Dr Dorota SK
@drdorotask.bsky.social
Aging Eye laboratory. https://faculty.sites.uci.edu/skowronska-krawczyk/
Reposted by Dr Dorota SK
... And if you want to know more, here's the featured Article: Methylarginine targeting chimeras for lysosomal degradation of intracellular proteins ($) doi.org/10.1038/s415...
Methylarginine targeting chimeras for lysosomal degradation of intracellular proteins - Nature Chemical Biology
Development of a targeted protein degradation platform, methylarginine targeting chimera (MrTAC), enables arginine methylation-driven degradation of intracellular proteins in lysosomes.
doi.org
December 19, 2024 at 11:27 AM
... And if you want to know more, here's the featured Article: Methylarginine targeting chimeras for lysosomal degradation of intracellular proteins ($) doi.org/10.1038/s415...
This is so low. www.nytimes.com/2025/10/28/o...
Opinion | She Was Elected to Congress. She Can’t Get Into Her Office After Hours.
www.nytimes.com
October 29, 2025 at 7:20 AM
This is so low. www.nytimes.com/2025/10/28/o...
Up for a treat! @stimulatedraman.bsky.social presenting.
October 7, 2025 at 5:25 PM
Up for a treat! @stimulatedraman.bsky.social presenting.
💲💲💲 This research would not have been possible without the support of several funding agencies, including #NIH National Eye Institute, @brightfocus.bsky.social, Thome Foundation, #RPB, the #NSF, and the Simons Foundation. Our collaborators also received support from #FNP and #NCN. Thank you!!! 💲💲💲
Our work is finally out! Learning from mechanism of #aging to presenting potential therapeutic strategy to slow down #age-related #vision loss! Very proud of my team including several undergrads and thankful for fantastic collaborations across the world! www.science.org/doi/10.1126/...
Retinal polyunsaturated fatty acid supplementation reverses aging-related vision decline in mice
Intravitreal delivery of an ELOVL2 product reduces age-related molecular changes in the retina and restores visual function.
www.science.org
September 25, 2025 at 12:50 AM
Our work is finally out! Learning from mechanism of #aging to presenting potential therapeutic strategy to slow down #age-related #vision loss! Very proud of my team including several undergrads and thankful for fantastic collaborations across the world! www.science.org/doi/10.1126/...
Retinal polyunsaturated fatty acid supplementation reverses aging-related vision decline in mice
Intravitreal delivery of an ELOVL2 product reduces age-related molecular changes in the retina and restores visual function.
www.science.org
September 24, 2025 at 7:31 PM
Our work is finally out! Learning from mechanism of #aging to presenting potential therapeutic strategy to slow down #age-related #vision loss! Very proud of my team including several undergrads and thankful for fantastic collaborations across the world! www.science.org/doi/10.1126/...
Reposted by Dr Dorota SK
New York Times story with profiles of researchers whose grants were terminated.
[Gift Link]
www.nytimes.com/2025/08/24/o...
[Gift Link]
www.nytimes.com/2025/08/24/o...
Opinion | America First? Not When It Comes to Your Health.
www.nytimes.com
August 24, 2025 at 1:08 PM
New York Times story with profiles of researchers whose grants were terminated.
[Gift Link]
www.nytimes.com/2025/08/24/o...
[Gift Link]
www.nytimes.com/2025/08/24/o...
Reposted by Dr Dorota SK
Thank you @ash.hematology.org for supporting our research spearheaded by @silviavicenzi.bsky.social in the lab! Excited to have the opportunity to jump-start the next stage of our exploration into #bloodstemcell #aging with our collab & #lipidomics expert @drdorotask.bsky.social! #Fight4Hematology
This year the ASH Bridge Grant is funding 25 scientists with $3.75M, 5X more than last year, to keep hematology research moving forward. Congratulations to the recipients! https://bit.ly/3HJ51Ma
#HemeSky #MedSKy #ASHAwards
#HemeSky #MedSKy #ASHAwards
August 22, 2025 at 9:35 PM
Thank you @ash.hematology.org for supporting our research spearheaded by @silviavicenzi.bsky.social in the lab! Excited to have the opportunity to jump-start the next stage of our exploration into #bloodstemcell #aging with our collab & #lipidomics expert @drdorotask.bsky.social! #Fight4Hematology
Reposted by Dr Dorota SK
I’ll take every bit of good news I can get. “Senators from both parties endorsed a $400 million increase to the budget of the National Institutes of Health… in an Appropriations Committee vote that represents a clear rebuke of President Trump’s plan to dramatically reduce the agency’s spending.”
Senate committee endorses NIH budget increase, rebuking Trump administration’s proposed 40% cut
Senators from both parties endorsed a $400 million increase to the budget of the National Institutes of Health on Thursday
www.statnews.com
July 31, 2025 at 9:56 PM
I’ll take every bit of good news I can get. “Senators from both parties endorsed a $400 million increase to the budget of the National Institutes of Health… in an Appropriations Committee vote that represents a clear rebuke of President Trump’s plan to dramatically reduce the agency’s spending.”
Fantastic work of @evgenykvon.bsky.social team. @gracebower.bsky.social did an amazing job. It was a pleasure to assist them even as little as we did. Hope for more collaborations in the future!!! Congratulations!!!!!
Our paper describing the Range Extender element which is required and sufficient for long-range enhancer activation at the Shh locus is now available at @nature.com. Congrats to @gracebower.bsky.social who led the study. Below is a brief summary of the main findings www.nature.com/articles/s41... 1/
Range extender mediates long-distance enhancer activity - Nature
The REX element is associated with long-range enhancer–promoter interactions.
www.nature.com
July 3, 2025 at 1:33 PM
Fantastic work of @evgenykvon.bsky.social team. @gracebower.bsky.social did an amazing job. It was a pleasure to assist them even as little as we did. Hope for more collaborations in the future!!! Congratulations!!!!!
Reposted by Dr Dorota SK
Even though cataract surgery is generally safe and effective, cataract is still a leading cause of blindness worldwide. We need to understand the optical and materials properties of the eye lens to make better replacement lenses. This budget would eliminate that, including my lab's work.
The White House proposed budget for 2026 does not include the National Eye Institute…
The institute that has funded almost the entirety of my career.
The proposal is to merge it in with neuroscience, despite a whole half of the eye (the front part) which has little to do with neuroscience per se.
The institute that has funded almost the entirety of my career.
The proposal is to merge it in with neuroscience, despite a whole half of the eye (the front part) which has little to do with neuroscience per se.
June 1, 2025 at 6:10 PM
Even though cataract surgery is generally safe and effective, cataract is still a leading cause of blindness worldwide. We need to understand the optical and materials properties of the eye lens to make better replacement lenses. This budget would eliminate that, including my lab's work.
Reposted by Dr Dorota SK
Senator Durbin noted that some (I believe Republican Senators) had indicated the US had been doing more than its share of biomedical research and it was time for other countries take a turn.
I felt I had to interrupt to respond...
I felt I had to interrupt to respond...
May 23, 2025 at 8:53 PM
Senator Durbin noted that some (I believe Republican Senators) had indicated the US had been doing more than its share of biomedical research and it was time for other countries take a turn.
I felt I had to interrupt to respond...
I felt I had to interrupt to respond...
Reposted by Dr Dorota SK
David Liu @harvard.edu beautifully articulates the criticality of basic science funding for developing revolutionary therapeutics like life-saving base editors 👏
youtu.be/8YhJM6zxYDw?...
youtu.be/8YhJM6zxYDw?...
Breakthrough Prize-Winning Biochemist on the Deadly Cost of Funding Cuts | Amanpour and Company
YouTube video by Amanpour and Company
youtu.be
May 24, 2025 at 1:13 AM
David Liu @harvard.edu beautifully articulates the criticality of basic science funding for developing revolutionary therapeutics like life-saving base editors 👏
youtu.be/8YhJM6zxYDw?...
youtu.be/8YhJM6zxYDw?...
Reposted by Dr Dorota SK
📣 TRAVEL GRANTS AVAILABLE for trainees and young investigators! Deadline: May 26
Don’t miss the opportunity to attend the ISER/BrightFocus Glaucoma Symposium & Fast Track with the support of a travel grant! @iser.bsky.social @brightfocus.bsky.social
👉 iserbrightfocusglaucoma.org/abstract-sub...
Don’t miss the opportunity to attend the ISER/BrightFocus Glaucoma Symposium & Fast Track with the support of a travel grant! @iser.bsky.social @brightfocus.bsky.social
👉 iserbrightfocusglaucoma.org/abstract-sub...
Abstract Submission – Iser/Bright Focus Glaucoma Symposium
iserbrightfocusglaucoma.org
May 23, 2025 at 1:57 AM
📣 TRAVEL GRANTS AVAILABLE for trainees and young investigators! Deadline: May 26
Don’t miss the opportunity to attend the ISER/BrightFocus Glaucoma Symposium & Fast Track with the support of a travel grant! @iser.bsky.social @brightfocus.bsky.social
👉 iserbrightfocusglaucoma.org/abstract-sub...
Don’t miss the opportunity to attend the ISER/BrightFocus Glaucoma Symposium & Fast Track with the support of a travel grant! @iser.bsky.social @brightfocus.bsky.social
👉 iserbrightfocusglaucoma.org/abstract-sub...
Reposted by Dr Dorota SK
The 80-year recipe stoking America’s Prosperity:
1) Free-market capital investments in brilliant ideas…
2) enabled by Engineering Innovations…
3) based on Science Research in Universities…
4) funded by Grants from the US Government.
It’s time more people understood this.
1) Free-market capital investments in brilliant ideas…
2) enabled by Engineering Innovations…
3) based on Science Research in Universities…
4) funded by Grants from the US Government.
It’s time more people understood this.
May 17, 2025 at 1:36 PM
The 80-year recipe stoking America’s Prosperity:
1) Free-market capital investments in brilliant ideas…
2) enabled by Engineering Innovations…
3) based on Science Research in Universities…
4) funded by Grants from the US Government.
It’s time more people understood this.
1) Free-market capital investments in brilliant ideas…
2) enabled by Engineering Innovations…
3) based on Science Research in Universities…
4) funded by Grants from the US Government.
It’s time more people understood this.
Reposted by Dr Dorota SK
In #myfirstpost here, I'm excited to share the news that the Crews Lab's latest research on #immunesystem #aging is now published in @geroscience.bsky.social! This work is the culmination of a wonderful collaboration with @drdorotask.bsky.social Lab with major efforts by @silviavicenzi.bsky.social!
📣 I'm thrilled to share that my first-author paper, published in my current position as a CIRM Postdoctoral Fellow in the Crews Lab at UC San Diego, is now officially available! 💪🔬 1/n
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Systemic deficits in lipid homeostasis promote aging-associated impairments in B cell progenitor development - GeroScience
Organismal aging has been associated with diverse metabolic and functional changes across tissues. Within the immune system, key features of physiological hematopoietic cell aging include increased fa...
link.springer.com
April 18, 2025 at 9:38 PM
In #myfirstpost here, I'm excited to share the news that the Crews Lab's latest research on #immunesystem #aging is now published in @geroscience.bsky.social! This work is the culmination of a wonderful collaboration with @drdorotask.bsky.social Lab with major efforts by @silviavicenzi.bsky.social!
It was a great collaboration with @crewslab.bsky.social ! Complementary expertise, curiosity and unique mouse model. Congrats @silviavicenzi.bsky.social and looking forward to working together to decipher the mechanism! #aging #Bcells #PUFA #ELOVL2 @ucirvine.bsky.social
📣 I'm thrilled to share that my first-author paper, published in my current position as a CIRM Postdoctoral Fellow in the Crews Lab at UC San Diego, is now officially available! 💪🔬 1/n
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Systemic deficits in lipid homeostasis promote aging-associated impairments in B cell progenitor development - GeroScience
Organismal aging has been associated with diverse metabolic and functional changes across tissues. Within the immune system, key features of physiological hematopoietic cell aging include increased fa...
link.springer.com
April 17, 2025 at 11:38 PM
It was a great collaboration with @crewslab.bsky.social ! Complementary expertise, curiosity and unique mouse model. Congrats @silviavicenzi.bsky.social and looking forward to working together to decipher the mechanism! #aging #Bcells #PUFA #ELOVL2 @ucirvine.bsky.social
Third time’s overrated — fourth time’s where the magic happens! I just got awarded a BrightFocus Foundation National Glaucoma Research grant! Thank you @brightfocus.bsky.social for your support!!! #agingeye #glaucoma #epigeneticmemory
April 13, 2025 at 12:19 AM
Third time’s overrated — fourth time’s where the magic happens! I just got awarded a BrightFocus Foundation National Glaucoma Research grant! Thank you @brightfocus.bsky.social for your support!!! #agingeye #glaucoma #epigeneticmemory
Reposted by Dr Dorota SK
We're disappointed to see Ben Barres's powerful book "The Autobiography of a Transgender Scientist" among the ~400 titles removed from the Naval Academy Library. Needless to say, we're proud to have published his book and will keep it — and his memory — alive.
The Coming Out of a Transgender Scientist
"I know that I am making the right decision because whenever I think about changing my gender role, I am flooded with feelings of relief."
thereader.mitpress.mit.edu
April 8, 2025 at 8:24 PM
We're disappointed to see Ben Barres's powerful book "The Autobiography of a Transgender Scientist" among the ~400 titles removed from the Naval Academy Library. Needless to say, we're proud to have published his book and will keep it — and his memory — alive.
Reposted by Dr Dorota SK
14 pages of terminated NIH grants--everyone should read through the list. The sweep is VERY broad, including "The Impact of the Herpes Zoster Vaccine on Herpes Zoster Ophthalmicus" & "Mitochondrial-based Determinants of Sex Differences in Acute Kidney Injury"🧪 1/n
taggs.hhs.gov/Content/Data...
taggs.hhs.gov/Content/Data...
taggs.hhs.gov
March 26, 2025 at 3:38 PM
14 pages of terminated NIH grants--everyone should read through the list. The sweep is VERY broad, including "The Impact of the Herpes Zoster Vaccine on Herpes Zoster Ophthalmicus" & "Mitochondrial-based Determinants of Sex Differences in Acute Kidney Injury"🧪 1/n
taggs.hhs.gov/Content/Data...
taggs.hhs.gov/Content/Data...
I had an amazing visit at #WilmerEyeInstitute! Great discussions and fantastic host, blueskyless Malia Edwards. See you all soon at @arvoinfo.bsky.social !!!
March 18, 2025 at 11:28 AM
I had an amazing visit at #WilmerEyeInstitute! Great discussions and fantastic host, blueskyless Malia Edwards. See you all soon at @arvoinfo.bsky.social !!!
On my way to Baltimore!Doing research and meeting colleagues!! #Standingwithscience
March 15, 2025 at 11:30 PM
On my way to Baltimore!Doing research and meeting colleagues!! #Standingwithscience
Is age-related macular degeneration (AMD) a type of retinal aging or a disease? Is there a difference between aging and early AMD? You can read about what we think about it here: www.sciencedirect.com/science/article/abs/pii/S0014483525000740 #AMD #aging #AgingEye
Features that distinguish age-related macular degeneration from aging
Age-related macular degeneration (AMD) is a complex, multifactorial retinal degenerative disease that is influenced by both genetic and environmental …
www.sciencedirect.com
March 10, 2025 at 1:00 AM
Is age-related macular degeneration (AMD) a type of retinal aging or a disease? Is there a difference between aging and early AMD? You can read about what we think about it here: www.sciencedirect.com/science/article/abs/pii/S0014483525000740 #AMD #aging #AgingEye
Reposted by Dr Dorota SK
