Systems and Signals
@syssig.bsky.social
mtDNA, nets, noise, inference
https://profiles.imperial.ac.uk/nick.jones/about
https://profiles.imperial.ac.uk/nick.jones/about
Pinned
Systems and Signals
@syssig.bsky.social
· Nov 22
Systems and signals group in Imperial maths led by Nick Jones. Stay tuned for our latest research on #mitochondria #aging #genetics #biomathematics #physicalbiology #networks and #ML.
We blog at systems-signals.blogspot.com and there's more about us here profiles.imperial.ac.uk/nick.jones/a...
We blog at systems-signals.blogspot.com and there's more about us here profiles.imperial.ac.uk/nick.jones/a...
Reposted by Systems and Signals
How can mitophagy be an effective quality control mechanism if mtDNA mutations reach high enough levels to cause disease?
This question led us into a dark path, full of concepts of evolutionary genetics, germline stem cell biology and mito-nuclear compatibility.
www.science.org/doi/10.1126/...
This question led us into a dark path, full of concepts of evolutionary genetics, germline stem cell biology and mito-nuclear compatibility.
www.science.org/doi/10.1126/...
Ubiquitin-mediated mitophagy regulates the inheritance of mitochondrial DNA mutations
Mitochondrial synthesis of adenosine triphosphate is essential for eukaryotic life but is dependent on the cooperation of two genomes: nuclear and mitochondrial DNA (mtDNA). mtDNA mutates ~15 times as...
www.science.org
October 10, 2025 at 8:45 AM
How can mitophagy be an effective quality control mechanism if mtDNA mutations reach high enough levels to cause disease?
This question led us into a dark path, full of concepts of evolutionary genetics, germline stem cell biology and mito-nuclear compatibility.
www.science.org/doi/10.1126/...
This question led us into a dark path, full of concepts of evolutionary genetics, germline stem cell biology and mito-nuclear compatibility.
www.science.org/doi/10.1126/...
Reposted by Systems and Signals
Studying cancer evolution needs multi-region or single cell seq for phylogenetics, right? Amazingly (I think!) we found single-sample bulk methylation suffices, via analysis of "fluctuating methylation". In @nature.com today led by brilliant @calumgabbutt.bsky.social www.nature.com/articles/s41...
Fluctuating DNA methylation tracks cancer evolution at clinical scale - Nature
Cancer evolutionary dynamics are quantitatively inferred using a method, EVOFLUx, applied to fluctuating DNA methylation.
www.nature.com
September 10, 2025 at 3:21 PM
Studying cancer evolution needs multi-region or single cell seq for phylogenetics, right? Amazingly (I think!) we found single-sample bulk methylation suffices, via analysis of "fluctuating methylation". In @nature.com today led by brilliant @calumgabbutt.bsky.social www.nature.com/articles/s41...
Our paper 'Limits of message passing for node classification: How class-bottlenecks restrict signal-to-noise ratio' is now out as a preprint on Arxiv: arxiv.org/abs/2508.17822. 1/8
Limits of message passing for node classification: How class-bottlenecks restrict signal-to-noise ratio
Message passing neural networks (MPNNs) are powerful models for node classification but suffer from performance limitations under heterophily (low same-class connectivity) and structural bottlenecks i...
arxiv.org
August 29, 2025 at 3:04 PM
Our paper 'Limits of message passing for node classification: How class-bottlenecks restrict signal-to-noise ratio' is now out as a preprint on Arxiv: arxiv.org/abs/2508.17822. 1/8
Reposted by Systems and Signals
🚀 AI in Science Fellowships – Applications Now Open!
The I-X Centre for AI in Science is recruiting up to 19 fellows to join their prestigious programme and accelerate artificial intelligence research in Engineering, Natural and Mathematical Sciences.
1/5
The I-X Centre for AI in Science is recruiting up to 19 fellows to join their prestigious programme and accelerate artificial intelligence research in Engineering, Natural and Mathematical Sciences.
1/5
LinkedIn
This link will take you to a page that’s not on LinkedIn
lnkd.in
July 18, 2025 at 9:36 AM
🚀 AI in Science Fellowships – Applications Now Open!
The I-X Centre for AI in Science is recruiting up to 19 fellows to join their prestigious programme and accelerate artificial intelligence research in Engineering, Natural and Mathematical Sciences.
1/5
The I-X Centre for AI in Science is recruiting up to 19 fellows to join their prestigious programme and accelerate artificial intelligence research in Engineering, Natural and Mathematical Sciences.
1/5
Reposted by Systems and Signals
🚨 Opening in mid-July:
🔹 Up to 8x 2-year Independent Fellowships in AI in Science, supported by @schmidtsciences.bsky.social
🔹 Up to 2x 2-year Joint Fellowships with ICR & CNRS
🔹 Up to 3x 1-year Linked Fellowships at Imperial (followed by a 1 year linked fellowship at AIMS and NCBS).
2/2
🔹 Up to 8x 2-year Independent Fellowships in AI in Science, supported by @schmidtsciences.bsky.social
🔹 Up to 2x 2-year Joint Fellowships with ICR & CNRS
🔹 Up to 3x 1-year Linked Fellowships at Imperial (followed by a 1 year linked fellowship at AIMS and NCBS).
2/2
June 19, 2025 at 8:58 AM
🚨 Opening in mid-July:
🔹 Up to 8x 2-year Independent Fellowships in AI in Science, supported by @schmidtsciences.bsky.social
🔹 Up to 2x 2-year Joint Fellowships with ICR & CNRS
🔹 Up to 3x 1-year Linked Fellowships at Imperial (followed by a 1 year linked fellowship at AIMS and NCBS).
2/2
🔹 Up to 8x 2-year Independent Fellowships in AI in Science, supported by @schmidtsciences.bsky.social
🔹 Up to 2x 2-year Joint Fellowships with ICR & CNRS
🔹 Up to 3x 1-year Linked Fellowships at Imperial (followed by a 1 year linked fellowship at AIMS and NCBS).
2/2
Reposted by Systems and Signals
🚨 AI in Science Fellowship Opportunities 🚨
🔹Now open: Up to 6x 4-year Independent Fellowships dedicated to AI in Science in a program supported by Schmidt Sciences and Imperial College London [@imperialcollegeldn.bsky.social].
🔗 Find out more and apply: www.imperial.ac.uk/research-and...
1/2
🔹Now open: Up to 6x 4-year Independent Fellowships dedicated to AI in Science in a program supported by Schmidt Sciences and Imperial College London [@imperialcollegeldn.bsky.social].
🔗 Find out more and apply: www.imperial.ac.uk/research-and...
1/2
Imperial College Research Fellowships | Research | Imperial College London
www.imperial.ac.uk
June 19, 2025 at 8:58 AM
🚨 AI in Science Fellowship Opportunities 🚨
🔹Now open: Up to 6x 4-year Independent Fellowships dedicated to AI in Science in a program supported by Schmidt Sciences and Imperial College London [@imperialcollegeldn.bsky.social].
🔗 Find out more and apply: www.imperial.ac.uk/research-and...
1/2
🔹Now open: Up to 6x 4-year Independent Fellowships dedicated to AI in Science in a program supported by Schmidt Sciences and Imperial College London [@imperialcollegeldn.bsky.social].
🔗 Find out more and apply: www.imperial.ac.uk/research-and...
1/2
An approachable interview published today www.imperial.ac.uk/news/264393/... about this paper www.nature.com/articles/s41...
Cryptic mitochondrial DNA mutations reveal a hidden layer of the ageing process | Imperial News | Imperial College London
Single-cell analysis of over 120,000 cells reveals how mitochondrial DNA mutations accumulate with age and may affect ageing and neurodegeneration.
www.imperial.ac.uk
May 29, 2025 at 2:27 PM
An approachable interview published today www.imperial.ac.uk/news/264393/... about this paper www.nature.com/articles/s41...
We're pleased our exciting paper 'Cryptic mitochondrial ageing coincides with mid-late life and is pathophysiologically informative in single cells across tissues and species' is now out in Nature Comms: www.nature.com/articles/s41...
March 7, 2025 at 10:50 AM
We're pleased our exciting paper 'Cryptic mitochondrial ageing coincides with mid-late life and is pathophysiologically informative in single cells across tissues and species' is now out in Nature Comms: www.nature.com/articles/s41...
Merry Cristae! Thanks to Hetvi for the art: @vuisnotabot.bsky.social
December 12, 2024 at 7:21 PM
Merry Cristae! Thanks to Hetvi for the art: @vuisnotabot.bsky.social
Systems and signals group in Imperial maths led by Nick Jones. Stay tuned for our latest research on #mitochondria #aging #genetics #biomathematics #physicalbiology #networks and #ML.
We blog at systems-signals.blogspot.com and there's more about us here profiles.imperial.ac.uk/nick.jones/a...
We blog at systems-signals.blogspot.com and there's more about us here profiles.imperial.ac.uk/nick.jones/a...
November 22, 2024 at 12:20 PM
Systems and signals group in Imperial maths led by Nick Jones. Stay tuned for our latest research on #mitochondria #aging #genetics #biomathematics #physicalbiology #networks and #ML.
We blog at systems-signals.blogspot.com and there's more about us here profiles.imperial.ac.uk/nick.jones/a...
We blog at systems-signals.blogspot.com and there's more about us here profiles.imperial.ac.uk/nick.jones/a...