Wieczorek Lab
@mike-wieczorek.bsky.social
Structural biology, biophysics and microtubules @ ETH Zurich
Pinned
Wieczorek Lab
@mike-wieczorek.bsky.social
· Oct 10
Structure and assembly of the A-C linker connecting microtubule triplets in centrioles
Multiscale cryo-EM of centrioles reveals the structure and polymorphism of the A-C linker connecting microtubule triplets.
www.science.org
Huge congratulations to Wieczorek Lab PhD student Bin Cai and now-PI Jingwei Xu @xujwet.bsky.social on figuring out the surprisingly complex structure of the A-C linker crosslinking microtubule triplets in Tetrahymena basal body centrioles! www.science.org/doi/10.1126/...
Reposted by Wieczorek Lab
The centriole is crucial for cilia formation, but its molecular architecture is not known. Research from the @Wieczorek Group at ETH Zurich reports structures of the centriole’s A-C linker, revealing how it crosslinks neighboring microtubule triplets. More: biol.ethz.ch/en/news-and-...
October 20, 2025 at 2:57 PM
The centriole is crucial for cilia formation, but its molecular architecture is not known. Research from the @Wieczorek Group at ETH Zurich reports structures of the centriole’s A-C linker, revealing how it crosslinks neighboring microtubule triplets. More: biol.ethz.ch/en/news-and-...
Reposted by Wieczorek Lab
Thrilled to share that the final piece of my PhD work is now on bioRxiv! biorxiv.org/content/10.1... With support from @nvidia and the @NSF, we used AlphaFold to screen 1.6M+ protein pairs, revealing thousands of potential novel PPIs. All data can be viewed at predictomes.org/hp
Proteome-wide in silico screening for human protein-protein interactions
Protein-protein interactions (PPIs) drive virtually all biological processes, yet most PPIs have not been identified and even more remain structurally unresolved. We developed a two-step computational...
biorxiv.org
November 12, 2025 at 9:26 PM
Thrilled to share that the final piece of my PhD work is now on bioRxiv! biorxiv.org/content/10.1... With support from @nvidia and the @NSF, we used AlphaFold to screen 1.6M+ protein pairs, revealing thousands of potential novel PPIs. All data can be viewed at predictomes.org/hp
Reposted by Wieczorek Lab
957 proposals were submitted in the latest round of ERC Synergy applications. They expect to fund 50 which means around 5% success rate. This is really not sustainable and a lot of people are likely avoiding doing this knowing how poor the chances are.
erc.europa.eu/news-events/...
erc.europa.eu/news-events/...
Applications for ERC Synergy Grants 2026: Facts and figures
The ERC Synergy Grants 2026 call closed for applications on 5 November 2025. These are the preliminary data on the submitted proposals:
erc.europa.eu
November 11, 2025 at 1:22 PM
957 proposals were submitted in the latest round of ERC Synergy applications. They expect to fund 50 which means around 5% success rate. This is really not sustainable and a lot of people are likely avoiding doing this knowing how poor the chances are.
erc.europa.eu/news-events/...
erc.europa.eu/news-events/...
Reposted by Wieczorek Lab
Our latest collaborative effort - with Eva Gluenz and @zephyris-science.bsky.social - to understand how the various proteins and complexes of the axoneme contribute to ciliary motility:
November 10, 2025 at 7:58 PM
Our latest collaborative effort - with Eva Gluenz and @zephyris-science.bsky.social - to understand how the various proteins and complexes of the axoneme contribute to ciliary motility:
Reposted by Wieczorek Lab
Scientific Reports meanwhile on course to publish 40K papers = >$100M pubmed.ncbi.nlm.nih.gov?term=%22Scie...
October 28, 2025 at 3:51 PM
Scientific Reports meanwhile on course to publish 40K papers = >$100M pubmed.ncbi.nlm.nih.gov?term=%22Scie...
Reposted by Wieczorek Lab
Nature Communications will publish ~10K papers in 2025 pubmed.ncbi.nlm.nih.gov?term=%22Natu...
That's ~$70M in revenue, while many of the non-profit journals that used to occupy that slot in the journal hierarchy have seen a precipitous decline in submissions in the 15 years it's existed.
That's ~$70M in revenue, while many of the non-profit journals that used to occupy that slot in the journal hierarchy have seen a precipitous decline in submissions in the 15 years it's existed.
October 27, 2025 at 8:38 PM
Nature Communications will publish ~10K papers in 2025 pubmed.ncbi.nlm.nih.gov?term=%22Natu...
That's ~$70M in revenue, while many of the non-profit journals that used to occupy that slot in the journal hierarchy have seen a precipitous decline in submissions in the 15 years it's existed.
That's ~$70M in revenue, while many of the non-profit journals that used to occupy that slot in the journal hierarchy have seen a precipitous decline in submissions in the 15 years it's existed.
Reposted by Wieczorek Lab
@science.org 🧬🔬🐛🔭🌊🌳🧫🐳
A reminder that @science.org is a learned society journal, owned & published by the non-profit @aaas.org. It's green open access, with no article processing fees for authors - compatible with all major funder mandates. All subscription revenue is reinvested in science, not paid to shareholders.
🔭⚛️🧪
🔭⚛️🧪
October 25, 2025 at 3:12 PM
@science.org 🧬🔬🐛🔭🌊🌳🧫🐳
Reposted by Wieczorek Lab
I’m sure this guy is great, not the point, but to think the solution to Canadian scoence is to attract a few dozen scientists from abroad is complete nonsense. There are just as good scientists here. The problem is chronic underfunding. But this does not make headlines www.ctvnews.ca/health/artic...
Canada’s brain gain: A scientific migration amid U.S turmoil
More than 600 scientists – about half from the U.S. – ‘raise their hands’ as they compete for positions at a Canadian Hospital.
www.ctvnews.ca
October 19, 2025 at 5:22 PM
I’m sure this guy is great, not the point, but to think the solution to Canadian scoence is to attract a few dozen scientists from abroad is complete nonsense. There are just as good scientists here. The problem is chronic underfunding. But this does not make headlines www.ctvnews.ca/health/artic...
Reposted by Wieczorek Lab
New video 📹 ! Changes to #eligibility #rules for ERC Starting & Consolidator Grant applicants, as explained by ERC President Maria Leptin.
Watch the full 🆕 interview bit.ly/4otIva9 👀
Read the explanatory text (from 15/9/25) 📑 link.europa.eu/hP3WWF
#Research #Grant #Funding #AcademicSky 🧪
Watch the full 🆕 interview bit.ly/4otIva9 👀
Read the explanatory text (from 15/9/25) 📑 link.europa.eu/hP3WWF
#Research #Grant #Funding #AcademicSky 🧪
October 16, 2025 at 2:35 PM
New video 📹 ! Changes to #eligibility #rules for ERC Starting & Consolidator Grant applicants, as explained by ERC President Maria Leptin.
Watch the full 🆕 interview bit.ly/4otIva9 👀
Read the explanatory text (from 15/9/25) 📑 link.europa.eu/hP3WWF
#Research #Grant #Funding #AcademicSky 🧪
Watch the full 🆕 interview bit.ly/4otIva9 👀
Read the explanatory text (from 15/9/25) 📑 link.europa.eu/hP3WWF
#Research #Grant #Funding #AcademicSky 🧪
Reposted by Wieczorek Lab
Now out in Science! Cyclin-dependent kinases (CDKs) are key regulators of the cell cycle. In @vcushing.bsky.social's magnum opus, we use #cryoEM to figure out how the CDK-activating kinase recognises CDKs to fully activate them - a key step in cell cycle control.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Structural basis of T-loop–independent recognition and activation of CDKs by the CDK-activating kinase
Cyclin-dependent kinases (CDKs) are prototypical regulators of the cell cycle. The CDK-activating kinase (CAK) acts as a master regulator of CDK activity by catalyzing the activating phosphorylation o...
www.science.org
October 16, 2025 at 7:17 PM
Now out in Science! Cyclin-dependent kinases (CDKs) are key regulators of the cell cycle. In @vcushing.bsky.social's magnum opus, we use #cryoEM to figure out how the CDK-activating kinase recognises CDKs to fully activate them - a key step in cell cycle control.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Incredible story - congratulations @klanglab.bsky.social
!
!
🚨Our paper is out! 🥳
Hijacking a bacterial ABC transporter for efficient genetic code expansion.
Many congrats to everyone involved - a multi-year effort led by @taruniype.bsky.social @maxfottner.bsky.social
www.nature.com/articles/s41...
it all started years ago with a failed experiment
🧵👇 1/9
Hijacking a bacterial ABC transporter for efficient genetic code expansion.
Many congrats to everyone involved - a multi-year effort led by @taruniype.bsky.social @maxfottner.bsky.social
www.nature.com/articles/s41...
it all started years ago with a failed experiment
🧵👇 1/9
Hijacking a bacterial ABC transporter for genetic code expansion - Nature
Bacterial ATP-binding cassette (ABC) transporters can be utilized and engineered to transport non-canonical amino acids into Escherichia coli for highly efficient synthesis of proteins with novel func...
www.nature.com
October 16, 2025 at 4:19 PM
Incredible story - congratulations @klanglab.bsky.social
!
!
Reposted by Wieczorek Lab
new preprint: Ubiquitin is a protein modification linked with degradation but known to regulate other functions. Over 100k ubiquitination sites have been discovered and here we (@julianvangerwen.bsky.social + others) try to prioritize those most critical to the cell www.biorxiv.org/content/10.1...
The functional landscape of the human ubiquitinome
Protein ubiquitination regulates cell biology through diverse avenues, from quality control-linked protein degradation to signaling functions such as modulating protein-protein interactions and enzyme...
www.biorxiv.org
October 9, 2025 at 7:07 AM
new preprint: Ubiquitin is a protein modification linked with degradation but known to regulate other functions. Over 100k ubiquitination sites have been discovered and here we (@julianvangerwen.bsky.social + others) try to prioritize those most critical to the cell www.biorxiv.org/content/10.1...
Reposted by Wieczorek Lab
Congrats🥳 to @mike-wieczorek.bsky.social, Bin Cai, and our former lab member Jingwei Xu @xujwet.bsky.social to their multiscale imaging 🔬 story of the centriolar AC linker #teamtomo
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Structure and assembly of the A-C linker connecting microtubule triplets in centrioles
Multiscale cryo-EM of centrioles reveals the structure and polymorphism of the A-C linker connecting microtubule triplets.
www.science.org
October 8, 2025 at 7:07 PM
Congrats🥳 to @mike-wieczorek.bsky.social, Bin Cai, and our former lab member Jingwei Xu @xujwet.bsky.social to their multiscale imaging 🔬 story of the centriolar AC linker #teamtomo
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Wieczorek Lab
🧐Checkout our preprint revealing the stepwise firing💥 mechanism of a Contractile Injection System @xujwet.bsky.social&@chipericson.bsky.social trapped the complex by structure-guided engineering🧪 in multiple intermediate states and imaged them by multimodal #cryoEM❄️🔬
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
October 8, 2025 at 9:18 PM
🧐Checkout our preprint revealing the stepwise firing💥 mechanism of a Contractile Injection System @xujwet.bsky.social&@chipericson.bsky.social trapped the complex by structure-guided engineering🧪 in multiple intermediate states and imaged them by multimodal #cryoEM❄️🔬
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Huge congratulations to Wieczorek Lab PhD student Bin Cai and now-PI Jingwei Xu @xujwet.bsky.social on figuring out the surprisingly complex structure of the A-C linker crosslinking microtubule triplets in Tetrahymena basal body centrioles! www.science.org/doi/10.1126/...
Structure and assembly of the A-C linker connecting microtubule triplets in centrioles
Multiscale cryo-EM of centrioles reveals the structure and polymorphism of the A-C linker connecting microtubule triplets.
www.science.org
October 10, 2025 at 1:14 PM
Huge congratulations to Wieczorek Lab PhD student Bin Cai and now-PI Jingwei Xu @xujwet.bsky.social on figuring out the surprisingly complex structure of the A-C linker crosslinking microtubule triplets in Tetrahymena basal body centrioles! www.science.org/doi/10.1126/...
Reposted by Wieczorek Lab
Out in Science Advances: Our #cryoEM structure of HFTV1, a virus infecting the halophile #archaea. *First full atomic structure (containing all structural proteins) of any tailed virus!* Congrats and thanks to all co-authors and our fantastic collaborators! www.science.org/doi/10.1126/...
Cryo-EM resolves the structure of the archaeal dsDNA virus HFTV1 from head to tail
This structure of an archaeal tailed virus (arTV) provides detailed insights into arTV assembly and infection mechanisms.
www.science.org
October 6, 2025 at 11:31 AM
Out in Science Advances: Our #cryoEM structure of HFTV1, a virus infecting the halophile #archaea. *First full atomic structure (containing all structural proteins) of any tailed virus!* Congrats and thanks to all co-authors and our fantastic collaborators! www.science.org/doi/10.1126/...
Reposted by Wieczorek Lab
Today, @rcsbpdb.bsky.social introduces Q-score in EM validation reports. Q-score assesses model-map fit. A new percentile slider will compare an entry’s average Q-score to the full archive and a resolution-matched subset. This would help judge whether the fit is typical for the reported resolution.
Introducing the first 3DEM Model-Map percentile slider to the wwPDB validation report
Introducing the latest wwPDB Percentile slider based on the Q-score model-map validation metric
www.rcsb.org
October 1, 2025 at 12:25 AM
Today, @rcsbpdb.bsky.social introduces Q-score in EM validation reports. Q-score assesses model-map fit. A new percentile slider will compare an entry’s average Q-score to the full archive and a resolution-matched subset. This would help judge whether the fit is typical for the reported resolution.
Huge congratulations to Girish and team on this beautiful study!
Happy to share the inaugural paper from the lab. We describe a molecular mechanism for the activation of outer dynein arm motors that power the vital motion of cilia.
Open access link below:
www.nature.com/articles/s41...
Here's a cool animated summary
Open access link below:
www.nature.com/articles/s41...
Here's a cool animated summary
September 30, 2025 at 7:39 AM
Huge congratulations to Girish and team on this beautiful study!
Reposted by Wieczorek Lab
Paper alert! 📢 How do cells strike the perfect balance during meiosis? ⚖️ A new study from the Matos lab in @natureportfolio.nature.com uncovers how Holliday junctions and the synaptonemal complex safeguard crossovers ➡️ tinyurl.com/2k4mmpzu
@univie.ac.at
@meduniwien.ac.at
@univie.ac.at
@meduniwien.ac.at
September 25, 2025 at 7:04 AM
Paper alert! 📢 How do cells strike the perfect balance during meiosis? ⚖️ A new study from the Matos lab in @natureportfolio.nature.com uncovers how Holliday junctions and the synaptonemal complex safeguard crossovers ➡️ tinyurl.com/2k4mmpzu
@univie.ac.at
@meduniwien.ac.at
@univie.ac.at
@meduniwien.ac.at
Reposted by Wieczorek Lab
Feeling excited & grateful 🌟
Honored to receive the Falling Walls Science Breakthrough 2025 (Life Sciences) — for our team’s live ovulation imaging.
Thanks to Tabea Lilian Marx, Christopher Thomas & our lab!
www.mpinat.mpg.de/5118437/pr_2...
#FallingWalls #ScienceSummit25 #ScienceBreakthroughs
Honored to receive the Falling Walls Science Breakthrough 2025 (Life Sciences) — for our team’s live ovulation imaging.
Thanks to Tabea Lilian Marx, Christopher Thomas & our lab!
www.mpinat.mpg.de/5118437/pr_2...
#FallingWalls #ScienceSummit25 #ScienceBreakthroughs
September 17, 2025 at 7:26 AM
Feeling excited & grateful 🌟
Honored to receive the Falling Walls Science Breakthrough 2025 (Life Sciences) — for our team’s live ovulation imaging.
Thanks to Tabea Lilian Marx, Christopher Thomas & our lab!
www.mpinat.mpg.de/5118437/pr_2...
#FallingWalls #ScienceSummit25 #ScienceBreakthroughs
Honored to receive the Falling Walls Science Breakthrough 2025 (Life Sciences) — for our team’s live ovulation imaging.
Thanks to Tabea Lilian Marx, Christopher Thomas & our lab!
www.mpinat.mpg.de/5118437/pr_2...
#FallingWalls #ScienceSummit25 #ScienceBreakthroughs
Reposted by Wieczorek Lab
Exciting new study from new-PI Mohinder Pal on the role of CCDC103 and it's links to PCD as the most recent dynein assembly factor (DNAAF19). Congratulations to the entire team.
@Mohinder Pal (currently not on Bluesky)
@mike-wieczorek.bsky.social
@laurencepearl.bsky.social
@Mohinder Pal (currently not on Bluesky)
@mike-wieczorek.bsky.social
@laurencepearl.bsky.social
New pre-print on the role of CCDC103/DNAAF19 in dynein assembly highlighting it's link to PCD.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
CCDC103-mediated assembly of the R2C complex links RUVBL1-RUVBL2 to Primary Ciliary Dyskinesia
Primary ciliary dyskinesia (PCD) is a genetic disorder caused by defective cilia motility, powered by axonemal dynein motors. Assembly of these motors is facilitated by the molecular chaperone HSP90, ...
www.biorxiv.org
September 15, 2025 at 8:00 PM
Exciting new study from new-PI Mohinder Pal on the role of CCDC103 and it's links to PCD as the most recent dynein assembly factor (DNAAF19). Congratulations to the entire team.
@Mohinder Pal (currently not on Bluesky)
@mike-wieczorek.bsky.social
@laurencepearl.bsky.social
@Mohinder Pal (currently not on Bluesky)
@mike-wieczorek.bsky.social
@laurencepearl.bsky.social
Reposted by Wieczorek Lab
New pre-print on the role of CCDC103/DNAAF19 in dynein assembly highlighting it's link to PCD.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
CCDC103-mediated assembly of the R2C complex links RUVBL1-RUVBL2 to Primary Ciliary Dyskinesia
Primary ciliary dyskinesia (PCD) is a genetic disorder caused by defective cilia motility, powered by axonemal dynein motors. Assembly of these motors is facilitated by the molecular chaperone HSP90, ...
www.biorxiv.org
September 15, 2025 at 7:56 PM
New pre-print on the role of CCDC103/DNAAF19 in dynein assembly highlighting it's link to PCD.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Wieczorek Lab
CCDC103-mediated assembly of the R2C complex links RUVBL1-RUVBL2 to Primary Ciliary Dyskinesia https://www.biorxiv.org/content/10.1101/2025.09.11.675549v1
September 14, 2025 at 5:45 AM
CCDC103-mediated assembly of the R2C complex links RUVBL1-RUVBL2 to Primary Ciliary Dyskinesia https://www.biorxiv.org/content/10.1101/2025.09.11.675549v1
Reposted by Wieczorek Lab
Asgard archaea were first found in mud at the bottom of the North Sea. Today, cellular biologists Martin Pilhofer and Christa Schleper are exploring one of their more elusive structural elements: a totally tubular system that looks a lot like our own.
www.quantamagazine.org/tiny-tubes-r...
www.quantamagazine.org/tiny-tubes-r...
September 9, 2025 at 3:46 PM
Asgard archaea were first found in mud at the bottom of the North Sea. Today, cellular biologists Martin Pilhofer and Christa Schleper are exploring one of their more elusive structural elements: a totally tubular system that looks a lot like our own.
www.quantamagazine.org/tiny-tubes-r...
www.quantamagazine.org/tiny-tubes-r...
Reposted by Wieczorek Lab
Patrick's paper is finally out, a label-free method to measure the composition of multicomponent biomolecular condensates!
September 3, 2025 at 11:53 AM
Patrick's paper is finally out, a label-free method to measure the composition of multicomponent biomolecular condensates!