SCALE - SubCellular Architecture of LifE
@scale-cluster-ffm.bsky.social
We are a Cluster of Excellence (EXC) based in Frankfurt, Germany, that explore the SubCellular Architecture of LifE. Our goal is to understand how the organizational principles within cells give rise to functional biological outcomes.
Reposted by SCALE - SubCellular Architecture of LifE
Exciting week in Frankfurt! Our CEOS energy filter and ASI Timepix3 are installed and we're looking forward to running the first tests :) #CryoEM #timepix #REELanalysis #4DSTEM @mpibp.bsky.social
November 5, 2025 at 12:12 PM
Exciting week in Frankfurt! Our CEOS energy filter and ASI Timepix3 are installed and we're looking forward to running the first tests :) #CryoEM #timepix #REELanalysis #4DSTEM @mpibp.bsky.social
Reposted by SCALE - SubCellular Architecture of LifE
Glushkova, Böhm, & Beck @maxplanck.de develop a publicly available computational method to measure the thickness of biological membranes in cryo-electron tomograms. Analysis of algae & human cells reveals systematic membrane thickness variations within & across organelles rupress.org/jcb/article/...
November 4, 2025 at 5:30 PM
Glushkova, Böhm, & Beck @maxplanck.de develop a publicly available computational method to measure the thickness of biological membranes in cryo-electron tomograms. Analysis of algae & human cells reveals systematic membrane thickness variations within & across organelles rupress.org/jcb/article/...
Reposted by SCALE - SubCellular Architecture of LifE
Just published! We share an open-source workflow to measure membrane thickness from tomograms, including a tutorial with 3D visualizations. We analyze thickness variations across organelles and reflect on where to define a membrane boundary. @becklab.bsky.social #teamtomo rupress.org/jcb/article/...
November 6, 2025 at 7:38 AM
Just published! We share an open-source workflow to measure membrane thickness from tomograms, including a tutorial with 3D visualizations. We analyze thickness variations across organelles and reflect on where to define a membrane boundary. @becklab.bsky.social #teamtomo rupress.org/jcb/article/...
Congratulations Melanie!
Our first lab paper is out! We identify and solve the first structure of the SND3 translocon involved in fungal membrane protein insertion. Congratulations @tzujingyang.bsky.social, and our colleagues @saumyakm.bsky.social, @hummerlab.bsky.social and Julian Langer. Read more ⬇️ and ➡️ rdcu.be/eNgIO
SNDing proteins into the membrane! Our new publication from @melaniemcdowell.bsky.social ’s group identifies the SND3 protein as a new route for membrane protein insertion! 🍄 📘 Read more here: www.mpg.de/25599408/102... Image: Louise Duever.
October 30, 2025 at 10:30 PM
Congratulations Melanie!
Reposted by SCALE - SubCellular Architecture of LifE
SNDing proteins into the membrane! Our new publication from @melaniemcdowell.bsky.social ’s group identifies the SND3 protein as a new route for membrane protein insertion! 🍄 📘 Read more here: www.mpg.de/25599408/102... Image: Louise Duever.
October 30, 2025 at 8:55 AM
SNDing proteins into the membrane! Our new publication from @melaniemcdowell.bsky.social ’s group identifies the SND3 protein as a new route for membrane protein insertion! 🍄 📘 Read more here: www.mpg.de/25599408/102... Image: Louise Duever.
Reposted by SCALE - SubCellular Architecture of LifE
🧬 Der Paul Ehrlich- und Ludwig Darmstaedter-Preis 2026 geht an Davor Solter & Azim Surani – sie entdeckten, dass wir für ein gesundes Leben die Gene beider Eltern brauchen. Ihre Arbeit zur genomischen Prägung öffnete das Tor zur modernen Epigenetik. | tinygu.de/PELD-Preis-2...
October 27, 2025 at 11:06 AM
🧬 Der Paul Ehrlich- und Ludwig Darmstaedter-Preis 2026 geht an Davor Solter & Azim Surani – sie entdeckten, dass wir für ein gesundes Leben die Gene beider Eltern brauchen. Ihre Arbeit zur genomischen Prägung öffnete das Tor zur modernen Epigenetik. | tinygu.de/PELD-Preis-2...
Reposted by SCALE - SubCellular Architecture of LifE
Im Exzellenzcluster @cpi-exstra.bsky.social untersuchen #Forschende interdisziplinär das Zusammenspiel von Herz und Lunge, Ziel ist u.a. die Entwicklung neuartiger Therapeutika. Zum Interview mit Prof. Dr. Dr. h.c. Stefanie Dimmeler von der @goetheuni.bsky.social geht es hier: youtu.be/aik52E5AlXg
RMU Insights: Exzellenzcluster Cardiopulmonary Institute (CPI)
YouTube video by Rhein-Main-Universitäten (RMU)
youtu.be
October 27, 2025 at 4:32 PM
Im Exzellenzcluster @cpi-exstra.bsky.social untersuchen #Forschende interdisziplinär das Zusammenspiel von Herz und Lunge, Ziel ist u.a. die Entwicklung neuartiger Therapeutika. Zum Interview mit Prof. Dr. Dr. h.c. Stefanie Dimmeler von der @goetheuni.bsky.social geht es hier: youtu.be/aik52E5AlXg
🚀 Exciting Job Opportunity: Project Coordinator at the Cluster of Excellence SCALE
We’re thrilled to announce an exceptional opportunity to join the newly founded Cluster of Excellence SCALE – Subcellular Architecture of Life from the @goetheuni.bsky.social.
👉 Learn more and apply here:
We’re thrilled to announce an exceptional opportunity to join the newly founded Cluster of Excellence SCALE – Subcellular Architecture of Life from the @goetheuni.bsky.social.
👉 Learn more and apply here:
October 22, 2025 at 9:41 AM
🚀 Exciting Job Opportunity: Project Coordinator at the Cluster of Excellence SCALE
We’re thrilled to announce an exceptional opportunity to join the newly founded Cluster of Excellence SCALE – Subcellular Architecture of Life from the @goetheuni.bsky.social.
👉 Learn more and apply here:
We’re thrilled to announce an exceptional opportunity to join the newly founded Cluster of Excellence SCALE – Subcellular Architecture of Life from the @goetheuni.bsky.social.
👉 Learn more and apply here:
Reposted by SCALE - SubCellular Architecture of LifE
I just made an account and voted for this biology laboratory made of LEGO to "promote biological research and inspire more people into the world of biology". They need 10K votes. Reposting and/or voting below would be helpful. 🤗
beta.ideas.lego.com/product-idea...
beta.ideas.lego.com/product-idea...
Biological Laboratory | LEGO® Ideas
This is a two-floor realistic Biological Laboratory building. In this design, I try to tell stories about biologists, introduce biology concepts to general publ…
beta.ideas.lego.com
October 16, 2025 at 8:07 AM
I just made an account and voted for this biology laboratory made of LEGO to "promote biological research and inspire more people into the world of biology". They need 10K votes. Reposting and/or voting below would be helpful. 🤗
beta.ideas.lego.com/product-idea...
beta.ideas.lego.com/product-idea...
Reposted by SCALE - SubCellular Architecture of LifE
It was a tremendous pleasure to have @zhixingchen2.bsky.social visiting us today in Frankfurt and listen to his great science on developing photostable and gentle fluorophores for microscopy.
Thank you, Zhixing, for this inspiring seminar! 🙏
@goetheuni.bsky.social @scale-cluster-ffm.bsky.social
Thank you, Zhixing, for this inspiring seminar! 🙏
@goetheuni.bsky.social @scale-cluster-ffm.bsky.social
October 7, 2025 at 3:29 PM
It was a tremendous pleasure to have @zhixingchen2.bsky.social visiting us today in Frankfurt and listen to his great science on developing photostable and gentle fluorophores for microscopy.
Thank you, Zhixing, for this inspiring seminar! 🙏
@goetheuni.bsky.social @scale-cluster-ffm.bsky.social
Thank you, Zhixing, for this inspiring seminar! 🙏
@goetheuni.bsky.social @scale-cluster-ffm.bsky.social
Reposted by SCALE - SubCellular Architecture of LifE
Proud that our work is online now in @jacs.acspublications.org 🎉 A big thanks to everyone involved in this project! If you are interested have a read:
doi.org/10.1021/jacs...
doi.org/10.1021/jacs...
Conformational Plasticity of LptC Regulates Lipopolysaccharide Transport by the LptB2FGC Complex
The outer membrane of Gram-negative bacteria is coated with lipopolysaccharide (LPS). The Lpt system generates membrane asymmetry by transporting LPS from the inner to the outer membrane. Transport be...
doi.org
September 23, 2025 at 5:30 PM
Proud that our work is online now in @jacs.acspublications.org 🎉 A big thanks to everyone involved in this project! If you are interested have a read:
doi.org/10.1021/jacs...
doi.org/10.1021/jacs...
Reposted by SCALE - SubCellular Architecture of LifE
GBM Compact Focus on Condensate Biology is opened by Edward Lemke. Looking forward to a great meeting!
September 18, 2025 at 11:09 AM
GBM Compact Focus on Condensate Biology is opened by Edward Lemke. Looking forward to a great meeting!
Reposted by SCALE - SubCellular Architecture of LifE
This morning we travelled into the fascinating world of neurons and synapses with @erin-schuman.bsky.social. We learnt how protein synthesis takes place in neuronal dendrites. 🧠
@mpibrain.bsky.social
#imprs_cbp #gradschool #brain
@mpibrain.bsky.social
#imprs_cbp #gradschool #brain
September 18, 2025 at 2:21 PM
This morning we travelled into the fascinating world of neurons and synapses with @erin-schuman.bsky.social. We learnt how protein synthesis takes place in neuronal dendrites. 🧠
@mpibrain.bsky.social
#imprs_cbp #gradschool #brain
@mpibrain.bsky.social
#imprs_cbp #gradschool #brain
Reposted by SCALE - SubCellular Architecture of LifE
We followed with a day packed with CryoEM! We heard about the cryoEM from Werner Kühlbrandt, STEM-EELs from Bonnie Murphy and CryoET from Martin Beck.
September 18, 2025 at 3:28 PM
We followed with a day packed with CryoEM! We heard about the cryoEM from Werner Kühlbrandt, STEM-EELs from Bonnie Murphy and CryoET from Martin Beck.
Reposted by SCALE - SubCellular Architecture of LifE
We're very excited to welcome the new generation of #IMPRS students during our Symposium on Cellular Biophysics 🧪 This morning, we heard spokespersons Volker Dötsch and Martin Beck, and coordinator Pamela Ornelas, introduce the doctoral program to the new students!
#imprs_cbp #biophysics #gradschool
#imprs_cbp #biophysics #gradschool
September 15, 2025 at 12:17 PM
We're very excited to welcome the new generation of #IMPRS students during our Symposium on Cellular Biophysics 🧪 This morning, we heard spokespersons Volker Dötsch and Martin Beck, and coordinator Pamela Ornelas, introduce the doctoral program to the new students!
#imprs_cbp #biophysics #gradschool
#imprs_cbp #biophysics #gradschool
Reposted by SCALE - SubCellular Architecture of LifE
We had a great start of the #IMPRS Symposium on Cellular Biophysics to welcome our new students. Thank you for your fascinating talks Michaela Müller-McNicoll, Bernhard Hampölz and Christian Münch 👏
#imprs_cbp #phd #biophysics
#imprs_cbp #phd #biophysics
September 15, 2025 at 3:04 PM
We had a great start of the #IMPRS Symposium on Cellular Biophysics to welcome our new students. Thank you for your fascinating talks Michaela Müller-McNicoll, Bernhard Hampölz and Christian Münch 👏
#imprs_cbp #phd #biophysics
#imprs_cbp #phd #biophysics
Reposted by SCALE - SubCellular Architecture of LifE
I am sooo excited. Starting tomorrow the next edition of the fabulous #emboiclip2 course begins. @koenig-lab.bsky.social, @zarnack-group.bsky.social, moi & Elias Bechara will present 3 improvements to the method, a semi-automated workflow for data analysis and an exciting line up of speakers. Ready?
Apply to our #EMBOiCLIP2 course in beautiful Genova this fall. Learn the latest version of the protocol, meet the experts in the field, analyze your own data and get to know fellow RNA aficionados.
meetings.embo.org/event/25-icl...
meetings.embo.org/event/25-icl...
iCLIP2, mapping protein-RNA interactions: from A to Z
RNA is increasingly recognized as a key therapeutic target , driving the development of RNA-based therapeutics for a broad spectrum of diseases. RNA-binding proteins (RBPs) play a fundamental ro…
meetings.embo.org
September 6, 2025 at 8:42 PM
I am sooo excited. Starting tomorrow the next edition of the fabulous #emboiclip2 course begins. @koenig-lab.bsky.social, @zarnack-group.bsky.social, moi & Elias Bechara will present 3 improvements to the method, a semi-automated workflow for data analysis and an exciting line up of speakers. Ready?
Reposted by SCALE - SubCellular Architecture of LifE
Congratulations! 🎉
September 8, 2025 at 5:45 AM
Congratulations! 🎉
🎉 We congratulate Prof. Dr. Eric Helfrich on nomination for the Paul Ehrlich & Ludwig Darmstaedter Early Career Award 2026! 🔬👏
September 3, 2025 at 1:36 PM
🎉 We congratulate Prof. Dr. Eric Helfrich on nomination for the Paul Ehrlich & Ludwig Darmstaedter Early Career Award 2026! 🔬👏
Reposted by SCALE - SubCellular Architecture of LifE
We’re looking forward to the IMPRS-CBP Symposium on Cellular Biophysics at the @mpibp.bsky.social ! Join us on Sept 15–22 for a week+ of talks from our faculty as we welcome our new students! 🧑🎓Learn more here: imprs-cbp.mpg.de/symposium-on...
August 30, 2025 at 11:34 AM
We’re looking forward to the IMPRS-CBP Symposium on Cellular Biophysics at the @mpibp.bsky.social ! Join us on Sept 15–22 for a week+ of talks from our faculty as we welcome our new students! 🧑🎓Learn more here: imprs-cbp.mpg.de/symposium-on...
Reposted by SCALE - SubCellular Architecture of LifE
Fresh in Nature Communications: a big update from the international biocondensate community featuring SFB1551 spokespersons @dormannlab.bsky.social and @lemkelab.bsky.social
Read more 👉 www.nature.com/articles/s41...
Congrats to all authors!
Read more 👉 www.nature.com/articles/s41...
Congrats to all authors!
Current practices in the study of biomolecular condensates: a community comment - Nature Communications
The realization that the cell is abundantly compartmentalized into biomolecular condensates has opened new opportunities for understanding the physics and chemistry underlying many cellular processes1...
www.nature.com
August 22, 2025 at 8:51 AM
Fresh in Nature Communications: a big update from the international biocondensate community featuring SFB1551 spokespersons @dormannlab.bsky.social and @lemkelab.bsky.social
Read more 👉 www.nature.com/articles/s41...
Congrats to all authors!
Read more 👉 www.nature.com/articles/s41...
Congrats to all authors!
Reposted by SCALE - SubCellular Architecture of LifE
We’re hosting the @embo.org Practical Course on In-situ structural biology by CryoFIB and CryoET in April 2026! 🧬❄️ You can expect hands-on training, cutting-edge methods, and a chance to work alongside leading experts in structural biology. 🔗 Apply by Dec 8, 2025: meetings.embo.org/event/26-in-...
August 18, 2025 at 11:29 AM
We’re hosting the @embo.org Practical Course on In-situ structural biology by CryoFIB and CryoET in April 2026! 🧬❄️ You can expect hands-on training, cutting-edge methods, and a chance to work alongside leading experts in structural biology. 🔗 Apply by Dec 8, 2025: meetings.embo.org/event/26-in-...
Congratulations Jenny, Martin and Bernhard 🥳!
My PhD paper is in press @cellpress.bsky.social and now online: www.sciencedirect.com/science/arti...!
Contents: weird #NPCs in yeast and flies, #CLEM, in situ #cryoET and more!
Made possible by the amazing @becklab.bsky.social team at @mpibp.bsky.social and collaborators! #TeamTomo
Contents: weird #NPCs in yeast and flies, #CLEM, in situ #cryoET and more!
Made possible by the amazing @becklab.bsky.social team at @mpibp.bsky.social and collaborators! #TeamTomo
The small GTPase Ran defines nuclear pore complex asymmetry
Nuclear pore complexes (NPCs) bridge across the nuclear envelope and mediate nucleocytoplasmic exchange. They consist of hundreds of nucleoporin build…
www.sciencedirect.com
August 19, 2025 at 12:39 PM
Congratulations Jenny, Martin and Bernhard 🥳!
Reposted by SCALE - SubCellular Architecture of LifE
🚀 Spotlight on early #career #science! On Sept 15, six outstanding young #researchers present their work at the Paul Ehrlich & Ludwig Darmstaedter Early Career Award 2026 – #Symposium in Frankfurt. Don’t miss it! | 🔗Register now lmy.de/MzPjd #GoetheUni
August 19, 2025 at 8:14 AM
🚀 Spotlight on early #career #science! On Sept 15, six outstanding young #researchers present their work at the Paul Ehrlich & Ludwig Darmstaedter Early Career Award 2026 – #Symposium in Frankfurt. Don’t miss it! | 🔗Register now lmy.de/MzPjd #GoetheUni
Reposted by SCALE - SubCellular Architecture of LifE
🧪 Who is Erin M. Schuman, winner of the 2026 HFSP Nakasone Award?
She uncovered that synapses — the brain’s communication hubs — can make their own proteins, rewriting how we think memories form.
Discover her research 👉zurl.co/niEzX
#HFSPNakasoneAward #sts
She uncovered that synapses — the brain’s communication hubs — can make their own proteins, rewriting how we think memories form.
Discover her research 👉zurl.co/niEzX
#HFSPNakasoneAward #sts
August 18, 2025 at 9:17 AM
🧪 Who is Erin M. Schuman, winner of the 2026 HFSP Nakasone Award?
She uncovered that synapses — the brain’s communication hubs — can make their own proteins, rewriting how we think memories form.
Discover her research 👉zurl.co/niEzX
#HFSPNakasoneAward #sts
She uncovered that synapses — the brain’s communication hubs — can make their own proteins, rewriting how we think memories form.
Discover her research 👉zurl.co/niEzX
#HFSPNakasoneAward #sts