ISER
@iser.bsky.social
ISER provides a unique international platform for the exchange of ideas on contemporary topics in eye and vision research.
http://iser.org
http://iser.org
Reposted by ISER
Fantastic new paper from @pierre-mattar.bsky.social lab!
Chd4 remodels chromatin to control retinal cell type specification and lineage termination
Read this #LifelongDevSI #OA Research Article by Sujay Shah, Pierre Mattar and colleagues
doi.org/10.1242/dev....
Read this #LifelongDevSI #OA Research Article by Sujay Shah, Pierre Mattar and colleagues
doi.org/10.1242/dev....
October 28, 2025 at 8:22 PM
Fantastic new paper from @pierre-mattar.bsky.social lab!
Reposted by ISER
Ending my #FluorescenceFriday with this beautiful avian retina image depicting the beautiful stratification in the avian eyes.
This is where complexity meets art.
#retina #avian #bird #plexiformlayer
This is where complexity meets art.
#retina #avian #bird #plexiformlayer
November 14, 2025 at 4:18 PM
Ending my #FluorescenceFriday with this beautiful avian retina image depicting the beautiful stratification in the avian eyes.
This is where complexity meets art.
#retina #avian #bird #plexiformlayer
This is where complexity meets art.
#retina #avian #bird #plexiformlayer
Reposted by ISER
Axonal pathfinding of zebrafish retinal ganglion cells forms the optic nerve. Credit to Dr. Matthew Bostock @houartlab.bsky.social. #ZebrafishZunday 🧪
November 16, 2025 at 8:30 PM
Axonal pathfinding of zebrafish retinal ganglion cells forms the optic nerve. Credit to Dr. Matthew Bostock @houartlab.bsky.social. #ZebrafishZunday 🧪
Reposted by ISER
Excellent work @victorcalbiagueg.bsky.social !!!
In this #TopicalReview, Victor Calbiague-Garcia of sorbonne-universite.fr et al. review current knowledge of #amacrine cells & discuss how emerging approaches are advancing our understanding of their function 👁️ 🐁
🔗 Read it here: physoc.onlinelibrary.wiley.com/doi/10.1113/...
🔗 Read it here: physoc.onlinelibrary.wiley.com/doi/10.1113/...
November 17, 2025 at 3:55 PM
Excellent work @victorcalbiagueg.bsky.social !!!
Reposted by ISER
Our new preprint is out.
Our study on Retinitis Pigmentosa animal model shows improved photoreceptor survival when rod transducin, a key protein involved in light signaling, is reduced.
@fvinberg.bsky.social
@moraneyecenter.bsky.social
@utah.edu
www.biorxiv.org/content/10.1...
Our study on Retinitis Pigmentosa animal model shows improved photoreceptor survival when rod transducin, a key protein involved in light signaling, is reduced.
@fvinberg.bsky.social
@moraneyecenter.bsky.social
@utah.edu
www.biorxiv.org/content/10.1...
Downregulation of Transducin Delays Photoreceptor Degeneration in P23H Rhodopsin Retinitis Pigmentosa
In inherited blinding diseases, such as Retinitis Pigmentosa (RP), photoreceptors progressively degenerate, eventually leading to blindness. Unfortunately, effective treatments to prevent or delay vis...
www.biorxiv.org
October 7, 2025 at 2:18 AM
Our new preprint is out.
Our study on Retinitis Pigmentosa animal model shows improved photoreceptor survival when rod transducin, a key protein involved in light signaling, is reduced.
@fvinberg.bsky.social
@moraneyecenter.bsky.social
@utah.edu
www.biorxiv.org/content/10.1...
Our study on Retinitis Pigmentosa animal model shows improved photoreceptor survival when rod transducin, a key protein involved in light signaling, is reduced.
@fvinberg.bsky.social
@moraneyecenter.bsky.social
@utah.edu
www.biorxiv.org/content/10.1...
Reposted by ISER
In the retina, amacrine cells boost contrast by silencing nearby signals, helping your brain detect edges and details. Retinal ganglion cells then send that refined picture to your brain through the optic nerve.
Data from @neuralmapping.bsky.social 👀🧠
Data from @neuralmapping.bsky.social 👀🧠
October 8, 2025 at 1:14 PM
In the retina, amacrine cells boost contrast by silencing nearby signals, helping your brain detect edges and details. Retinal ganglion cells then send that refined picture to your brain through the optic nerve.
Data from @neuralmapping.bsky.social 👀🧠
Data from @neuralmapping.bsky.social 👀🧠
Reposted by ISER
🚨 New preprint out from our lab!
📄 The Rod Bipolar Cell Pathway Contributes to Surround Responses in OFF Retinal Ganglion Cells
👉 www.biorxiv.org/content/10.1...
📄 The Rod Bipolar Cell Pathway Contributes to Surround Responses in OFF Retinal Ganglion Cells
👉 www.biorxiv.org/content/10.1...
The Rod Bipolar Cell Pathway Contributes To Surround Responses In OFF Retinal Ganglion Cells
Sensory neurons can be influenced by stimuli beyond their receptive field center, yet the mechanisms underlying this surround modulation remain poorly understood. In the retina, many OFF ganglion cell...
www.biorxiv.org
October 7, 2025 at 12:19 PM
🚨 New preprint out from our lab!
📄 The Rod Bipolar Cell Pathway Contributes to Surround Responses in OFF Retinal Ganglion Cells
👉 www.biorxiv.org/content/10.1...
📄 The Rod Bipolar Cell Pathway Contributes to Surround Responses in OFF Retinal Ganglion Cells
👉 www.biorxiv.org/content/10.1...
Reposted by ISER
A new article on our National Eye Institute (NEI) - funded project on the mechanisms underlying color vision!
@umassboston.bsky.social
🪰👀🧪
www.umb.edu/news/recent-...
@umassboston.bsky.social
🪰👀🧪
www.umb.edu/news/recent-...
In Fruit Fly Eyes, UMass Boston Researcher Sees Potential Medical Discoveries
Jens Rister, an associate professor in UMass Boston’s biology department, has just been awarded more than $1,700,000 in funding from the National Eye Institute of the NIH to research a protein that gu...
www.umb.edu
October 21, 2025 at 3:54 PM
A new article on our National Eye Institute (NEI) - funded project on the mechanisms underlying color vision!
@umassboston.bsky.social
🪰👀🧪
www.umb.edu/news/recent-...
@umassboston.bsky.social
🪰👀🧪
www.umb.edu/news/recent-...
Reposted by ISER
4 sets of vision researcher feet
@john-ash8831.bsky.social
@fvinberg.bsky.social
Jeffrey Goldberg
And @bwjones.bsky.social
@john-ash8831.bsky.social
@fvinberg.bsky.social
Jeffrey Goldberg
And @bwjones.bsky.social
October 28, 2025 at 1:31 AM
4 sets of vision researcher feet
@john-ash8831.bsky.social
@fvinberg.bsky.social
Jeffrey Goldberg
And @bwjones.bsky.social
@john-ash8831.bsky.social
@fvinberg.bsky.social
Jeffrey Goldberg
And @bwjones.bsky.social
Reposted by ISER
First neurons didn’t appear overnight. We trace their roots to ancient secretory cells - showing how lifestyle & behavior shaped the evolution of first synapses.🧠🌊 #Evolution #Neuroscience
Our latest in @natrevneuro.nature.com
Link: rdcu.be/eMX3E
@jeffcolgren.bsky.social @msarscentre.bsky.social
Our latest in @natrevneuro.nature.com
Link: rdcu.be/eMX3E
@jeffcolgren.bsky.social @msarscentre.bsky.social
The evolutionary origins of synaptic proteins and their changing roles in different organisms across evolution
Nature Reviews Neuroscience - Recent studies have shed further light on the evolutionary origins of chemical synapses, In this Review, Colgren and Burkhardt explore how ancient proteins were...
rdcu.be
October 27, 2025 at 6:48 PM
First neurons didn’t appear overnight. We trace their roots to ancient secretory cells - showing how lifestyle & behavior shaped the evolution of first synapses.🧠🌊 #Evolution #Neuroscience
Our latest in @natrevneuro.nature.com
Link: rdcu.be/eMX3E
@jeffcolgren.bsky.social @msarscentre.bsky.social
Our latest in @natrevneuro.nature.com
Link: rdcu.be/eMX3E
@jeffcolgren.bsky.social @msarscentre.bsky.social
Reposted by ISER
October 27, 2025 at 6:37 PM
Reposted by ISER
👁️ UPMC Vision Institute is restoring sight! The PRIMA wireless retinal implant + camera glasses helped patients with advanced macular degeneration regain functional vision. Over 80% saw measurable improvement. #VisionRestoration #Neuroprosthetics #UPMC #Pitt www.nejm.org/doi/full/10....
Subretinal Photovoltaic Implant to Restore Vision in Geographic Atrophy Due to AMD | NEJM
Geographic atrophy due to age-related macular degeneration (AMD) is the leading cause
of irreversible blindness and affects more than 5 million persons worldwide. No therapies
to restore vision in ...
www.nejm.org
October 27, 2025 at 4:18 PM
👁️ UPMC Vision Institute is restoring sight! The PRIMA wireless retinal implant + camera glasses helped patients with advanced macular degeneration regain functional vision. Over 80% saw measurable improvement. #VisionRestoration #Neuroprosthetics #UPMC #Pitt www.nejm.org/doi/full/10....
Reposted by ISER
Thanks Bryan! Nice pic of me. I don't even remember you taking it. Eagerly awaiting the Visionarium pics 😊
October 27, 2025 at 4:33 AM
Thanks Bryan! Nice pic of me. I don't even remember you taking it. Eagerly awaiting the Visionarium pics 😊
Reposted by ISER
Finally got around to posting the snapshots of walking around in Prague after the RD 2025 Meeting: bryanwjones.com/2025/09/walk...
October 27, 2025 at 1:49 AM
Finally got around to posting the snapshots of walking around in Prague after the RD 2025 Meeting: bryanwjones.com/2025/09/walk...
Reposted by ISER
October 27, 2025 at 12:33 AM
Reposted by ISER
Maison Deyrolle Avrill, 1953 by Robert Doisneau
October 26, 2025 at 12:44 PM
Maison Deyrolle Avrill, 1953 by Robert Doisneau
Reposted by ISER
#Visual #salience generation involves center-surround dynamics, but what performs these computations? This study shows that the #SuperiorColliculus encodes center-surround dynamics under isolated conditions, and provides insights into the circuit implementation @plosbiology.org 🧪 plos.io/4n7RpsA
October 20, 2025 at 11:28 AM
#Visual #salience generation involves center-surround dynamics, but what performs these computations? This study shows that the #SuperiorColliculus encodes center-surround dynamics under isolated conditions, and provides insights into the circuit implementation @plosbiology.org 🧪 plos.io/4n7RpsA
Reposted by ISER
#FluorescenceFriday 🌿🔬 post:
Avian retina transduced with my AAVs carrying the #GluSNFR biosensor.
Bright blobs at the top mark photoreceptor terminals; meanwhile below, an RGC connects beautifully with bipolar cells, giving a glimpse of retinal circuitry in action.
#Retina #Neuroscience #AAV #2-P
Avian retina transduced with my AAVs carrying the #GluSNFR biosensor.
Bright blobs at the top mark photoreceptor terminals; meanwhile below, an RGC connects beautifully with bipolar cells, giving a glimpse of retinal circuitry in action.
#Retina #Neuroscience #AAV #2-P
October 24, 2025 at 7:10 PM
#FluorescenceFriday 🌿🔬 post:
Avian retina transduced with my AAVs carrying the #GluSNFR biosensor.
Bright blobs at the top mark photoreceptor terminals; meanwhile below, an RGC connects beautifully with bipolar cells, giving a glimpse of retinal circuitry in action.
#Retina #Neuroscience #AAV #2-P
Avian retina transduced with my AAVs carrying the #GluSNFR biosensor.
Bright blobs at the top mark photoreceptor terminals; meanwhile below, an RGC connects beautifully with bipolar cells, giving a glimpse of retinal circuitry in action.
#Retina #Neuroscience #AAV #2-P
Reposted by ISER
Team BrightFocus Foundation is on the ground in Atlanta for our #GlaucomaFastTrack program, the official pre-symposium workshop to the ISER/BrightFocus Glaucoma Symposium.
Glaucoma Fast Track brings together top researchers from across the globe to accelerate vision research. 💪 🔬
Glaucoma Fast Track brings together top researchers from across the globe to accelerate vision research. 💪 🔬
October 8, 2025 at 5:37 PM
Team BrightFocus Foundation is on the ground in Atlanta for our #GlaucomaFastTrack program, the official pre-symposium workshop to the ISER/BrightFocus Glaucoma Symposium.
Glaucoma Fast Track brings together top researchers from across the globe to accelerate vision research. 💪 🔬
Glaucoma Fast Track brings together top researchers from across the globe to accelerate vision research. 💪 🔬
Reposted by ISER
YEEEEEAAAAAAAHHHH, Teresa!!!
Teresa Puthussery, a UC Berkeley vision scientist whose insights into the retina could one day help those with vision loss regain their sight, has been named a 2025 MacArthur “genius” Fellow. news.berkeley.edu/2025/10/08/v...
Vision scientist Teresa Puthussery receives MacArthur ‘genius’ award - Berkeley News
Puthussery’s discoveries about the retina are paving the way for new treatments for eye disease and vision loss
news.berkeley.edu
October 8, 2025 at 11:26 PM
YEEEEEAAAAAAAHHHH, Teresa!!!
Reposted by ISER
I'm so excited to be hiring my first postdoc! If you love retinal biology and developing new therapeutics to cure blindness, please apply! Thank you to the @brightfocus.bsky.social for supporting my research and enabling me to grow my research team! external-careers.jobs.unsw.edu.au/cw/en/job/53...
September 30, 2025 at 8:36 AM
I'm so excited to be hiring my first postdoc! If you love retinal biology and developing new therapeutics to cure blindness, please apply! Thank you to the @brightfocus.bsky.social for supporting my research and enabling me to grow my research team! external-careers.jobs.unsw.edu.au/cw/en/job/53...
Reposted by ISER
Our work is finally out! Learning from mechanism of #aging to presenting potential therapeutic strategy to slow down #age-related #vision loss! Very proud of my team including several undergrads and thankful for fantastic collaborations across the world! www.science.org/doi/10.1126/...
Retinal polyunsaturated fatty acid supplementation reverses aging-related vision decline in mice
Intravitreal delivery of an ELOVL2 product reduces age-related molecular changes in the retina and restores visual function.
www.science.org
September 24, 2025 at 7:31 PM
Our work is finally out! Learning from mechanism of #aging to presenting potential therapeutic strategy to slow down #age-related #vision loss! Very proud of my team including several undergrads and thankful for fantastic collaborations across the world! www.science.org/doi/10.1126/...
Reposted by ISER
Congratulations to the winners of our image competition with the @mblscience.bsky.social Embryology course. The winner of the Editor’s choice is an image of a anole lizard eye, acquired by Arthur Boutillon @campaslab.bsky.social.
thenode.biologists.com/results-from...
#devbio 🔬🎉
thenode.biologists.com/results-from...
#devbio 🔬🎉
September 11, 2025 at 2:16 PM
Congratulations to the winners of our image competition with the @mblscience.bsky.social Embryology course. The winner of the Editor’s choice is an image of a anole lizard eye, acquired by Arthur Boutillon @campaslab.bsky.social.
thenode.biologists.com/results-from...
#devbio 🔬🎉
thenode.biologists.com/results-from...
#devbio 🔬🎉
Reposted by ISER
A nice shift in perceived colour between central and peripheral vision. The fixated disc looks purple while the others look blue.
The effect presumably comes from the absence of S-cones in the fovea.
From Hinnerk Schulz-Hildebrandt:
arxiv.org/pdf/2509.115...
The effect presumably comes from the absence of S-cones in the fovea.
From Hinnerk Schulz-Hildebrandt:
arxiv.org/pdf/2509.115...
September 24, 2025 at 12:04 PM
A nice shift in perceived colour between central and peripheral vision. The fixated disc looks purple while the others look blue.
The effect presumably comes from the absence of S-cones in the fovea.
From Hinnerk Schulz-Hildebrandt:
arxiv.org/pdf/2509.115...
The effect presumably comes from the absence of S-cones in the fovea.
From Hinnerk Schulz-Hildebrandt:
arxiv.org/pdf/2509.115...
Reposted by ISER
September 22, 2025 at 1:59 PM