Payam Gammage
@mito-oncogene.bsky.social
Mitochondrial genetics, genome engineering, cancer metabolism. Lab supported by ERC, NCI, CRUK & EMBO YIP.
Lab website: https://shorturl.at/lowCL
Lab website: https://shorturl.at/lowCL
Pinned
Functionally dominant hotspot mutations of mitochondrial ribosomal RNA genes in cancer
Nature Genetics - Analysis of 14,106 tumor genomes highlights recurrent mutations in mitochondrial ribosomal RNA encoded within the mitochondrial genome. Mutations occur at hotspot positions and...
rdcu.be
Excited to share our latest work in collaboration with the @edreznik.bsky.social lab @mskcancercenter.bsky.social, where we describe functionally dominant mitochondrial DNA mutations in patient tumors. So, what is functional dominance in mitochondrial genetics, I hear you ask?
rdcu.be/eN1jm
rdcu.be/eN1jm
Bravo 👏 @ryanlab.bsky.social - big moment for the lab and important findings re potential pathogenic mechanisms of mitochondrial disease
Very excited to announce that the first paper from the lab is now live @natcomms.nature.com #mitochondria #immunometabolism
This work was led by postdoc Eloise marques with many important contributions from all of our co-authors.
Please check it out!
www.nature.com/articles/s41...
This work was led by postdoc Eloise marques with many important contributions from all of our co-authors.
Please check it out!
www.nature.com/articles/s41...
An inherited mitochondrial DNA mutation remodels inflammatory cytokine responses in macrophages and in vivo in mice - Nature Communications
Inherited mitochondrial DNA mutations can result in diverse clinical phenotypes. Here, the authors characterise a heteroplasmic tRNAAla mutation (m.5019A>G) in mice and demonstrate that macrophages...
www.nature.com
November 20, 2025 at 5:21 PM
Bravo 👏 @ryanlab.bsky.social - big moment for the lab and important findings re potential pathogenic mechanisms of mitochondrial disease
And finally - if you'd like to have our recent paper on functionally dominant mutations in mtDNA explained in podcast form, please see youtu.be/TY1hxrJzq5Q?...
p.s. thank you @albertosanzmon1.bsky.social :)
p.s. thank you @albertosanzmon1.bsky.social :)
Mitochondrial Ribosome Mutations: A Hidden Driver in Cancer
YouTube video by The Sanz Science Experience
youtu.be
November 5, 2025 at 1:49 PM
And finally - if you'd like to have our recent paper on functionally dominant mutations in mtDNA explained in podcast form, please see youtu.be/TY1hxrJzq5Q?...
p.s. thank you @albertosanzmon1.bsky.social :)
p.s. thank you @albertosanzmon1.bsky.social :)
For those who’d like a high level summary of our paper today, please check out the accompanying research briefing:
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Functional dominance in the central dogma of tumor mitochondrial genetics - Nature Genetics
We have discovered recurrent, somatic mutations in mitochondrial ribosomal RNA genes across all tumor types assessed. In contrast with the established idea that the majority of mitochondrial DNA molec...
www.nature.com
November 3, 2025 at 2:56 PM
For those who’d like a high level summary of our paper today, please check out the accompanying research briefing:
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Excited to share our latest work in collaboration with the @edreznik.bsky.social lab @mskcancercenter.bsky.social, where we describe functionally dominant mitochondrial DNA mutations in patient tumors. So, what is functional dominance in mitochondrial genetics, I hear you ask?
rdcu.be/eN1jm
rdcu.be/eN1jm
Functionally dominant hotspot mutations of mitochondrial ribosomal RNA genes in cancer
Nature Genetics - Analysis of 14,106 tumor genomes highlights recurrent mutations in mitochondrial ribosomal RNA encoded within the mitochondrial genome. Mutations occur at hotspot positions and...
rdcu.be
November 3, 2025 at 11:15 AM
Excited to share our latest work in collaboration with the @edreznik.bsky.social lab @mskcancercenter.bsky.social, where we describe functionally dominant mitochondrial DNA mutations in patient tumors. So, what is functional dominance in mitochondrial genetics, I hear you ask?
rdcu.be/eN1jm
rdcu.be/eN1jm
Reposted by Payam Gammage
I've been asked about this paper (www.nature.com/articles/s41...) enough times that I finally had to read it.
The basic claim is that mRNA vaccines had huge synergistic benefit with checkpoint blockade against lung cancer melanoma.
tl;dr it's glam-slop & everyone involved should be embarrassed
The basic claim is that mRNA vaccines had huge synergistic benefit with checkpoint blockade against lung cancer melanoma.
tl;dr it's glam-slop & everyone involved should be embarrassed
SARS-CoV-2 mRNA vaccines sensitize tumours to immune checkpoint blockade - Nature
mRNA vaccines targeting SARS-CoV-2 also sensitize tumours to immune checkpoint inhibitors.
www.nature.com
October 30, 2025 at 3:35 PM
I've been asked about this paper (www.nature.com/articles/s41...) enough times that I finally had to read it.
The basic claim is that mRNA vaccines had huge synergistic benefit with checkpoint blockade against lung cancer melanoma.
tl;dr it's glam-slop & everyone involved should be embarrassed
The basic claim is that mRNA vaccines had huge synergistic benefit with checkpoint blockade against lung cancer melanoma.
tl;dr it's glam-slop & everyone involved should be embarrassed
Hugely important paper for those with an interest in how mitochondrial genetic diversity develops. Bravo 👏
We're pleased our exciting paper 'Cryptic mitochondrial ageing coincides with mid-late life and is pathophysiologically informative in single cells across tissues and species' is now out in Nature Comms: www.nature.com/articles/s41...
March 7, 2025 at 11:57 AM
Hugely important paper for those with an interest in how mitochondrial genetic diversity develops. Bravo 👏
Reposted by Payam Gammage
Ya-Ting Chang, @nanigrotjahn.bsky.social et al. @scripps.edu present a membrane-guided approach for identifying a subset of cytoplasmic #ribosomes oriented for protein import on the surface of #mitochondria in budding yeast using #cryoET: rupress.org/jcb/article/...
March 6, 2025 at 6:26 PM
Ya-Ting Chang, @nanigrotjahn.bsky.social et al. @scripps.edu present a membrane-guided approach for identifying a subset of cytoplasmic #ribosomes oriented for protein import on the surface of #mitochondria in budding yeast using #cryoET: rupress.org/jcb/article/...
Reposted by Payam Gammage
If you are interested in mitochondria, Nashville is the place to be June 1-5. Check out this FASEB meeting. Please RT. events.faseb.org/event/mitoch...
Mechanisms of Mitochondrial DNA Mutation and Repair
events.faseb.org
March 5, 2025 at 2:32 PM
If you are interested in mitochondria, Nashville is the place to be June 1-5. Check out this FASEB meeting. Please RT. events.faseb.org/event/mitoch...
A fantastic lab and environment doing exciting science - check these guys out! 👍
We are hiring! After the publication of our last paper, our lab has openings for #postdoc fellows in projects looking at the interactions between tumor metabolism and immunology. Direct inquiries to pere_puigserver@dfci.harvard.edu. Please share! (1/2)
January 29, 2025 at 1:42 AM
A fantastic lab and environment doing exciting science - check these guys out! 👍
While this is an interesting piece - there are quite a few issues that have slipped through peer review here: e.g. controlling for heteroplasmy levels in their patient associations (the mutation calls for which are not properly provided in source data) ED Fig 9 @natureportfolio.bsky.social
It’s a big week for mtDNA @nature - tumours taking up mtDNA from the stroma is an increasingly established phenomenon (without much solid mechanism yet), but the backflow of mtDNA into immune cells is an intriguing observation. www.nature.com/articles/s41...
Immune evasion through mitochondrial transfer in the tumour microenvironment - Nature
Mitochondria with mutations in their DNA from cancer cells can be transferred to T cells in the tumour microenvironment, which leads to T cell dysfunction and impaired antitumour immunity.
www.nature.com
January 23, 2025 at 7:32 PM
While this is an interesting piece - there are quite a few issues that have slipped through peer review here: e.g. controlling for heteroplasmy levels in their patient associations (the mutation calls for which are not properly provided in source data) ED Fig 9 @natureportfolio.bsky.social
It’s a big week for mtDNA @nature - tumours taking up mtDNA from the stroma is an increasingly established phenomenon (without much solid mechanism yet), but the backflow of mtDNA into immune cells is an intriguing observation. www.nature.com/articles/s41...
Immune evasion through mitochondrial transfer in the tumour microenvironment - Nature
Mitochondria with mutations in their DNA from cancer cells can be transferred to T cells in the tumour microenvironment, which leads to T cell dysfunction and impaired antitumour immunity.
www.nature.com
January 23, 2025 at 2:12 PM
It’s a big week for mtDNA @nature - tumours taking up mtDNA from the stroma is an increasingly established phenomenon (without much solid mechanism yet), but the backflow of mtDNA into immune cells is an intriguing observation. www.nature.com/articles/s41...
Really cool work from @ppuigserverb.bsky.social lab! Further strengthening the emerging links between perturbed bioenergetics and effectiveness of immunotherapy 👌👍
New studies from our lab by Tevis Vitale and Jason Liang in @naturecancer.bsky.social Selective deficiency of complex I subunits causes tumor immunogenicity via T cell surveillance and Immune Checkpoint Blockade responsiveness Collaboration with Widlund, Gygi and Wucherpfennig labs rdcu.be/d6BgJ
January 17, 2025 at 4:27 PM
Really cool work from @ppuigserverb.bsky.social lab! Further strengthening the emerging links between perturbed bioenergetics and effectiveness of immunotherapy 👌👍
Reposted by Payam Gammage
Fine-tuning tumor immunogenicity with mitochondrial complex I
Our views on a very cool paper from @ppuigserverb.bsky.social
we hope you like it!
www.nature.com/articles/s43...
Our views on a very cool paper from @ppuigserverb.bsky.social
we hope you like it!
www.nature.com/articles/s43...
www.nature.com
January 17, 2025 at 3:43 PM
Fine-tuning tumor immunogenicity with mitochondrial complex I
Our views on a very cool paper from @ppuigserverb.bsky.social
we hope you like it!
www.nature.com/articles/s43...
Our views on a very cool paper from @ppuigserverb.bsky.social
we hope you like it!
www.nature.com/articles/s43...
Reposted by Payam Gammage
🆕Opportunity for a Computational Biologist/Bioinformatician to join @mito-oncogene.bsky.social leading on the interrogation and integration of multi-modal data arising from preclinical models and patients
📅Closing date: 7 February 2025
www.crukscotlandinstitute.ac.uk/careers/comp...
📅Closing date: 7 February 2025
www.crukscotlandinstitute.ac.uk/careers/comp...
January 17, 2025 at 10:23 AM
🆕Opportunity for a Computational Biologist/Bioinformatician to join @mito-oncogene.bsky.social leading on the interrogation and integration of multi-modal data arising from preclinical models and patients
📅Closing date: 7 February 2025
www.crukscotlandinstitute.ac.uk/careers/comp...
📅Closing date: 7 February 2025
www.crukscotlandinstitute.ac.uk/careers/comp...
Really cool work from @ryanlab.bsky.social !! A lot to chew over here 👌👌👌
1/🧵for our latest research now out as a preprint on #biorxiv, led by @EloiseMLMrqs 💫
**An inherited mtDNA mutation remodels inflammatory cytokine responses in macrophages and in vivo**
#mitochondria #immunometabolism #macrophages
📄Read here: www.biorxiv.org/content/10.1...
**An inherited mtDNA mutation remodels inflammatory cytokine responses in macrophages and in vivo**
#mitochondria #immunometabolism #macrophages
📄Read here: www.biorxiv.org/content/10.1...
An inherited mtDNA mutation remodels inflammatory cytokine responses in macrophages and in vivo
Impaired mitochondrial bioenergetics in macrophages can drive hyperinflammatory cytokine responses[1][1]–[6][2], but whether this may also be caused by inherited mtDNA mutations is unknown. Here, we a...
www.biorxiv.org
January 16, 2025 at 8:48 AM
Really cool work from @ryanlab.bsky.social !! A lot to chew over here 👌👌👌
Really pumped to see our paper on how mtDNA mutations modify tumour biology with @edreznik.bsky.social & colleagues highlighted by the US National Cancer Institute’s Division of Cancer Biology as one of their advances of 2024! If you’re interested do check it out 😊 www.cancer.gov/about-nci/or...
Research Advances in Cancer Biology
Research projects funded by the Division of Cancer Biology have led to many new discoveries and advances in basic cancer research that continue to lay the groundwork for future clinical breakthroughs ...
www.cancer.gov
January 14, 2025 at 5:56 PM
Really pumped to see our paper on how mtDNA mutations modify tumour biology with @edreznik.bsky.social & colleagues highlighted by the US National Cancer Institute’s Division of Cancer Biology as one of their advances of 2024! If you’re interested do check it out 😊 www.cancer.gov/about-nci/or...
Okey dokey here goes! First real post - please reshare if appropriate 🙏
🔔We’ve got two postdoc level positions opening in our lab! One wet lab, one computational🔔
We’re a scientifically diverse, friendly bunch working at the interface of mitochondrial biology, metabolism & cancer in Glasgow, UK.
🔔We’ve got two postdoc level positions opening in our lab! One wet lab, one computational🔔
We’re a scientifically diverse, friendly bunch working at the interface of mitochondrial biology, metabolism & cancer in Glasgow, UK.
January 7, 2025 at 5:13 PM
Okey dokey here goes! First real post - please reshare if appropriate 🙏
🔔We’ve got two postdoc level positions opening in our lab! One wet lab, one computational🔔
We’re a scientifically diverse, friendly bunch working at the interface of mitochondrial biology, metabolism & cancer in Glasgow, UK.
🔔We’ve got two postdoc level positions opening in our lab! One wet lab, one computational🔔
We’re a scientifically diverse, friendly bunch working at the interface of mitochondrial biology, metabolism & cancer in Glasgow, UK.
Hey #science people - new kid on the block, fresh from the other place, over here 👈
I mostly post papers on mitochondria, cancer and genome editing, with a side helping of dumb internet humour, UK political satire and occasional exasperation with #arsenalFC.
TLDR; science meets dad jokes 😎
I mostly post papers on mitochondria, cancer and genome editing, with a side helping of dumb internet humour, UK political satire and occasional exasperation with #arsenalFC.
TLDR; science meets dad jokes 😎
November 13, 2024 at 9:13 PM
Hey #science people - new kid on the block, fresh from the other place, over here 👈
I mostly post papers on mitochondria, cancer and genome editing, with a side helping of dumb internet humour, UK political satire and occasional exasperation with #arsenalFC.
TLDR; science meets dad jokes 😎
I mostly post papers on mitochondria, cancer and genome editing, with a side helping of dumb internet humour, UK political satire and occasional exasperation with #arsenalFC.
TLDR; science meets dad jokes 😎