CRC1218
@crc1218.bsky.social
The #CRC1218 tackles the challenge of understanding how #mitochondria communicate with the rest of the #cell to regulate fundamental processes. Funded by #dfg
https://sfb1218.uni-koeln.de/
https://sfb1218.uni-koeln.de/
A publication rarity these days: An author list significantly shorter than the paper title!
www.nature.com/articles/s41...
Congratulations to our Advanced PostDoc Grant Awardee, Qiaochu Li (@qiaochuli.bsky.social), for her discoveries published in NCB [see thread]:
www.nature.com/articles/s41...
Congratulations to our Advanced PostDoc Grant Awardee, Qiaochu Li (@qiaochuli.bsky.social), for her discoveries published in NCB [see thread]:
Leucine inhibits degradation of outer mitochondrial membrane proteins to adapt mitochondrial respiration - Nature Cell Biology
Li et al. uncover a connection between metabolic cues and mitochondrial protein degradation, showing that specifically leucine stabilizes outer mitochondrial membrane proteins by inhibiting ubiquityla...
www.nature.com
November 14, 2025 at 7:58 AM
A publication rarity these days: An author list significantly shorter than the paper title!
www.nature.com/articles/s41...
Congratulations to our Advanced PostDoc Grant Awardee, Qiaochu Li (@qiaochuli.bsky.social), for her discoveries published in NCB [see thread]:
www.nature.com/articles/s41...
Congratulations to our Advanced PostDoc Grant Awardee, Qiaochu Li (@qiaochuli.bsky.social), for her discoveries published in NCB [see thread]:
Congratulation also to the @riemerlab.bsky.social who just identified FAM136A as a new substrate of the mitochondrial disulphide relay and its implementations in IMS proteostasis and cellular fitness.
Check it out: www.sciencedirect.com/science/arti...
Check it out: www.sciencedirect.com/science/arti...
The mitochondrial disulphide relay substrate FAM136A safeguards IMS proteostasis and cellular fitness
The mitochondrial disulphide relay is the key machinery for import and oxidative protein folding in the mitochondrial intermembrane space. Among IMS p…
www.sciencedirect.com
November 4, 2025 at 2:29 PM
Congratulation also to the @riemerlab.bsky.social who just identified FAM136A as a new substrate of the mitochondrial disulphide relay and its implementations in IMS proteostasis and cellular fitness.
Check it out: www.sciencedirect.com/science/arti...
Check it out: www.sciencedirect.com/science/arti...
👉Paper alert👈
Check out the latest read from the Schwarz lab: Fu and Kohl identify persulfidation loss and hydrogen sulfide release as consequence of full-body SOX-deficiency in mice. Congratulations to everybody involved!👏
www.jci.org/articles/vie...
Check out the latest read from the Schwarz lab: Fu and Kohl identify persulfidation loss and hydrogen sulfide release as consequence of full-body SOX-deficiency in mice. Congratulations to everybody involved!👏
www.jci.org/articles/vie...
JCI -
Sulfite oxidase deficiency causes persulfidation loss and hydrogen sulfide release
www.jci.org
November 4, 2025 at 2:14 PM
👉Paper alert👈
Check out the latest read from the Schwarz lab: Fu and Kohl identify persulfidation loss and hydrogen sulfide release as consequence of full-body SOX-deficiency in mice. Congratulations to everybody involved!👏
www.jci.org/articles/vie...
Check out the latest read from the Schwarz lab: Fu and Kohl identify persulfidation loss and hydrogen sulfide release as consequence of full-body SOX-deficiency in mice. Congratulations to everybody involved!👏
www.jci.org/articles/vie...
📣Publication alert📣
A wonderful collaborative effort of the CRC 1218:
The lab of Mafalda Escobar-Henriques reveals that C-terminally extended ubiquitin (CxUb) is essential for mitophagy, proteostasis and longevity through a previously undefined CxUb-Ufd2 axis.
www.sciencedirect.com/science/arti...
A wonderful collaborative effort of the CRC 1218:
The lab of Mafalda Escobar-Henriques reveals that C-terminally extended ubiquitin (CxUb) is essential for mitophagy, proteostasis and longevity through a previously undefined CxUb-Ufd2 axis.
www.sciencedirect.com/science/arti...
Ubiquitin precursor with C-terminal extension promotes proteostasis and longevity
Ubiquitin is a conserved modifier regulating the stability and function of numerous target proteins. In all eukaryotes, polyubiquitin precursors are g…
www.sciencedirect.com
November 4, 2025 at 2:12 PM
📣Publication alert📣
A wonderful collaborative effort of the CRC 1218:
The lab of Mafalda Escobar-Henriques reveals that C-terminally extended ubiquitin (CxUb) is essential for mitophagy, proteostasis and longevity through a previously undefined CxUb-Ufd2 axis.
www.sciencedirect.com/science/arti...
A wonderful collaborative effort of the CRC 1218:
The lab of Mafalda Escobar-Henriques reveals that C-terminally extended ubiquitin (CxUb) is essential for mitophagy, proteostasis and longevity through a previously undefined CxUb-Ufd2 axis.
www.sciencedirect.com/science/arti...
A big thank you to Thomas Splettstößer for leading an insightful Adobe Illustrator workshop on visual communication in science for our PhDs & PostDocs! We’re excited to apply what we’ve learned! 🙌
#AdobeIllustrator #VisualCommunication #Science #WorkshopSuccess
#AdobeIllustrator #VisualCommunication #Science #WorkshopSuccess
September 3, 2025 at 9:33 AM
A big thank you to Thomas Splettstößer for leading an insightful Adobe Illustrator workshop on visual communication in science for our PhDs & PostDocs! We’re excited to apply what we’ve learned! 🙌
#AdobeIllustrator #VisualCommunication #Science #WorkshopSuccess
#AdobeIllustrator #VisualCommunication #Science #WorkshopSuccess
Publication alert! Congratulations to everybody involved in this collaborative effort👏
Congratulations to Harshita and the rest of the Trifunovic lab for this exciting piece of work: www.nature.com/articles/s42...
2-hydroxyglutarate mediates whitening of brown adipocytes coupled to nuclear softening upon mitochondrial dysfunction - Nature Metabolism
CLPP-deficiency-driven mitochondrial dysfunction in brown adipose tissue leads to the accumulation of d-2-hydroxyglutarate, in turn promoting lipid-droplet enlargement by altering gene expression and ...
www.nature.com
August 11, 2025 at 9:08 AM
Publication alert! Congratulations to everybody involved in this collaborative effort👏
🌟 What an incredible event! Amazing location & fantastic science. 🌟
Our Graduation Symposium PhDone last Friday was a great success!
Huge thanks to our speakers for their insightful and emotional presentations, and to everyone for the valuable networking.
#ECR #mitoCRC #PhDone
Our Graduation Symposium PhDone last Friday was a great success!
Huge thanks to our speakers for their insightful and emotional presentations, and to everyone for the valuable networking.
#ECR #mitoCRC #PhDone
August 4, 2025 at 12:44 PM
What an exciting step in the careers of Camilla Franchino, Deniz Savcigil and Sandrina Campos Macas, who just joined our Mentoring Program! Promoting career advancement and professional development through impactful networking. We wish you a successful journey!👩🔬🚀
#CareerDevelopment #WomenEmpowerment
#CareerDevelopment #WomenEmpowerment
July 24, 2025 at 7:17 AM
What an exciting step in the careers of Camilla Franchino, Deniz Savcigil and Sandrina Campos Macas, who just joined our Mentoring Program! Promoting career advancement and professional development through impactful networking. We wish you a successful journey!👩🔬🚀
#CareerDevelopment #WomenEmpowerment
#CareerDevelopment #WomenEmpowerment
🚴 This. was. great! 🚴♀️
In this year‘s #CityCycling, the #mitoCRC made it into the #Top10 of the Uniclinis, which was the best team in all of Cologne! Well done! We are really impressed by all the #sustainability enthusiasts around us!
Photo: Our youngest team member😍
#Stadtradeln #Köln #Klimaschutz
In this year‘s #CityCycling, the #mitoCRC made it into the #Top10 of the Uniclinis, which was the best team in all of Cologne! Well done! We are really impressed by all the #sustainability enthusiasts around us!
Photo: Our youngest team member😍
#Stadtradeln #Köln #Klimaschutz
July 3, 2025 at 1:45 PM
🚴 This. was. great! 🚴♀️
In this year‘s #CityCycling, the #mitoCRC made it into the #Top10 of the Uniclinis, which was the best team in all of Cologne! Well done! We are really impressed by all the #sustainability enthusiasts around us!
Photo: Our youngest team member😍
#Stadtradeln #Köln #Klimaschutz
In this year‘s #CityCycling, the #mitoCRC made it into the #Top10 of the Uniclinis, which was the best team in all of Cologne! Well done! We are really impressed by all the #sustainability enthusiasts around us!
Photo: Our youngest team member😍
#Stadtradeln #Köln #Klimaschutz
What an outstanding achievement by our #mitoRTG member Annamaria Regina, (@annamariaregina.bsky.social)! We are extremely proud of your #passion and engagement in #ScienceCommunication!
#FameLab
#FameLab
Took part in the FameLab germany final✨ 1,000 people, great vibes! Thanks to all, and good luck to the winners Naomi & Artem at the international stage! 🌍🎤 #FameLab #ScienceCommunication
June 30, 2025 at 7:31 AM
What an outstanding achievement by our #mitoRTG member Annamaria Regina, (@annamariaregina.bsky.social)! We are extremely proud of your #passion and engagement in #ScienceCommunication!
#FameLab
#FameLab
📣Lecture Announcement📣
Join us: Next Monday, the CRC 1218 and the CRC 1403, will host an interactive lecture on #ResearchDataManagement - "Folders and File Names 101: Because organising data can be hard".
Don't miss it:
🗓️ 23.06. at 10 AM
📍CECAD Lecture Hall
@sfb1403.bsky.social #datascience
Join us: Next Monday, the CRC 1218 and the CRC 1403, will host an interactive lecture on #ResearchDataManagement - "Folders and File Names 101: Because organising data can be hard".
Don't miss it:
🗓️ 23.06. at 10 AM
📍CECAD Lecture Hall
@sfb1403.bsky.social #datascience
June 17, 2025 at 12:57 PM
📣Lecture Announcement📣
Join us: Next Monday, the CRC 1218 and the CRC 1403, will host an interactive lecture on #ResearchDataManagement - "Folders and File Names 101: Because organising data can be hard".
Don't miss it:
🗓️ 23.06. at 10 AM
📍CECAD Lecture Hall
@sfb1403.bsky.social #datascience
Join us: Next Monday, the CRC 1218 and the CRC 1403, will host an interactive lecture on #ResearchDataManagement - "Folders and File Names 101: Because organising data can be hard".
Don't miss it:
🗓️ 23.06. at 10 AM
📍CECAD Lecture Hall
@sfb1403.bsky.social #datascience
🏆We are extremely proud of our Vice Spokesperson Prof. Aleksandra Trifunovic who just received the Max Delbrück Award 2025 of @unicologne.bsky.social. A well-deserved recognition of her outstanding scientific achievements. Congrats!🎉
▶️ youtu.be/ayE9q9nKvyc
#mitochondria #lifescience #UniKöln
▶️ youtu.be/ayE9q9nKvyc
#mitochondria #lifescience #UniKöln
Prof. Dr. Aleksandra Trifunovic // Max Delbrück-Preis 2025
YouTube video by UniversitaetzuKoeln
youtu.be
May 19, 2025 at 9:47 AM
🏆We are extremely proud of our Vice Spokesperson Prof. Aleksandra Trifunovic who just received the Max Delbrück Award 2025 of @unicologne.bsky.social. A well-deserved recognition of her outstanding scientific achievements. Congrats!🎉
▶️ youtu.be/ayE9q9nKvyc
#mitochondria #lifescience #UniKöln
▶️ youtu.be/ayE9q9nKvyc
#mitochondria #lifescience #UniKöln
Congratulations to our mitoCRC project leader Prof. Jens Brüning on receiving the University Award 2024 in the category of Research of @unicologne.bsky.social in recognition of his exceptional scientific achievements!
🎉 Herzlichen Glückwunsch an Prof. Dr. Jens C. Brüning für den diesjährigen #Universitätspreis Forschung. 🏆
🧠 Er hat herausgefunden, wie das #Gehirn den Energiehaushalt und den Appetit reguliert, besonders bei #Übergewicht und #Diabetes.
Mehr dazu ▶️ youtu.be/isnxCcTMBBA
@cecad.bsky.social
🧠 Er hat herausgefunden, wie das #Gehirn den Energiehaushalt und den Appetit reguliert, besonders bei #Übergewicht und #Diabetes.
Mehr dazu ▶️ youtu.be/isnxCcTMBBA
@cecad.bsky.social
Universitätspreis 2024 - Forschung
YouTube video by UniversitaetzuKoeln
youtu.be
May 19, 2025 at 9:14 AM
Congratulations to our mitoCRC project leader Prof. Jens Brüning on receiving the University Award 2024 in the category of Research of @unicologne.bsky.social in recognition of his exceptional scientific achievements!
Big congratulations to the three awardees of our mitoCRC Advanced PostDoc Grant! We're thrilled to support Dr. Qiaochu Li, Dr. @aleksandra-zecic.bsky.social and Dr. Andromachi in their first steps toward an independent research line. Well-deserved success! 🎉
#mitochondria #PostDoc #womeninscience
#mitochondria #PostDoc #womeninscience
May 15, 2025 at 9:47 AM
Big congratulations to the three awardees of our mitoCRC Advanced PostDoc Grant! We're thrilled to support Dr. Qiaochu Li, Dr. @aleksandra-zecic.bsky.social and Dr. Andromachi in their first steps toward an independent research line. Well-deserved success! 🎉
#mitochondria #PostDoc #womeninscience
#mitochondria #PostDoc #womeninscience
Reposted by CRC1218
In their Review, Eleonora Zilio, Elena Rugarli and colleagues @cecad.bsky.social @crc1218.bsky.social discuss the role of mitochondrial mRNA translation in cellular communication.
journals.biologists.com/jcs/article/...
#JCSMitoSI #Mitochondria
journals.biologists.com/jcs/article/...
#JCSMitoSI #Mitochondria
May 13, 2025 at 2:04 PM
In their Review, Eleonora Zilio, Elena Rugarli and colleagues @cecad.bsky.social @crc1218.bsky.social discuss the role of mitochondrial mRNA translation in cellular communication.
journals.biologists.com/jcs/article/...
#JCSMitoSI #Mitochondria
journals.biologists.com/jcs/article/...
#JCSMitoSI #Mitochondria
🚴♂️ mitoCRC joins #Stadtradeln 2025!
From June 11–July 1, we’re cycling for climate & health – and challenging @crc1678.bsky.social & CRC 1403!
Join our team “CRC 1218 – mitoCRC” (under Gesunde Uniklinik) and help us pedal to victory! 🌍💪
🔗 Register: www.stadtradeln.de/koeln
#BikeForClimate #mitoCRC
From June 11–July 1, we’re cycling for climate & health – and challenging @crc1678.bsky.social & CRC 1403!
Join our team “CRC 1218 – mitoCRC” (under Gesunde Uniklinik) and help us pedal to victory! 🌍💪
🔗 Register: www.stadtradeln.de/koeln
#BikeForClimate #mitoCRC
STADTRADELN - Radeln für ein gutes Klima
Beim Wettbewerb STADTRADELN trittst du 21 Tage in die Pedale für mehr Radförderung, Klimaschutz und Lebensqualität in deiner Kommune.
www.stadtradeln.de
April 24, 2025 at 1:26 PM
🚴♂️ mitoCRC joins #Stadtradeln 2025!
From June 11–July 1, we’re cycling for climate & health – and challenging @crc1678.bsky.social & CRC 1403!
Join our team “CRC 1218 – mitoCRC” (under Gesunde Uniklinik) and help us pedal to victory! 🌍💪
🔗 Register: www.stadtradeln.de/koeln
#BikeForClimate #mitoCRC
From June 11–July 1, we’re cycling for climate & health – and challenging @crc1678.bsky.social & CRC 1403!
Join our team “CRC 1218 – mitoCRC” (under Gesunde Uniklinik) and help us pedal to victory! 🌍💪
🔗 Register: www.stadtradeln.de/koeln
#BikeForClimate #mitoCRC
In recognition of his key role in the #mitoCRC and his valuable skill set, we’ve awarded our talented PostDoc Robert Düster a Family Support Grant! We hope to support the reconciliation of work and family life to better promote young talents in science.
#mitoResearch #Equality #FamiliesInScience
#mitoResearch #Equality #FamiliesInScience
April 15, 2025 at 11:46 AM
In recognition of his key role in the #mitoCRC and his valuable skill set, we’ve awarded our talented PostDoc Robert Düster a Family Support Grant! We hope to support the reconciliation of work and family life to better promote young talents in science.
#mitoResearch #Equality #FamiliesInScience
#mitoResearch #Equality #FamiliesInScience
📢Registration open!📢
So proud to see our very own Elisa Motori co-hosting this exciting EMBO Workshop: “Mitochondria in the Nervous System”
Co-sponsored by the CRC1218! Two invited speakers of the CRC1218! Don’t miss out!
🗓 29.09.-02.10.2025
📍Engelberg, CH
👉 meetings.embo.org/event/25-mit...
So proud to see our very own Elisa Motori co-hosting this exciting EMBO Workshop: “Mitochondria in the Nervous System”
Co-sponsored by the CRC1218! Two invited speakers of the CRC1218! Don’t miss out!
🗓 29.09.-02.10.2025
📍Engelberg, CH
👉 meetings.embo.org/event/25-mit...
April 15, 2025 at 8:28 AM
📢Registration open!📢
So proud to see our very own Elisa Motori co-hosting this exciting EMBO Workshop: “Mitochondria in the Nervous System”
Co-sponsored by the CRC1218! Two invited speakers of the CRC1218! Don’t miss out!
🗓 29.09.-02.10.2025
📍Engelberg, CH
👉 meetings.embo.org/event/25-mit...
So proud to see our very own Elisa Motori co-hosting this exciting EMBO Workshop: “Mitochondria in the Nervous System”
Co-sponsored by the CRC1218! Two invited speakers of the CRC1218! Don’t miss out!
🗓 29.09.-02.10.2025
📍Engelberg, CH
👉 meetings.embo.org/event/25-mit...
👩🔬mito-RTG at KölnerKinderUni👨🔬
The mitoRTG hosted 2 workshops at the KölnerKinderUni! Future scientists aged 8 to 12 learned in hands-on experiments how the uniqueness of individuals is encoded in the DNA🧬
A big thank you to Lara, Lilli and Eileen for making it all happen!
#KKU2025 #ScienceForKids
The mitoRTG hosted 2 workshops at the KölnerKinderUni! Future scientists aged 8 to 12 learned in hands-on experiments how the uniqueness of individuals is encoded in the DNA🧬
A big thank you to Lara, Lilli and Eileen for making it all happen!
#KKU2025 #ScienceForKids
March 21, 2025 at 2:28 PM
👩🔬mito-RTG at KölnerKinderUni👨🔬
The mitoRTG hosted 2 workshops at the KölnerKinderUni! Future scientists aged 8 to 12 learned in hands-on experiments how the uniqueness of individuals is encoded in the DNA🧬
A big thank you to Lara, Lilli and Eileen for making it all happen!
#KKU2025 #ScienceForKids
The mitoRTG hosted 2 workshops at the KölnerKinderUni! Future scientists aged 8 to 12 learned in hands-on experiments how the uniqueness of individuals is encoded in the DNA🧬
A big thank you to Lara, Lilli and Eileen for making it all happen!
#KKU2025 #ScienceForKids
🌟The mitoRetreat 2025 was a huge success🌟
Great science, inspiring feedback, fantastic networking, and outstanding performances from our young researchers. The perfect weather truly reflected the retreat’s success☀️
A big thank you to all participants for making it unforgettable!
#Research #SFB1218
Great science, inspiring feedback, fantastic networking, and outstanding performances from our young researchers. The perfect weather truly reflected the retreat’s success☀️
A big thank you to all participants for making it unforgettable!
#Research #SFB1218
March 10, 2025 at 3:07 PM
📣👨🔬Publication alert!👨🔬📣
Check out this interesting review on mitochondrial protein import stress, co-written by our mitoCRC member Prof. Thomas Becker!
Recently published in @naturecellbiology.bsky.social
www.nature.com/articles/s41...
#mitochondria #mitoCRC
Check out this interesting review on mitochondrial protein import stress, co-written by our mitoCRC member Prof. Thomas Becker!
Recently published in @naturecellbiology.bsky.social
www.nature.com/articles/s41...
#mitochondria #mitoCRC
Mitochondrial protein import stress - Nature Cell Biology
Cells respond to mitochondrial protein import stress by regenerating clogged import sites and inducing stress responses. Mitochondria are thus tightly integrated into the cellular proteostasis and str...
www.nature.com
February 5, 2025 at 12:41 PM
📣👨🔬Publication alert!👨🔬📣
Check out this interesting review on mitochondrial protein import stress, co-written by our mitoCRC member Prof. Thomas Becker!
Recently published in @naturecellbiology.bsky.social
www.nature.com/articles/s41...
#mitochondria #mitoCRC
Check out this interesting review on mitochondrial protein import stress, co-written by our mitoCRC member Prof. Thomas Becker!
Recently published in @naturecellbiology.bsky.social
www.nature.com/articles/s41...
#mitochondria #mitoCRC
📢🚨The mitoCRC calls for applications for an Advanced PostDoc grant.🚨📢
The grant aims at supporting advanced PostDocs in Cologne on their way to an independent research line in the field of #mitochondria.
A prior association to the #mitoCRC is not necessary to apply.
#postdoc #science
The grant aims at supporting advanced PostDocs in Cologne on their way to an independent research line in the field of #mitochondria.
A prior association to the #mitoCRC is not necessary to apply.
#postdoc #science
February 5, 2025 at 11:21 AM
📢🚨The mitoCRC calls for applications for an Advanced PostDoc grant.🚨📢
The grant aims at supporting advanced PostDocs in Cologne on their way to an independent research line in the field of #mitochondria.
A prior association to the #mitoCRC is not necessary to apply.
#postdoc #science
The grant aims at supporting advanced PostDocs in Cologne on their way to an independent research line in the field of #mitochondria.
A prior association to the #mitoCRC is not necessary to apply.
#postdoc #science