Narita Lab
@narita-lab.bsky.social
Studying cellular #stress responses, particularly #senescence and its impact on #immune response, #ageing and #cancer, #tumorigenesis at Cancer Research UK CI @cruk-ci.bsky.social, University of Cambridge @cam.ac.uk
Website: naritalab.com
Website: naritalab.com
Pinned
Narita Lab
@narita-lab.bsky.social
· Aug 1
The rise of RAS: how gradual oncogene activation shapes the OIS spectrum
A biweekly scientific journal publishing high-quality research in molecular biology and genetics, cancer biology, biochemistry, and related fields
genesdev.cshlp.org
👓 Our latest review is out in the Genes&Dev special issue on Aging and Senescence @genesdev.bsky.social released today: The rise of RAS: how gradual oncogene activation shapes the OIS spectrum genesdev.cshlp.org/content/39/1...
genesdev.cshlp.org/content/curr...
genesdev.cshlp.org/content/curr...
Reposted by Narita Lab
Fine-scale chromatin mapping uncovers principles of cis-regulatory element interactions. #NBThighlight www.cell.com/cell/fulltex...
Mapping chromatin structure at base-pair resolution unveils a unified model of cis-regulatory element interactions
Li et al. apply base-pair resolution Micro Capture-C ultra to map chromatin contacts
between individual motifs within cis-regulatory elements and reveal a unified model
of biophysically mediated enhan...
www.cell.com
November 10, 2025 at 8:58 AM
Fine-scale chromatin mapping uncovers principles of cis-regulatory element interactions. #NBThighlight www.cell.com/cell/fulltex...
Reposted by Narita Lab
What an honour to have been awarded the CRUK Cambridge Institute Thesis Prize 2025 for my PhD project focusing on chromatin architecture in the @narita-lab.bsky.social at @cruk-ci.bsky.social 🎉 Big thank you to Masashi for allowing me to to this exciting project and the CI community for all support!
November 7, 2025 at 11:59 PM
What an honour to have been awarded the CRUK Cambridge Institute Thesis Prize 2025 for my PhD project focusing on chromatin architecture in the @narita-lab.bsky.social at @cruk-ci.bsky.social 🎉 Big thank you to Masashi for allowing me to to this exciting project and the CI community for all support!
Congratulations 🎉 to our PhD student Aleksandra @atjanowska.bsky.social for winning the Best Thesis Prize 🥇. She and Jack (PhD student) presented their work today at the Annual Retreat @cruk-ci.bsky.social We had so much fun with the Team Building, congrats to @hana-aliee.bsky.social for winning! 🏆
November 7, 2025 at 11:51 PM
Congratulations 🎉 to our PhD student Aleksandra @atjanowska.bsky.social for winning the Best Thesis Prize 🥇. She and Jack (PhD student) presented their work today at the Annual Retreat @cruk-ci.bsky.social We had so much fun with the Team Building, congrats to @hana-aliee.bsky.social for winning! 🏆
Reposted by Narita Lab
🚨 Exciting conference for stem cell aficionados!
‘Frontiers in Stem Cell Innovation’ will bring together experts in stem cell biology from academia & industry to discuss key developments as well as challenges in regenerative medicine and disease modelling.
fisci2026.eventbrite.co.uk
Please repost 🙏
‘Frontiers in Stem Cell Innovation’ will bring together experts in stem cell biology from academia & industry to discuss key developments as well as challenges in regenerative medicine and disease modelling.
fisci2026.eventbrite.co.uk
Please repost 🙏
Frontiers in Stem Cell Innovation 2026
Join leading academics and industry professionals exploring cutting-edge stem cell technologies and disease modelling for drug discovery
FISCI2026.eventbrite.co.uk
November 1, 2025 at 8:56 PM
🚨 Exciting conference for stem cell aficionados!
‘Frontiers in Stem Cell Innovation’ will bring together experts in stem cell biology from academia & industry to discuss key developments as well as challenges in regenerative medicine and disease modelling.
fisci2026.eventbrite.co.uk
Please repost 🙏
‘Frontiers in Stem Cell Innovation’ will bring together experts in stem cell biology from academia & industry to discuss key developments as well as challenges in regenerative medicine and disease modelling.
fisci2026.eventbrite.co.uk
Please repost 🙏
Yesterday our lab group had the pleasure of hosting CRIses, the department-wide social at CRUK. The theme was The Beatles, featuring some of their classic tunes and a Sgt. Pepper-inspired cocktail. Thanks to all who came! 🎸
October 25, 2025 at 8:54 AM
Yesterday our lab group had the pleasure of hosting CRIses, the department-wide social at CRUK. The theme was The Beatles, featuring some of their classic tunes and a Sgt. Pepper-inspired cocktail. Thanks to all who came! 🎸
Reposted by Narita Lab
I'm recruiting ML postdocs to join my lab at the University of Cambridge. Our research focuses on generative modelling, counterfactual reasoning, and sequence modelling to reason about and intervene in complex cellular functions in disease.
www.cam.ac.uk/jobs/researc...
www.cam.ac.uk/jobs/researc...
October 19, 2025 at 10:36 AM
I'm recruiting ML postdocs to join my lab at the University of Cambridge. Our research focuses on generative modelling, counterfactual reasoning, and sequence modelling to reason about and intervene in complex cellular functions in disease.
www.cam.ac.uk/jobs/researc...
www.cam.ac.uk/jobs/researc...
Ioana in our lab is participating in the Shine Night Walk Cambridge 10k 2025 tomorrow. Please join/support/share her team page:
fundraise.cancerresearchuk.org/team/the-fit... @cruk-ci.bsky.social
fundraise.cancerresearchuk.org/team/the-fit... @cruk-ci.bsky.social
The Fit Fellas
Cancer is happening right now, which is why we're fundraising right now for Cancer Research UK. There’s no time to lose! Donate today and help bring forward the day when all cancers are cured. Donatin...
fundraise.cancerresearchuk.org
October 17, 2025 at 1:24 PM
Ioana in our lab is participating in the Shine Night Walk Cambridge 10k 2025 tomorrow. Please join/support/share her team page:
fundraise.cancerresearchuk.org/team/the-fit... @cruk-ci.bsky.social
fundraise.cancerresearchuk.org/team/the-fit... @cruk-ci.bsky.social
Reposted by Narita Lab
Really excited to share our latest work led by @mattiaubertini.bsky.social and @nesslfy.bsky.social: we report that cohesin loop extrusion creates rare but long-lived encounters between genomic sequences which underlie efficient enhancer-promoter communication.
www.biorxiv.org/content/10.1...
A🧵👇
www.biorxiv.org/content/10.1...
A🧵👇
September 24, 2025 at 9:45 PM
Really excited to share our latest work led by @mattiaubertini.bsky.social and @nesslfy.bsky.social: we report that cohesin loop extrusion creates rare but long-lived encounters between genomic sequences which underlie efficient enhancer-promoter communication.
www.biorxiv.org/content/10.1...
A🧵👇
www.biorxiv.org/content/10.1...
A🧵👇
We are greatly enjoying the exciting science (and location) at ICSA 2025 Rome #ICSA2025Rome @icsasenescence.bsky.social
September 19, 2025 at 7:49 AM
We are greatly enjoying the exciting science (and location) at ICSA 2025 Rome #ICSA2025Rome @icsasenescence.bsky.social
Tonight, we had a send off dinner for Hiro. We hope you enjoyed your time in our lab and in the UK as much as we enjoyed having you around!
September 12, 2025 at 9:57 PM
Tonight, we had a send off dinner for Hiro. We hope you enjoyed your time in our lab and in the UK as much as we enjoyed having you around!
We were honoured to host Prof. Makoto Nakanishi from the University of Tokyo, presenting his work on the senolytic activity of GLS1 inhibition.
September 8, 2025 at 5:29 PM
We were honoured to host Prof. Makoto Nakanishi from the University of Tokyo, presenting his work on the senolytic activity of GLS1 inhibition.
Dinner with the two summer students we are hosting and who just presented the results of their hard work to the lab 🧪🧫💻
August 21, 2025 at 8:54 PM
Dinner with the two summer students we are hosting and who just presented the results of their hard work to the lab 🧪🧫💻
Introducing Cell Biology to Students from Aichi Prefectural Asahigaoka High School (July 2024 & July 2025)
aichi-asahigaoka.ed.jp/news/-Cjth-tx
aichi-asahigaoka.ed.jp/news/-Cjth-tx
August 20, 2025 at 1:17 PM
Introducing Cell Biology to Students from Aichi Prefectural Asahigaoka High School (July 2024 & July 2025)
aichi-asahigaoka.ed.jp/news/-Cjth-tx
aichi-asahigaoka.ed.jp/news/-Cjth-tx
Reposted by Narita Lab
It’s out!!!!! We hope our review on aging, immunity, and cancer is helpful.
Such a rewarding group effort led by Melissa Dolan, with Kendra Libby, Alison Ringle, and @vangalenlab.bsky.social
So grateful to @gabriellebrewer.bsky.social @natrevcancer.nature.com for her efforts and support
Such a rewarding group effort led by Melissa Dolan, with Kendra Libby, Alison Ringle, and @vangalenlab.bsky.social
So grateful to @gabriellebrewer.bsky.social @natrevcancer.nature.com for her efforts and support
August 14, 2025 at 1:17 PM
It’s out!!!!! We hope our review on aging, immunity, and cancer is helpful.
Such a rewarding group effort led by Melissa Dolan, with Kendra Libby, Alison Ringle, and @vangalenlab.bsky.social
So grateful to @gabriellebrewer.bsky.social @natrevcancer.nature.com for her efforts and support
Such a rewarding group effort led by Melissa Dolan, with Kendra Libby, Alison Ringle, and @vangalenlab.bsky.social
So grateful to @gabriellebrewer.bsky.social @natrevcancer.nature.com for her efforts and support
👓 Our latest review is out in the Genes&Dev special issue on Aging and Senescence @genesdev.bsky.social released today: The rise of RAS: how gradual oncogene activation shapes the OIS spectrum genesdev.cshlp.org/content/39/1...
genesdev.cshlp.org/content/curr...
genesdev.cshlp.org/content/curr...
The rise of RAS: how gradual oncogene activation shapes the OIS spectrum
A biweekly scientific journal publishing high-quality research in molecular biology and genetics, cancer biology, biochemistry, and related fields
genesdev.cshlp.org
August 1, 2025 at 2:27 PM
👓 Our latest review is out in the Genes&Dev special issue on Aging and Senescence @genesdev.bsky.social released today: The rise of RAS: how gradual oncogene activation shapes the OIS spectrum genesdev.cshlp.org/content/39/1...
genesdev.cshlp.org/content/curr...
genesdev.cshlp.org/content/curr...
Only a few days left to apply to join our lab and do exciting senescence research at the University of Cambridge Cancer Research UK Cambridge Institute @cruk-ci.bsky.social @cam.ac.uk 🧪🧬
You can also send informal enquiries (info below):
www.jobs.cam.ac.uk/job/52026/
www.jobs.cam.ac.uk/job/52027/
You can also send informal enquiries (info below):
www.jobs.cam.ac.uk/job/52026/
www.jobs.cam.ac.uk/job/52027/
a cartoon character is surrounded by cats and the caption says when someone asks you what your dream job is
ALT: a cartoon character is surrounded by cats and the caption says when someone asks you what your dream job is
media.tenor.com
July 29, 2025 at 10:15 AM
Only a few days left to apply to join our lab and do exciting senescence research at the University of Cambridge Cancer Research UK Cambridge Institute @cruk-ci.bsky.social @cam.ac.uk 🧪🧬
You can also send informal enquiries (info below):
www.jobs.cam.ac.uk/job/52026/
www.jobs.cam.ac.uk/job/52027/
You can also send informal enquiries (info below):
www.jobs.cam.ac.uk/job/52026/
www.jobs.cam.ac.uk/job/52027/
Reposted by Narita Lab
Combined single-cell profiling of chromatin–transcriptome and splicing across brain cell types, regions and disease state - @hagentilgner.bsky.social @liganlab.bsky.social go.nature.com/3IKlcJn
Combined single-cell profiling of chromatin–transcriptome and splicing across brain cell types, regions and disease state - Nature Biotechnology
Joint profiling of chromatin and splicing in the brain uncovers shared and distinct patterns.
go.nature.com
July 22, 2025 at 2:43 PM
Combined single-cell profiling of chromatin–transcriptome and splicing across brain cell types, regions and disease state - @hagentilgner.bsky.social @liganlab.bsky.social go.nature.com/3IKlcJn
Reposted by Narita Lab
A recent paper reveals a surprising insight. The length of the cell cycle in a particular tissue determines the oncogenic transformation capacity of particular oncogenes, with tissues with shorter cell cycles most susceptible 3/n
July 26, 2025 at 2:14 PM
A recent paper reveals a surprising insight. The length of the cell cycle in a particular tissue determines the oncogenic transformation capacity of particular oncogenes, with tissues with shorter cell cycles most susceptible 3/n
Reposted by Narita Lab
🚨 Big news! The 10th Annual ICSA Meeting is coming to Rome 🇮🇹 on Sept 17-19, 2025!
Join us Sept 16th for the 2nd Phaedon Institute-ICSA SenoTherapeutics Summit!
🎟️ Register now—early bird & abstract submissions close June 15!
🔗 icsa2025rome.com
#ICSARome2025
Join us Sept 16th for the 2nd Phaedon Institute-ICSA SenoTherapeutics Summit!
🎟️ Register now—early bird & abstract submissions close June 15!
🔗 icsa2025rome.com
#ICSARome2025
March 25, 2025 at 2:16 PM
🚨 Big news! The 10th Annual ICSA Meeting is coming to Rome 🇮🇹 on Sept 17-19, 2025!
Join us Sept 16th for the 2nd Phaedon Institute-ICSA SenoTherapeutics Summit!
🎟️ Register now—early bird & abstract submissions close June 15!
🔗 icsa2025rome.com
#ICSARome2025
Join us Sept 16th for the 2nd Phaedon Institute-ICSA SenoTherapeutics Summit!
🎟️ Register now—early bird & abstract submissions close June 15!
🔗 icsa2025rome.com
#ICSARome2025
Reposted by Narita Lab
ICYMI: New online: scNanoHi-C2 uncovers dynamic reorganization of 3D chromatin structure in mammalian germ cells
scNanoHi-C2 uncovers dynamic reorganization of 3D chromatin structure in mammalian germ cells
Nature Structural & Molecular Biology, Published online: 16 July 2025; doi:10.1038/s41594-025-01603-8By leveraging long-read sequencing, single-cell input scNanoHi-C2 systematically delineates chromatin structural reprogramming in embryonic-stage germ cells (EGCs), highlighting the functional importance of three-dimensional (3D) genome structure in mammalian EGC development. This method provides a powerful tool for probing chromatin architecture in individual cells, particularly in rare or precious biological samples.
go.nature.com
July 17, 2025 at 3:10 PM
ICYMI: New online: scNanoHi-C2 uncovers dynamic reorganization of 3D chromatin structure in mammalian germ cells
Reposted by Narita Lab
🗞️Our July issue is live!📷 This month, we're featuring work on intrinsic capacity, senescence, and more. Read it all here: www.nature.com/nataging/vol...
July 18, 2025 at 11:09 AM
🗞️Our July issue is live!📷 This month, we're featuring work on intrinsic capacity, senescence, and more. Read it all here: www.nature.com/nataging/vol...
Reposted by Narita Lab
🔥NEW paper from our lab! Ever wondered how the metabolite/lipid composition of human bone marrow HSCs changes during differentiation,aging,AML? Check our work www.nature.com/articles/s41... driven by the brilliant Marialena & Maricarmen with Jörg! @mpi-ie.bsky.social @ethz.ch @natcellbio.nature.com
Differentiation, ageing and leukaemia alter the metabolic profile of human bone marrow haematopoietic stem and progenitor cells - Nature Cell Biology
Lalioti, Romero-Mulero et al. combine metabolomics, lipidomics and transcriptomics of haematopoietic stem and progenitor cells during differentiation, ageing and leukaemia, finding a role for choline ...
www.nature.com
July 16, 2025 at 10:13 AM
🔥NEW paper from our lab! Ever wondered how the metabolite/lipid composition of human bone marrow HSCs changes during differentiation,aging,AML? Check our work www.nature.com/articles/s41... driven by the brilliant Marialena & Maricarmen with Jörg! @mpi-ie.bsky.social @ethz.ch @natcellbio.nature.com
Reposted by Narita Lab
#Perspective 🚨
Lazure and Gomes argue that metabolic changes that occur as a result of #ageing may shape tumour initiation and progression and the development of metastatic disease.
⬇️ 📖
https://bit.ly/3IkNY...
@moffittnews.bsky.social
Lazure and Gomes argue that metabolic changes that occur as a result of #ageing may shape tumour initiation and progression and the development of metastatic disease.
⬇️ 📖
https://bit.ly/3IkNY...
@moffittnews.bsky.social
Cancer progression through the lens of age-induced metabolic reprogramming - Nature Reviews Cancer
In this Perspective, Lazure and Gomes argue that metabolic changes that occur as a result of ageing may shape tumour initiation and progression and the development of metastatic disease.
bit.ly
July 18, 2025 at 10:29 AM
#Perspective 🚨
Lazure and Gomes argue that metabolic changes that occur as a result of #ageing may shape tumour initiation and progression and the development of metastatic disease.
⬇️ 📖
https://bit.ly/3IkNY...
@moffittnews.bsky.social
Lazure and Gomes argue that metabolic changes that occur as a result of #ageing may shape tumour initiation and progression and the development of metastatic disease.
⬇️ 📖
https://bit.ly/3IkNY...
@moffittnews.bsky.social
Reposted by Narita Lab
Nature research paper: NNMT inhibition in cancer-associated fibroblasts restores antitumour immunity
go.nature.com/3II8HhA
go.nature.com/3II8HhA
NNMT inhibition in cancer-associated fibroblasts restores antitumour immunity - Nature
An NNMT inhibitor reduces tumour burden and metastasis in multiple mouse cancer models and restores immune checkpoint blockade efficacy by decreasing cancer-associated-fibroblast-mediated recruitment of myeloid-derived suppressor cells and reinvigorating CD8+ T cell activation.
go.nature.com
July 26, 2025 at 10:25 AM
Nature research paper: NNMT inhibition in cancer-associated fibroblasts restores antitumour immunity
go.nature.com/3II8HhA
go.nature.com/3II8HhA
We are the Narita Lab at Cancer Research UK Cambridge Institute. Excited to join Bluesky and share our research with like-minded scientists!
July 25, 2025 at 10:29 PM
We are the Narita Lab at Cancer Research UK Cambridge Institute. Excited to join Bluesky and share our research with like-minded scientists!