Jonathan Keats, PhD 🇨🇦
@pedalheadphx.bsky.social
🇨🇦 boiling in the Arizona desert and not riding my bikes enough. Cancer researcher focused on multiple myeloma and clinical genomics at TGen, part of City of Hope. Creator of MyelomaSky and Sequencing Tech feeds. Director, Collaborative Sequencing Center
Pinned
go.bsky.app/BtBs6xj Still slowly building a myeloma research oriented starter pack, let me know if you are missing.
Wow, two myeloma talks as late breaking abstracts at #ASH2025, one on in vivo CAR-T and another on teclistamab+daratumumab versus DPd or DVd
November 24, 2025 at 6:58 PM
Wow, two myeloma talks as late breaking abstracts at #ASH2025, one on in vivo CAR-T and another on teclistamab+daratumumab versus DPd or DVd
I missed it but as of November 12 the @thermofishersci.bsky.social and Binding Site Maldi-TOF assay got FDA 510(k) clearance. Big milestone in moving the myeloma field forward. Many thanks to the Mayo Clinic team for putting in years of hard work to bring this transformative approach forward
November 21, 2025 at 4:04 AM
I missed it but as of November 12 the @thermofishersci.bsky.social and Binding Site Maldi-TOF assay got FDA 510(k) clearance. Big milestone in moving the myeloma field forward. Many thanks to the Mayo Clinic team for putting in years of hard work to bring this transformative approach forward
Vaccines work wonders, need thing like this more than ever with the stupidity on the CDC website
November 20, 2025 at 3:35 AM
Vaccines work wonders, need thing like this more than ever with the stupidity on the CDC website
Reposted by Jonathan Keats, PhD 🇨🇦
VACCINES DO NOT CAUSE AUTISM, YOU FLAMING SHITBIRDS.
WE HAVE, IN FACT, NOT IGNORED YOUR NOW-DEFUNCT HYPOTHESIS. WE INVESTIGATED IT TO THE TUNE OF STUDIES WITH DATA FROM MILLIONS OF KIDS.
WE HAVE, IN FACT, NOT IGNORED YOUR NOW-DEFUNCT HYPOTHESIS. WE INVESTIGATED IT TO THE TUNE OF STUDIES WITH DATA FROM MILLIONS OF KIDS.
November 20, 2025 at 3:08 AM
VACCINES DO NOT CAUSE AUTISM, YOU FLAMING SHITBIRDS.
WE HAVE, IN FACT, NOT IGNORED YOUR NOW-DEFUNCT HYPOTHESIS. WE INVESTIGATED IT TO THE TUNE OF STUDIES WITH DATA FROM MILLIONS OF KIDS.
WE HAVE, IN FACT, NOT IGNORED YOUR NOW-DEFUNCT HYPOTHESIS. WE INVESTIGATED IT TO THE TUNE OF STUDIES WITH DATA FROM MILLIONS OF KIDS.
Reposted by Jonathan Keats, PhD 🇨🇦
First time on Bsky and first big announcement!
I am excited to announce that our new study explaining the missing heritability of many phenotypes using WGS data from ~347,000 UK Biobank participants has just been published in @Nature.
Our manuscript is here: www.nature.com/articles/s41....
I am excited to announce that our new study explaining the missing heritability of many phenotypes using WGS data from ~347,000 UK Biobank participants has just been published in @Nature.
Our manuscript is here: www.nature.com/articles/s41....
Estimation and mapping of the missing heritability of human phenotypes - Nature
WGS data were used from 347,630 individuals with European ancestry in the UK Biobank to obtain high-precision estimates of coding and non-coding rare variant heritability for 34 co...
www.nature.com
November 12, 2025 at 5:57 PM
First time on Bsky and first big announcement!
I am excited to announce that our new study explaining the missing heritability of many phenotypes using WGS data from ~347,000 UK Biobank participants has just been published in @Nature.
Our manuscript is here: www.nature.com/articles/s41....
I am excited to announce that our new study explaining the missing heritability of many phenotypes using WGS data from ~347,000 UK Biobank participants has just been published in @Nature.
Our manuscript is here: www.nature.com/articles/s41....
Reposted by Jonathan Keats, PhD 🇨🇦
@epicypher.bsky.social's is new Fiber-seq Kit works with PacBio long-read sequencing to reveal chromatin accessibility, DNA methylation, and protein footprints on single molecules, expanding access to powerful multiomic analysis.
Learn more: bit.ly/4qSMa3d
Learn more: bit.ly/4qSMa3d
Fiber-seq is your complete solution for profiling chromatin accessibility, DNA methylation, and protein footprints in ONE multiomic experiment. This kit contains everything you need to get this assay up and running in your lab.
🔗 Try CUTANA™ Fiber-seq: https://www.epicypher.com/products/fiber-seq/
🔗 Try CUTANA™ Fiber-seq: https://www.epicypher.com/products/fiber-seq/
November 12, 2025 at 1:22 AM
@epicypher.bsky.social's is new Fiber-seq Kit works with PacBio long-read sequencing to reveal chromatin accessibility, DNA methylation, and protein footprints on single molecules, expanding access to powerful multiomic analysis.
Learn more: bit.ly/4qSMa3d
Learn more: bit.ly/4qSMa3d
Very important work from a great Canadian team. Building an important part of how we will monitor myeloma patients in the future and maybe define a cure
Cell-free DNA Whole Genome Sequencing for Non-Invasive Minimal Residual Disease Detection in Multiple Myeloma https://www.medrxiv.org/content/10.1101/2025.10.24.25338566v1
October 28, 2025 at 3:57 AM
Very important work from a great Canadian team. Building an important part of how we will monitor myeloma patients in the future and maybe define a cure
Reposted by Jonathan Keats, PhD 🇨🇦
Common diseases can be misdiagnosed as actually being due to rare, disease-causing genome variants. DNA and RNA sequencing can make the true diagnosis, which affects response to therapy @nejm.org
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
October 22, 2025 at 9:17 PM
Common diseases can be misdiagnosed as actually being due to rare, disease-causing genome variants. DNA and RNA sequencing can make the true diagnosis, which affects response to therapy @nejm.org
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
Reposted by Jonathan Keats, PhD 🇨🇦
Transcriptional interferences ensure one olfactory receptor per ant neuron
www.nature.com/articles/s41...
Caviar for RNA-Seq nerds! Check this out
www.nature.com/articles/s41...
Caviar for RNA-Seq nerds! Check this out
October 22, 2025 at 8:40 PM
Transcriptional interferences ensure one olfactory receptor per ant neuron
www.nature.com/articles/s41...
Caviar for RNA-Seq nerds! Check this out
www.nature.com/articles/s41...
Caviar for RNA-Seq nerds! Check this out
@cityofhope.bsky.social multiple myeloma leader Dr. Amrita Krishnan is now the SWOG multiple myeloma chair.
October 21, 2025 at 4:14 PM
@cityofhope.bsky.social multiple myeloma leader Dr. Amrita Krishnan is now the SWOG multiple myeloma chair.
Way to go Blue Jays
October 21, 2025 at 3:15 AM
Way to go Blue Jays
Reposted by Jonathan Keats, PhD 🇨🇦
Vaccines are safe and effective.
Autism isn't caused by vaccines, and autistic people and their families deserve our support.
When you want information, ask your doctor.
It's more important than ever for all of us to speak plainly, truthfully, and directly about public health.
Autism isn't caused by vaccines, and autistic people and their families deserve our support.
When you want information, ask your doctor.
It's more important than ever for all of us to speak plainly, truthfully, and directly about public health.
October 14, 2025 at 1:33 AM
Vaccines are safe and effective.
Autism isn't caused by vaccines, and autistic people and their families deserve our support.
When you want information, ask your doctor.
It's more important than ever for all of us to speak plainly, truthfully, and directly about public health.
Autism isn't caused by vaccines, and autistic people and their families deserve our support.
When you want information, ask your doctor.
It's more important than ever for all of us to speak plainly, truthfully, and directly about public health.
@sci-bri.bsky.social moving from 2 weeks of sunshine to a year of it, great line
October 14, 2025 at 12:16 AM
@sci-bri.bsky.social moving from 2 weeks of sunshine to a year of it, great line
Reposted by Jonathan Keats, PhD 🇨🇦
Bridging therapy with #talquetamab enabled patients with high-risk #myeloma #MMsm to successfully transition to #BCMA #CARTcell therapy, with 88% experiencing rapid disease control and proceeding to treatment with ide-cel or cilta-cel: ow.ly/7JkM50X8KYa
#HemeSky #MyelomaSky #MultipleMyeloma
#HemeSky #MyelomaSky #MultipleMyeloma
Talquetamab Bridging Therapy Enables Transition to BCMA CAR-T for Patients With High-Risk Myeloma | ASH Clinical News | American Society of Hematology
ow.ly
October 9, 2025 at 5:34 PM
Bridging therapy with #talquetamab enabled patients with high-risk #myeloma #MMsm to successfully transition to #BCMA #CARTcell therapy, with 88% experiencing rapid disease control and proceeding to treatment with ide-cel or cilta-cel: ow.ly/7JkM50X8KYa
#HemeSky #MyelomaSky #MultipleMyeloma
#HemeSky #MyelomaSky #MultipleMyeloma
Reposted by Jonathan Keats, PhD 🇨🇦
What an amazing assay.
DAF-seq, the evolution of Fiber-seq from the Andrew Stergachis group, using the @pacbio.bsky.social platform:
www.biorxiv.org/content/10.1...
This will revolutionise our understanding of transcriptional regulation and functional non-coding variants.
DAF-seq, the evolution of Fiber-seq from the Andrew Stergachis group, using the @pacbio.bsky.social platform:
www.biorxiv.org/content/10.1...
This will revolutionise our understanding of transcriptional regulation and functional non-coding variants.
Deaminase-assisted single-molecule and single-cell chromatin fiber sequencing
Gene regulation is mediated by the co-occupancy of numerous proteins along individual chromatin fibers. However, our tools for deeply profiling how proteins co-occupy individual fibers, especially at ...
www.biorxiv.org
October 4, 2025 at 12:06 PM
What an amazing assay.
DAF-seq, the evolution of Fiber-seq from the Andrew Stergachis group, using the @pacbio.bsky.social platform:
www.biorxiv.org/content/10.1...
This will revolutionise our understanding of transcriptional regulation and functional non-coding variants.
DAF-seq, the evolution of Fiber-seq from the Andrew Stergachis group, using the @pacbio.bsky.social platform:
www.biorxiv.org/content/10.1...
This will revolutionise our understanding of transcriptional regulation and functional non-coding variants.
How old is this plane, don’t remember the last time I saw volume and channel controls in the arm rest
October 7, 2025 at 3:04 PM
How old is this plane, don’t remember the last time I saw volume and channel controls in the arm rest
Interesting work on genes that regulate anti-BCMA CAR-T efficacy in myeloma.
Nature research paper: In vivo CRISPR screens identify modifiers of CAR T cell function in myeloma
go.nature.com/3IeODUh
go.nature.com/3IeODUh
In vivo CRISPR screens identify modifiers of CAR T cell function in myeloma - Nature
In vivo loss-of-function CRISPR screens were performed to identify genes influencing CAR T cell persistence and function in human multiple myeloma, highlighting CDKN1B as a promising target.
go.nature.com
September 28, 2025 at 8:03 PM
Interesting work on genes that regulate anti-BCMA CAR-T efficacy in myeloma.
Awesome to see a 🇨🇦 in the rainbow jersey
'I saw she was fading a little bit, so I told myself I just had to go all in now and try something...'
How the first-ever Canadian rainbow jersey in the elite UCI road world championships was won
https://bit.ly/4nmaaJH
How the first-ever Canadian rainbow jersey in the elite UCI road world championships was won
https://bit.ly/4nmaaJH
‘It Is Crazy’: Magdeleine Vallieres Reflects on Shock World Championships Win
Alison Jackson celebrates success of teammate Vallieres, with her own Paris-Roubaix victory a likely catalyst.
velo.outsideonline.com
September 28, 2025 at 12:16 AM
Awesome to see a 🇨🇦 in the rainbow jersey
Reposted by Jonathan Keats, PhD 🇨🇦
I am excited to share my first work in @schapirolab.bsky.social on Multiple Myeloma (MM) in collaboration with the Standal Lab from NTNU Norway. We use Imaging Mass Cytometry (IMC) on bone marrow biopsies from MM and precursor patients (details below): www.biorxiv.org/content/10.1...
Highly multiplexed imaging recovers immune and metabolic niches in multiple myeloma associated with disease progression and bone involvement
Multiple myeloma (MM) is a cancer arising from genetically aberrant plasma cells (PCs) that remain dependent on the bone marrow (BM) microenvironment for disease establishment and progression. Here, w...
www.biorxiv.org
September 13, 2025 at 8:25 AM
I am excited to share my first work in @schapirolab.bsky.social on Multiple Myeloma (MM) in collaboration with the Standal Lab from NTNU Norway. We use Imaging Mass Cytometry (IMC) on bone marrow biopsies from MM and precursor patients (details below): www.biorxiv.org/content/10.1...
Reposted by Jonathan Keats, PhD 🇨🇦
🚨 Our parent-of-origin study is out in Nature! 🧬
Maternal and paternal alleles can have distinct — even opposite — effects on human traits, revealing a hidden layer of genetic architecture that standard GWAS miss.
🔗 www.nature.com/articles/s41...
Highlights below!
Maternal and paternal alleles can have distinct — even opposite — effects on human traits, revealing a hidden layer of genetic architecture that standard GWAS miss.
🔗 www.nature.com/articles/s41...
Highlights below!
August 6, 2025 at 6:27 PM
🚨 Our parent-of-origin study is out in Nature! 🧬
Maternal and paternal alleles can have distinct — even opposite — effects on human traits, revealing a hidden layer of genetic architecture that standard GWAS miss.
🔗 www.nature.com/articles/s41...
Highlights below!
Maternal and paternal alleles can have distinct — even opposite — effects on human traits, revealing a hidden layer of genetic architecture that standard GWAS miss.
🔗 www.nature.com/articles/s41...
Highlights below!
Interesting @nebanovich.bsky.social @florisbarthel.bsky.social glad we just installed an @elembio.bsky.social Aviti24 @tgenresearch.bsky.social. @aphillippy.bsky.social is this with standard cloudbreak chemistry or the high accuracy ultraQ chemistry
Definitely hard to measure, but here is our best attempt from a new benchmarking paper to be preprinted in the next few weeks. Element appears to be the current king of homopolymers. Illumina does worse than HiFi beyond 20 bp. (This is all measured on human DNA)
September 6, 2025 at 7:15 PM
Interesting @nebanovich.bsky.social @florisbarthel.bsky.social glad we just installed an @elembio.bsky.social Aviti24 @tgenresearch.bsky.social. @aphillippy.bsky.social is this with standard cloudbreak chemistry or the high accuracy ultraQ chemistry
Reposted by Jonathan Keats, PhD 🇨🇦
Reposted by Jonathan Keats, PhD 🇨🇦
The latest human GENCODE releases for Human (49) and Mouse (M38), have just been released. They're available via gencodegenes.org and visible in @ensembl genome browser as part of Ensembl 115 ensembl.org
GENCODE - Home page
gencodegenes.org
September 3, 2025 at 11:16 AM
The latest human GENCODE releases for Human (49) and Mouse (M38), have just been released. They're available via gencodegenes.org and visible in @ensembl genome browser as part of Ensembl 115 ensembl.org
Asking for a friend, to my pathology colleagues, please ensure ISCN sections are on your FISH reports
September 3, 2025 at 12:29 AM
Asking for a friend, to my pathology colleagues, please ensure ISCN sections are on your FISH reports
Reposted by Jonathan Keats, PhD 🇨🇦
Thank you Tommy!
The link you gave is good but points to a 2yr old rendering. This one uses recent versions of R and all packages and has all the latest typo fixes:
www.huber.embl.de/msmb/
The link you gave is good but points to a 2yr old rendering. This one uses recent versions of R and all packages and has all the latest typo fixes:
www.huber.embl.de/msmb/
Modern Statistics for Modern Biology
If you are a biologist and want to get the best out of the powerful methods of modern computational statistics, this is your book.
www.huber.embl.de
August 29, 2025 at 1:48 PM
Thank you Tommy!
The link you gave is good but points to a 2yr old rendering. This one uses recent versions of R and all packages and has all the latest typo fixes:
www.huber.embl.de/msmb/
The link you gave is good but points to a 2yr old rendering. This one uses recent versions of R and all packages and has all the latest typo fixes:
www.huber.embl.de/msmb/