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reichowlab.bsky.social
Reichow Lab
@reichowlab.bsky.social
1.1K followers 540 following 34 posts
Steve Reichow (PI), Laboratory of Biomolecular #CryoEM at Oregon Health & Science University (OHSU) and Pacific Northwest Cryo-EM Center (PNCC) ❄🔬 https://www.reichowlab.com/
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reichowlab.bsky.social
Reichow Lab @reichowlab.bsky.social · Feb 21
#NIHFundedDiscovery

How do cells avoid the "kiss of death"?

Gap junctions share life-saving signals—but under stress, they shut down to prevent spreading cytotoxic damage.

#CryoEM reveals the molecular switches behind this process!

www.biorxiv.org/content/10.1...

www.biorxiv.org/content/10.1...
Reposted by Reichow Lab
nanigrotjahn.bsky.social
Prohibitins aren’t hanging out just anywhere in the membrane — they prefer the 💁‍♀️💎✨VIP section💅🪩🥂

Lab all-star @mmedina300kv.bsky.social maps these microdomains using cryo-ET + surface morphometrics.

s/o to #teamtomo #cryoET co-authors
@hamid13r.bsky.social
@attychang.bsky.social
@baradlab.com
biorxiv-cellbio.bsky.social bioRxiv Cell Biology @biorxiv-cellbio.bsky.social · 2d
Prohibitin complexes associate with unique membrane microdomains in cells https://www.biorxiv.org/content/10.1101/2025.11.14.688579v1
November 17, 2025 at 12:22 AM
Reposted by Reichow Lab
andrewplested.bsky.social
Calcium and magnesium in the pore of NMDA receptors!

Lipids play an unexpected role. The hydration shells of Ca2+ and Mg2+ could be the difference between permeation and block. So much physiology in the energetics of H2O.

Very stimulating work! Congrats @lab-furukawa.bsky.social

#iglurs
Calcium bound at the tip of the selectivity filter in an NMDA-type glutamate receptor.
November 8, 2025 at 6:30 AM
Reposted by Reichow Lab
kevinguttenplan.bsky.social
Science, from Portland
October 31, 2025 at 4:44 PM
Reposted by Reichow Lab
mrclmb.bsky.social
Chris Russo and Anastasiia Gusach have developed a new method to prepare #cryoEM samples that avoids protein damage during freezing

Read more: www2.mrc-lmb.cam.ac.uk/a-new-method...

#LMBResearch
October 22, 2025 at 4:41 PM
Reposted by Reichow Lab
bronwynalucas.bsky.social
Nominations for the June Almeida award for Mid/Senior-Career Women in Cryo-EM are now open! Submit your nomination via this link www.biophysics.org/awards-fundi... by November 14th to recognize an exceptional woman in our community.
Subgroup Awards - The Biophysical Society
www.biophysics.org
October 16, 2025 at 7:08 PM
Reposted by Reichow Lab
meghnag27.bsky.social
Events celebrating women in electron microscopy are rare, which made my recent experience at the Ernst Ruska-Centre (ER-C), Forschungszentrum Jülich, Germany, truly special. I had the privilege of not only attending but also serving as a young keynote speaker at this inspiring gathering. 🎉
October 14, 2025 at 12:32 AM
Reposted by Reichow Lab
denkenny.bsky.social
✨Excited that the main project of my PhD is now available as a pre-print on #bioRxiv

Here, we used #CryoET to visualise mitochondrial proteostatic stress and together with SPA #CryoEM shed light into the functional cycle of the Hsp60:10 chaperone system. #TeamTomo

🔗 www.biorxiv.org/content/10.1...
October 8, 2025 at 3:59 PM
Reposted by Reichow Lab
edwardteng.bsky.social
Muyuan Chen has turned structural biology into an immersive experience with his new video game Meowtabolism, now available on Steam.
Try the demo here: store.steampowered.com/app/4045010/...
Give Muyuan feedback: steamcommunity.com/app/4045010
#ScienceGaming #StructuralBiology #CryoEM #STEMOutreach
October 4, 2025 at 1:34 PM
Reposted by Reichow Lab
ipiproteins.bsky.social
Frequent user of epitope tags? Try ours!

IPI epitope tag antibodies & plasmids are now available through our partner @addgene.bsky.social!

buff.ly/YEuZDIp
Epitope tag antibody collection
Epitope tags are short amino acid sequences fused to a protein’s N- or C-terminus. When paired with an antibody that specifically recognizes this sequence, epit
buff.ly
September 23, 2025 at 6:02 PM
Reposted by Reichow Lab
pacificnwcryoem.bsky.social
#Training 👨‍🏫 🧑‍🏫
#CryoEM ❄️ 🔬
#Science 🧬 🦠
#Education 📚

Huge shoutout to our SPoCs for making this a grand success! 👏
Marzia Miletto
Marcelo Alexandre de Farias
Omar Davulcu
September 23, 2025 at 9:59 PM
Reposted by Reichow Lab
nexperion.net
Happy to announce "Technical Innovations Using #SerialEM: A Community Meeting", a new format of hybrid meeting David Mastronarde and I are organizing in April 2026. For more info, a preliminary list of speakers, pre-registration etc. visit
www.nexperion.net/semcm2026
September 23, 2025 at 10:42 AM
Reposted by Reichow Lab
edwardteng.bsky.social
Join us for the next CryoEM Current Practices Webinar on 9/25/2025 at 12 PM ET / 9 AM PT with Dr. Sarah Clark who will sharing her research on the "Architecture of a Bridge-like Lipid Transfer Protein."

Register here:
us02web.zoom.us/webinar/regi...
September 22, 2025 at 10:43 PM
Reposted by Reichow Lab
reichlinmelnick.bsky.social
NEW: Hours before a new entry ban is supposed to go into effect, the federal government officially acknowledges for the first time that the restrictions do NOT apply to people who currently have H-1B visas.

Link: www.uscis.gov/sites/defaul...
J.S. Citizenshit and Immigratior Services September 20, 2025 Memorandum TO: Associate Directors, Deputy Associate Directors, Program Office Chiefs FROM: JOSEPH B Digitaly signed by JOSEPH B EDLOW Joseph B. Edlow EDLOW Date: 2025.09.20 Director, United States Citizenship and Immigration Services **00 SUBJECT: Proclamation, Restriction on Entry of Certain Nonimmigrant Workers, H-IB On September 19, 2025, the President issued a Proclamation, Restriction on Entry of Certain Nonimmigrant Workers, to address systemic abuse of H-1B nonimmigrant visas. Pursuant to sections 212(f) and 215(a) of the Immigration and Nationality Act (INA), 8 U.S.C. 1182(f) and 1185(a), the entry into the United States of aliens as nonimmigrants to perform services in a specialty occupation under section 101(a)(15)(H)(i)(b) of the INA, 8 U.S.C. 1101(a)(15)(H)(i)(b), is restricted, except for those aliens whose petitions are accompanied or supplemented by a payment of $100,000. This guidance applies to H-IB employment-based petitions filed after 12:01 AM ET on September 21, 2025.| This proclamation only applies prospectively to petitions that have not yet been filed. The proclamation does not apply to aliens who: are the beneficiaries of petitions that were filed prior to the effective date of the proclamation, are the beneficiaries of currently approved petitions, or are in possession of validly issued H-1B non-immigrant visas. All officers of United States Citizenship and Immigration Services shall ensure that their decisions are consistent with this guidance. The proclamation does not impact the ability of any current visa holder to travel to or rom the United States. cc: David V. Roy, Chief Counsel (A) FOUO, For Official Use Only
September 20, 2025 at 9:57 PM
Reposted by Reichow Lab
mansoorlabohsu.bsky.social
Another manuscript from our group this week with the first structures of the human P2X7 receptor facilitating development of a novel scaffold for P2X7R antagonists:

urldefense.com/v3/__https:/...

@pacificnwcryoem.bsky.social
@ohsunews.bsky.social
@ohsubrain.bsky.social
September 15, 2025 at 6:11 PM
Reposted by Reichow Lab
mansoorlabohsu.bsky.social
Our latest work on the human P2X2 receptor. We identified an alternate desensitized state conformation that provides insight into how ATP enters and/or leaves the pocket.

www.pnas.org/doi/10.1073/...

@pacificnwcryoem.bsky.social
@ohsunews.bsky.social
@ohsubrain.bsky.social
September 14, 2025 at 3:54 AM
Reposted by Reichow Lab
drwendyrocks.bsky.social
👏👏👏 👏👏
September 6, 2025 at 4:46 PM
Reposted by Reichow Lab
olibclarke.bsky.social
Happy to share a new preprint from the Clarke & Vallese (@fravallese.bsky.social) labs reporting #cryoem structures of two RBC stomatin complexes – with AQP1 & UT-B - continuing the SPFH theme from our recent vault preprint! This was a fun one and has been cooking for a while - read on for more! ⬇️
Upper - cryo-EM reconstruction of stomatin AQP1 complex. Lower - reconstruction of stomatin-UT-B complex.
August 30, 2025 at 2:11 PM
Reposted by Reichow Lab
jnpruneda.bsky.social
Come be my boss! We’re looking for a passionate and supportive leader for our Department of Molecular Microbiology and Immunology. Research in MMI spans diverse models and systems of host-pathogen interactions. Come join us in the beautiful Pacific NW!

facultycareers-ohsu.icims.com/jobs/35624/c...
Faculty Portal | OHSU
facultycareers-ohsu.icims.com
August 26, 2025 at 1:58 AM
Reposted by Reichow Lab
kiharalab.bsky.social
PNCC Cryo-EM modeling and validation workshop on Sep 3-5, 2025. Register now! tinyurl.com/Cryo-EMModel...
August 20, 2025 at 11:36 PM
Reposted by Reichow Lab
nanigrotjahn.bsky.social
🚨 #teamtomo!🚨
Did you know there's a dedicated cryoEM/ET Mini-Symposium at the upcoming ASCB/EMBO meeting in Philly (Dec 6–10)??
August 20, 2025 at 12:18 AM
Reposted by Reichow Lab
edwardteng.bsky.social
If you are at #MM2025 come by booth 1135 to learn more about the NIH sponsored transformative high resolution #cryoEM & #cryoET programs. We offer these technologies to the nation at no cost at the point of access.

cryoemcenters.org cryoetportal.org
July 29, 2025 at 12:00 AM
Reposted by Reichow Lab
bwjones.bsky.social
Wes Sundquist is one of the good guys. He is a scientists scientist and has carefully, passionately, and consistently carried his science out with this goal in mind. A cure for AIDS that is available to all.

This is an amazing recognition for him and for the @utah.edu where he has done his work.
egojunk.bsky.social eric gonzalez juenke @egojunk.bsky.social · Jul 28
Normalize talking about fed. $ when these headlines happen. Thousands of scientists, working for decades funded by the federal government did this. At times, people thought this was useless research. Below is some info about the HIV labs at the University of Utah. 🧵 www.science.org/doi/10.1126/...
July 28, 2025 at 1:49 PM
Reposted by Reichow Lab
ccemmp-outreach.bsky.social
Less than 2 weeks to go! 🤯Mare sure you prepare your entries for our 2nd @arc_gov_au CCeMMP 'Bench to Art' Exhibition during National Science Week & win cash prizes 💰! Please like & share 👍 More info: ccemmp.org/events/arc-c...
#CryoEM
#CryoET
#MembraneProtein
#GPCR
ARC CCeMMP 2nd Annual Bench to Art Exhibition 2025 | CCeMMP
The Australian Research Council Centre for Cryo-Electron Microscopy of Membrane Proteins (CCeMMP) is holding their 2nd Annual ‘Bench to Art’ Exhibition to showcase the artistic flair of structural bio...
ccemmp.org
July 26, 2025 at 12:16 AM
Reposted by Reichow Lab
edwardteng.bsky.social
The next #CryoEM Current Practices Webinar speaker will be Puja Majumder from MSKCC speaking on "From Micrographs to Maps: Structural Basis of a Filamentous CRISPR Effector Revealed by Cryo-EM" 7/31/2025 at 12 PM ET / 9AM PT

Sign up today:
us02web.zoom.us/webinar/regi...
July 27, 2025 at 12:08 AM
Reposted by Reichow Lab
drcontrexin.bsky.social
Exciting news! The EPIC/SGP Symposium at UC Davis will be accompanied by a special issue in the Journal of General Physiology. Stay tuned for more details about this incredible event celebrating cutting-edge research on ion channels!
jgp.org Journal of General Physiology @jgp.org · Jul 22
📣 #CallForPapers 📣 on the topic of the inaugural in-person Electrophysiology & Ion Channel (EpIC) meeting, “Emerging Research on Ion Channels in Health & Disease” – w/ Guest Editors Jelena Baranovic, Osama Harraz, Conor McClenaghan, & Lejla Zubcevic 👉 rupress.org/JGP/pages/ca...
July 23, 2025 at 2:05 AM