David Landeira
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davidlandeira.bsky.social
David Landeira
@davidlandeira.bsky.social
Cells forget. We’re learning how to make them remember. @GENYO University of Granada, Spain. www.landeiralab.ugr.es
Pinned
¿Quieres descifrar los mecanismos epigenéticos del rejuvenecimiento celular? Si tienes un expediente académico superior a 8.5 y buscas realizar tu tesis doctoral en un entorno de excelencia (GENYO, Granada), contáctanos para solicitar becas FPU/Junta. Deadline inminente! ⏩
¿Quieres descifrar los mecanismos epigenéticos del rejuvenecimiento celular? Si tienes un expediente académico superior a 8.5 y buscas realizar tu tesis doctoral en un entorno de excelencia (GENYO, Granada), contáctanos para solicitar becas FPU/Junta. Deadline inminente! ⏩
January 13, 2026 at 2:32 PM
Reposted by David Landeira
"Freezing forgetting in C. elegans to extend memory retention" - check out the "research briefing" about our new paper in Nature Neuro
rdcu.be/eYlXY
Client Challenge
rdcu.be
January 9, 2026 at 4:27 PM
Reposted by David Landeira
New Year, New Paper!🎊

Pervasive cis-regulatory co-option of a transposable element family reinforces cell identity across the mouse immune system
www.biorxiv.org/content/10.6...

Centerpiece of Jason Chobirko's PhD, talented PhD student co-mentored by Andrew Grimson & me. Really excited about it!🧵
Pervasive cis-regulatory co-option of a transposable element family reinforces cell identity across the mouse immune system
Transposable elements (TEs) make up about half of the human and mouse genomes and play important regulatory roles in immune responses. However, the cis -regulatory contribution of TEs to immune cell d...
www.biorxiv.org
January 7, 2026 at 7:45 PM
x.com
January 2, 2026 at 3:52 PM
Reposted by David Landeira
An early Christmas present for those interested in chromatin and transcription! Fantastic work from @au-ho-yu.bsky.social and @aleksszczurek.bsky.social . Thanks to Inge and Michiel for their help. Please repost!

www.biorxiv.org/content/10.6...
SET1/MLL complexes control transcription independently of H3K4me3
Histone H3 lysine 4 trimethylation (H3K4me3) at gene promoters is thought to play a central role in gene transcription. H3K4 methylation is deposited by the SET1 (A/B) and MLL (1-4) multi-protein comp...
www.biorxiv.org
December 11, 2025 at 6:09 AM
Reposted by David Landeira
OFERTA DE EMPLEO (por favor difundir):

Ofrecemos un contrato predoctoral de 4 años asociado a nuestro proyecto PID2024-157249OB-I00. El objetivo del proyecto es evaluar un nuevo mecanismo patológico según el cual la competición entre promotores puede llegar a ocasionar enfermedades congénitas
👇
November 6, 2025 at 5:24 PM
Reposted by David Landeira
NIH Director Jay Bhattacharya has struggled to convince observers he has the agency’s best interests in mind—and is truly in charge. https://scim.ag/3MMXDSh
Will NIH’s new director reform his agency—or destroy it?
Jay Bhattacharya is struggling to make the case he’s in charge and has the agency’s best interests at heart
scim.ag
December 22, 2025 at 3:55 PM
Reposted by David Landeira
Congrats to @allanaschooley.bsky.social et al. @jobdekker.bsky.social on this beautiful paper, using a very elegant experimental system, to discover a chromosome intrinsic 3D genome folding program and microcompartmentalization of CREs at mitotic exit:
December 22, 2025 at 6:56 PM
Reposted by David Landeira
🚨Our story is published! Same bones but + dissection of MERVL’s role integrating signals from #ZGA factors, & + about pathological DUX4 activation of NOXA #TEsky. Thanks to all revs for their helpful comments improving the ms. Even #rev3 - until they ghosted us 😜

www.science.org/doi/epdf/10....
December 22, 2025 at 12:32 PM
Reposted by David Landeira
Be sure to also check out the great paper from @andersshansen.bsky.social and colleagues where they discover microcompartments on mitotic chromosomes using Region Capture Micro-C. Exciting times for those interested in chromosome conformation during cell division!
www.nature.com/articles/s41...
Dynamics of microcompartment formation at the mitosis-to-G1 transition - Nature Structural & Molecular Biology
Goel et al. produce high-resolution three-dimensional genome structure mapping from mitosis to G1 phase to show unseen interactions between enhancers and promoters in prometaphase. Polymer modeling in...
www.nature.com
December 23, 2025 at 2:51 AM
Reposted by David Landeira
ChatGPT no pasa la prueba: así pone en peligro la vida de menores.
ChatGPT no pasa la prueba: así pone en peligro la vida de menores
EL PAÍS experimenta con tres cuentas ficticias los filtros de OpenAI para proteger a los niños. Expertos en salud mental critican el resultado, porque las medidas son insuficientes y no alertan a los ...
elpais.com
December 21, 2025 at 8:43 AM
Reposted by David Landeira
Ponencia de Ángel Carracedo en las XIII Jornadas científicas de Genyo.
December 11, 2025 at 10:39 AM
Reposted by David Landeira
📖 El 24 de noviembre de 1859 se publicó #ElOrigenDeLasEspecies de #Darwin donde se establece su teoría de la #Evolución por #SelecciónNatural

🧬 Una de las obras científicas que más impacto ha tenido en todo el mundo occidental.
#díamundialdelaevolución
November 24, 2025 at 6:21 PM
Reposted by David Landeira
Origins of chromosome instability unveiled by coupled imaging and genomics @nature.com
www.nature.com/articles/s41...
October 29, 2025 at 11:37 PM
Reposted by David Landeira
There is one point of agreement among both enthusiasts and sceptics: the future has already arrived

go.nature.com/48M5Xuu
Universities are embracing AI: will students get smarter or stop thinking?
Nature - Millions of students arriving at campuses are now using artificial intelligence. Worries abound.
go.nature.com
October 26, 2025 at 12:38 PM
Reposted by David Landeira
We are recuiting two new Associate Professors here in Oxford Biochemistry. Come join us! Reach out to me if you have any questions. Please repost! tinyurl.com/mr3m7bd3
October 17, 2025 at 2:56 PM
Reposted by David Landeira
Y aquí tenéis la noticia en vídeo con entrevista a @davidlandeira.bsky.social en @canalsurradiotv.bsky.social (sí, parece que ha salido en un programa infantil; despertando vocaciones ☺️). labanda.canalsur.es/noticias/and...
El envejecimiento empieza en el embrión, antes de nacer
El programa infantil de Canal Sur. Desde 1994 para todos los niños andaluces. ¡En La Banda Tú Mandas!
labanda.canalsur.es
September 24, 2025 at 1:44 PM
Our new study supports that aging begins in the early stages of embryo development, and not only in adulthood @canalugr canal.ugr.es/noticia/a-ne...
A new study suggests that aging begins in the early stages of embryo development, and not only in adulthood - Canal UGR
This work by the University of Granada, published in Nature Communications, opens up a new paradigm in biomedicine by examining the role of the BMAL1 protein in aging and the… Seguir Leyendo A new stu...
canal.ugr.es
September 22, 2025 at 7:23 AM
When and how do we start aging? Our recent work, led by Amador Gallardo, suggests that aberrant expression of ancient viral remnants in our genome—already during embryonic development—may induce aging in adults. 😮https://www.nature.com/articles/s41467-025-63778-4.pdf
September 12, 2025 at 1:30 PM
Reposted by David Landeira
🔴 ¡Acaba de publicarse en Nature Communications (@natcomms.nature.com)! 🎉 Feliz de haber contribuido a este increíble trabajo del grupo de David Landeira (@davidlandeira.bsky.social), con Amador Gallardo como primer autor. (1/2)
September 10, 2025 at 9:35 AM
Ahi va la nota redactada por nuestro equipo de divulgación sobre nuestro ultimo trabajo! canal.ugr.es/noticia/enve...
Un nuevo estudio sugiere que el envejecimiento empieza en las primeras fases del desarrollo del embrión, y no solo en la vida adulta - Canal UGR
Este trabajo de la UGR, publicado en Nature Communications, abre un paradigma en biomedicina al examinar el papel de la proteína BMAL1 en la vejez y el desarrollo de enfermedades
canal.ugr.es
September 10, 2025 at 2:42 PM
Thrilled to share our story in its final form! nature.com/articles/s41... 💥 After ~10 years, we show that BMAL1 represses transposons via chromatin regulation in embryonic stem cells—rather than circadian rhythms as in adult tissues.
https://nature.com/articles/s41467-025-63778-4💥
September 10, 2025 at 2:26 PM
Reposted by David Landeira
Thomas Mann describiendo con un asombroso realismo las redes sociales (como esta) en «La montaña mágica», escrito hace más de 100 años.
September 6, 2025 at 9:03 AM
Reposted by David Landeira
💬 “Science is the mother of industry”

In the latest ERC Magazine, Jean-François van Boxmeer of the European Round Table for Industry argues Europe must do more to turn scientific discovery into economic value; and that research is central to future strength and sovereignty.

🔗 europa.eu/!m3hK7c
July 1, 2025 at 7:01 AM