André Nadler
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nadlerlab.bsky.social
André Nadler
@nadlerlab.bsky.social
2.1K followers 1.7K following 520 posts
Chemist in a CellBio place. Fan of lipids & membranes

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nadlerlab.bsky.social
André Nadler @nadlerlab.bsky.social · Aug 21
Out today in @nature.com: Together with the Honigmann, Shevchenko, Drobot and Hof labs, we present a general workflow for imaging the localization and transport of individual lipids in cells and mapping their metabolism.
www.nature.com/articles/s41...
Reposted by André Nadler
janinebrunner.bsky.social
MISO: microfluidic protein isolation enables single-particle cryo-EM structure determination from a single cell colony.

Or from a single dish of HEK cell culture in the case of two membrane proteins.

Out in Nature Methods now! lnkd.in/gpyBSceg

Wonderful collaboration with the Efremov lab.
November 14, 2025 at 6:38 PM
Reposted by André Nadler
mpi-cbg.de
Research team @nadlerlab.bsky.social @hzdr.bsky.social & EPFL with first author Kristin Böhlig develops probes to vizualize transport of ether lipids in the cell. Publication in @angewandtechemie.bsky.social www.mpi-cbg.de/news-outreac...
New toolkit to study ether lipids
Research team develops probes to vizualize transport of ether lipids in the cell. 
www.mpi-cbg.de
November 14, 2025 at 2:31 PM
nadlerlab.bsky.social
Beautiful work as per usual - Congratulations!!!
November 12, 2025 at 7:44 PM
Reposted by André Nadler
joachimgoedhart.bsky.social
Independent validation of the SnxA biosensor as a sensitive reporter of PI(3,5)P₂ dynamics by Gerald R Hammond and team: www.biorxiv.org/content/10.1...
(C) Recruitment of the WT PIKfyve-CCR-Kina to Rab5 endosomes and changes in biosensor localization at these membranes is shown by the fluorescence intensity ratios of the constructs at Rab5 endosomes over the whole cell. Data shown is the grand mean ± SEM of 3 experiments. A total of 35 cells were analyzed. Confocal images over time are shown to the right. (D) As in C, but now utilizing the catalytically dead K1876E/V1883I mutant of the FKBP-PIKfyve-CCR-Kina as a negative control.
November 12, 2025 at 6:57 PM
Reposted by André Nadler
bedform.org
ooof this feels like most every university rn
bunch of executives on the deck of a ship with only one guy rowing and a quote "I don't understand, after so many budget cuts why dont we move faster?"
November 12, 2025 at 3:28 AM
Reposted by André Nadler
pedrobeltrao.bsky.social
957 proposals were submitted in the latest round of ERC Synergy applications. They expect to fund 50 which means around 5% success rate. This is really not sustainable and a lot of people are likely avoiding doing this knowing how poor the chances are.
erc.europa.eu/news-events/...
Applications for ERC Synergy Grants 2026: Facts and figures
The ERC Synergy Grants 2026 call closed for applications on 5 November 2025. These are the preliminary data on the submitted proposals:
erc.europa.eu
November 11, 2025 at 1:22 PM
Reposted by André Nadler
buzzbaum.bsky.social
We have wondered what a complex archaeal cell might look like ever since 2014. It’s been a long road (and the journey is far from over), but it’s a good time to pause for breath and look. These Asgard archaeal cells are a surprise! And that is the joy of being a cell biologist.
November 7, 2025 at 11:02 AM
Reposted by André Nadler
tbharat-lab.bsky.social
An Asgard archaeon with internal membrane compartments

Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!

www.biorxiv.org/content/10.1...
November 7, 2025 at 10:44 AM
Reposted by André Nadler
dereklowe.bsky.social
It’s true that some scientific results can’t be replicated. And it’s also true that some people do the right thing when that happens:
Taking It Back, The Right Way
www.science.org
November 4, 2025 at 7:50 PM
Reposted by André Nadler
deglushk.bsky.social
Just published! We share an open-source workflow to measure membrane thickness from tomograms, including a tutorial with 3D visualizations. We analyze thickness variations across organelles and reflect on where to define a membrane boundary. @becklab.bsky.social #teamtomo rupress.org/jcb/article/...
November 6, 2025 at 7:38 AM
Reposted by André Nadler
maxplanck.de
Congratulations! In the current call of the European Research Council, Max Planck researchers have secured five Synergy Grants. Together with the University of Cambridge, we are among the top three most successful #research institutions in #Europe ! 🙌 www.mpg.de/25684336/erc... @erc.europa.eu
Strong as a team
Five Max Planck researchers secure prestigious ERC Synergy Grants in 2025, enhancing collaborative research in Europe.
www.mpg.de
November 6, 2025 at 1:28 PM
Reposted by André Nadler
grill-lab.bsky.social
The Lab of Stephan Grill at MPI-CBG has finally made it to Bluesky and we also have a brand new homepage: grill-lab.org
Check it out.
November 6, 2025 at 1:09 PM
Reposted by André Nadler
dudinlab.bsky.social
🚨Our collaboration with @centriolelab.bsky.social & @gautamdey.bsky.social is out today in @cp-cell.bsky.social
We show that #Expansion #Microscopy is a broad-spectrum modality for Euks, enabling 3D phenotypic maps rooted to phylogeny.
#ProtistsOnSky #SciComm #SciSky

www.cell.com/cell/fulltex...
October 31, 2025 at 2:42 PM
Reposted by André Nadler
olzmannlab.bsky.social
Excited to share our study out in @natcellbio.nature.com! Led by @mikelangelipid.bsky.social, we identify the first #LipidDroplet lipid quality control pathway: LD-localized FSP1 protects stored lipids from oxidative damage and prevents LD-initiated #ferroptosis.
www.nature.com/articles/s41...
FSP1-mediated lipid droplet quality control prevents neutral lipid peroxidation and ferroptosis - Nature Cell Biology
Lange et al. identify a lipid droplet quality control pathway in which FSP1 safeguards stored neutral lipids from lipid peroxidation, thereby preventing the induction of ferroptosis.
www.nature.com
October 29, 2025 at 5:21 PM
Reposted by André Nadler
mikelangelipid.bsky.social
Excited to share my postdoc work @olzmannlab.bsky.social! We found lipid droplets, the cell’s lipid storage depots, are subject to oxidative damage and are protected by FSP1. Loss of FSP1 triggers droplet peroxidation and cell death, revealing a new layer of lipid quality control!

shorturl.at/B5XYD
FSP1-mediated lipid droplet quality control prevents neutral lipid peroxidation and ferroptosis - Nature Cell Biology
Lange et al. identify a lipid droplet quality control pathway in which FSP1 safeguards stored neutral lipids from lipid peroxidation, thereby preventing the induction of ferroptosis.
www.nature.com
October 29, 2025 at 8:45 PM
Reposted by André Nadler
campaslab.bsky.social
Really excited to present the results of a fantastic collaboration with Jesse Veenvliet @jesseveenvliet.bsky.social @mpi-cbg.de @poldresden.bsky.social 🤩

We find a unique mechanism for body axis elongation in mammals, different from other vertebrate species

➡️ www.biorxiv.org/content/10.1...
October 28, 2025 at 8:25 AM
nadlerlab.bsky.social
Beautiful piece of work! Congratulations!
October 25, 2025 at 3:37 PM
Reposted by André Nadler
alleninstitute.org
#CellBio community, this one is for you! Applications are open for the #LakeConference on Modeling Life from Cells to Tissues – co-hosted with Circuit Neuroscience Basel!

📆 April 20-22, 2026
📍 Seattle, USA
🔬 All career stages welcomed.

Apply to attend by 12/12: alleninstitute.org/events/aics-...
2026 Lake Conference: Modeling Life from Cells to Tissues
Join the Allen Institute for Cell Science and Circuit Neuroscience Basel in Seattle, Washington, April 20–22, 2026, for a 3 day conference, Modeling...
alleninstitute.org
October 20, 2025 at 9:33 PM
Reposted by André Nadler
clairedeo.bsky.social
Our photoswitchable HaloTag is out in Angewandte Chemie @angewandtechemie.bsky.social ! We now also show that this system can be used to control emitter density in SMLM. Congrats to Franzi, Bego, and our amazing collaborators. Check it out: onlinelibrary.wiley.com/doi/full/10....
A Photoswitchable HaloTag for Spatiotemporal Control of Fluorescence in Living Cells
Photoswitchable fluorophores are critical for advanced bioimaging. Here, we develop a photoswitchable self-labeling HaloTag that can reversibly modulate the emission of a bound fluorogenic dye via a ....
onlinelibrary.wiley.com
October 25, 2025 at 8:56 AM
Reposted by André Nadler
dereklowe.bsky.social
Startlingly good effects of LNP-mRNA vaccines when given to cancer patients receiving immune checkpoint therapy. More vaccine research please. More mRNA!
mRNA Vaccines and Immuno-oncology: Good News
www.science.org
October 23, 2025 at 6:47 PM
nadlerlab.bsky.social
At this rate the NBA needs to take care that it doesn't turn into FIFA 2.0
October 23, 2025 at 5:55 PM
Reposted by André Nadler
elishakrieg.bsky.social
Multiplexed detection of viral pathogens on an AUTONOMOUSLY LOADING chip for point-of-care #diagnostics.

Congrats to first authors Beatrise Berzina and Krishna Gupta and the entire EKFZ-funded *VirChip* team!
October 23, 2025 at 2:21 PM
Reposted by André Nadler
faldalf.bsky.social
mStayRose is published in JBC 🥳🎉

Congratulations @wsctt.bsky.social @sporemohan.bsky.social and team for the monumental effort to make a non-natural amino acid incorporating fluorescent protein accessible. It's based on mStayGold, bright, and photostable:

www.jbc.org/article/S002...
StayRose: a photostable StayGold derivative red-shifted by genetic code expansion
Photobleaching of fluorescent proteins often limits the acquisition of high-quality images in microscopy. StayGold, a novel dimeric green fluorescent protein recently monomerised through sequence engi...
www.jbc.org
October 22, 2025 at 4:58 PM
Reposted by André Nadler
scale-cluster-ffm.bsky.social
🚀 Exciting Job Opportunity: Project Coordinator at the Cluster of Excellence SCALE

We’re thrilled to announce an exceptional opportunity to join the newly founded Cluster of Excellence SCALE – Subcellular Architecture of Life from the @goetheuni.bsky.social.

👉 Learn more and apply here:
October 22, 2025 at 9:41 AM
Reposted by André Nadler
andersshansen.bsky.social
Our collab w. V Goel, @nicholas-aboreden.bsky.social , J Jusuf, G Blobel, L Mirny, @irate-physicist.bsky.social out in @natsmb.nature.com www.nature.com/articles/s41...

Was co-submitted with @allanaschooley.bsky.social @jobdekker.bsky.social whose paper should also come out soon

Brief thread 👇
October 20, 2025 at 6:36 PM