Silas Maniatis
@manimota.bsky.social
Father and scientist. Doing dad stuff in Brooklyn and science at New York Genome Center.
𝘈𝘴𝘴𝘰𝘤𝘪𝘢𝘵𝘦 𝘋𝘪𝘳𝘦𝘤𝘵𝘰𝘳, 𝘚𝘱𝘢𝘵𝘪𝘢𝘭 𝘎𝘦𝘯𝘰𝘮𝘪𝘤𝘴
𝘈𝘳𝘤𝘩𝘪𝘷𝘦 𝘰𝘧 𝘮𝘺 𝘵𝘪𝘮𝘦 𝘢𝘵 𝘵𝘩𝘦 𝘰𝘭𝘥 𝘱𝘭𝘢𝘤𝘦 @𝘮𝘢𝘯𝘪𝘮𝘰𝘵𝘢𝘴𝘰𝘭𝘥𝘴𝘵𝘶𝘧𝘧.𝘣𝘴𝘬𝘺.𝘴𝘰𝘤𝘪𝘢𝘭
@𝘮𝘢𝘯𝘪𝘮𝘰𝘵𝘢 𝘰𝘯 𝘮𝘰𝘴𝘵 𝘱𝘭𝘢𝘵𝘧𝘰𝘳𝘮𝘴
𝘈𝘴𝘴𝘰𝘤𝘪𝘢𝘵𝘦 𝘋𝘪𝘳𝘦𝘤𝘵𝘰𝘳, 𝘚𝘱𝘢𝘵𝘪𝘢𝘭 𝘎𝘦𝘯𝘰𝘮𝘪𝘤𝘴
𝘈𝘳𝘤𝘩𝘪𝘷𝘦 𝘰𝘧 𝘮𝘺 𝘵𝘪𝘮𝘦 𝘢𝘵 𝘵𝘩𝘦 𝘰𝘭𝘥 𝘱𝘭𝘢𝘤𝘦 @𝘮𝘢𝘯𝘪𝘮𝘰𝘵𝘢𝘴𝘰𝘭𝘥𝘴𝘵𝘶𝘧𝘧.𝘣𝘴𝘬𝘺.𝘴𝘰𝘤𝘪𝘢𝘭
@𝘮𝘢𝘯𝘪𝘮𝘰𝘵𝘢 𝘰𝘯 𝘮𝘰𝘴𝘵 𝘱𝘭𝘢𝘵𝘧𝘰𝘳𝘮𝘴
Reposted by Silas Maniatis
"It may take time to prove you're right, but you have to stick to it."
- Fred Korematsu
Jailed for refusing to abide by FDR's Exec Order 9066, he took his case against internment all the way to the Supreme Court - and lost. Remember him on Korematsu Day, January 30th. 1/
- Fred Korematsu
Jailed for refusing to abide by FDR's Exec Order 9066, he took his case against internment all the way to the Supreme Court - and lost. Remember him on Korematsu Day, January 30th. 1/
January 30, 2026 at 10:32 PM
"It may take time to prove you're right, but you have to stick to it."
- Fred Korematsu
Jailed for refusing to abide by FDR's Exec Order 9066, he took his case against internment all the way to the Supreme Court - and lost. Remember him on Korematsu Day, January 30th. 1/
- Fred Korematsu
Jailed for refusing to abide by FDR's Exec Order 9066, he took his case against internment all the way to the Supreme Court - and lost. Remember him on Korematsu Day, January 30th. 1/
Reposted by Silas Maniatis
10 of the greatest songs by Sly Dunbar – from reggae classics to Grace Jones and Bob Dylan
10 of the greatest songs by Sly Dunbar – from reggae classics to Grace Jones and Bob Dylan
After his death aged 73, we look back at a selection of the hundreds of tracks the Sly and Robbie drummer had a hand in making
www.theguardian.com
January 27, 2026 at 4:03 PM
10 of the greatest songs by Sly Dunbar – from reggae classics to Grace Jones and Bob Dylan
Just called both of my senators @schumer.senate.gov and @kirstengillibrand.bsky.social to let them know that appropriations for DHS are not compatible with a free society and that personnel shuffles do not matter. Even if my federal funding ends as a result, DHS must go and Holman Bondi et al too
January 27, 2026 at 3:23 PM
Just called both of my senators @schumer.senate.gov and @kirstengillibrand.bsky.social to let them know that appropriations for DHS are not compatible with a free society and that personnel shuffles do not matter. Even if my federal funding ends as a result, DHS must go and Holman Bondi et al too
Reposted by Silas Maniatis
Fighting through snow so I can do my science. Animal care staff, building staff, clinical staff, nurses, doctors, veterinarians all work through these weather conditions to make the NIH run.
January 25, 2026 at 7:35 PM
Fighting through snow so I can do my science. Animal care staff, building staff, clinical staff, nurses, doctors, veterinarians all work through these weather conditions to make the NIH run.
Reposted by Silas Maniatis
This is the most astonishing graph of what the Trump regime has done to US science. They have destroyed the federal science workforce across the board. The negative impacts on Americans will be felt for generations, and the US might never be the same again.
www.nature.com/immersive/d4...
www.nature.com/immersive/d4...
January 20, 2026 at 10:53 PM
This is the most astonishing graph of what the Trump regime has done to US science. They have destroyed the federal science workforce across the board. The negative impacts on Americans will be felt for generations, and the US might never be the same again.
www.nature.com/immersive/d4...
www.nature.com/immersive/d4...
Seems like voluntarily installing a secret police surveillance node at one’s own expense might be an action that one’s neighbors find upsetting. Would be weird and totally unrelated if all of a sudden lots of these went missing, or had sensors damaged with lasers etc
techcrunch.com/2025/10/16/a...
techcrunch.com/2025/10/16/a...
Amazon's Ring to partner with Flock, a network of AI cameras used by ICE, feds, and police | TechCrunch
Agencies that use Flock can request that Ring doorbell users share footage to help with "evidence collection and investigative work."
techcrunch.com
January 19, 2026 at 4:37 PM
Seems like voluntarily installing a secret police surveillance node at one’s own expense might be an action that one’s neighbors find upsetting. Would be weird and totally unrelated if all of a sudden lots of these went missing, or had sensors damaged with lasers etc
techcrunch.com/2025/10/16/a...
techcrunch.com/2025/10/16/a...
Reposted by Silas Maniatis
I’m one of the ProPublica reporters who has been documenting the aggressive tactics federal agents are using against immigrants & U.S. citizens
All eyes are on Minnesota right now, but I want to tell you about Arnoldo Bazan, a 16-YO citizen in Houston who was choked by immigration agents in October
All eyes are on Minnesota right now, but I want to tell you about Arnoldo Bazan, a 16-YO citizen in Houston who was choked by immigration agents in October
January 15, 2026 at 9:31 PM
I’m one of the ProPublica reporters who has been documenting the aggressive tactics federal agents are using against immigrants & U.S. citizens
All eyes are on Minnesota right now, but I want to tell you about Arnoldo Bazan, a 16-YO citizen in Houston who was choked by immigration agents in October
All eyes are on Minnesota right now, but I want to tell you about Arnoldo Bazan, a 16-YO citizen in Houston who was choked by immigration agents in October
Reposted by Silas Maniatis
3 papers in Cell @cellpress.bsky.social today exploring the mechanistic connection between Epstein-Barr virus and multiple sclerosis #MultipleSclerosis
cell.com/cell/fulltex...
cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
cell.com/cell/fulltex...
cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
January 13, 2026 at 4:25 PM
3 papers in Cell @cellpress.bsky.social today exploring the mechanistic connection between Epstein-Barr virus and multiple sclerosis #MultipleSclerosis
cell.com/cell/fulltex...
cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
cell.com/cell/fulltex...
cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
TDP43 dysfunction in ALS leads to transposon mayhem in the transcriptome. Nice work from @nygenome.org ‘s ALS consortium, lead by Hemali Phatnani, and @nyulangone.bsky.social ‘s @karthiknatarajan.bsky.social & @mollygale.bsky.social. Nice work guys!
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
www.biorxiv.org
January 13, 2026 at 12:49 PM
TDP43 dysfunction in ALS leads to transposon mayhem in the transcriptome. Nice work from @nygenome.org ‘s ALS consortium, lead by Hemali Phatnani, and @nyulangone.bsky.social ‘s @karthiknatarajan.bsky.social & @mollygale.bsky.social. Nice work guys!
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Reposted by Silas Maniatis
“Analysis of Biological Data with Python” started today for biology bachelor students 🧬🐍
Want to learn Python for data analysis?
Slides are freely available:
github.com/bpucker/teac...
#Python #DataAnalysis #Biology #OpenScience #BigData #Bioinformatics #DataScience @puckerlab.bsky.social
Want to learn Python for data analysis?
Slides are freely available:
github.com/bpucker/teac...
#Python #DataAnalysis #Biology #OpenScience #BigData #Bioinformatics #DataScience @puckerlab.bsky.social
January 12, 2026 at 9:18 PM
“Analysis of Biological Data with Python” started today for biology bachelor students 🧬🐍
Want to learn Python for data analysis?
Slides are freely available:
github.com/bpucker/teac...
#Python #DataAnalysis #Biology #OpenScience #BigData #Bioinformatics #DataScience @puckerlab.bsky.social
Want to learn Python for data analysis?
Slides are freely available:
github.com/bpucker/teac...
#Python #DataAnalysis #Biology #OpenScience #BigData #Bioinformatics #DataScience @puckerlab.bsky.social
Reposted by Silas Maniatis
New York City turned OUT.
@handsoffnyc.bsky.social ✊❤️
@handsoffnyc.bsky.social ✊❤️
January 11, 2026 at 7:31 PM
New York City turned OUT.
@handsoffnyc.bsky.social ✊❤️
@handsoffnyc.bsky.social ✊❤️
Reposted by Silas Maniatis
Never forget. 🇺🇸
January 6, 2026 at 3:22 PM
Never forget. 🇺🇸
Reposted by Silas Maniatis
Zohran just went out and fixed the Williamsburg Bridge bike entrance. Just did it. No faffing, no nonsense. Bam. Fixed.
January 6, 2026 at 7:37 PM
Zohran just went out and fixed the Williamsburg Bridge bike entrance. Just did it. No faffing, no nonsense. Bam. Fixed.
Reposted by Silas Maniatis
A comprehensive spatial splicing analysis in the brain under normal and neoplastic conditions @natbiotech.nature.com @raulrabadan.bsky.social @columbiauniversity.bsky.social @davidaknowles.bsky.social @nygenome.org
www.nature.com/articles/s41...
www.nature.com/articles/s41...
January 6, 2026 at 4:17 AM
A comprehensive spatial splicing analysis in the brain under normal and neoplastic conditions @natbiotech.nature.com @raulrabadan.bsky.social @columbiauniversity.bsky.social @davidaknowles.bsky.social @nygenome.org
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Silas Maniatis
SPARK-seq: A high-throughput platform for aptamer discovery and kinetic profiling @science.org
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
January 2, 2026 at 1:09 AM
SPARK-seq: A high-throughput platform for aptamer discovery and kinetic profiling @science.org
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Silas Maniatis
20-plex volumetric super-resolution imaging of cellular ultrastructure. Preprint, led by @seweryn-galecki.bsky.social, dropping soon.
January 1, 2026 at 11:10 PM
20-plex volumetric super-resolution imaging of cellular ultrastructure. Preprint, led by @seweryn-galecki.bsky.social, dropping soon.
Reposted by Silas Maniatis
I was wondering what Mamdani's first executive order would be, and I'm not disappointed by this.
He has wiped off the books EVERY Eric Adams executive order issued on or after September 26, 2024, the day Adams was indicted on federal bribery charges.
He has wiped off the books EVERY Eric Adams executive order issued on or after September 26, 2024, the day Adams was indicted on federal bribery charges.
January 1, 2026 at 11:07 PM
I was wondering what Mamdani's first executive order would be, and I'm not disappointed by this.
He has wiped off the books EVERY Eric Adams executive order issued on or after September 26, 2024, the day Adams was indicted on federal bribery charges.
He has wiped off the books EVERY Eric Adams executive order issued on or after September 26, 2024, the day Adams was indicted on federal bribery charges.
It’s been amazing to watch the growth of the biomedical industry in NYC over the past decade. It’s also terrible watching it be destroyed by federal actions. To remain competitive with respect to national and global centers of biomedical research and industry, NY state must step in and invest!
📢 SIGN & SHARE THE PETITION! 📢
New York needs an Empire Biomedical Research Institute to create new statewide funding opportunities for scientists & physician-scientists so that patients and their families get the life-saving and life-changing new therapeutics they're hoping for ✏️ c.org/TDMy2H9JTW
New York needs an Empire Biomedical Research Institute to create new statewide funding opportunities for scientists & physician-scientists so that patients and their families get the life-saving and life-changing new therapeutics they're hoping for ✏️ c.org/TDMy2H9JTW
Sign the Petition
Support a New York State Biomedical Institute for a Healthier, More Affordable Future
c.org
November 24, 2025 at 4:48 PM
It’s been amazing to watch the growth of the biomedical industry in NYC over the past decade. It’s also terrible watching it be destroyed by federal actions. To remain competitive with respect to national and global centers of biomedical research and industry, NY state must step in and invest!
Reposted by Silas Maniatis
Still my favorite 3D reconstruction of a pancreatic tissue.
Using the CODA workflow, we mapped a billion individual cells in 3D.
Red: pre-cancer lesions
Navy blue: ducts
Light blue: islets of Langerhans
Purple: acini
Green: blood vessels
Yellow: fat
More here: www.nature.com/articles/s41...
Using the CODA workflow, we mapped a billion individual cells in 3D.
Red: pre-cancer lesions
Navy blue: ducts
Light blue: islets of Langerhans
Purple: acini
Green: blood vessels
Yellow: fat
More here: www.nature.com/articles/s41...
November 20, 2025 at 6:34 PM
Still my favorite 3D reconstruction of a pancreatic tissue.
Using the CODA workflow, we mapped a billion individual cells in 3D.
Red: pre-cancer lesions
Navy blue: ducts
Light blue: islets of Langerhans
Purple: acini
Green: blood vessels
Yellow: fat
More here: www.nature.com/articles/s41...
Using the CODA workflow, we mapped a billion individual cells in 3D.
Red: pre-cancer lesions
Navy blue: ducts
Light blue: islets of Langerhans
Purple: acini
Green: blood vessels
Yellow: fat
More here: www.nature.com/articles/s41...
Reposted by Silas Maniatis
Another new policy from the geniuses in NIH leadership.
Apparently, ~70% of grant applications for most mechanisms will not be "triaged", i.e. not discussed at study section.
This is an increase from the ~50% level that has been in place for many years.
I don't know the rationale for this
1/13
Apparently, ~70% of grant applications for most mechanisms will not be "triaged", i.e. not discussed at study section.
This is an increase from the ~50% level that has been in place for many years.
I don't know the rationale for this
1/13
a man with a beard is looking at the camera with the words priorities written on the bottom
ALT: a man with a beard is looking at the camera with the words priorities written on the bottom
media.tenor.com
November 14, 2025 at 3:31 PM
Another new policy from the geniuses in NIH leadership.
Apparently, ~70% of grant applications for most mechanisms will not be "triaged", i.e. not discussed at study section.
This is an increase from the ~50% level that has been in place for many years.
I don't know the rationale for this
1/13
Apparently, ~70% of grant applications for most mechanisms will not be "triaged", i.e. not discussed at study section.
This is an increase from the ~50% level that has been in place for many years.
I don't know the rationale for this
1/13
Reposted by Silas Maniatis
NEW: The first two years of Massachusetts' millionaire tax has raised $3 billion more than expected.
And rather than driving the rich away, IPS researchers found that the number of millionaires has *increased.*
Tax the rich. Greg Ryan in @bloomberg.com:
And rather than driving the rich away, IPS researchers found that the number of millionaires has *increased.*
Tax the rich. Greg Ryan in @bloomberg.com:
Millionaire Tax That Inspired Mamdani Fuels $5.7 Billion Haul in Massachusetts
A millionaire levy in Massachusetts that New York City mayoral frontrunner Zohran Mamdani holds up as a model for taxing the rich has generated $3 billion more in revenue than expected without forcing...
www.bloomberg.com
November 12, 2025 at 4:01 PM
NEW: The first two years of Massachusetts' millionaire tax has raised $3 billion more than expected.
And rather than driving the rich away, IPS researchers found that the number of millionaires has *increased.*
Tax the rich. Greg Ryan in @bloomberg.com:
And rather than driving the rich away, IPS researchers found that the number of millionaires has *increased.*
Tax the rich. Greg Ryan in @bloomberg.com:
If they send the money out $2k at a time to 100s of millions of people, it will be that much harder for the Supreme Court to rule the tariffs unconstitutional because it would be impossible to claw the money back. So heads trump is emperor, tails there’s no consequences when he does illegal stuff.
Trump: "We're gonna issue a dividend to our middle income people and lower income people of about $2,000, and we're gonna use the remaining tariffs to lower our debt."
November 10, 2025 at 9:02 PM
If they send the money out $2k at a time to 100s of millions of people, it will be that much harder for the Supreme Court to rule the tariffs unconstitutional because it would be impossible to claw the money back. So heads trump is emperor, tails there’s no consequences when he does illegal stuff.
Reposted by Silas Maniatis
Q: Will you assure House Democrats they'll get a vote on ACA subsidies by a date certain?
MIKE JOHNSON: Ah -- no. I'm not promising anyone anything.
MIKE JOHNSON: Ah -- no. I'm not promising anyone anything.
November 6, 2025 at 3:47 PM
Q: Will you assure House Democrats they'll get a vote on ACA subsidies by a date certain?
MIKE JOHNSON: Ah -- no. I'm not promising anyone anything.
MIKE JOHNSON: Ah -- no. I'm not promising anyone anything.