Mito@GU
@mito-at-gu.bsky.social
The Human Mitochondrial DNA Replication and Gene Expression Team at the University of Gothenburg
http://falkenberglab.org
http://gustafssonlab.org
http://falkenberglab.org
http://gustafssonlab.org
Pinned
Mito@GU
@mito-at-gu.bsky.social
· Apr 9
Small molecules restore mutant mitochondrial DNA polymerase activity - Nature
An activator of DNA polymerase γ restores function to disease-causing mutant variants and demonstrates a potential route to treatments for inherited mitochondrial disorders involving POLG mutations.
www.nature.com
New paper out from the Falkenberg and Gustafsson labs. Thanks to Pretzel for a successful collaboration.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Another great mitoretreat with the @nils-goranlarsson.bsky.social group!
October 1, 2025 at 7:54 AM
Another great mitoretreat with the @nils-goranlarsson.bsky.social group!
Reposted by Mito@GU
The future is visiting again! We are seeking applicants for the 7th season of MITOchats. Deadline for submission is October 17th. Visit www.mitotalks.org for details or submit your application at forms.gle/5D6vWE92yYCi...
September 25, 2025 at 9:59 PM
The future is visiting again! We are seeking applicants for the 7th season of MITOchats. Deadline for submission is October 17th. Visit www.mitotalks.org for details or submit your application at forms.gle/5D6vWE92yYCi...
Reposted by Mito@GU
🎉 You asked for it… and here it is! The Euromit 2026 website is officially live!
Take advantage of the preferential rate today thanks to EARLY-BIRD Registration
👉 www.euromit2026.eu
#MitochondrialDisease #mtDNA #mitochondria #euromit2026
@ua-recherche.bsky.social
Take advantage of the preferential rate today thanks to EARLY-BIRD Registration
👉 www.euromit2026.eu
#MitochondrialDisease #mtDNA #mitochondria #euromit2026
@ua-recherche.bsky.social
September 18, 2025 at 2:57 PM
🎉 You asked for it… and here it is! The Euromit 2026 website is officially live!
Take advantage of the preferential rate today thanks to EARLY-BIRD Registration
👉 www.euromit2026.eu
#MitochondrialDisease #mtDNA #mitochondria #euromit2026
@ua-recherche.bsky.social
Take advantage of the preferential rate today thanks to EARLY-BIRD Registration
👉 www.euromit2026.eu
#MitochondrialDisease #mtDNA #mitochondria #euromit2026
@ua-recherche.bsky.social
Reposted by Mito@GU
Don't forget to register and submit your abstract for our #MitoCellFate conference in Malta next year ☀️
📢Check out our wonderful speaker line-up so far!
📅Early-bird & talk deadline: 10 Nov 2025
bit.ly/46xBYVt
#FusionStemCells #FusionAgingResearch
📢Check out our wonderful speaker line-up so far!
📅Early-bird & talk deadline: 10 Nov 2025
bit.ly/46xBYVt
#FusionStemCells #FusionAgingResearch
September 11, 2025 at 9:40 AM
Don't forget to register and submit your abstract for our #MitoCellFate conference in Malta next year ☀️
📢Check out our wonderful speaker line-up so far!
📅Early-bird & talk deadline: 10 Nov 2025
bit.ly/46xBYVt
#FusionStemCells #FusionAgingResearch
📢Check out our wonderful speaker line-up so far!
📅Early-bird & talk deadline: 10 Nov 2025
bit.ly/46xBYVt
#FusionStemCells #FusionAgingResearch
Reposted by Mito@GU
On Thursday 3 July we are hosting a webinar with @focalplane.bsky.social & @mitotalks.bsky.social to celebrate our recent special issue on the cell biology of #mitochondria, featuring talks from Yuli Buckley, Mireia Nager and Dikaia Tsagkari.
To register: focalplane.biologists.com/2025/06/09/m...
To register: focalplane.biologists.com/2025/06/09/m...
June 23, 2025 at 12:59 PM
On Thursday 3 July we are hosting a webinar with @focalplane.bsky.social & @mitotalks.bsky.social to celebrate our recent special issue on the cell biology of #mitochondria, featuring talks from Yuli Buckley, Mireia Nager and Dikaia Tsagkari.
To register: focalplane.biologists.com/2025/06/09/m...
To register: focalplane.biologists.com/2025/06/09/m...
Reposted by Mito@GU
#Postdoc – #ExcellenceByChoice programme!
Our lab & the Kohler Mito lab are seeking researchers to study specialized mitoribosomes under stress & ageing.
Apply by Aug 17
👉https://www.vkohler-lab.com/join-our-team
#ExcellenceByChoice #Mitochondria #Ageing #Proteostasis
Our lab & the Kohler Mito lab are seeking researchers to study specialized mitoribosomes under stress & ageing.
Apply by Aug 17
👉https://www.vkohler-lab.com/join-our-team
#ExcellenceByChoice #Mitochondria #Ageing #Proteostasis
June 23, 2025 at 8:04 PM
Reposted by Mito@GU
Our newest paper on mitochondrial Topoisomerase 1 shows that Top1mt has only weak endoribonuclease activity and it therefore does not often generate deletions at incorporated ribonucleotides. This helps explain why ribonucleotides are tolerated in mtDNA. Read more:
academic.oup.com/nar/article-...
academic.oup.com/nar/article-...
The low endoribonuclease activity and lack of rNMP preference of human mitochondrial topoisomerase 1 protect against ribonucleotide-dependent deletions
Abstract. The incorporation of ribonucleotides (rNMPs) into the nuclear genome leads to severe genomic instability, including strand breaks and short 2–5 b
academic.oup.com
June 8, 2025 at 11:31 AM
Our newest paper on mitochondrial Topoisomerase 1 shows that Top1mt has only weak endoribonuclease activity and it therefore does not often generate deletions at incorporated ribonucleotides. This helps explain why ribonucleotides are tolerated in mtDNA. Read more:
academic.oup.com/nar/article-...
academic.oup.com/nar/article-...
Reposted by Mito@GU
Scientific American has a new (open) article by Columbia’s Martin Picard, comparing mitochondria to microprocessors.
It follows landmark pieces from July 1957 (“Powerhouse of the Cell”) and Aug 1997 (Wallace on mtDNA in aging & disease).
Read our summary:
mitoworld.org/mitochondria...
It follows landmark pieces from July 1957 (“Powerhouse of the Cell”) and Aug 1997 (Wallace on mtDNA in aging & disease).
Read our summary:
mitoworld.org/mitochondria...
Mitochondria Are More Than Powerhouses — They’re the Motherboard of the Cell - MitoWorld
Columbia University mitochondria researcher Martin Picard’s life changed in 2014 when he peered through a microscope in Douglas Wallace’s lab at the Children’s Hospital Philadelphia. He saw something ...
mitoworld.org
May 26, 2025 at 11:21 AM
Scientific American has a new (open) article by Columbia’s Martin Picard, comparing mitochondria to microprocessors.
It follows landmark pieces from July 1957 (“Powerhouse of the Cell”) and Aug 1997 (Wallace on mtDNA in aging & disease).
Read our summary:
mitoworld.org/mitochondria...
It follows landmark pieces from July 1957 (“Powerhouse of the Cell”) and Aug 1997 (Wallace on mtDNA in aging & disease).
Read our summary:
mitoworld.org/mitochondria...
Reposted by Mito@GU
A must-read for anyone in mitochondria research!
Journal of Cell Science has released a Special Issue on the Cell Biology of Mitochondria - articles, reviews, and expert insights covering dynamics, disease, and more!
View our summary mitoworld.org/special-issu...
Journal of Cell Science has released a Special Issue on the Cell Biology of Mitochondria - articles, reviews, and expert insights covering dynamics, disease, and more!
View our summary mitoworld.org/special-issu...
Special Issue: Cell Biology of Mitochondria - MitoWorld
The special issue of Journal of Cell Science (JCS) on the “Cell Biology of Mitochondria” looks to be one of the most comprehensive open series of papers, opinions, perspectives, interviews, reviews an...
mitoworld.org
May 26, 2025 at 11:31 AM
A must-read for anyone in mitochondria research!
Journal of Cell Science has released a Special Issue on the Cell Biology of Mitochondria - articles, reviews, and expert insights covering dynamics, disease, and more!
View our summary mitoworld.org/special-issu...
Journal of Cell Science has released a Special Issue on the Cell Biology of Mitochondria - articles, reviews, and expert insights covering dynamics, disease, and more!
View our summary mitoworld.org/special-issu...
Reposted by Mito@GU
Researchers in Science have developed a tool to silence specific mitochondria-encoded mRNAs in living cells, which could help scientists understand the origins of certain mitochondria-related diseases. scim.ag/3F6Wm5d
Silencing mitochondrial gene expression in living cells
Mitochondria fulfill central functions in metabolism and energy supply. They express their own genome, which encodes key subunits of the oxidative phosphorylation system. However, central mechanisms u...
scim.ag
May 23, 2025 at 7:23 PM
Researchers in Science have developed a tool to silence specific mitochondria-encoded mRNAs in living cells, which could help scientists understand the origins of certain mitochondria-related diseases. scim.ag/3F6Wm5d
Reposted by Mito@GU
If you are interested in mito-nuclear communication and organelle crosstalk, stress responses, and inflammatory signaling, the #IOSCD25 Fusion Conference is for you!
Short talk and early-bird deadline is June 2nd. Travel awards available.
Check it out: www.fusion-conferences.com/conference/182
Short talk and early-bird deadline is June 2nd. Travel awards available.
Check it out: www.fusion-conferences.com/conference/182
May 10, 2025 at 9:15 PM
If you are interested in mito-nuclear communication and organelle crosstalk, stress responses, and inflammatory signaling, the #IOSCD25 Fusion Conference is for you!
Short talk and early-bird deadline is June 2nd. Travel awards available.
Check it out: www.fusion-conferences.com/conference/182
Short talk and early-bird deadline is June 2nd. Travel awards available.
Check it out: www.fusion-conferences.com/conference/182
Reposted by Mito@GU
Only just over a week left to apply for a postdoc position in our lab - if you are passionate about mtDNA maintenance and biochemistry or signaling, here is your chance!
Hello fellow mitochondriacs! Are you passionate about mtDNA? We now offer a 2-year postdoc opportunity for studies of mtDNA instability and its signaling. Apply by May 18th to join our international team in exotic Umeå. Please share!
www.umu.se/en/work-with...
www.umu.se/en/work-with...
Postdoctoral fellowship (2 years) to study mitochondrial DNA stability
www.umu.se
May 9, 2025 at 4:57 PM
Only just over a week left to apply for a postdoc position in our lab - if you are passionate about mtDNA maintenance and biochemistry or signaling, here is your chance!
Reposted by Mito@GU
Join experts at Mitochondrial Medicine 2025! #MitoMed25
Strengthen your understanding of disease mechanisms, and explore the latest research shaping the future of therapeutic development. #Mitochondria
Leaders will discuss lessons learned from clinical trials.💊
📎 Find out more: bit.ly/4lm1W3L
Strengthen your understanding of disease mechanisms, and explore the latest research shaping the future of therapeutic development. #Mitochondria
Leaders will discuss lessons learned from clinical trials.💊
📎 Find out more: bit.ly/4lm1W3L
May 6, 2025 at 7:00 AM
Join experts at Mitochondrial Medicine 2025! #MitoMed25
Strengthen your understanding of disease mechanisms, and explore the latest research shaping the future of therapeutic development. #Mitochondria
Leaders will discuss lessons learned from clinical trials.💊
📎 Find out more: bit.ly/4lm1W3L
Strengthen your understanding of disease mechanisms, and explore the latest research shaping the future of therapeutic development. #Mitochondria
Leaders will discuss lessons learned from clinical trials.💊
📎 Find out more: bit.ly/4lm1W3L
Reposted by Mito@GU
I'm thrilled to share that our story is now out in Science Advances! 🎉 We use quantitative imaging to map the mito central dogma, define translation hubs in the mitochondrial matrix, and show that they're replaced by Mitochondrial Stress Bodies (MSB) when mtRNA processing is perturbed 1/4
Spatial analysis of mitochondrial gene expression reveals dynamic translation hubs and remodeling in stress | Science Advances www.science.org/doi/10.1126/...
Spatial analysis of mitochondrial gene expression reveals dynamic translation hubs and remodeling in stress
Quantitative imaging of the mitochondrial central dogma identifies translation hubs that are suppressed during stress.
www.science.org
April 18, 2025 at 10:56 PM
I'm thrilled to share that our story is now out in Science Advances! 🎉 We use quantitative imaging to map the mito central dogma, define translation hubs in the mitochondrial matrix, and show that they're replaced by Mitochondrial Stress Bodies (MSB) when mtRNA processing is perturbed 1/4
Reposted by Mito@GU
Mitochondria – the CEO of the cell
journals.biologists.com/jcs/article-...
journals.biologists.com/jcs/article-...
Mitochondria – the CEO of the cell
Summary: In light of research advances recognizing the roles mitochondria play in directing cellular processes and behaviors, we propose reframing mitochondria as the chief executive organelle of the ...
journals.biologists.com
May 4, 2025 at 8:01 PM
Mitochondria – the CEO of the cell
journals.biologists.com/jcs/article-...
journals.biologists.com/jcs/article-...
Reposted by Mito@GU
Last chance to join us for the Meeting on Mechanisms of Mitochondrial DNA Mutation and Repair, June 1 - 5, 2025 | Nashville, Tennessee @faseborg.bsky.social
Last call for genetics scientists to save $150 at #MDNASRC 2025 with a can't-miss keynote presentation from Thomas Langer from @mpiage.bsky.social ... Save your seat by May 12: buff.ly/A12895w
May 6, 2025 at 3:24 PM
Last chance to join us for the Meeting on Mechanisms of Mitochondrial DNA Mutation and Repair, June 1 - 5, 2025 | Nashville, Tennessee @faseborg.bsky.social
Reposted by Mito@GU
Our latest special issue is ‘Cell Biology of Mitochondria’. Over the next few weeks, we’ll be highlighting all the articles from this issue, which was guest edited by Ana Garcia-Saez and Heidi McBride @mitodynamics.bsky.social. Keep an eye on the hashtag #JCSMitoSI.
May 6, 2025 at 9:40 AM
Our latest special issue is ‘Cell Biology of Mitochondria’. Over the next few weeks, we’ll be highlighting all the articles from this issue, which was guest edited by Ana Garcia-Saez and Heidi McBride @mitodynamics.bsky.social. Keep an eye on the hashtag #JCSMitoSI.
Reposted by Mito@GU
I'm thrilled to be co-organizing the very first EMBO Workshop bridging mitochondria and brain research - a powerhouse of science, ideas, and amazing speakers! 🧠🔬
📅 registration closes MAY 30th, so don’t wait to snag your spot!
Stay tuned - more updates about the topics and speakers coming soon! 🎙️
📅 registration closes MAY 30th, so don’t wait to snag your spot!
Stay tuned - more updates about the topics and speakers coming soon! 🎙️
📢Registration open!📢
So proud to see our very own Elisa Motori co-hosting this exciting EMBO Workshop: “Mitochondria in the Nervous System”
Co-sponsored by the CRC1218! Two invited speakers of the CRC1218! Don’t miss out!
🗓 29.09.-02.10.2025
📍Engelberg, CH
👉 meetings.embo.org/event/25-mit...
So proud to see our very own Elisa Motori co-hosting this exciting EMBO Workshop: “Mitochondria in the Nervous System”
Co-sponsored by the CRC1218! Two invited speakers of the CRC1218! Don’t miss out!
🗓 29.09.-02.10.2025
📍Engelberg, CH
👉 meetings.embo.org/event/25-mit...
May 5, 2025 at 2:37 PM
I'm thrilled to be co-organizing the very first EMBO Workshop bridging mitochondria and brain research - a powerhouse of science, ideas, and amazing speakers! 🧠🔬
📅 registration closes MAY 30th, so don’t wait to snag your spot!
Stay tuned - more updates about the topics and speakers coming soon! 🎙️
📅 registration closes MAY 30th, so don’t wait to snag your spot!
Stay tuned - more updates about the topics and speakers coming soon! 🎙️
Reposted by Mito@GU
The brain’s energy landscape as a potential window into brain health
www.nature.com/articles/d41...
(study led by Martin Picard and Michel Thiebaut de Schotten)
www.nature.com/articles/d41...
(study led by Martin Picard and Michel Thiebaut de Schotten)
First map of human brain mitochondria is ‘groundbreaking’ achievement
Hundreds of cubes of human brain tissue help scientists to chart the energy-making capabilities of various brain regions.
www.nature.com
March 27, 2025 at 9:08 AM
The brain’s energy landscape as a potential window into brain health
www.nature.com/articles/d41...
(study led by Martin Picard and Michel Thiebaut de Schotten)
www.nature.com/articles/d41...
(study led by Martin Picard and Michel Thiebaut de Schotten)
Reposted by Mito@GU
🚨 #Postdoc Opportunity! 🚨
The @vkohler-lab.bsky.social @umeauniversitet.bsky.social
is hiring! Join a dynamic team tackling #proteostasis in #ageing, with outstanding mentorship from
@verenakohler.bsky.social - a PI deeply committed to your career development and scientific growth.
Apply now!
The @vkohler-lab.bsky.social @umeauniversitet.bsky.social
is hiring! Join a dynamic team tackling #proteostasis in #ageing, with outstanding mentorship from
@verenakohler.bsky.social - a PI deeply committed to your career development and scientific growth.
Apply now!
🗓️ Apply by May 30, 2025 | Start: Early Autumn 2025
📄 Full details & apply: www.vkohler-lab.com/join-our-team
📄 Full details & apply: www.vkohler-lab.com/join-our-team
Join our Team — Kohler Proteostasis Lab
www.vkohler-lab.com
April 28, 2025 at 9:57 AM
🚨 #Postdoc Opportunity! 🚨
The @vkohler-lab.bsky.social @umeauniversitet.bsky.social
is hiring! Join a dynamic team tackling #proteostasis in #ageing, with outstanding mentorship from
@verenakohler.bsky.social - a PI deeply committed to your career development and scientific growth.
Apply now!
The @vkohler-lab.bsky.social @umeauniversitet.bsky.social
is hiring! Join a dynamic team tackling #proteostasis in #ageing, with outstanding mentorship from
@verenakohler.bsky.social - a PI deeply committed to your career development and scientific growth.
Apply now!
Reposted by Mito@GU
🚨 Join us for the @faseborg.bsky.social
Meeting on Mechanisms of Mitochondrial DNA Mutation and Repair, June 1 - 5, 2025 | Nashville, Tennessee. 📅 Abstract submission & Early Registration close on April 20, 2025! Don't miss out: events.faseb.org/event/mitoch... Please re-post!
Meeting on Mechanisms of Mitochondrial DNA Mutation and Repair, June 1 - 5, 2025 | Nashville, Tennessee. 📅 Abstract submission & Early Registration close on April 20, 2025! Don't miss out: events.faseb.org/event/mitoch... Please re-post!
April 12, 2025 at 1:42 PM
🚨 Join us for the @faseborg.bsky.social
Meeting on Mechanisms of Mitochondrial DNA Mutation and Repair, June 1 - 5, 2025 | Nashville, Tennessee. 📅 Abstract submission & Early Registration close on April 20, 2025! Don't miss out: events.faseb.org/event/mitoch... Please re-post!
Meeting on Mechanisms of Mitochondrial DNA Mutation and Repair, June 1 - 5, 2025 | Nashville, Tennessee. 📅 Abstract submission & Early Registration close on April 20, 2025! Don't miss out: events.faseb.org/event/mitoch... Please re-post!
Reposted by Mito@GU
Swiss Federal Institute of Technology Lausanne (CH): Postdoctoral Position in Human Metabolism, Mitochondria & Behavior (1509) leibniz-psychology.org/produkte/job... #Stellenangebot
Lausanne (CH): Postdoctoral Position (1509)
Swiss Federal Institute of Technology: Postdoctoral Position in Human Metabolism, Mitochondria & Behavior (1509)
leibniz-psychology.org
April 22, 2025 at 10:21 AM
Swiss Federal Institute of Technology Lausanne (CH): Postdoctoral Position in Human Metabolism, Mitochondria & Behavior (1509) leibniz-psychology.org/produkte/job... #Stellenangebot
Reposted by Mito@GU
Nature reports on how researchers are studying why mitochondria are moving between cells and whether the process can be harnessed to treat cancer and other diseases. 🧪
Cells are swapping their mitochondria. What does this mean for our health?
Researchers are studying why the energy factories are moving between cells and whether the process can be harnessed to treat cancer and other diseases.
go.nature.com
April 21, 2025 at 1:01 AM
Nature reports on how researchers are studying why mitochondria are moving between cells and whether the process can be harnessed to treat cancer and other diseases. 🧪
Reposted by Mito@GU
New research from our lab on mitochondrial DNA stability
RRM2B is essential for making dNTPs in non-dividing cells and its loss causes mt DNA depletion syndromes.
Surprisingly, we found that RRM2B deficiency leads to a drop in dATP and dGTP.
www.pnas.org/doi/10.1073/...
RRM2B is essential for making dNTPs in non-dividing cells and its loss causes mt DNA depletion syndromes.
Surprisingly, we found that RRM2B deficiency leads to a drop in dATP and dGTP.
www.pnas.org/doi/10.1073/...
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
www.pnas.org
April 21, 2025 at 12:17 PM
New research from our lab on mitochondrial DNA stability
RRM2B is essential for making dNTPs in non-dividing cells and its loss causes mt DNA depletion syndromes.
Surprisingly, we found that RRM2B deficiency leads to a drop in dATP and dGTP.
www.pnas.org/doi/10.1073/...
RRM2B is essential for making dNTPs in non-dividing cells and its loss causes mt DNA depletion syndromes.
Surprisingly, we found that RRM2B deficiency leads to a drop in dATP and dGTP.
www.pnas.org/doi/10.1073/...
New paper out from the Falkenberg and Gustafsson labs. Thanks to Pretzel for a successful collaboration.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Small molecules restore mutant mitochondrial DNA polymerase activity - Nature
An activator of DNA polymerase γ restores function to disease-causing mutant variants and demonstrates a potential route to treatments for inherited mitochondrial disorders involving POLG mutations.
www.nature.com
April 9, 2025 at 4:30 PM
New paper out from the Falkenberg and Gustafsson labs. Thanks to Pretzel for a successful collaboration.
www.nature.com/articles/s41...
www.nature.com/articles/s41...