Nicolas Gutierrez-Castellanos
@neuronico.bsky.social
Ramon y Cajal Investigator @University of Valencia. Junior group leader interested in the neural basis of social behaviors. Previously postdoc @Champalimaud Research
https://socialplasticity.wordpress.com/
https://socialplasticity.wordpress.com/
Pinned
A hypothalamic node for the cyclical control of female sexual rejection
Internal state-dependent behavioral flexibility, such as the ability to switch between rejecting and accepting sexual advances based on a female’s rep…
www.sciencedirect.com
I’m thrilled to share our latest work from my postdoc in the Lima lab at the Champalimaud Foundation! In this study, published today in Neuron, we explore the neural mechanisms behind female sexual rejection. Check it out!
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Nicolas Gutierrez-Castellanos
🚨Job alert🚨
The lab has up to *3 postdoc openings* for comp systems neuroscientists interested in describing and manipulating neural population dynamics mediating behaviour
This is part of a collaborative ARIA grant "4D precision control of cortical dynamics"
euraxess.ec.europa.eu/jobs/383909
The lab has up to *3 postdoc openings* for comp systems neuroscientists interested in describing and manipulating neural population dynamics mediating behaviour
This is part of a collaborative ARIA grant "4D precision control of cortical dynamics"
euraxess.ec.europa.eu/jobs/383909
3 Postdoctoral Research Fellows
Champalimaud Foundation (Fundação D. Anna de Sommer Champalimaud e Dr.
euraxess.ec.europa.eu
November 4, 2025 at 5:11 PM
🚨Job alert🚨
The lab has up to *3 postdoc openings* for comp systems neuroscientists interested in describing and manipulating neural population dynamics mediating behaviour
This is part of a collaborative ARIA grant "4D precision control of cortical dynamics"
euraxess.ec.europa.eu/jobs/383909
The lab has up to *3 postdoc openings* for comp systems neuroscientists interested in describing and manipulating neural population dynamics mediating behaviour
This is part of a collaborative ARIA grant "4D precision control of cortical dynamics"
euraxess.ec.europa.eu/jobs/383909
Reposted by Nicolas Gutierrez-Castellanos
Out today in Nature: We uncover a neural mechanism for the integration of two internal states - hunger and estrous state - and how this integration shapes pup-directed behaviors in mice.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Integration of hunger and hormonal state gates infant-directed aggression - Nature
Combined behavioural, circuit-level and cellular approaches are used to demonstrate how hypothalamic neurons integrate hunger and oestrous state to drive a switch in how female mice interact with pups...
www.nature.com
October 22, 2025 at 3:30 PM
Out today in Nature: We uncover a neural mechanism for the integration of two internal states - hunger and estrous state - and how this integration shapes pup-directed behaviors in mice.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Nicolas Gutierrez-Castellanos
Very excited to announce our latest paper uncovering circuit, cellular and molecular mechanisms underlying the formation and maintenance of social hierarchy, another terrific collaboration with @neurovenki.bsky.social, Vic Kapoor and Adam Nelson (not on bsky) www.sciencedirect.com/science/arti...
August 11, 2025 at 6:44 PM
Very excited to announce our latest paper uncovering circuit, cellular and molecular mechanisms underlying the formation and maintenance of social hierarchy, another terrific collaboration with @neurovenki.bsky.social, Vic Kapoor and Adam Nelson (not on bsky) www.sciencedirect.com/science/arti...
Reposted by Nicolas Gutierrez-Castellanos
How do animals decide if they should forage for food or stay home to take care of newborn offspring? Whose needs come first? For my PhD work now out in Nature, we examined how hunger and parenting neurons interact and are reshaped postpartum in mice 🧵⬇️ www.nature.com/articles/s41...
A hypothalamic circuit that modulates feeding and parenting behaviours - Nature
Single-cell transcriptomic analysis of mouse hypothalamus and behavioural experiments show that specific hypothalamic networks regulate conflicting feeding versus parenting behaviours of female mice.
www.nature.com
July 30, 2025 at 4:35 PM
How do animals decide if they should forage for food or stay home to take care of newborn offspring? Whose needs come first? For my PhD work now out in Nature, we examined how hunger and parenting neurons interact and are reshaped postpartum in mice 🧵⬇️ www.nature.com/articles/s41...
Thrilled to announce that my proposal to further investigate the neural basis of sexual rejection has been funded by the Spanish Ministry for Science and Innovation through the Projects for Knowledge Generation call! Exciting times ahead!
@ageinves.bsky.social
@ageinves.bsky.social
July 29, 2025 at 7:13 PM
Thrilled to announce that my proposal to further investigate the neural basis of sexual rejection has been funded by the Spanish Ministry for Science and Innovation through the Projects for Knowledge Generation call! Exciting times ahead!
@ageinves.bsky.social
@ageinves.bsky.social
Reposted by Nicolas Gutierrez-Castellanos
Excellent EBBS 2025 plenary by Inbal Goshen @inbalgoshen.bsky.social
“Astrocytes are beautiful and smart, too” - convinced ✅
@ebbsociety.bsky.social
“Astrocytes are beautiful and smart, too” - convinced ✅
@ebbsociety.bsky.social
June 28, 2025 at 1:36 PM
Excellent EBBS 2025 plenary by Inbal Goshen @inbalgoshen.bsky.social
“Astrocytes are beautiful and smart, too” - convinced ✅
@ebbsociety.bsky.social
“Astrocytes are beautiful and smart, too” - convinced ✅
@ebbsociety.bsky.social
Excited to share our latest review on the neural mechanisms regulating female sexual behavior—co-authored with the brilliant PhD student Ines Dias, Constanze Lenschow and Susana Lima. Check it out!
Check out our most recent review on the neural mechanisms of female sexual behavior! @neuronico.bsky.social
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Ready or not: Neural mechanisms regulating female sexual behavior
Female sexual behavior is essential for reproduction and species survival. It is orchestrated by hormonal and neuronal mechanisms that coordinate sexu…
www.sciencedirect.com
June 24, 2025 at 10:01 AM
Excited to share our latest review on the neural mechanisms regulating female sexual behavior—co-authored with the brilliant PhD student Ines Dias, Constanze Lenschow and Susana Lima. Check it out!
I'm thrilled to be part of this incredible symposium. Looking forward to seeing everyone in Bordeaux soon!
Heading to EBBS? (ebbs2025.azuleon.org) Don’t miss our session (co-chaired with Suzanne Dickson) on how physiological states shape behavior. We have a fantastic lineup of speakers (Linda Engström-Ruud, @amdouglass.bsky.social, @neuronico.bsky.social, @neuroadept.bsky.social). See you in Bordeaux! 🍷
June 24, 2025 at 9:18 AM
I'm thrilled to be part of this incredible symposium. Looking forward to seeing everyone in Bordeaux soon!
Reposted by Nicolas Gutierrez-Castellanos
Reposted by Nicolas Gutierrez-Castellanos
🧠 🍄 ⚡️🐭
Now published in @natneuro.nature.com
Psilocybin enhances fear extinction by reshaping retrosplenial cortex ensembles—suppressing fear neurons, recruiting extinction neurons + boosting plasticity to enable behavioral flexibility
nature.com/articles/s4159…
Now published in @natneuro.nature.com
Psilocybin enhances fear extinction by reshaping retrosplenial cortex ensembles—suppressing fear neurons, recruiting extinction neurons + boosting plasticity to enable behavioral flexibility
nature.com/articles/s4159…
May 26, 2025 at 1:36 PM
🧠 🍄 ⚡️🐭
Now published in @natneuro.nature.com
Psilocybin enhances fear extinction by reshaping retrosplenial cortex ensembles—suppressing fear neurons, recruiting extinction neurons + boosting plasticity to enable behavioral flexibility
nature.com/articles/s4159…
Now published in @natneuro.nature.com
Psilocybin enhances fear extinction by reshaping retrosplenial cortex ensembles—suppressing fear neurons, recruiting extinction neurons + boosting plasticity to enable behavioral flexibility
nature.com/articles/s4159…
After an incredible postdoc journey at Champalimaud Research, full of great science and inspiring mentors and colleagues, this week it is officially time to say goodbye to this amazing place
May 26, 2025 at 2:46 PM
After an incredible postdoc journey at Champalimaud Research, full of great science and inspiring mentors and colleagues, this week it is officially time to say goodbye to this amazing place
Reposted by Nicolas Gutierrez-Castellanos
As the Canadian Association for Neuroscience meeting approaches, we are still offering subsidies for Childcare, Dependent, or Disability Care.
Please apply or share with others who may benefit: can-acn.org/meeting-2025...
Please apply or share with others who may benefit: can-acn.org/meeting-2025...
Canadian Association for Neuroscience Conference Childcare, Dependent, or Disability Care Subsidy – Canadian Association for Neuroscience
can-acn.org
May 9, 2025 at 12:32 PM
As the Canadian Association for Neuroscience meeting approaches, we are still offering subsidies for Childcare, Dependent, or Disability Care.
Please apply or share with others who may benefit: can-acn.org/meeting-2025...
Please apply or share with others who may benefit: can-acn.org/meeting-2025...
Reposted by Nicolas Gutierrez-Castellanos
Stochastic activity in low-rank recurrent neural networks https://www.biorxiv.org/content/10.1101/2025.04.22.649933v1
April 29, 2025 at 6:15 PM
Stochastic activity in low-rank recurrent neural networks https://www.biorxiv.org/content/10.1101/2025.04.22.649933v1
Reposted by Nicolas Gutierrez-Castellanos
Annual Meeting of the International Behavioral Neuroscience Society (IBNS), June 24-29, in Tromso, Norway. @ibnsconnect.bsky.social
April 22, 2025 at 5:45 PM
Annual Meeting of the International Behavioral Neuroscience Society (IBNS), June 24-29, in Tromso, Norway. @ibnsconnect.bsky.social
Reposted by Nicolas Gutierrez-Castellanos
Registration open for UK Neural Computation 2025 @Imperial neuralcomputation.uk/registration...
ECR day: 9 July, ~30 free places
Main meeting: 10-11 July
Pls share!
Sponsors @aria-research.bsky.social @crick.ac.uk
Organisers: @danakarca.bsky.social @neuralreckoning.bsky.social & me
ECR day: 9 July, ~30 free places
Main meeting: 10-11 July
Pls share!
Sponsors @aria-research.bsky.social @crick.ac.uk
Organisers: @danakarca.bsky.social @neuralreckoning.bsky.social & me
Registration |
neuralcomputation.uk
April 17, 2025 at 8:35 AM
Registration open for UK Neural Computation 2025 @Imperial neuralcomputation.uk/registration...
ECR day: 9 July, ~30 free places
Main meeting: 10-11 July
Pls share!
Sponsors @aria-research.bsky.social @crick.ac.uk
Organisers: @danakarca.bsky.social @neuralreckoning.bsky.social & me
ECR day: 9 July, ~30 free places
Main meeting: 10-11 July
Pls share!
Sponsors @aria-research.bsky.social @crick.ac.uk
Organisers: @danakarca.bsky.social @neuralreckoning.bsky.social & me
Reposted by Nicolas Gutierrez-Castellanos
🚨new paper alert
Blind mice use stereo olfaction, comparing smells between nostrils, to maintain a stable sense of direction. Blocking this ability disrupts their internal compass.
Kudos to @kasumbisa.bsky.social! Another cool chapter of the Trenholm-Peyrache collab😉
www.nature.com/articles/s41...
Blind mice use stereo olfaction, comparing smells between nostrils, to maintain a stable sense of direction. Blocking this ability disrupts their internal compass.
Kudos to @kasumbisa.bsky.social! Another cool chapter of the Trenholm-Peyrache collab😉
www.nature.com/articles/s41...
Stereo olfaction underlies stable coding of head direction in blind mice - Nature Communications
Stereo olfaction involves comparing odor differences between the two nostrils. Here, using neuronal recordings and a behavioral test, the authors demonstrate that blind mice use stereo olfaction to fo...
www.nature.com
April 14, 2025 at 6:37 PM
🚨new paper alert
Blind mice use stereo olfaction, comparing smells between nostrils, to maintain a stable sense of direction. Blocking this ability disrupts their internal compass.
Kudos to @kasumbisa.bsky.social! Another cool chapter of the Trenholm-Peyrache collab😉
www.nature.com/articles/s41...
Blind mice use stereo olfaction, comparing smells between nostrils, to maintain a stable sense of direction. Blocking this ability disrupts their internal compass.
Kudos to @kasumbisa.bsky.social! Another cool chapter of the Trenholm-Peyrache collab😉
www.nature.com/articles/s41...
Reposted by Nicolas Gutierrez-Castellanos
1/ Why do patients with late-stage cancer lose motivation & sink into apathy?
🔥 Our new Science paper shows chronic inflammation activates a cytokine-sensing brain circuit that lowers motivation. Huge team effort: Aelita Zhu, Sarah Starosta, Pignatelli & Janowitz labs! 🧵
🔗 doi.org/10.1126/scie...
🔥 Our new Science paper shows chronic inflammation activates a cytokine-sensing brain circuit that lowers motivation. Huge team effort: Aelita Zhu, Sarah Starosta, Pignatelli & Janowitz labs! 🧵
🔗 doi.org/10.1126/scie...
A neuroimmune circuit mediates cancer cachexia-associated apathy
Cachexia, a severe wasting syndrome associated with inflammatory conditions, often leads to multiorgan failure and death. Patients with cachexia experience extreme fatigue, apathy, and clinical depres...
doi.org
April 11, 2025 at 2:00 PM
1/ Why do patients with late-stage cancer lose motivation & sink into apathy?
🔥 Our new Science paper shows chronic inflammation activates a cytokine-sensing brain circuit that lowers motivation. Huge team effort: Aelita Zhu, Sarah Starosta, Pignatelli & Janowitz labs! 🧵
🔗 doi.org/10.1126/scie...
🔥 Our new Science paper shows chronic inflammation activates a cytokine-sensing brain circuit that lowers motivation. Huge team effort: Aelita Zhu, Sarah Starosta, Pignatelli & Janowitz labs! 🧵
🔗 doi.org/10.1126/scie...
Reposted by Nicolas Gutierrez-Castellanos
🚨 JOB OFFER in our lab at Institut Pasteur 🚨
We are looking for a postdoc! Please repost 🙏
We are looking for a postdoc! Please repost 🙏
April 7, 2025 at 7:16 AM
🚨 JOB OFFER in our lab at Institut Pasteur 🚨
We are looking for a postdoc! Please repost 🙏
We are looking for a postdoc! Please repost 🙏
Reposted by Nicolas Gutierrez-Castellanos
Kicking off Bluesky with BlueBerry, our open-access, multichannel wireless optogenetic device for freely moving rodents. Visit www.OptoBlueBerry.org for documentation and see its neuroscience applications from large-scale to social settings in our recent preprint: www.biorxiv.org/content/10.1...
BlueBerry Wireless Optogenetics
BlueBerry is a multi-channel wireless optogenetic system for freely moving mice and rats.
www.OptoBlueBerry.org
March 30, 2025 at 4:52 PM
Kicking off Bluesky with BlueBerry, our open-access, multichannel wireless optogenetic device for freely moving rodents. Visit www.OptoBlueBerry.org for documentation and see its neuroscience applications from large-scale to social settings in our recent preprint: www.biorxiv.org/content/10.1...
Reposted by Nicolas Gutierrez-Castellanos
(1/n) Why is it so hard to stop eating when something tastes amazing? Our new @ science.org paper reveals that dopamine helps sustain our drive for tasty treats—and may explain how anti-obesity Ozempic tames those urges. doi.org/10.1126/science.adt0773
March 30, 2025 at 2:54 AM
(1/n) Why is it so hard to stop eating when something tastes amazing? Our new @ science.org paper reveals that dopamine helps sustain our drive for tasty treats—and may explain how anti-obesity Ozempic tames those urges. doi.org/10.1126/science.adt0773
Reposted by Nicolas Gutierrez-Castellanos
Long thought to have little relevance to ovarian physiology, the rete ovarii may have a role in follicular dynamics and reproductive health.
buff.ly/JhwpURU
buff.ly/JhwpURU
March 30, 2025 at 10:01 AM
Long thought to have little relevance to ovarian physiology, the rete ovarii may have a role in follicular dynamics and reproductive health.
buff.ly/JhwpURU
buff.ly/JhwpURU
Reposted by Nicolas Gutierrez-Castellanos
The latest work from the Lammel lab is out today!
Discover how changes in neurotensin signaling from the NAc Lat to the VTA lead to food devaluation in a mouse model of obesity 🧀🐭
www.nature.com/articles/s41...
Discover how changes in neurotensin signaling from the NAc Lat to the VTA lead to food devaluation in a mouse model of obesity 🧀🐭
www.nature.com/articles/s41...
Changes in neurotensin signalling drive hedonic devaluation in obesity - Nature
In mice, prolonged consumption of a high-fat diet decreases interest in calorie-rich foods as a result of reduced neurotensin expression and signalling, which uncouples hedonic feeding behaviour linke...
www.nature.com
March 27, 2025 at 4:19 AM
The latest work from the Lammel lab is out today!
Discover how changes in neurotensin signaling from the NAc Lat to the VTA lead to food devaluation in a mouse model of obesity 🧀🐭
www.nature.com/articles/s41...
Discover how changes in neurotensin signaling from the NAc Lat to the VTA lead to food devaluation in a mouse model of obesity 🧀🐭
www.nature.com/articles/s41...
Reposted by Nicolas Gutierrez-Castellanos
The first paper from the lab is out on biorxiv - enjoy reading! Social context and interactions influence our behavioral decisions - the same is true for the little fly larva!
March 24, 2025 at 8:28 PM
The first paper from the lab is out on biorxiv - enjoy reading! Social context and interactions influence our behavioral decisions - the same is true for the little fly larva!
Reposted by Nicolas Gutierrez-Castellanos
I am hiring a PhD student in my lab in beautiful Edinburgh to keep investigating the neural mechanisms underlying flexible decision-making and individual variability.
Email or DM me with any questions, or let's chat at the CoSyNe Main Meeting next week!
Apply here: tinyurl.com/2cxr6nbg
Email or DM me with any questions, or let's chat at the CoSyNe Main Meeting next week!
Apply here: tinyurl.com/2cxr6nbg
March 24, 2025 at 7:55 PM
I am hiring a PhD student in my lab in beautiful Edinburgh to keep investigating the neural mechanisms underlying flexible decision-making and individual variability.
Email or DM me with any questions, or let's chat at the CoSyNe Main Meeting next week!
Apply here: tinyurl.com/2cxr6nbg
Email or DM me with any questions, or let's chat at the CoSyNe Main Meeting next week!
Apply here: tinyurl.com/2cxr6nbg