David Kuster
@rnadavid.bsky.social
RNA & Metabolism. Ancient companions for Life. RNA as spatial organizer of the Cell. IDPs, biomolecular condensates and RNA fun @HymanLab. And birds.
ebird.org/profile/MjcyMDU0Nw
inaturalist.org/people/9261834
ebird.org/profile/MjcyMDU0Nw
inaturalist.org/people/9261834
Reposted by David Kuster
Congratulations again, Xiao-Xiao! It is a pleasure to host you as a Humboldt Research Fellow @humboldt-foundation.de. Looking forward to the exciting science ahead!
Thrilled to share that my Alexander von Humboldt Research Fellowship officially started this month!✨
I am deeply grateful to @humboldt-foundation.de for this honor, to my host @murat-sunbul.bsky.social and to all collaborators for their support.
Excited to start on this new adventure in Germany!🇩🇪
I am deeply grateful to @humboldt-foundation.de for this honor, to my host @murat-sunbul.bsky.social and to all collaborators for their support.
Excited to start on this new adventure in Germany!🇩🇪
November 7, 2025 at 4:03 PM
Congratulations again, Xiao-Xiao! It is a pleasure to host you as a Humboldt Research Fellow @humboldt-foundation.de. Looking forward to the exciting science ahead!
Reposted by David Kuster
It was an honor to present the laudation for the 2025 STS Honorary Medal Awardee, Hao Wu (@harvardmed.bsky.social @bostonchildrens.bsky.social), at the 28th Signal Transduction Meeting. Her groundbreaking work has transformed our understanding of innate immune signaling.
@sigtrans.bsky.social #STS
@sigtrans.bsky.social #STS
November 7, 2025 at 12:00 PM
It was an honor to present the laudation for the 2025 STS Honorary Medal Awardee, Hao Wu (@harvardmed.bsky.social @bostonchildrens.bsky.social), at the 28th Signal Transduction Meeting. Her groundbreaking work has transformed our understanding of innate immune signaling.
@sigtrans.bsky.social #STS
@sigtrans.bsky.social #STS
Reposted by David Kuster
Check out the latest work from our lab, led by Daniel Lin and Lara Elcavage: www.biorxiv.org/content/10.1... (1/3)
mRNA 3′ UTRs direct microRNA degradation to participate in imprinted gene networks and regulate growth
MicroRNAs direct downregulation of target mRNAs. Sometimes, however, this regulatory paradigm inverts, and a target RNA triggers the degradation of a microRNA. This target-directed microRNA degradatio...
www.biorxiv.org
November 7, 2025 at 6:33 PM
Check out the latest work from our lab, led by Daniel Lin and Lara Elcavage: www.biorxiv.org/content/10.1... (1/3)
Reposted by David Kuster
An Asgard archaeon with internal membrane compartments
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
November 7, 2025 at 10:44 AM
An Asgard archaeon with internal membrane compartments
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
Reposted by David Kuster
Review @natrevmcb.nature.com Regulation of RNA-binding proteins by small biomolecules
www.nature.com/articles/s41... @stanforduniversity.bsky.social
www.nature.com/articles/s41... @stanforduniversity.bsky.social
November 7, 2025 at 1:58 AM
Review @natrevmcb.nature.com Regulation of RNA-binding proteins by small biomolecules
www.nature.com/articles/s41... @stanforduniversity.bsky.social
www.nature.com/articles/s41... @stanforduniversity.bsky.social
Reposted by David Kuster
Das erwartet euch bei der letzten #Beerology2025: Ich spreche über das #Immunsystem und #Viren – Wissenschaft ohne Fachchinesisch, auf Deutsch!
📅 12. November
📍 Mondpalast, Dresden
🎟️ Eintritt frei!
livesciencedresden.de
#WissKomm #SciComm
📅 12. November
📍 Mondpalast, Dresden
🎟️ Eintritt frei!
livesciencedresden.de
#WissKomm #SciComm
November 6, 2025 at 4:38 PM
Das erwartet euch bei der letzten #Beerology2025: Ich spreche über das #Immunsystem und #Viren – Wissenschaft ohne Fachchinesisch, auf Deutsch!
📅 12. November
📍 Mondpalast, Dresden
🎟️ Eintritt frei!
livesciencedresden.de
#WissKomm #SciComm
📅 12. November
📍 Mondpalast, Dresden
🎟️ Eintritt frei!
livesciencedresden.de
#WissKomm #SciComm
Reposted by David Kuster
New paper alert! Scientists in Clemens Plaschka’s lab at the IMP and @juliusbrennecke.bsky.social's lab at
@imbavienna.bsky.social solved a decade-old puzzle, uncovering how the information molecule mRNA travels from the cell’s nucleus to its periphery. More: bit.ly/4nHcvys
@imbavienna.bsky.social solved a decade-old puzzle, uncovering how the information molecule mRNA travels from the cell’s nucleus to its periphery. More: bit.ly/4nHcvys
November 6, 2025 at 4:04 PM
New paper alert! Scientists in Clemens Plaschka’s lab at the IMP and @juliusbrennecke.bsky.social's lab at
@imbavienna.bsky.social solved a decade-old puzzle, uncovering how the information molecule mRNA travels from the cell’s nucleus to its periphery. More: bit.ly/4nHcvys
@imbavienna.bsky.social solved a decade-old puzzle, uncovering how the information molecule mRNA travels from the cell’s nucleus to its periphery. More: bit.ly/4nHcvys
Reposted by David Kuster
Our latest paper has just been published in Cell!
doi.org/10.1016/j.ce...
We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.
doi.org/10.1016/j.ce...
We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.
November 5, 2025 at 5:20 PM
Our latest paper has just been published in Cell!
doi.org/10.1016/j.ce...
We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.
doi.org/10.1016/j.ce...
We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.
Reposted by David Kuster
Annexin A7 enhances TIA1 axonal trafficking to counteract pathological aggregation in neurons
Tong Wang and coworkers
www.embopress.org/doi/full/10....
Tong Wang and coworkers
www.embopress.org/doi/full/10....
November 5, 2025 at 6:45 AM
Annexin A7 enhances TIA1 axonal trafficking to counteract pathological aggregation in neurons
Tong Wang and coworkers
www.embopress.org/doi/full/10....
Tong Wang and coworkers
www.embopress.org/doi/full/10....
Reposted by David Kuster
(1/10) How do diverse leukemia mutations converge on the same molecular program? In #RibackLab first manuscript @cp-cell.bsky.social, collaboration with @goodell-lab.bsky.social shows that disparate mutations rewire shared protein networks to form nuclear condensates called C-bodies.
November 4, 2025 at 5:58 PM
(1/10) How do diverse leukemia mutations converge on the same molecular program? In #RibackLab first manuscript @cp-cell.bsky.social, collaboration with @goodell-lab.bsky.social shows that disparate mutations rewire shared protein networks to form nuclear condensates called C-bodies.
Reposted by David Kuster
The BUB1 and BUBR1 paralogs scaffold the kinetochore fibrous corona | Science Advances www.science.org/doi/10.1126/...
Congratulations @vcmentowski.bsky.social for solving a remarkably challenging molecular puzzle
Congratulations @vcmentowski.bsky.social for solving a remarkably challenging molecular puzzle
The BUB1 and BUBR1 paralogs scaffold the kinetochore fibrous corona
The kinetochore fibrous corona docks on CENP-E and a second elusive receptor identified as the checkpoint protein BUB1.
www.science.org
September 15, 2025 at 4:50 AM
The BUB1 and BUBR1 paralogs scaffold the kinetochore fibrous corona | Science Advances www.science.org/doi/10.1126/...
Congratulations @vcmentowski.bsky.social for solving a remarkably challenging molecular puzzle
Congratulations @vcmentowski.bsky.social for solving a remarkably challenging molecular puzzle
Reposted by David Kuster
Now online - the Review "Structured protein domains enter the spotlight: modulators of #biomolecularcondensate form and function" from Nathaniel Hess and @jerelleaj.bsky.social.
#PhaseSeparation #ProteinProteinInteraction #Oligomerization #ProteinRNAInteraction
authors.elsevier.com/sd/article/S...
#PhaseSeparation #ProteinProteinInteraction #Oligomerization #ProteinRNAInteraction
authors.elsevier.com/sd/article/S...
January 23, 2025 at 3:07 PM
Now online - the Review "Structured protein domains enter the spotlight: modulators of #biomolecularcondensate form and function" from Nathaniel Hess and @jerelleaj.bsky.social.
#PhaseSeparation #ProteinProteinInteraction #Oligomerization #ProteinRNAInteraction
authors.elsevier.com/sd/article/S...
#PhaseSeparation #ProteinProteinInteraction #Oligomerization #ProteinRNAInteraction
authors.elsevier.com/sd/article/S...
Reposted by David Kuster
November 1, 2025 at 10:39 PM
Reposted by David Kuster
Excited about #Ubiquitin and protein degradation?
Have a look at my recent talk at the @danafarber.bsky.social Targeted Protein Degradation Webinar Series now out on YouTube. Here, I talk about my recent publication (see Blue-torial below)
www.youtube.com/watch?v=Cpg0...
Have a look at my recent talk at the @danafarber.bsky.social Targeted Protein Degradation Webinar Series now out on YouTube. Here, I talk about my recent publication (see Blue-torial below)
www.youtube.com/watch?v=Cpg0...
July 9, 2025 at 8:13 AM
Excited about #Ubiquitin and protein degradation?
Have a look at my recent talk at the @danafarber.bsky.social Targeted Protein Degradation Webinar Series now out on YouTube. Here, I talk about my recent publication (see Blue-torial below)
www.youtube.com/watch?v=Cpg0...
Have a look at my recent talk at the @danafarber.bsky.social Targeted Protein Degradation Webinar Series now out on YouTube. Here, I talk about my recent publication (see Blue-torial below)
www.youtube.com/watch?v=Cpg0...
Reposted by David Kuster
Excited to share my first PhD student’s @biorxivpreprint.bsky.social!
Tracking 5 dyes simultaneously Kavan Gor @embl.org tracks nascent #RNA folding during #ribosome assembly to correlate structural with functional information on single RNA molecules!
Check it out!
www.biorxiv.org/content/10.1...
Tracking 5 dyes simultaneously Kavan Gor @embl.org tracks nascent #RNA folding during #ribosome assembly to correlate structural with functional information on single RNA molecules!
Check it out!
www.biorxiv.org/content/10.1...
November 1, 2025 at 5:56 AM
Excited to share my first PhD student’s @biorxivpreprint.bsky.social!
Tracking 5 dyes simultaneously Kavan Gor @embl.org tracks nascent #RNA folding during #ribosome assembly to correlate structural with functional information on single RNA molecules!
Check it out!
www.biorxiv.org/content/10.1...
Tracking 5 dyes simultaneously Kavan Gor @embl.org tracks nascent #RNA folding during #ribosome assembly to correlate structural with functional information on single RNA molecules!
Check it out!
www.biorxiv.org/content/10.1...
Reposted by David Kuster
It was absolutely incredible to have the honor of giving the “Mendel Lecture” at the Augustinian Abbey in Brno, where Mendel lived and worked. While Mendel is the greatest hero of genetics, the lessons from his story were never learned 👇
October 31, 2025 at 5:48 AM
It was absolutely incredible to have the honor of giving the “Mendel Lecture” at the Augustinian Abbey in Brno, where Mendel lived and worked. While Mendel is the greatest hero of genetics, the lessons from his story were never learned 👇
Reposted by David Kuster
🔬 Applications are now open!
Join MBL’s world-renowned Advanced Research Training Courses, where scientists from around the globe come together to explore new ideas, master cutting-edge techniques, and become part of a dynamic network.
➡️Apply today: go.mbl.edu/courses
Join MBL’s world-renowned Advanced Research Training Courses, where scientists from around the globe come together to explore new ideas, master cutting-edge techniques, and become part of a dynamic network.
➡️Apply today: go.mbl.edu/courses
Course Offerings | Marine Biological Laboratory
go.mbl.edu
October 28, 2025 at 6:08 PM
🔬 Applications are now open!
Join MBL’s world-renowned Advanced Research Training Courses, where scientists from around the globe come together to explore new ideas, master cutting-edge techniques, and become part of a dynamic network.
➡️Apply today: go.mbl.edu/courses
Join MBL’s world-renowned Advanced Research Training Courses, where scientists from around the globe come together to explore new ideas, master cutting-edge techniques, and become part of a dynamic network.
➡️Apply today: go.mbl.edu/courses
Reposted by David Kuster
“Cellular Olympics” our catalog of freeky ultra fast cellular superhero’s is freely available “Ann Rev of microbiology”
www.annualreviews.org/content/jour...
This is a compilation of world’s fastest single cell organisms - enjoy this buffet of rare delightful protists with mind bending speeds. 🧪
www.annualreviews.org/content/jour...
This is a compilation of world’s fastest single cell organisms - enjoy this buffet of rare delightful protists with mind bending speeds. 🧪
October 24, 2025 at 10:57 AM
“Cellular Olympics” our catalog of freeky ultra fast cellular superhero’s is freely available “Ann Rev of microbiology”
www.annualreviews.org/content/jour...
This is a compilation of world’s fastest single cell organisms - enjoy this buffet of rare delightful protists with mind bending speeds. 🧪
www.annualreviews.org/content/jour...
This is a compilation of world’s fastest single cell organisms - enjoy this buffet of rare delightful protists with mind bending speeds. 🧪
Reposted by David Kuster
Congratulations to our PhD student David @rnadavid.bsky.social for his successful defense of his PhD thesis! @mpi-cbg.de imprs.mpi-cbg.de
As you see the lab was very creative with his hat! David gave his insights on the nucleocapsid protein and even better arranged a great buffet for celebrations!
As you see the lab was very creative with his hat! David gave his insights on the nucleocapsid protein and even better arranged a great buffet for celebrations!
October 29, 2025 at 2:07 PM
Congratulations to our PhD student David @rnadavid.bsky.social for his successful defense of his PhD thesis! @mpi-cbg.de imprs.mpi-cbg.de
As you see the lab was very creative with his hat! David gave his insights on the nucleocapsid protein and even better arranged a great buffet for celebrations!
As you see the lab was very creative with his hat! David gave his insights on the nucleocapsid protein and even better arranged a great buffet for celebrations!
Reposted by David Kuster
Reposted by David Kuster
EMBL scientists have new detailed info about Asgard archaea DNA structures offering important clues to more complex cell evolution.
With #cryoEM, scientists found both open and closed chomatin structures with a possible role in regulating chromatin.
doi.org/10.1016/j.mo...
With #cryoEM, scientists found both open and closed chomatin structures with a possible role in regulating chromatin.
doi.org/10.1016/j.mo...
October 29, 2025 at 8:29 AM
EMBL scientists have new detailed info about Asgard archaea DNA structures offering important clues to more complex cell evolution.
With #cryoEM, scientists found both open and closed chomatin structures with a possible role in regulating chromatin.
doi.org/10.1016/j.mo...
With #cryoEM, scientists found both open and closed chomatin structures with a possible role in regulating chromatin.
doi.org/10.1016/j.mo...
Reposted by David Kuster
1/ Excited to share our new study with @brumbaugh-lab.bsky.social, out in @natbiotech.nature.com! P-bodies selectively sequester RNAs encoding cell fate regulators, often from the preceding developmental stage. Releasing these RNAs can drive changes in cell identity. 🧵 www.nature.com/articles/s41...
Selective RNA sequestration in biomolecular condensates directs cell fate transitions - Nature Biotechnology
Stem cell differentiation is controlled by manipulating RNA condensates.
www.nature.com
October 28, 2025 at 4:02 PM
1/ Excited to share our new study with @brumbaugh-lab.bsky.social, out in @natbiotech.nature.com! P-bodies selectively sequester RNAs encoding cell fate regulators, often from the preceding developmental stage. Releasing these RNAs can drive changes in cell identity. 🧵 www.nature.com/articles/s41...
Reposted by David Kuster
Lab’s first paper is out!! We show the first structures of #Asgard #chromatin by #cryo-EM 🧬❄️
Asgard histones form closed and open hypernucleosomes. Closed are conserved across #Archaea, while open resemble eukaryotic H3–H4 octasomes and are Asgard-specific. More here: www.cell.com/molecular-ce...
Asgard histones form closed and open hypernucleosomes. Closed are conserved across #Archaea, while open resemble eukaryotic H3–H4 octasomes and are Asgard-specific. More here: www.cell.com/molecular-ce...
October 28, 2025 at 3:07 PM
Lab’s first paper is out!! We show the first structures of #Asgard #chromatin by #cryo-EM 🧬❄️
Asgard histones form closed and open hypernucleosomes. Closed are conserved across #Archaea, while open resemble eukaryotic H3–H4 octasomes and are Asgard-specific. More here: www.cell.com/molecular-ce...
Asgard histones form closed and open hypernucleosomes. Closed are conserved across #Archaea, while open resemble eukaryotic H3–H4 octasomes and are Asgard-specific. More here: www.cell.com/molecular-ce...
Reposted by David Kuster
Huge congrats to DOCTOR @rnadavid.bsky.social for successfully defending! Amazing presentation 💙
October 28, 2025 at 6:13 PM
Huge congrats to DOCTOR @rnadavid.bsky.social for successfully defending! Amazing presentation 💙
Reposted by David Kuster
First neurons didn’t appear overnight. We trace their roots to ancient secretory cells - showing how lifestyle & behavior shaped the evolution of first synapses.🧠🌊 #Evolution #Neuroscience
Our latest in @natrevneuro.nature.com
Link: rdcu.be/eMX3E
@jeffcolgren.bsky.social @msarscentre.bsky.social
Our latest in @natrevneuro.nature.com
Link: rdcu.be/eMX3E
@jeffcolgren.bsky.social @msarscentre.bsky.social
The evolutionary origins of synaptic proteins and their changing roles in different organisms across evolution
Nature Reviews Neuroscience - Recent studies have shed further light on the evolutionary origins of chemical synapses, In this Review, Colgren and Burkhardt explore how ancient proteins were...
rdcu.be
October 27, 2025 at 6:48 PM
First neurons didn’t appear overnight. We trace their roots to ancient secretory cells - showing how lifestyle & behavior shaped the evolution of first synapses.🧠🌊 #Evolution #Neuroscience
Our latest in @natrevneuro.nature.com
Link: rdcu.be/eMX3E
@jeffcolgren.bsky.social @msarscentre.bsky.social
Our latest in @natrevneuro.nature.com
Link: rdcu.be/eMX3E
@jeffcolgren.bsky.social @msarscentre.bsky.social