Richard Mead
@richardmead.bsky.social
Senior Lecturer in Translational Neuroscience at SITraN, @sheffielduni.bsky.social
Reposted by Richard Mead
Standing with all my fellow scientists in solidarity 🧪 www.nature.com/articles/d41...
‘Scientists will not be silenced’: thousands protest Trump research cuts
Researchers at Stand Up for Science rallies voice defiance against the policies of US President Donald Trump’s administration.
www.nature.com
March 7, 2025 at 8:39 PM
Standing with all my fellow scientists in solidarity 🧪 www.nature.com/articles/d41...
Reposted by Richard Mead
Reposted by Richard Mead
Wow. Read this 👇
Wrote up something about Techdirt's recent coverage, and why (whether we like it or not) we need to be a "democracy blog" now, rather than just a "tech" blog (not that we've ever been just a tech blog).
This story is *the* story and it impacts everything else.
www.techdirt.com/2025/03/04/w...
This story is *the* story and it impacts everything else.
www.techdirt.com/2025/03/04/w...
Why Techdirt Is Now A Democracy Blog (Whether We Like It Or Not)
While political reporters are still doing their view-from-nowhere “Democrats say this, Republicans say that” dance, tech and legal journalists have been watching an unfortunately recogn…
www.techdirt.com
March 5, 2025 at 10:00 PM
Wow. Read this 👇
Reposted by Richard Mead
Nice to see this finally published!
Congratulations @jack-humphrey.bsky.social
www.nature.com/articles/s41...
(Collaborative work with Panos Roussos and his team! )
Long-read RNA sequencing atlas of human microglia isoforms elucidates disease-associated genetic regulation of splicing
Congratulations @jack-humphrey.bsky.social
www.nature.com/articles/s41...
(Collaborative work with Panos Roussos and his team! )
Long-read RNA sequencing atlas of human microglia isoforms elucidates disease-associated genetic regulation of splicing
Long-read RNA sequencing atlas of human microglia isoforms elucidates disease-associated genetic regulation of splicing - Nature Genetics
This isoform-centric microglia genomic atlas includes 35,879 novel human microglia isoforms identified by long-read RNA sequencing. A multi-ancestry quantitative trait locus meta-analysis of known and...
www.nature.com
March 4, 2025 at 1:31 AM
Nice to see this finally published!
Congratulations @jack-humphrey.bsky.social
www.nature.com/articles/s41...
(Collaborative work with Panos Roussos and his team! )
Long-read RNA sequencing atlas of human microglia isoforms elucidates disease-associated genetic regulation of splicing
Congratulations @jack-humphrey.bsky.social
www.nature.com/articles/s41...
(Collaborative work with Panos Roussos and his team! )
Long-read RNA sequencing atlas of human microglia isoforms elucidates disease-associated genetic regulation of splicing
Reposted by Richard Mead
It is very important that our research programme is visible and accessible to everyone, because it is funded by the generosity of our supporters.
February 27, 2025 at 10:27 AM
It is very important that our research programme is visible and accessible to everyone, because it is funded by the generosity of our supporters.
Reposted by Richard Mead
US President Donald Trump is taking a wrecking ball to science and to international institutions. The global research community must take a stand against these attacks.
https://go.nature.com/4kd1vIu
https://go.nature.com/4kd1vIu
Trump 2.0: an assault on science anywhere is an assault on science everywhere
US President Donald Trump is taking a wrecking ball to science and to international institutions. The global research community must take a stand against these attacks.
go.nature.com
February 25, 2025 at 9:53 PM
US President Donald Trump is taking a wrecking ball to science and to international institutions. The global research community must take a stand against these attacks.
https://go.nature.com/4kd1vIu
https://go.nature.com/4kd1vIu
Reposted by Richard Mead
Really excited this is out! We found polyunsaturated fatty acids (PUFAs) were beneficial in models of C9orf72 FTD/ALS and the greatest benefit occurred when increasing levels specifically within neurons @ukdri.ac.uk @uclqsion.bsky.social @ucl.ac.uk @cziscience.bsky.social
rdcu.be/ebbZf
rdcu.be/ebbZf
Neuronal polyunsaturated fatty acids are protective in ALS/FTD
Nature Neuroscience - Lipidomics revealed that neurons of patients with ALS/FTD have reduced levels of polyunsaturated fatty acid (PUFA)-containing phospholipids. Increasing neuronal PUFA levels...
rdcu.be
February 25, 2025 at 1:31 PM
Really excited this is out! We found polyunsaturated fatty acids (PUFAs) were beneficial in models of C9orf72 FTD/ALS and the greatest benefit occurred when increasing levels specifically within neurons @ukdri.ac.uk @uclqsion.bsky.social @ucl.ac.uk @cziscience.bsky.social
rdcu.be/ebbZf
rdcu.be/ebbZf
Reposted by Richard Mead
I'm looking to see if the cuts & chaos at CDC and NIH have affected any clinical trials or research for drugs for the treatment of cancer, Alzheimer's, Parkinson's, or other serious diseases. If you know anything, please contact me at DavidCorn.99 at Signal.
Or if you have any other good stories.
Or if you have any other good stories.
February 24, 2025 at 6:33 PM
I'm looking to see if the cuts & chaos at CDC and NIH have affected any clinical trials or research for drugs for the treatment of cancer, Alzheimer's, Parkinson's, or other serious diseases. If you know anything, please contact me at DavidCorn.99 at Signal.
Or if you have any other good stories.
Or if you have any other good stories.
Reposted by Richard Mead
Check out our new review of C9orf72 ALS in @thelancetneuro.bsky.social with Sarah Mizielinska, Rosa Rademakers and others! Was fun to co-write but tough to collate such incredible progress into a one article: authors.elsevier.com/c/1ke765FFzL...
February 21, 2025 at 9:56 AM
Check out our new review of C9orf72 ALS in @thelancetneuro.bsky.social with Sarah Mizielinska, Rosa Rademakers and others! Was fun to co-write but tough to collate such incredible progress into a one article: authors.elsevier.com/c/1ke765FFzL...
New paper in collaboration with James Alix and others. No phenotype in the Liu et al (2016) C9orf72 BAC ALS model on either the Jax labs or Janvier FVB genetic backgrounds. The background itself has a known neurological phenotype which we confirmed.
journals.biologists.com/dmm/article/...
journals.biologists.com/dmm/article/...
A bacterial artificial chromosome mouse model of amyotrophic lateral sclerosis manifests ‘space cadet syndrome’ on two FVB backgrounds
Summary: A C9orf72 bacterial artificial chromosome mouse model of amyotrophic lateral sclerosis manifested ‘space cadet syndrome’ on two FVB backgrounds. Genetic backgrounds should thus be considered ...
journals.biologists.com
February 17, 2025 at 10:16 AM
New paper in collaboration with James Alix and others. No phenotype in the Liu et al (2016) C9orf72 BAC ALS model on either the Jax labs or Janvier FVB genetic backgrounds. The background itself has a known neurological phenotype which we confirmed.
journals.biologists.com/dmm/article/...
journals.biologists.com/dmm/article/...
Reposted by Richard Mead
What better way to bring #NationalApprenticeshipWeek to a close than by taking note of our achievements as a health apprenticeships provider?🎉
Here's just some of the reasons we have to celebrate this #CelebrationFriday ⬇️
@sheffielduni.bsky.social
Here's just some of the reasons we have to celebrate this #CelebrationFriday ⬇️
@sheffielduni.bsky.social
February 14, 2025 at 9:29 AM
What better way to bring #NationalApprenticeshipWeek to a close than by taking note of our achievements as a health apprenticeships provider?🎉
Here's just some of the reasons we have to celebrate this #CelebrationFriday ⬇️
@sheffielduni.bsky.social
Here's just some of the reasons we have to celebrate this #CelebrationFriday ⬇️
@sheffielduni.bsky.social
Reposted by Richard Mead
🚨 A groundbreaking drug screening programme is set to transform MND treatment!
🔬 EXPERTS-ALS will rapidly assess potential ALS drugs, testing their ability to slow nerve damage before large trials.
www.sheffield.ac.uk/news/groundb...
🔬 EXPERTS-ALS will rapidly assess potential ALS drugs, testing their ability to slow nerve damage before large trials.
www.sheffield.ac.uk/news/groundb...
February 7, 2025 at 12:16 PM
🚨 A groundbreaking drug screening programme is set to transform MND treatment!
🔬 EXPERTS-ALS will rapidly assess potential ALS drugs, testing their ability to slow nerve damage before large trials.
www.sheffield.ac.uk/news/groundb...
🔬 EXPERTS-ALS will rapidly assess potential ALS drugs, testing their ability to slow nerve damage before large trials.
www.sheffield.ac.uk/news/groundb...
Please sign if you believe the Royal Society needs to stand up for values we all hold dear
OK folks, I have now created a google form that allows people to sign to show their support for my open letter to the President of the Royal Society. Please sign and share widely: forms.gle/miDciq35oxyw...
February 11, 2025 at 7:31 PM
Please sign if you believe the Royal Society needs to stand up for values we all hold dear
Reposted by Richard Mead
Our statement on Ellorarxine in #ALS #MND
Testing a drug takes a lot of time, a lot of commitment from people living with MND, and a lot of money. We must be sure that we put our efforts in the right place to find new and effective treatments as quickly as possible.
ukmndri.org/2025/02/07/a...
Testing a drug takes a lot of time, a lot of commitment from people living with MND, and a lot of money. We must be sure that we put our efforts in the right place to find new and effective treatments as quickly as possible.
ukmndri.org/2025/02/07/a...
An update on Ellorarxine - UKMNDRI
Why this statement?
As neurologists specialising in the care of people living with motor neuron disease, we are receiving increasing enquiries about a drug called ellorarxine. Many of our patients are...
ukmndri.org
February 7, 2025 at 11:23 AM
Our statement on Ellorarxine in #ALS #MND
Testing a drug takes a lot of time, a lot of commitment from people living with MND, and a lot of money. We must be sure that we put our efforts in the right place to find new and effective treatments as quickly as possible.
ukmndri.org/2025/02/07/a...
Testing a drug takes a lot of time, a lot of commitment from people living with MND, and a lot of money. We must be sure that we put our efforts in the right place to find new and effective treatments as quickly as possible.
ukmndri.org/2025/02/07/a...
Reposted by Richard Mead
My team @naturecomms.bsky.social is looking for a new editor! We need someone to help handle all of the awesome #stemcell and #devbio papers we're getting. DM me if you're interested or have questions about the role or interview process.
springernature.wd3.myworkdayjobs.com/en-US/Spring...
springernature.wd3.myworkdayjobs.com/en-US/Spring...
Associate or Senior Editor, Nature Communications (Stem Cell and Developmental Biology)
Title: Associate or Senior Editor, Nature Communications (Stem Cell and Developmental Biology) Location(s): New York, Jersey City, Philadelphia, Berlin or Heidelberg Application Deadline: About Spring...
springernature.wd3.myworkdayjobs.com
February 3, 2025 at 3:24 PM
My team @naturecomms.bsky.social is looking for a new editor! We need someone to help handle all of the awesome #stemcell and #devbio papers we're getting. DM me if you're interested or have questions about the role or interview process.
springernature.wd3.myworkdayjobs.com/en-US/Spring...
springernature.wd3.myworkdayjobs.com/en-US/Spring...
Reposted by Richard Mead
Reminder that @europepmc.org is a mirror of Pubmed with better search and that it indexes *all* bioRxiv preprints (as well as ResearchSquare), not just the ones funded by NIH like chauvinist Pubmed
I’m very scared to see what happens to PubMed
January 31, 2025 at 8:44 PM
Reminder that @europepmc.org is a mirror of Pubmed with better search and that it indexes *all* bioRxiv preprints (as well as ResearchSquare), not just the ones funded by NIH like chauvinist Pubmed
Reposted by Richard Mead
This is a big deal, y'all. Federal health websites are being stripped of content or removed in their entirety. Stick with this thread for a look at what's disappeared so far! 1/x
January 31, 2025 at 7:28 PM
This is a big deal, y'all. Federal health websites are being stripped of content or removed in their entirety. Stick with this thread for a look at what's disappeared so far! 1/x
Nice paper from the Barmada lab (not on here?) and highly actionable target for TDP-43 proteinopathy in ALS? We certainly need more of those!
Nemo-like kinase disrupts nuclear import and drives TDP43 mislocalization in ALS https://www.biorxiv.org/content/10.1101/2025.01.27.635090v1
January 28, 2025 at 5:03 PM
Nice paper from the Barmada lab (not on here?) and highly actionable target for TDP-43 proteinopathy in ALS? We certainly need more of those!
Well not all tech titans are alike. Bill Gates is indeed doing God's work! www.theguardian.com/us-news/2025...
Bill Gates calls Elon Musk’s embrace of far-right politicians abroad ‘insane shit’
Microsoft co-founder and philanthropist calls fellow tech titan ‘super-smart’ but guilty of ‘overreach’
www.theguardian.com
January 27, 2025 at 9:58 PM
Well not all tech titans are alike. Bill Gates is indeed doing God's work! www.theguardian.com/us-news/2025...
Please check out our new paper using CMAP to bridge from preclinical to clinical studies in ALS.
Mouse models have been blamed for clinical failures, but how you use them is key. This approach is one step towards improving discovery of new drugs for ALS
www.tandfonline.com/doi/full/10....
Mouse models have been blamed for clinical failures, but how you use them is key. This approach is one step towards improving discovery of new drugs for ALS
www.tandfonline.com/doi/full/10....
Maximizing the translational potential of neurophysiology in amyotrophic lateral sclerosis: a study on compound muscle action potentials
Mouse models of amyotrophic lateral sclerosis (ALS) enable testing of novel therapeutic interventions. However, treatments that have extended survival in mice have often failed to translate into hu...
www.tandfonline.com
January 23, 2025 at 12:51 PM
Please check out our new paper using CMAP to bridge from preclinical to clinical studies in ALS.
Mouse models have been blamed for clinical failures, but how you use them is key. This approach is one step towards improving discovery of new drugs for ALS
www.tandfonline.com/doi/full/10....
Mouse models have been blamed for clinical failures, but how you use them is key. This approach is one step towards improving discovery of new drugs for ALS
www.tandfonline.com/doi/full/10....