Schneider lab
@sabschn.bsky.social
Structural biologist, nucleic acids, chemical biology, Group leader at the University of Munich (LMU)
Reposted by Schneider lab
Great work from my colleague and neighbor Shuo Gu and his team! #RNAsky #RNAbiology
New online: DICER1 hotspot mutation induces 3p microRNA gain of function via Argonaute strand switch
DICER1 hotspot mutation induces 3p microRNA gain of function via Argonaute strand switch
Nature Structural & Molecular Biology, Published online: 04 November 2025; doi:10.1038/s41594-025-01671-wMalagobadan et al. show that a DICER1 hotspot mutation, previously thought to cause partial loss of function, also leads to unexpected gain of function by activating normally silent 3p passenger microRNAs, revealing a strand-switch mechanism in tumorigenesis.
go.nature.com
November 4, 2025 at 11:47 AM
Great work from my colleague and neighbor Shuo Gu and his team! #RNAsky #RNAbiology
Reposted by Schneider lab
This work was a collaboration between our former Group Leader @zaminiqbal.bsky.social and colleagues at @sangerinstitute.bsky.social and the @uniofbath.bsky.social.
Explore the full paper:
www.science.org/doi/10.1126/...
Explore the full paper:
www.science.org/doi/10.1126/...
Pre- and postantibiotic epoch: The historical spread of antimicrobial resistance
Plasmids are now the primary vectors of antimicrobial resistance, but our understanding of how human industrialisation of antibiotics influenced their evolution is limited by a paucity of data predati...
www.science.org
September 26, 2025 at 12:04 PM
This work was a collaboration between our former Group Leader @zaminiqbal.bsky.social and colleagues at @sangerinstitute.bsky.social and the @uniofbath.bsky.social.
Explore the full paper:
www.science.org/doi/10.1126/...
Explore the full paper:
www.science.org/doi/10.1126/...
Reposted by Schneider lab
The final version of our article about PLD3 AMPylation is now out shorturl.at/iTxWx. One protein, many proteoforms. Congratulations to Laura and thanks to @marleenberouti.bsky.social @v-hornung.bsky.social @jaelab.bsky.social @hellmichgroup.bsky.social
September 23, 2025 at 7:11 AM
The final version of our article about PLD3 AMPylation is now out shorturl.at/iTxWx. One protein, many proteoforms. Congratulations to Laura and thanks to @marleenberouti.bsky.social @v-hornung.bsky.social @jaelab.bsky.social @hellmichgroup.bsky.social
Reposted by Schneider lab
New from our Pioneering Investigators collection 🎉
'Towards a hydrolysis stable artificial base pair with C-glycosides' by Stephanie Kath-Schorr (@kathlab.bsky.social) and colleagues.
#OpenAccess 🔓
'Towards a hydrolysis stable artificial base pair with C-glycosides' by Stephanie Kath-Schorr (@kathlab.bsky.social) and colleagues.
#OpenAccess 🔓
Towards a hydrolysis stable artificial base pair with C-glycosides
Artificial base-pairs expand the genetic alphabet and allow for site-specific labeling, for example with fluorophores or spin labels, thereby enhancing the capabilities of biomolecular sensing. We…
buff.ly
July 14, 2025 at 2:01 PM
New from our Pioneering Investigators collection 🎉
'Towards a hydrolysis stable artificial base pair with C-glycosides' by Stephanie Kath-Schorr (@kathlab.bsky.social) and colleagues.
#OpenAccess 🔓
'Towards a hydrolysis stable artificial base pair with C-glycosides' by Stephanie Kath-Schorr (@kathlab.bsky.social) and colleagues.
#OpenAccess 🔓
Reposted by Schneider lab
"m6A in the coding sequence: linking deposition, translation and decay"
by Kathi Zarnack (@zarnack-group.bsky.social) & colleagues
"This review explores [m6A in] mRNA decay, with a focus on the newly discovered CDS–m6A decay (CMD) pathway..."
Read it here:
authors.elsevier.com/sd/article/S...
by Kathi Zarnack (@zarnack-group.bsky.social) & colleagues
"This review explores [m6A in] mRNA decay, with a focus on the newly discovered CDS–m6A decay (CMD) pathway..."
Read it here:
authors.elsevier.com/sd/article/S...
July 8, 2025 at 12:07 PM
"m6A in the coding sequence: linking deposition, translation and decay"
by Kathi Zarnack (@zarnack-group.bsky.social) & colleagues
"This review explores [m6A in] mRNA decay, with a focus on the newly discovered CDS–m6A decay (CMD) pathway..."
Read it here:
authors.elsevier.com/sd/article/S...
by Kathi Zarnack (@zarnack-group.bsky.social) & colleagues
"This review explores [m6A in] mRNA decay, with a focus on the newly discovered CDS–m6A decay (CMD) pathway..."
Read it here:
authors.elsevier.com/sd/article/S...
Reposted by Schneider lab
Hier kann man sich noch anmelden für unsere Experimentalvorlesung mit JJ
Chemistry: form.hhu.de/institut-fue... 🙂
Chemistry: form.hhu.de/institut-fue... 🙂
September 1, 2025 at 3:50 PM
Hier kann man sich noch anmelden für unsere Experimentalvorlesung mit JJ
Chemistry: form.hhu.de/institut-fue... 🙂
Chemistry: form.hhu.de/institut-fue... 🙂
Reposted by Schneider lab
Our research has been engulfed by an endless torrent of lab leak conspiracy theories about the origin of the pandemic - even as the evidence for zoonosis has only grown stronger.
This fuels anti-science agendas and erodes public trust.
Now, we respond 👇
theconversation.com/how-conspira...
This fuels anti-science agendas and erodes public trust.
Now, we respond 👇
theconversation.com/how-conspira...
How conspiracy theories about COVID’s origins are hampering our ability to prevent the next pandemic
The COVID pandemic likely began when the virus jumped from animals to humans, and didn’t start in a lab. But false narratives continue to circulate.
theconversation.com
July 30, 2025 at 12:45 AM
Our research has been engulfed by an endless torrent of lab leak conspiracy theories about the origin of the pandemic - even as the evidence for zoonosis has only grown stronger.
This fuels anti-science agendas and erodes public trust.
Now, we respond 👇
theconversation.com/how-conspira...
This fuels anti-science agendas and erodes public trust.
Now, we respond 👇
theconversation.com/how-conspira...
Reposted by Schneider lab
First copies of my book are here!! As a new faculty member, I realized that in addition to my research job, I also had a leadership job…and I wasn’t prepared for that.
This book is the guide I wish I’d had then, with the goal of helping others now.
jenheemstra.com/book
This book is the guide I wish I’d had then, with the goal of helping others now.
jenheemstra.com/book
July 26, 2025 at 5:35 PM
First copies of my book are here!! As a new faculty member, I realized that in addition to my research job, I also had a leadership job…and I wasn’t prepared for that.
This book is the guide I wish I’d had then, with the goal of helping others now.
jenheemstra.com/book
This book is the guide I wish I’d had then, with the goal of helping others now.
jenheemstra.com/book
Reposted by Schneider lab
Our new article published in Chem. Science on improving protein contact by varying foldamer side chains is now available!
pubs.rsc.org/en/content/a...
pubs.rsc.org/en/content/a...
Structure-based design of an aromatic helical foldamer–protein interface
The starting point of this study is the solid state structure of a complex between human carbonic anhydrase II (HCAII) and a helically folded tetradecaamide aromatic foldamer with a nanomolar HCAII li...
pubs.rsc.org
July 17, 2025 at 12:46 PM
Our new article published in Chem. Science on improving protein contact by varying foldamer side chains is now available!
pubs.rsc.org/en/content/a...
pubs.rsc.org/en/content/a...
Reposted by Schneider lab
I am very excited to share the second paper of my PhD published in @cp-cell.bsky.social.
Many thanks to all co-authors, especially from Thomas Carell's group, and my supervisor @v-hornung.bsky.social for their great support and collaboration!
www.cell.com/cell/fulltex...
Many thanks to all co-authors, especially from Thomas Carell's group, and my supervisor @v-hornung.bsky.social for their great support and collaboration!
www.cell.com/cell/fulltex...
Pseudouridine RNA avoids immune detection through impaired endolysosomal processing and TLR engagement
Toll-like receptors (TLRs) 7 and 8 detect RNA degradation products to sense infection.
However, modified nucleosides common in self-RNA—most notably pseudouridine—evade
recognition. This study finds t...
www.cell.com
June 30, 2025 at 5:01 PM
I am very excited to share the second paper of my PhD published in @cp-cell.bsky.social.
Many thanks to all co-authors, especially from Thomas Carell's group, and my supervisor @v-hornung.bsky.social for their great support and collaboration!
www.cell.com/cell/fulltex...
Many thanks to all co-authors, especially from Thomas Carell's group, and my supervisor @v-hornung.bsky.social for their great support and collaboration!
www.cell.com/cell/fulltex...
Reposted by Schneider lab
Beautiful paper
Exogenous RNA surveillance by proton-sensing TRIM25
Exogenous messenger RNAs (mRNAs) require cellular machinery for delivery and translation but also encounter inhibitory factors. To investigate their regulation, we performed genome-wide CRISPR screens...
www.science.org
April 7, 2025 at 9:43 PM
Beautiful paper
Reposted by Schneider lab
Bei ihr trifft Fachwissen auf didaktische Kompetenz: Die Studierenden von Prof. Dr. Lena Daumann @daumannl.bsky.social aus der Chemie @hhu.de sind begeistert und haben sie für den #hhuLehrpreis2025 nominiert. 🧪
February 19, 2025 at 6:31 AM
Bei ihr trifft Fachwissen auf didaktische Kompetenz: Die Studierenden von Prof. Dr. Lena Daumann @daumannl.bsky.social aus der Chemie @hhu.de sind begeistert und haben sie für den #hhuLehrpreis2025 nominiert. 🧪
Reposted by Schneider lab
Reposted by Schneider lab
November 19, 2024 at 12:05 AM
Reposted by Schneider lab
Huge congratulations to Andreas Marx on winning the Albrecht Kossel Preis 2024 of @gdchbiochem.bsky.social. An inspiring award lecture highlighting his diverse contributions to understanding DNA polymerases and PTMs as well as his discovery of a human RNA ligase.
October 1, 2024 at 4:29 PM
Huge congratulations to Andreas Marx on winning the Albrecht Kossel Preis 2024 of @gdchbiochem.bsky.social. An inspiring award lecture highlighting his diverse contributions to understanding DNA polymerases and PTMs as well as his discovery of a human RNA ligase.
Reposted by Schneider lab
When dealing with pseudoscience, the devil is in the detail - in this case, narrowing down a specific "Lab Leak" hypothesis.
In Dr. Chan's @nytimes.com OpEd there is, however, a very specific hypothesis for COVID-19 origin.
It's a prime example of conspiracism vs empiricism, so let's dive in.
🧵
In Dr. Chan's @nytimes.com OpEd there is, however, a very specific hypothesis for COVID-19 origin.
It's a prime example of conspiracism vs empiricism, so let's dive in.
🧵
On the day of Dr. Fauci's testimony, @nytimes.com decides to run a deeply unethical OpEd with snazzy graphics and snappy headlines about the Lab Leak.
The article itself contains multiple falsehoods and deep mischaracterizations.
Let's take every point in turn 👇🧵
www.nytimes.com/interactive/...
The article itself contains multiple falsehoods and deep mischaracterizations.
Let's take every point in turn 👇🧵
www.nytimes.com/interactive/...
Opinion | Why the Pandemic Probably Started in a Lab, in 5 Key Points
The world must not continue to bear the intolerable risks of research with the potential to cause pandemics.
www.nytimes.com
June 5, 2024 at 7:35 PM
When dealing with pseudoscience, the devil is in the detail - in this case, narrowing down a specific "Lab Leak" hypothesis.
In Dr. Chan's @nytimes.com OpEd there is, however, a very specific hypothesis for COVID-19 origin.
It's a prime example of conspiracism vs empiricism, so let's dive in.
🧵
In Dr. Chan's @nytimes.com OpEd there is, however, a very specific hypothesis for COVID-19 origin.
It's a prime example of conspiracism vs empiricism, so let's dive in.
🧵
Reposted by Schneider lab
RNA has taken center stage, with remarkable versatility, such as >400 drugs approved and many more to come.
My conversation with Tom Cech, Nobel laureate, pioneer of RNA biology, with a new book called THE CATALYST, w/transcript
erictopol.substack.com/p/tom-cech-r...
My conversation with Tom Cech, Nobel laureate, pioneer of RNA biology, with a new book called THE CATALYST, w/transcript
erictopol.substack.com/p/tom-cech-r...
Tom Cech: RNA Takes Center Stage
Listen now (49 mins) | A pioneer and Nobel laureate for advancing the biology of RNA has a new book THE CATALYST
erictopol.substack.com
June 5, 2024 at 10:05 PM
RNA has taken center stage, with remarkable versatility, such as >400 drugs approved and many more to come.
My conversation with Tom Cech, Nobel laureate, pioneer of RNA biology, with a new book called THE CATALYST, w/transcript
erictopol.substack.com/p/tom-cech-r...
My conversation with Tom Cech, Nobel laureate, pioneer of RNA biology, with a new book called THE CATALYST, w/transcript
erictopol.substack.com/p/tom-cech-r...
Reposted by Schneider lab
Thanks @skyview.social for existing (bsky doesn't love long threads). Here's the very informative thread by @kgandersen.bsky.social on the #OriginOfCovid.
Nothing to add: there will always be missing data, but parsimony rulez. As he says, time to move on!
skyview.social?url=https%3A...
Nothing to add: there will always be missing data, but parsimony rulez. As he says, time to move on!
skyview.social?url=https%3A...
A BlueSky thread by Kristian G. Andersen on Skyview
When dealing with pseudoscience, the devil is in the detail - in this case, narrowing down a specific
skyview.social
June 6, 2024 at 6:55 PM
Thanks @skyview.social for existing (bsky doesn't love long threads). Here's the very informative thread by @kgandersen.bsky.social on the #OriginOfCovid.
Nothing to add: there will always be missing data, but parsimony rulez. As he says, time to move on!
skyview.social?url=https%3A...
Nothing to add: there will always be missing data, but parsimony rulez. As he says, time to move on!
skyview.social?url=https%3A...
Reposted by Schneider lab
Pulitzer-prize-winning writer Michael Hiltzik from the @latimes.com is among the few voices left in mainstream media who have not lost the plot on political attacks on scientists.
Chilling read:
www.latimes.com/business/sto...
Chilling read:
www.latimes.com/business/sto...
Column: After smearing Anthony Fauci, House Republicans proceed to defame a prominent vaccine scientist
Dr. Peter Hotez is a vaccination expert who has nothing to do with COVID. The GOP's COVID committee just put him in its crosshairs -- but why?
www.latimes.com
June 6, 2024 at 6:57 PM
Pulitzer-prize-winning writer Michael Hiltzik from the @latimes.com is among the few voices left in mainstream media who have not lost the plot on political attacks on scientists.
Chilling read:
www.latimes.com/business/sto...
Chilling read:
www.latimes.com/business/sto...