Rosado lab
@rosadolab.bsky.social
Molecular biology lab interested on the mechanisms of replication fork stability and translational aspects of the Fanconi cáncer síndrome
Reposted by Rosado lab
#ÚLTIMAHORA | Muere a los 91 años la etóloga británica Jane Goodall
Muere a los 91 años la etóloga británica Jane Goodall
La etóloga británica Jane Goodall ha fallecido a los 91 años de edad en la ciudad estadounidense de...
www.europapress.es
October 1, 2025 at 6:45 PM
#ÚLTIMAHORA | Muere a los 91 años la etóloga británica Jane Goodall
Reposted by Rosado lab
Our new study supports that aging begins in the early stages of embryo development, and not only in adulthood @canalugr canal.ugr.es/noticia/a-ne...
A new study suggests that aging begins in the early stages of embryo development, and not only in adulthood - Canal UGR
This work by the University of Granada, published in Nature Communications, opens up a new paradigm in biomedicine by examining the role of the BMAL1 protein in aging and the… Seguir Leyendo A new stu...
canal.ugr.es
September 22, 2025 at 7:23 AM
Our new study supports that aging begins in the early stages of embryo development, and not only in adulthood @canalugr canal.ugr.es/noticia/a-ne...
Reposted by Rosado lab
congratulations to our DB colleague Maria Jasin, recognized by the Greengard Prize! when she started her lab @mskcancercenter.bsky.social, she was the first to insert DNA into a defined location of a mammalian genome! her work underlies today's CRISPR-mediated HDR. here in convo with Rick Lifton.🧬
September 17, 2025 at 12:10 PM
congratulations to our DB colleague Maria Jasin, recognized by the Greengard Prize! when she started her lab @mskcancercenter.bsky.social, she was the first to insert DNA into a defined location of a mammalian genome! her work underlies today's CRISPR-mediated HDR. here in convo with Rick Lifton.🧬
Si quieres hacer una tesis doctoral en tumorogenesis asociada a la inestabilidad genética, contáctanos!!
Please RT!!
Please RT!!
September 2, 2025 at 12:18 PM
Si quieres hacer una tesis doctoral en tumorogenesis asociada a la inestabilidad genética, contáctanos!!
Please RT!!
Please RT!!
Reposted by Rosado lab
It is not always safe to repair DNA Damage. Sometimes, cells "just bypass it".
During DNA replication, repair of lesions on DNA can be dangerous. Cells instead "tolerate" DNA damage and focus on finishing replication.
Read our review and find out why and how: doi.org/10.1016/j.ti...
During DNA replication, repair of lesions on DNA can be dangerous. Cells instead "tolerate" DNA damage and focus on finishing replication.
Read our review and find out why and how: doi.org/10.1016/j.ti...
August 22, 2025 at 11:48 AM
It is not always safe to repair DNA Damage. Sometimes, cells "just bypass it".
During DNA replication, repair of lesions on DNA can be dangerous. Cells instead "tolerate" DNA damage and focus on finishing replication.
Read our review and find out why and how: doi.org/10.1016/j.ti...
During DNA replication, repair of lesions on DNA can be dangerous. Cells instead "tolerate" DNA damage and focus on finishing replication.
Read our review and find out why and how: doi.org/10.1016/j.ti...
Reposted by Rosado lab
Excited to share my first PhD paper published in @narjournal.bsky.social! This project was led by amazing supervisor Belén Gómez González in @aguilerloop.bsky.social lab. Thanks to all colaborators of Blanco and Diffley teams. I hope you like it!
Now online here 👇🏼 academic.oup.com/nar/article/...
Now online here 👇🏼 academic.oup.com/nar/article/...
S-phase checkpoint protects from aberrant replication fork processing and degradation
Abstract. Replication stress, a hallmark of cancer cells, is detected by checkpoint mechanisms that trigger a range of cellular responses. Among these, the
academic.oup.com
July 31, 2025 at 4:25 PM
Excited to share my first PhD paper published in @narjournal.bsky.social! This project was led by amazing supervisor Belén Gómez González in @aguilerloop.bsky.social lab. Thanks to all colaborators of Blanco and Diffley teams. I hope you like it!
Now online here 👇🏼 academic.oup.com/nar/article/...
Now online here 👇🏼 academic.oup.com/nar/article/...
Reposted by Rosado lab
Happy to see this out, great work from Niels, combining kinetic analysis, cryoEM and an unexpected gain-of-function mutant, nice work from master students Jan and Nina, from Kaustav and from Alex for the kinetics
@oncodeinstitute.bsky.social,
@nkinl.bsky.social
@oncodeinstitute.bsky.social,
@nkinl.bsky.social
I'm very proud that our paper, and with that the main project of my PhD, has just been published by @natcomms.nature.com! 🎉
Here, we reveal the unique, molecular mechanism by which USP1/UAF1 cleaves ubiquitin chains on PCNA, which may direct DNA damage tolerance.
doi.org/10.1038/s414...
Here, we reveal the unique, molecular mechanism by which USP1/UAF1 cleaves ubiquitin chains on PCNA, which may direct DNA damage tolerance.
doi.org/10.1038/s414...
USP1/UAF1 targets polyubiquitinated PCNA with an exo-cleavage mechanism that can temporarily enrich for monoubiquitinated PCNA - Nature Communications
DNA damage tolerance is regulated by ubiquitination of PCNA. Here, the authors present kinetic and structural studies showing that USP1/UAF1 prefers trimming K63- and K48-ubiquitin chains down over cl...
doi.org
July 31, 2025 at 12:38 PM
Happy to see this out, great work from Niels, combining kinetic analysis, cryoEM and an unexpected gain-of-function mutant, nice work from master students Jan and Nina, from Kaustav and from Alex for the kinetics
@oncodeinstitute.bsky.social,
@nkinl.bsky.social
@oncodeinstitute.bsky.social,
@nkinl.bsky.social
Reposted by Rosado lab
A study in Nature shows that respiratory viruses trigger metastatic breast cancer cells to proliferate in lungs in mouse models of breast cancer. These findings are supported by human observational data. go.nature.com/4l7NZ8l #medsky 🧪
July 31, 2025 at 7:13 PM
A study in Nature shows that respiratory viruses trigger metastatic breast cancer cells to proliferate in lungs in mouse models of breast cancer. These findings are supported by human observational data. go.nature.com/4l7NZ8l #medsky 🧪
Reposted by Rosado lab
One often hears that DNA is the blueprint of life. Today, I read a really nice paper that begins with "proteins are the cornerstone of life". By that logic, I might start referring to RNA as the scaffold, and chromatin as the framework that shapes it all.
Regardless, the paper is a must-read:
Regardless, the paper is a must-read:
Comprehensive human proteome profiles across a 50-year lifespan reveal aging trajectories and signatures
Proteins are the cornerstone of life. However, the proteomic blueprint of aging across human tissues remains uncharted. Here, we present a comprehensi…
www.sciencedirect.com
July 31, 2025 at 7:19 PM
One often hears that DNA is the blueprint of life. Today, I read a really nice paper that begins with "proteins are the cornerstone of life". By that logic, I might start referring to RNA as the scaffold, and chromatin as the framework that shapes it all.
Regardless, the paper is a must-read:
Regardless, the paper is a must-read:
My grant application to follow up my research line has preliminary been accepted. Thanks to those involved in peer reviewing and to @CienciaGob for this great news! Let's keep science moving!!!
July 29, 2025 at 2:15 PM
My grant application to follow up my research line has preliminary been accepted. Thanks to those involved in peer reviewing and to @CienciaGob for this great news! Let's keep science moving!!!
Reposted by Rosado lab
🧪To the science feed you go... if you like #neutrophil #metabolism #metastasis #UPP1 #Uracil #fibronectin, then you are in for a treat 👇
Delighted to share that our work “Uridine Phosphorylase-1 supports metastasis by altering immune and extracellular matrix landscapes” was published today in @emboreports.org, describing how neutrophil metabolism influences niche priming to support metastasis (1/14) www.embopress.org/doi/full/10....
Uridine phosphorylase-1 supports metastasis by altering immune and extracellular matrix landscapes | EMBO reports
imageimageMetastatic primary tumours upregulate Upp1 in neutrophils, which elevates circulating uracil. UPP1-expressing neutrophils accumulate
in the lung where they inhibit CD8+ T cells, promote fibr...
www.embopress.org
July 23, 2025 at 9:13 PM
🧪To the science feed you go... if you like #neutrophil #metabolism #metastasis #UPP1 #Uracil #fibronectin, then you are in for a treat 👇
Reposted by Rosado lab
July 21, 2025 at 12:59 PM
Reposted by Rosado lab
New #preprint from the lab! Do you want to see the invisible? So did we! When DNA genomes get broken, cells somehow find related sequences to fix the break. But how do they find it? We developed a way to look at sequence *search*, not just sequence usage.
doi.org/10.1101/2025...
doi.org/10.1101/2025...
doi.org
February 12, 2025 at 4:00 PM
New #preprint from the lab! Do you want to see the invisible? So did we! When DNA genomes get broken, cells somehow find related sequences to fix the break. But how do they find it? We developed a way to look at sequence *search*, not just sequence usage.
doi.org/10.1101/2025...
doi.org/10.1101/2025...
Reposted by Rosado lab
🔴La convocatoria “Consolidación Investigadora” de este año vuelve a sufrir un recorte
📉Es un 50% menos que 2024, que a su vez ya fue recortada otro 50% respecto a 2023
👉¿Consecuencia? Aún más problemas para la estabilización @cienciagob.bsky.social @ageinves.bsky.social @dianamorantr.bsky.social
🧵
📉Es un 50% menos que 2024, que a su vez ya fue recortada otro 50% respecto a 2023
👉¿Consecuencia? Aún más problemas para la estabilización @cienciagob.bsky.social @ageinves.bsky.social @dianamorantr.bsky.social
🧵
July 8, 2025 at 9:07 AM
🔴La convocatoria “Consolidación Investigadora” de este año vuelve a sufrir un recorte
📉Es un 50% menos que 2024, que a su vez ya fue recortada otro 50% respecto a 2023
👉¿Consecuencia? Aún más problemas para la estabilización @cienciagob.bsky.social @ageinves.bsky.social @dianamorantr.bsky.social
🧵
📉Es un 50% menos que 2024, que a su vez ya fue recortada otro 50% respecto a 2023
👉¿Consecuencia? Aún más problemas para la estabilización @cienciagob.bsky.social @ageinves.bsky.social @dianamorantr.bsky.social
🧵
Reposted by Rosado lab
Really cool new cryoEM structure of RAD51 caught in the act of recombination initiation at a D-loop. elifesciences.org/reviewed-pre...
Structural mechanism of strand exchange by the RAD51 filament
elifesciences.org
June 15, 2025 at 9:37 PM
Really cool new cryoEM structure of RAD51 caught in the act of recombination initiation at a D-loop. elifesciences.org/reviewed-pre...
Reposted by Rosado lab
We’re #hiring, please share! A fully funded #postdoc position is available in my lab to work on DNA damage response mechanisms.
Please get in touch with your CV if you are interested; closing date: 27th June 2025.
More details here: candidate.hr-manager.net/ApplicationI...
Please get in touch with your CV if you are interested; closing date: 27th June 2025.
More details here: candidate.hr-manager.net/ApplicationI...
Postdoctoral Research Associate in the Blackford Group
A position as Postdoctoral Research Associate is available at the Department of Cellular and Molecular Medicine, in the group headed by Dr. Andrew Blackford. Th
candidate.hr-manager.net
May 29, 2025 at 11:26 AM
We’re #hiring, please share! A fully funded #postdoc position is available in my lab to work on DNA damage response mechanisms.
Please get in touch with your CV if you are interested; closing date: 27th June 2025.
More details here: candidate.hr-manager.net/ApplicationI...
Please get in touch with your CV if you are interested; closing date: 27th June 2025.
More details here: candidate.hr-manager.net/ApplicationI...
This is the reason why voting for right-hand parties must never be a choice! You 'll never know what they are capable of...
NIH stops development of HIV vaccine, terminates grants to consortia, including at Duke University.
www.science.org/content/arti...
www.science.org/content/arti...
‘Devasting.’ NIH cancels future funding plans for HIV vaccine consortia
Researchers decry agency’s decision just as new leads reinvigorate search for long-sought vaccine
www.science.org
May 31, 2025 at 11:59 AM
This is the reason why voting for right-hand parties must never be a choice! You 'll never know what they are capable of...
Reposted by Rosado lab
What is the E3 ligase/Deubiquinating enzyme for your protein?😁👇
UbiBrowser 2.0: a proteome-wide known & predicted E3/DUB-substrate interactions (~4k/1k & 1900k/300k) database in 39 eukaryotic species
ubibrowser.bio-it.cn/ubibrowser_v...
#NucAcisRes 2022
academic.oup.com/nar/article/...
UbiBrowser 2.0: a proteome-wide known & predicted E3/DUB-substrate interactions (~4k/1k & 1900k/300k) database in 39 eukaryotic species
ubibrowser.bio-it.cn/ubibrowser_v...
#NucAcisRes 2022
academic.oup.com/nar/article/...
May 31, 2025 at 11:14 AM
What is the E3 ligase/Deubiquinating enzyme for your protein?😁👇
UbiBrowser 2.0: a proteome-wide known & predicted E3/DUB-substrate interactions (~4k/1k & 1900k/300k) database in 39 eukaryotic species
ubibrowser.bio-it.cn/ubibrowser_v...
#NucAcisRes 2022
academic.oup.com/nar/article/...
UbiBrowser 2.0: a proteome-wide known & predicted E3/DUB-substrate interactions (~4k/1k & 1900k/300k) database in 39 eukaryotic species
ubibrowser.bio-it.cn/ubibrowser_v...
#NucAcisRes 2022
academic.oup.com/nar/article/...
Reposted by Rosado lab
What a great day to be at @childrensphila.bsky.social and @pennmedicine.bsky.social
Published today:
www.nejm.org/doi/full/10....
Published today:
www.nejm.org/doi/full/10....
May 16, 2025 at 4:25 AM
What a great day to be at @childrensphila.bsky.social and @pennmedicine.bsky.social
Published today:
www.nejm.org/doi/full/10....
Published today:
www.nejm.org/doi/full/10....
Investigadores sevillanos descubren un mecanismo que causa fragilidad cromosómica en la anemia de Fanconi www.diariodesevilla.es/sevilla/inve...
Investigadores sevillanos descubren un mecanismo que causa fragilidad cromosómica en la anemia de Fanconi
El hallazgo ha sido liderado por el departamento de Genética de la Universidad de Sevilla y el Instituto Cabimer
www.diariodesevilla.es
May 15, 2025 at 11:06 AM
Investigadores sevillanos descubren un mecanismo que causa fragilidad cromosómica en la anemia de Fanconi www.diariodesevilla.es/sevilla/inve...
Reposted by Rosado lab
I'm super excited to announce that registrations are now open for the 19th Australian Cell Cycle, DNA Repair and Telomere Workshop. Awesome international speaker line-up, with plenty of locals being invited! Book now to secure your earlybird rate. www.australiancellcycle.org
May 15, 2025 at 5:48 AM
I'm super excited to announce that registrations are now open for the 19th Australian Cell Cycle, DNA Repair and Telomere Workshop. Awesome international speaker line-up, with plenty of locals being invited! Book now to secure your earlybird rate. www.australiancellcycle.org
Reposted by Rosado lab
Massively parallel jumping assay (MPJA) enables to test the jumping potential of thousands of transposons. Analysis of >160,000 Alu haplotypes identified transposition-asssociated domains. Amazing work by Navneet Matharu, Jingjing Zhao, Martin Kircher and many others.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Massively parallel jumping assay decodes Alu retrotransposition activity - Nature Communications
Here, the authors develop a high-throughput assay to measure the jumping potential of thousands of transposons in parallel.
www.nature.com
May 9, 2025 at 3:50 AM
Massively parallel jumping assay (MPJA) enables to test the jumping potential of thousands of transposons. Analysis of >160,000 Alu haplotypes identified transposition-asssociated domains. Amazing work by Navneet Matharu, Jingjing Zhao, Martin Kircher and many others.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
¿Quieres investigar sobre el desarrollo tumoral causado por las proteinas que se pegan en el ADN y provocan inestabilidad genética? Entonces solicita #JAEIntro JAEINT25_EX_0519!!
May 6, 2025 at 11:08 AM
¿Quieres investigar sobre el desarrollo tumoral causado por las proteinas que se pegan en el ADN y provocan inestabilidad genética? Entonces solicita #JAEIntro JAEINT25_EX_0519!!
Reposted by Rosado lab
Please see our latest paper on the role of EXO1 in meiosis: "EXO1 promotes the meiotic MLH1-MLH3 endonuclease through conserved interactions with MLH1, MSH4 and DNA". Congratulations to both first authors, Megha Roy and Aurore Sanchez and thanks to all our collaborators!
May 5, 2025 at 7:22 AM
Please see our latest paper on the role of EXO1 in meiosis: "EXO1 promotes the meiotic MLH1-MLH3 endonuclease through conserved interactions with MLH1, MSH4 and DNA". Congratulations to both first authors, Megha Roy and Aurore Sanchez and thanks to all our collaborators!
