Lyle W. Ostrow MD PhD
@lyleostrow.bsky.social
Neurologist/Neuroscientist at Lewis Katz School of Medicine, Temple University, and the ALS Hope Foundation. Director, TUHS ALS Postmortem Core collab with CDC ALS Registry. Chair, DoD (CDMRP) ALS Research Programmatic Panel. Views my OWN.
Reposted by Lyle W. Ostrow MD PhD
I'm so excited to see this Perspective with @jasonsynaptic.bsky.social out in Neuron! About 8% of our genome is made up of the remnants of LTR-containing retroelements - here, Jason and I explore the activities of retroTEs in neurological health and disease!
authors.elsevier.com/c/1lzTx3BtfH...
authors.elsevier.com/c/1lzTx3BtfH...
authors.elsevier.com
October 23, 2025 at 3:15 PM
I'm so excited to see this Perspective with @jasonsynaptic.bsky.social out in Neuron! About 8% of our genome is made up of the remnants of LTR-containing retroelements - here, Jason and I explore the activities of retroTEs in neurological health and disease!
authors.elsevier.com/c/1lzTx3BtfH...
authors.elsevier.com/c/1lzTx3BtfH...
October 11, 2025 at 3:27 PM
Listener effort measures clinically meaningful change of dysarthria in amyotrophic lateral sclerosis url:https://academic.oup.com/braincomms/article/doi/10.1093/braincomms/fcaf232/8161195 #BetterTogether #EndALS
June 19, 2025 at 6:04 PM
Listener effort measures clinically meaningful change of dysarthria in amyotrophic lateral sclerosis url:https://academic.oup.com/braincomms/article/doi/10.1093/braincomms/fcaf232/8161195 #BetterTogether #EndALS
Reposted by Lyle W. Ostrow MD PhD
we're crowd-sourcing a searchable repository of tangible benefits stemming from federally-funded research. Come enjoy the great stories; or send in an idea; or volunteer to join the team.
publicusaresearchbenefits.com
please share and re-share so we get more great stories in there!
publicusaresearchbenefits.com
please share and re-share so we get more great stories in there!
Searchable database of tangible benefits that federally-funded research gave us.
A crowd-sourced site. Health and Well-being. National Security. Prosperity.
publicusaresearchbenefits.com
May 7, 2025 at 11:28 PM
we're crowd-sourcing a searchable repository of tangible benefits stemming from federally-funded research. Come enjoy the great stories; or send in an idea; or volunteer to join the team.
publicusaresearchbenefits.com
please share and re-share so we get more great stories in there!
publicusaresearchbenefits.com
please share and re-share so we get more great stories in there!
Reposted by Lyle W. Ostrow MD PhD
When you join the National ALS Registry, you can also join the National ALS Biorepository. Joining is a meaningful way for people with ALS to help in the search for answers. For more information visit cdc.gov/als
#ALSRegistry
#ALSBiorepository
#ALS
#ALSRegistry
#ALSBiorepository
#ALS
April 18, 2025 at 1:04 PM
When you join the National ALS Registry, you can also join the National ALS Biorepository. Joining is a meaningful way for people with ALS to help in the search for answers. For more information visit cdc.gov/als
#ALSRegistry
#ALSBiorepository
#ALS
#ALSRegistry
#ALSBiorepository
#ALS
Reposted by Lyle W. Ostrow MD PhD
Nonprofit agencies that assist ALS patients and support research sent a letter to the bipartisan ALS Congressional Caucus after a leaked proposed budget memo from the Health and Human Services Department called for defunding the registry and a biorepository with thousands of lab specimens.
Proposal would defund ALS registry for disease that afflicts veterans at higher rate than general public
Advocates for patients with amyotrophic lateral sclerosis — a fatal condition known as Lou Gehrig’s disease — urged lawmakers to keep funding the National ALS Registry that serves as a centralized dat...
www.stripes.com
April 25, 2025 at 9:05 PM
Nonprofit agencies that assist ALS patients and support research sent a letter to the bipartisan ALS Congressional Caucus after a leaked proposed budget memo from the Health and Human Services Department called for defunding the registry and a biorepository with thousands of lab specimens.
We own several games from www.neurdgames.com and love them all. I just ordered 2 copies of this new one and can't wait to play!
April 1, 2025 at 1:36 AM
We own several games from www.neurdgames.com and love them all. I just ordered 2 copies of this new one and can't wait to play!
Reposted by Lyle W. Ostrow MD PhD
Changes to MSc, PhD and postdoc funding programs from 🇨🇦 tri councils. Harmonization across councils, more awards, and new eligibility for international PhD and postdoc applicants!
NSERC - Latest News - Launch of the new Harmonized Tri-agency Scholarship and Fellowship programs
As announced in Budget 2024, the scholarship and fellowship programs administered by the three federal research funding agencies – the Canadian Institutes of Health Research (CIHR), the Natural Sciences and Engineering Research Council (NSERC), and the Social Sciences and Humanities Research Council (SSHRC) – have been streamlined into a new harmonized talent program called the Canada Research Training Awards Suite (CRTAS) that will open for applications in summer 2025.
www.nserc-crsng.gc.ca
March 14, 2025 at 11:06 PM
Changes to MSc, PhD and postdoc funding programs from 🇨🇦 tri councils. Harmonization across councils, more awards, and new eligibility for international PhD and postdoc applicants!
Reposted by Lyle W. Ostrow MD PhD
URGENT: Protect #ALS Research Funding! Congress may slash CDMRP funding in the CR, halting critical ALS research. ALS cases could rise 70% by 2030, & veterans face 2x the risk. We must act NOW! Tell your Senators to protect funding! als-ny.org/the-threat-t... #ALSResearch
March 13, 2025 at 4:58 PM
URGENT: Protect #ALS Research Funding! Congress may slash CDMRP funding in the CR, halting critical ALS research. ALS cases could rise 70% by 2030, & veterans face 2x the risk. We must act NOW! Tell your Senators to protect funding! als-ny.org/the-threat-t... #ALSResearch
Reposted by Lyle W. Ostrow MD PhD
We are very concerned about the proposed budget cuts at the NIH and the DOD that could impact ALS research. Our Board of Trustees and staff are taking to Capitol Hill on Wednesday to urge Congress to continue to fund ALS research.
March 10, 2025 at 11:51 PM
We are very concerned about the proposed budget cuts at the NIH and the DOD that could impact ALS research. Our Board of Trustees and staff are taking to Capitol Hill on Wednesday to urge Congress to continue to fund ALS research.
Reposted by Lyle W. Ostrow MD PhD
A vote for this legislation is a vote to cut federally funded cancer research. Please take action today to ask Congress to vote no on the CR and instead approve a full-year FY25 Defense Appropriations Act that fully funds the OCRP and CDMRP.
www.votervoice.net/Shares/B0Y6T...
www.votervoice.net/Shares/B0Y6T...
Oppose 57% Cut to Congressionally Directed Medical Research Programs Vote NO on the FY25 Continuing Resolution
As early as this Tuesday, the House will be voting on a continuing resolution to fund government programs through the end of fiscal year 2025 (FY25). The proposed legislation, introduced in the House,...
www.votervoice.net
March 10, 2025 at 9:52 PM
A vote for this legislation is a vote to cut federally funded cancer research. Please take action today to ask Congress to vote no on the CR and instead approve a full-year FY25 Defense Appropriations Act that fully funds the OCRP and CDMRP.
www.votervoice.net/Shares/B0Y6T...
www.votervoice.net/Shares/B0Y6T...
WOW. This is absolutely remarkable work!
Super happy to announce the latest work from my lab together with Hemali Phatnani @nygenome.org & NYGC ALS Consortium!
We've combined ALS patient profiling (100s!), ML classifiers and matched bulk/single-cell data to dive into ALS Molecular Subtypes
#NIHfundedResearch
www.cell.com/cell-reports...
We've combined ALS patient profiling (100s!), ML classifiers and matched bulk/single-cell data to dive into ALS Molecular Subtypes
#NIHfundedResearch
www.cell.com/cell-reports...
ALS molecular subtypes are a combination of cellular and pathological features learned by deep multiomics classifiers
O’Neill et al. present a deep exploration of molecular subtypes in ALS postmortem
tissues from the NYGC ALS Consortium. Matched bulk and single-cell profiles demonstrate
that ALS subtypes are a combin...
www.cell.com
March 10, 2025 at 10:27 PM
WOW. This is absolutely remarkable work!
March 7, 2025 at 8:39 PM
Please read this if you want to understand more about how indirect rates are set, and why indirect costs are critical to research. Then, sign the petition linked in the article. #ScienceMatters #BetterTogether
Tell ‘em Pops!
Ask a Greek, Don’t mess with a Maniot, especially one that’s got Receipts!
www.cell.com/cell/fulltex...
Ask a Greek, Don’t mess with a Maniot, especially one that’s got Receipts!
www.cell.com/cell/fulltex...
Safeguarding the future of biomedical science in the United States
NIH’s abrupt decision to cap indirect cost reimbursement at 15% threatens the critical
infrastructure supporting groundbreaking biomedical research in the United States.
This policy jeopardizes Americ...
www.cell.com
February 28, 2025 at 10:05 PM
Please read this if you want to understand more about how indirect rates are set, and why indirect costs are critical to research. Then, sign the petition linked in the article. #ScienceMatters #BetterTogether
Reposted by Lyle W. Ostrow MD PhD
Each year ALS advocates ask Congress to support the federal funding of ALS research through appropriations requests. Help these advocates supercharge their requests in YOUR district by becoming a constituent! iamals.org/action/help-...
Help The Legislative Team - I AM ALS - ALS is Relentless. So Are We!
ALS Advocates! I AM ALS’ Legislative Affairs Community Team needs your help. Every single day, this team reaches out to legislators to convince them to beco ...
iamals.org
February 24, 2025 at 2:38 PM
Each year ALS advocates ask Congress to support the federal funding of ALS research through appropriations requests. Help these advocates supercharge their requests in YOUR district by becoming a constituent! iamals.org/action/help-...
From Everything ALS:
🔬 Join us for a free webinar with Dr. Laura P.W. Ranum! 🧠
📅 Date: February 19, 2025
⏰ Time: 7 PM EDT | 4 PM PDT
📍 Free Online Webinar
📢 Register now and be part of the conversation: everythingals.org/events
🔬 Join us for a free webinar with Dr. Laura P.W. Ranum! 🧠
📅 Date: February 19, 2025
⏰ Time: 7 PM EDT | 4 PM PDT
📍 Free Online Webinar
📢 Register now and be part of the conversation: everythingals.org/events
February 19, 2025 at 7:06 PM
From Everything ALS:
🔬 Join us for a free webinar with Dr. Laura P.W. Ranum! 🧠
📅 Date: February 19, 2025
⏰ Time: 7 PM EDT | 4 PM PDT
📍 Free Online Webinar
📢 Register now and be part of the conversation: everythingals.org/events
🔬 Join us for a free webinar with Dr. Laura P.W. Ranum! 🧠
📅 Date: February 19, 2025
⏰ Time: 7 PM EDT | 4 PM PDT
📍 Free Online Webinar
📢 Register now and be part of the conversation: everythingals.org/events
Reposted by Lyle W. Ostrow MD PhD
Dear federal scientists: If you have been affected by the probationary firings and would be willing to speak with Science, please reach out to me by email (klangin@aaas.org) or on Signal. We can guarantee annonymity.
February 14, 2025 at 8:05 PM
Dear federal scientists: If you have been affected by the probationary firings and would be willing to speak with Science, please reach out to me by email (klangin@aaas.org) or on Signal. We can guarantee annonymity.
"GsMTx-4 can reverse hyperalgesia, restoring withdrawal thresholds to baseline levels." @ostrowkimber.bsky.social,
February 14, 2025 at 9:37 PM
"GsMTx-4 can reverse hyperalgesia, restoring withdrawal thresholds to baseline levels." @ostrowkimber.bsky.social,
Reposted by Lyle W. Ostrow MD PhD
Using data from the UK Biobank, Yi et al. identify two subtypes of preclinical type 2 diabetes: one with high leptin and BMI, and a greater susceptibility to psychiatric conditions; the other with abnormal glucose metabolism and increased risk of neurodegenerative disorders. tinyurl.com/mudt44kk
February 13, 2025 at 9:32 PM
Using data from the UK Biobank, Yi et al. identify two subtypes of preclinical type 2 diabetes: one with high leptin and BMI, and a greater susceptibility to psychiatric conditions; the other with abnormal glucose metabolism and increased risk of neurodegenerative disorders. tinyurl.com/mudt44kk
Reposted by Lyle W. Ostrow MD PhD
A Direct Hit, by @holdenthorp.bsky.social @science.org
www.science.org/doi/full/10....
"This is a moment to unite."
www.science.org/doi/full/10....
"This is a moment to unite."
February 11, 2025 at 3:18 PM
A Direct Hit, by @holdenthorp.bsky.social @science.org
www.science.org/doi/full/10....
"This is a moment to unite."
www.science.org/doi/full/10....
"This is a moment to unite."
Reposted by Lyle W. Ostrow MD PhD
NYGC is organizing a number of efforts to address the changes to NIH IDCs and other changes to federal policy. If you are a US citizen, or in the US working in science, please consider signing this petition. The more signatures the stronger our hand in interacting with law makers. chng.it/kK2HMP5pGk
Sign the Petition
Petition to Reverse the NIH Indirect Cost Cap (NOT-OD-25-068)
chng.it
February 10, 2025 at 3:42 PM
NYGC is organizing a number of efforts to address the changes to NIH IDCs and other changes to federal policy. If you are a US citizen, or in the US working in science, please consider signing this petition. The more signatures the stronger our hand in interacting with law makers. chng.it/kK2HMP5pGk
Reposted by Lyle W. Ostrow MD PhD
This is critically important. When asked to PROVE the claims that Elon is spewing on Xitter, Trump had nothing.
Nothing.
Until they present proof, no media outlet should repeat unsubstantiated claim this is about efficiency.
Nothing.
Until they present proof, no media outlet should repeat unsubstantiated claim this is about efficiency.
ust reviewed the coverage of Carl Nichols' decision enjoining Trump's shutdown of USAID. Only Politico (and my own post) note that Nichols specifically said that DOJ presented no evidence of fraud or corruption.
EVERY OUTLET should emphasize this.
www.politico.com/news/2025/02...
EVERY OUTLET should emphasize this.
www.politico.com/news/2025/02...
February 9, 2025 at 3:56 PM
This is critically important. When asked to PROVE the claims that Elon is spewing on Xitter, Trump had nothing.
Nothing.
Until they present proof, no media outlet should repeat unsubstantiated claim this is about efficiency.
Nothing.
Until they present proof, no media outlet should repeat unsubstantiated claim this is about efficiency.
Reposted by Lyle W. Ostrow MD PhD
