Pete Williams
@petetheteapot.bsky.social
Tea drinker and scientist. Neurons, NAD, stuff.
Professor in Vision Science, Research Group Leader - Glaucoma at Karolinska Institutet and St. Erik Eye Hospital, Stockholm (petewilliamslab.com)
CEO - Mim Neurosciences (mimneurosciences.com)
Professor in Vision Science, Research Group Leader - Glaucoma at Karolinska Institutet and St. Erik Eye Hospital, Stockholm (petewilliamslab.com)
CEO - Mim Neurosciences (mimneurosciences.com)
Reposted by Pete Williams
In this review @Andrea-Loreto.bsky.social and I discuss the breadth of therapeutic potential for the neurodegenerative enzyme SARM1
- Challenges for SARM1 therapeutic inhibition
- SARM1 in non-neuronal cells
- SARM1 activation for selective peripheral neuroablation.
www.cell.com/trends/pharm...
- Challenges for SARM1 therapeutic inhibition
- SARM1 in non-neuronal cells
- SARM1 activation for selective peripheral neuroablation.
www.cell.com/trends/pharm...
Targeting SARM1: from inhibition for neuroprotection to activation for neuroablation
Sterile alpha and TIR motif-containing protein 1 (SARM1),is a central enzyme that
drives programmed axon degeneration and has gathered significant interest as a therapeutic
target. Despite preclinical...
www.cell.com
October 21, 2025 at 6:16 AM
In this review @Andrea-Loreto.bsky.social and I discuss the breadth of therapeutic potential for the neurodegenerative enzyme SARM1
- Challenges for SARM1 therapeutic inhibition
- SARM1 in non-neuronal cells
- SARM1 activation for selective peripheral neuroablation.
www.cell.com/trends/pharm...
- Challenges for SARM1 therapeutic inhibition
- SARM1 in non-neuronal cells
- SARM1 activation for selective peripheral neuroablation.
www.cell.com/trends/pharm...
Reposted by Pete Williams
💉👀 Ozempic. What does the eye have to do with it?
Let’s take a look at the latest evidence published in @jamanetworkopen.com
Thank you to @aunz.theconversation.com for inviting me to write this piece. Was a pleasure to write with @petetheteapot.bsky.social from @ki.se
Let’s take a look at the latest evidence published in @jamanetworkopen.com
Thank you to @aunz.theconversation.com for inviting me to write this piece. Was a pleasure to write with @petetheteapot.bsky.social from @ki.se
A new study shows drugs such as Ozempic come with a small but increased risk of a condition known as an ‘eye stroke’.
👉 Read the full story: theconversation.com/ozempic...
👉 Read the full story: theconversation.com/ozempic...
August 12, 2025 at 11:40 PM
💉👀 Ozempic. What does the eye have to do with it?
Let’s take a look at the latest evidence published in @jamanetworkopen.com
Thank you to @aunz.theconversation.com for inviting me to write this piece. Was a pleasure to write with @petetheteapot.bsky.social from @ki.se
Let’s take a look at the latest evidence published in @jamanetworkopen.com
Thank you to @aunz.theconversation.com for inviting me to write this piece. Was a pleasure to write with @petetheteapot.bsky.social from @ki.se
Reposted by Pete Williams
Dr Pete Williams @petetheteapot.bsky.social @ki.se will be our next webinar speaker!
'From bench to bedside and back again: Targeting NAD for neuroprotection in #glaucoma'
Aug 11, 2025
10-11am ET
Host: Dr Diane Bovenkamp @dianebovenkamp.bsky.social @brightfocus.bsky.social
Register: bit.ly/4o6WrqY
'From bench to bedside and back again: Targeting NAD for neuroprotection in #glaucoma'
Aug 11, 2025
10-11am ET
Host: Dr Diane Bovenkamp @dianebovenkamp.bsky.social @brightfocus.bsky.social
Register: bit.ly/4o6WrqY
July 25, 2025 at 5:16 PM
Dr Pete Williams @petetheteapot.bsky.social @ki.se will be our next webinar speaker!
'From bench to bedside and back again: Targeting NAD for neuroprotection in #glaucoma'
Aug 11, 2025
10-11am ET
Host: Dr Diane Bovenkamp @dianebovenkamp.bsky.social @brightfocus.bsky.social
Register: bit.ly/4o6WrqY
'From bench to bedside and back again: Targeting NAD for neuroprotection in #glaucoma'
Aug 11, 2025
10-11am ET
Host: Dr Diane Bovenkamp @dianebovenkamp.bsky.social @brightfocus.bsky.social
Register: bit.ly/4o6WrqY
Reposted by Pete Williams
Doing science today feels like playing a video game on legendary difficulty.
With shrinking budgets, extreme publication fees, subjective rejections, and daily lab chaos, the path of a scientist is tougher than ever.
At least we have Parafilm to hold it all together.
Stay strong, scientists.
With shrinking budgets, extreme publication fees, subjective rejections, and daily lab chaos, the path of a scientist is tougher than ever.
At least we have Parafilm to hold it all together.
Stay strong, scientists.
May 14, 2025 at 8:53 PM
Doing science today feels like playing a video game on legendary difficulty.
With shrinking budgets, extreme publication fees, subjective rejections, and daily lab chaos, the path of a scientist is tougher than ever.
At least we have Parafilm to hold it all together.
Stay strong, scientists.
With shrinking budgets, extreme publication fees, subjective rejections, and daily lab chaos, the path of a scientist is tougher than ever.
At least we have Parafilm to hold it all together.
Stay strong, scientists.
Reposted by Pete Williams
Breaking News: A baby with a rare disorder made medical history by receiving the first custom gene-editing treatment. The technique used has the potential to help people with thousands of other uncommon genetic diseases. nyti.ms/4j49xBy
May 15, 2025 at 5:09 PM
Breaking News: A baby with a rare disorder made medical history by receiving the first custom gene-editing treatment. The technique used has the potential to help people with thousands of other uncommon genetic diseases. nyti.ms/4j49xBy
Reposted by Pete Williams
'we define how mitochondrial gene expression is spatially organized at sub-organellar scales into regulatory hubs that are subject to stress-induced remodeling. We propose that this remodeling into mitochondrial stress bodies may serve to aid in recovery of mitochondrial proteome quality control'
Spatial analysis of mitochondrial gene expression reveals dynamic translation hubs and remodeling in stress
Quantitative imaging of the mitochondrial central dogma identifies translation hubs that are suppressed during stress.
www.science.org
May 13, 2025 at 7:17 AM
'we define how mitochondrial gene expression is spatially organized at sub-organellar scales into regulatory hubs that are subject to stress-induced remodeling. We propose that this remodeling into mitochondrial stress bodies may serve to aid in recovery of mitochondrial proteome quality control'
Reposted by Pete Williams
“The visa fees are so exceedingly high that it makes coming here very difficult for some people. We are fishing for the best scientists in the world. They want to come and work here because we are such an effective country at science, but if we have these high costs, they can and will go elsewhere.”
Is the UK paying the price for world’s most expensive visas? | The Observer
Competing political and economic goals on immigration are resulting in the loss of valuable skills and talent in the UK
observer.co.uk
May 12, 2025 at 10:03 AM
“The visa fees are so exceedingly high that it makes coming here very difficult for some people. We are fishing for the best scientists in the world. They want to come and work here because we are such an effective country at science, but if we have these high costs, they can and will go elsewhere.”
Reposted by Pete Williams
Monitoring in real time and far-red imaging of H2O2 dynamics with subcellular resolution www.nature.com/articles/s41...
Monitoring in real time and far-red imaging of H2O2 dynamics with subcellular resolution - Nature Chemical Biology
This paper highlights the far-red chemigenetic H2O2 reporter oROS-HT635, which enables detailed insights into intricate intracellular and intercellular H2O2 dynamics, along with their environmental in...
www.nature.com
May 5, 2025 at 1:42 PM
Monitoring in real time and far-red imaging of H2O2 dynamics with subcellular resolution www.nature.com/articles/s41...
Reposted by Pete Williams
Remember to pick up your EyeVenture pins today. Collect 7 different ones during #ARVO2025, bring them to @arvoinfo.bsky.social Central by May 8 and you could win free registration to #ARVO2026 in Denver, Colo.! Check our website for today's collection locations. bit.ly/2GErnw4
May 4, 2025 at 3:06 PM
Remember to pick up your EyeVenture pins today. Collect 7 different ones during #ARVO2025, bring them to @arvoinfo.bsky.social Central by May 8 and you could win free registration to #ARVO2026 in Denver, Colo.! Check our website for today's collection locations. bit.ly/2GErnw4
Reposted by Pete Williams
The authors of a Comment article in Nature write that hopes are high that AI can accelerate scientific discovery but warn that the rush to adopt AI has consequences. “Establishing clear scientific guidelines on how to use these tools and techniques is urgent.” 🧪
Why an overreliance on AI-driven modelling is bad for science
Without clear protocols to catch errors, artificial intelligence’s growing role in science could do more harm than good.
go.nature.com
April 8, 2025 at 4:37 PM
The authors of a Comment article in Nature write that hopes are high that AI can accelerate scientific discovery but warn that the rush to adopt AI has consequences. “Establishing clear scientific guidelines on how to use these tools and techniques is urgent.” 🧪
Reposted by Pete Williams
Meta used at least 16 of my books, and numerous articles, to help train the AI it will use to make billions.
Authors, search your name here:
www.theatlantic.com/technology/a...
Authors, search your name here:
www.theatlantic.com/technology/a...
Search LibGen, the Pirated-Books Database That Meta Used to Train AI
Millions of books and scientific papers are captured in the collection’s current iteration.
www.theatlantic.com
March 20, 2025 at 12:16 PM
Meta used at least 16 of my books, and numerous articles, to help train the AI it will use to make billions.
Authors, search your name here:
www.theatlantic.com/technology/a...
Authors, search your name here:
www.theatlantic.com/technology/a...
Reposted by Pete Williams
New publication out with Katharina C Bell, Vicki Chrysostomou, Markus Karlsson, myself, Pete A Williams @petetheteapot.bsky.social , and Jonathan G Crowston
Excitatory and Inhibitory Neurotransmitter Alterations With Advancing Age and Injury in the Mouse Retina
bryanwjones.com/2025/03/exci...
Excitatory and Inhibitory Neurotransmitter Alterations With Advancing Age and Injury in the Mouse Retina
bryanwjones.com/2025/03/exci...
March 12, 2025 at 9:46 PM
New publication out with Katharina C Bell, Vicki Chrysostomou, Markus Karlsson, myself, Pete A Williams @petetheteapot.bsky.social , and Jonathan G Crowston
Excitatory and Inhibitory Neurotransmitter Alterations With Advancing Age and Injury in the Mouse Retina
bryanwjones.com/2025/03/exci...
Excitatory and Inhibitory Neurotransmitter Alterations With Advancing Age and Injury in the Mouse Retina
bryanwjones.com/2025/03/exci...
Reposted by Pete Williams
"What they have done is, frankly, destroy trust and good will within the university."
@leightonandrews.bsky.social
www.bbc.co.uk/news/article...
@leightonandrews.bsky.social
www.bbc.co.uk/news/article...
Cardiff Uni jobs threat leads to toxic culture - Leighton Andrews
Professor and former education minister says plan to cut 400 jobs has created a
www.bbc.co.uk
March 10, 2025 at 10:48 AM
"What they have done is, frankly, destroy trust and good will within the university."
@leightonandrews.bsky.social
www.bbc.co.uk/news/article...
@leightonandrews.bsky.social
www.bbc.co.uk/news/article...
Reposted by Pete Williams
Why academia is sleepwalking into self-destruction. My editorial @brain1878.bsky.social If you agree with the sentiments please repost. It's important for all our sakes to stop the madness
academic.oup.com/brain/articl...
academic.oup.com/brain/articl...
March 6, 2025 at 7:16 PM
Why academia is sleepwalking into self-destruction. My editorial @brain1878.bsky.social If you agree with the sentiments please repost. It's important for all our sakes to stop the madness
academic.oup.com/brain/articl...
academic.oup.com/brain/articl...
My favorite thing about journal editors in the upper echelons of impact is that they deem my manuscripts of not being of sufficient quality or impact for their journal, but within the same week they are very happy to have me as a reviewer to judge said quality...
March 7, 2025 at 10:12 AM
My favorite thing about journal editors in the upper echelons of impact is that they deem my manuscripts of not being of sufficient quality or impact for their journal, but within the same week they are very happy to have me as a reviewer to judge said quality...
Reposted by Pete Williams
What a fun review to write with @petetheteapot.bsky.social on metabolic dysfunction in glaucoma! It’s out today in Glaucoma Today 😆 enjoy the read at the link below🧪 #glaucoma
glaucomatoday.com/articles/202...
glaucomatoday.com/articles/202...
Metabolic Dysfunction in Glaucoma: From Bench to Bedside (and Back Again) - Glaucoma Today
A review of nicotinamide treatment for neuroprotection.
glaucomatoday.com
March 3, 2025 at 9:25 AM
What a fun review to write with @petetheteapot.bsky.social on metabolic dysfunction in glaucoma! It’s out today in Glaucoma Today 😆 enjoy the read at the link below🧪 #glaucoma
glaucomatoday.com/articles/202...
glaucomatoday.com/articles/202...
Another success for gene therapy!
From The Lancet: Gene therapy in children with AIPL1-associated severe retinal dystrophy: an open-label, first-in-human interventional study
www.thelancet.com/journals/lan...
#ophthalmology #genetherapy
@
From The Lancet: Gene therapy in children with AIPL1-associated severe retinal dystrophy: an open-label, first-in-human interventional study
www.thelancet.com/journals/lan...
#ophthalmology #genetherapy
@
Gene therapy in children with AIPL1-associated severe retinal dystrophy: an open-label, first-in-human interventional study
Our findings indicate that young children with AIPL1-related retinal dystrophy benefited
substantially from subretinal administration of rAAV8.hRKp.AIPL1, with improved visual
acuity and functional vi...
www.thelancet.com
February 21, 2025 at 10:17 AM
Another success for gene therapy!
From The Lancet: Gene therapy in children with AIPL1-associated severe retinal dystrophy: an open-label, first-in-human interventional study
www.thelancet.com/journals/lan...
#ophthalmology #genetherapy
@
From The Lancet: Gene therapy in children with AIPL1-associated severe retinal dystrophy: an open-label, first-in-human interventional study
www.thelancet.com/journals/lan...
#ophthalmology #genetherapy
@
Reposted by Pete Williams
Putting the brakes on mitochondrial fusion to prevent escape of mitochondrial DNA
www.nature.com/articles/d41...
www.nature.com/articles/d41...
Putting the brakes on mitochondrial fusion to prevent escape of mitochondrial DNA
Organelle network is regulated to prevent cellular inflammation.
www.nature.com
February 20, 2025 at 9:14 AM
Putting the brakes on mitochondrial fusion to prevent escape of mitochondrial DNA
www.nature.com/articles/d41...
www.nature.com/articles/d41...
Reposted by Pete Williams
Nice opinion piece by @adamsobel.bsky.social about destruction of U.S. science.
thebulletin.org/2025/02/how-...
thebulletin.org/2025/02/how-...
How the Trump administration could end a century of American scientific dominance
Slashing federal funding for scientific research will have catastrophic and long-lasting impacts far beyond the laboratories where government research funds are spent.
thebulletin.org
February 18, 2025 at 8:33 PM
Nice opinion piece by @adamsobel.bsky.social about destruction of U.S. science.
thebulletin.org/2025/02/how-...
thebulletin.org/2025/02/how-...
Reposted by Pete Williams
Hate that it has come to this, but it's time to consider PubMed vulnerable to enshittification. My latest post @plos.org discusses the lines we need to fight to hold – and alternatives we can rely on internationally:
absolutelymaybe.plos.org/2025/02/14/w...
#medlibs
absolutelymaybe.plos.org/2025/02/14/w...
#medlibs
What if We Can't Rely on PubMed? - Absolutely Maybe
PubMed is incredibly reliable. And a lot depends on it. It’s an ecosystem built around MEDLINE, the steady feed of new publications…
absolutelymaybe.plos.org
February 14, 2025 at 6:06 AM
Hate that it has come to this, but it's time to consider PubMed vulnerable to enshittification. My latest post @plos.org discusses the lines we need to fight to hold – and alternatives we can rely on internationally:
absolutelymaybe.plos.org/2025/02/14/w...
#medlibs
absolutelymaybe.plos.org/2025/02/14/w...
#medlibs
Reposted by Pete Williams
Hello Vision Science Peeps!
Be sure to put the @iser.bsky.social / @brightfocus.bsky.social Concepts and Breakthroughs In Glaucoma Meeting on your schedule. It will be in Atlanta, Georgia, USA from October 8-11, 2025
iserbrightfocusglaucoma.org
Be sure to put the @iser.bsky.social / @brightfocus.bsky.social Concepts and Breakthroughs In Glaucoma Meeting on your schedule. It will be in Atlanta, Georgia, USA from October 8-11, 2025
iserbrightfocusglaucoma.org
February 6, 2025 at 11:24 PM
Hello Vision Science Peeps!
Be sure to put the @iser.bsky.social / @brightfocus.bsky.social Concepts and Breakthroughs In Glaucoma Meeting on your schedule. It will be in Atlanta, Georgia, USA from October 8-11, 2025
iserbrightfocusglaucoma.org
Be sure to put the @iser.bsky.social / @brightfocus.bsky.social Concepts and Breakthroughs In Glaucoma Meeting on your schedule. It will be in Atlanta, Georgia, USA from October 8-11, 2025
iserbrightfocusglaucoma.org
Reposted by Pete Williams
The Howard Hughes Medical Institute, the nation’s largest private funder of biomedical research, yesterday killed a $60 million program aimed at making universities’ STEM education more inclusive. scim.ag/3EtS0US
HHMI kills program aimed at boosting inclusivity in STEM education
“Inclusive excellence” program had committed $60 million to 104 institutions
scim.ag
February 6, 2025 at 11:30 PM
The Howard Hughes Medical Institute, the nation’s largest private funder of biomedical research, yesterday killed a $60 million program aimed at making universities’ STEM education more inclusive. scim.ag/3EtS0US
Reposted by Pete Williams
Super cool new review by @caromenard666.bsky.social’s team on neuro-glio-vascular alterations #cerebrovascular
Neurogliovascular alterations in brain pathologies across lifespan
Neurological and psychiatric illnesses present significant challenges across different stages of life. Adolescence is associated with a high incidence…
www.sciencedirect.com
February 6, 2025 at 12:19 PM
Super cool new review by @caromenard666.bsky.social’s team on neuro-glio-vascular alterations #cerebrovascular
** Phillips then said: “So no youth mobility scheme?”
The home secretary said: “That’s not the right starting point for us at all because what we need to do is to bring net migration down.” **
Good times ahead for British science and academia /s
www.huffingtonpost.co.uk/entry/yvette...
The home secretary said: “That’s not the right starting point for us at all because what we need to do is to bring net migration down.” **
Good times ahead for British science and academia /s
www.huffingtonpost.co.uk/entry/yvette...
Yvette Cooper Rules Out The UK Signing Up To Giving Young People Free Movement To The EU
"That's not the right starting point for us at all," she told Sky News.
www.huffingtonpost.co.uk
February 2, 2025 at 9:37 AM
** Phillips then said: “So no youth mobility scheme?”
The home secretary said: “That’s not the right starting point for us at all because what we need to do is to bring net migration down.” **
Good times ahead for British science and academia /s
www.huffingtonpost.co.uk/entry/yvette...
The home secretary said: “That’s not the right starting point for us at all because what we need to do is to bring net migration down.” **
Good times ahead for British science and academia /s
www.huffingtonpost.co.uk/entry/yvette...
Reposted by Pete Williams
Celebrating this fantastic work lead by Kristýna Kárová (with some EvaLab contribution!), its new home in Molecular Therapy. Spinal cord axon regeneration with improvements in paw reaching, grip strength, and ladder walking using a gene therapy approach. Delta is the way! tinyurl.com/55en9z6d
January 26, 2025 at 3:50 PM
Celebrating this fantastic work lead by Kristýna Kárová (with some EvaLab contribution!), its new home in Molecular Therapy. Spinal cord axon regeneration with improvements in paw reaching, grip strength, and ladder walking using a gene therapy approach. Delta is the way! tinyurl.com/55en9z6d