁𝗲𝗮𝘀𝗼𝗺𝗮𝗹 𝗱𝗲𝗴𝗿𝗮𝗱𝗮𝘁𝗶𝗼𝗻 𝗰𝗼𝗱𝗲 𝗼𝗳 𝗵𝗼𝗺𝗼𝘁𝘆𝗽𝗶𝗰 𝗮𝗻𝗱 𝗯𝗿𝗮𝗻𝗰𝗵𝗲𝗱 𝗞48 𝗮𝗻𝗱 𝗞63 𝘂𝗯𝗶𝗾𝘂𝗶𝘁𝗶𝗻 𝗰𝗵𝗮𝗶𝗻𝘀”
@cp-molcell.bsky.social
1/8
www.cell.com/molecular-ce...
Reposted by Sebastian Falk
Great talks & discussions at the 76th Mosbacher Kolloquium last week - in particular fantastic Lynen Lecture by Tanja Kortemme @kortemmelab.bsky.social and Eduard-Buchner award lecture by Dorothee Kern! And great to see so many old and new friends. @gbmev.bsky.social
March 24, 2025 at 9:55 PM
Great talks & discussions at the 76th Mosbacher Kolloquium last week - in particular fantastic Lynen Lecture by Tanja Kortemme @kortemmelab.bsky.social and Eduard-Buchner award lecture by Dorothee Kern! And great to see so many old and new friends. @gbmev.bsky.social