Michael Hanna
@mike-hanna.bsky.social
Lysosomes|Membrane lipids|Microscopy|Cell Biology|Currently a postdoc in @pdc-lab.bsky.social
Incoming Assistant Professor in BMB Dept at Penn State: https://sites.psu.edu/hannalab/ & @hanna-lab.bsky.social
Incoming Assistant Professor in BMB Dept at Penn State: https://sites.psu.edu/hannalab/ & @hanna-lab.bsky.social
Fantastic new work revealing mechanisms of pro-apoptotic signaling as a result of lysosomal dysfunction and subsequent DNA damage.
New roles for lysosomes... and maybe new targets for Batten disease?
Loss of the lysosomal protein CLN3 triggers c-Abl-dependent YAP1 pro-apoptotic signaling | EMBO reports www.embopress.org/doi/full/10....
Loss of the lysosomal protein CLN3 triggers c-Abl-dependent YAP1 pro-apoptotic signaling | EMBO reports www.embopress.org/doi/full/10....
Loss of the lysosomal protein CLN3 triggers c-Abl-dependent YAP1 pro-apoptotic signaling | EMBO reports
imageimageLoss of Batten disease-associated lysosomal protein CLN3 leads to DNA damage and activation
of c-Abl-YAP1-dependent pro-apoptotic signaling which underlies increased apoptosis
susceptibility...
www.embopress.org
November 7, 2025 at 5:50 PM
Fantastic new work revealing mechanisms of pro-apoptotic signaling as a result of lysosomal dysfunction and subsequent DNA damage.
Reposted by Michael Hanna
In natural systems, form often determines function. Check out how this model of BLTP3A exhibits the tube-like form that allows it to bridge membranes, and how its partner protein, LC3, docked here near the C-terminus, can serve to orient BLTP3A towards its intended site of action/lipid delivery.
November 4, 2025 at 1:41 AM
In natural systems, form often determines function. Check out how this model of BLTP3A exhibits the tube-like form that allows it to bridge membranes, and how its partner protein, LC3, docked here near the C-terminus, can serve to orient BLTP3A towards its intended site of action/lipid delivery.
The Hanna lab is looking for an enthusiastic Research Technologist to join the team! 😊
You’ll help lead projects focused on organelle health & resilience to establish momentum in the lab. 🔬🥽
Job description and details can be found here: psu.wd1.myworkdayjobs.com/PSU_Staff/jo...
You’ll help lead projects focused on organelle health & resilience to establish momentum in the lab. 🔬🥽
Job description and details can be found here: psu.wd1.myworkdayjobs.com/PSU_Staff/jo...
Research Technologist
APPLICATION INSTRUCTIONS: CURRENT PENN STATE EMPLOYEE (faculty, staff, technical service, or student), please login to Workday to complete the internal application process. Please do not apply here, a...
psu.wd1.myworkdayjobs.com
October 22, 2025 at 7:09 PM
The Hanna lab is looking for an enthusiastic Research Technologist to join the team! 😊
You’ll help lead projects focused on organelle health & resilience to establish momentum in the lab. 🔬🥽
Job description and details can be found here: psu.wd1.myworkdayjobs.com/PSU_Staff/jo...
You’ll help lead projects focused on organelle health & resilience to establish momentum in the lab. 🔬🥽
Job description and details can be found here: psu.wd1.myworkdayjobs.com/PSU_Staff/jo...
Reposted by Michael Hanna
Recent @yale.edu research led by @adwolfe.bsky.social, Milind Singh & @dacolon.bsky.social reveals neurons' ability to store glycogen as a backup fuel ⛽️, keeping the brain running under stress — a process called “glycogen-dependent glycolytic plasticity” (GDGP).
Neurons use built-in ‘backup batteries’ that fuel the brain under stress
A new Yale study reveals that neurons store their own sugar reserves that kick in to keep the brain functioning during metabolic stress.
news.yale.edu
October 20, 2025 at 1:31 PM
Recent @yale.edu research led by @adwolfe.bsky.social, Milind Singh & @dacolon.bsky.social reveals neurons' ability to store glycogen as a backup fuel ⛽️, keeping the brain running under stress — a process called “glycogen-dependent glycolytic plasticity” (GDGP).
Reposted by Michael Hanna
🚨 We’re hiring a postdoc! 🚨
Interested in lysosomes, Parkinson’s disease, cell biology, microscopy — or all of the above? Come work with us at the Bonet-Ponce Lab!
Reach out directly: luis.bonetponce@osumc.edu
Learn more: bonetponcelab.com
Let’s chat!
Interested in lysosomes, Parkinson’s disease, cell biology, microscopy — or all of the above? Come work with us at the Bonet-Ponce Lab!
Reach out directly: luis.bonetponce@osumc.edu
Learn more: bonetponcelab.com
Let’s chat!
October 14, 2025 at 5:00 PM
🚨 We’re hiring a postdoc! 🚨
Interested in lysosomes, Parkinson’s disease, cell biology, microscopy — or all of the above? Come work with us at the Bonet-Ponce Lab!
Reach out directly: luis.bonetponce@osumc.edu
Learn more: bonetponcelab.com
Let’s chat!
Interested in lysosomes, Parkinson’s disease, cell biology, microscopy — or all of the above? Come work with us at the Bonet-Ponce Lab!
Reach out directly: luis.bonetponce@osumc.edu
Learn more: bonetponcelab.com
Let’s chat!
Reposted by Michael Hanna
The Hanna lab has a website! 🖥️
Come check it out to see what we’ll be up to 😁
sites.psu.edu/hannalab
Come check it out to see what we’ll be up to 😁
sites.psu.edu/hannalab
The Hanna Lab – Penn State Univeristy | Department of Biochemistry & Molecular Biology
sites.psu.edu
October 7, 2025 at 2:19 PM
The Hanna lab has a website! 🖥️
Come check it out to see what we’ll be up to 😁
sites.psu.edu/hannalab
Come check it out to see what we’ll be up to 😁
sites.psu.edu/hannalab
Reposted by Michael Hanna
Much needed good news!! Our paper is just out in @jcb.org. We found a crazy antagonistic motor function that explains the elongation/retraction phenotype we see during LRRK2-dependent lysosomal tubulation. I am especially proud of Tsion, Nuria, Mia and Irene's contribution. Check it out!
@lysoluis.bsky.social, @markrcookson.bsky.social et al. show how two distinct pRAB effectors and RHD members, JIP4 and RILPL1, provide antagonistic motor force to regulate #lysosome tubulation. rupress.org/jcb/article/...
September 24, 2025 at 3:49 PM
Much needed good news!! Our paper is just out in @jcb.org. We found a crazy antagonistic motor function that explains the elongation/retraction phenotype we see during LRRK2-dependent lysosomal tubulation. I am especially proud of Tsion, Nuria, Mia and Irene's contribution. Check it out!
New paper alert! I’m very excited to share our paper published in @embojournal.org! @pdc-lab.bsky.social @yaleneuro.bsky.social
Bridge-like lipid transfer protein 3A (BLTP3A) participates in endomembrane repair as an effector of #ATG8 conjugation to single membranes (CASM) - helping repair or minimize #lysosome damage
@mike-hanna.bsky.social et al, @pdc-lab.bsky.social
www.embopress.org/doi/full/10....
@mike-hanna.bsky.social et al, @pdc-lab.bsky.social
www.embopress.org/doi/full/10....
September 12, 2025 at 2:04 PM
New paper alert! I’m very excited to share our paper published in @embojournal.org! @pdc-lab.bsky.social @yaleneuro.bsky.social
Reposted by Michael Hanna
@anbangdai.bsky.social et al. @pdc-lab.bsky.social report the localization of BLTP2 in different human cell types & reveal binding partners that mediate its tethering to the PM & to PM-connected structures including certain #endosomes & #macropinosomes undergoing fusion rupress.org/jcb/article/...
September 3, 2025 at 4:15 PM
@anbangdai.bsky.social et al. @pdc-lab.bsky.social report the localization of BLTP2 in different human cell types & reveal binding partners that mediate its tethering to the PM & to PM-connected structures including certain #endosomes & #macropinosomes undergoing fusion rupress.org/jcb/article/...
Reposted by Michael Hanna
👏 We’re recognizing Ben Johnson (CRN Team De Camilli) as this month’s Open Science Champion!
Ben developed a color-coded Open Science compliance manual that makes ASAP policies easier to navigate and apply. Thank you for raising the bar for #OpenScience, Ben!
Check out the manual: bit.ly/46DuL6R
Ben developed a color-coded Open Science compliance manual that makes ASAP policies easier to navigate and apply. Thank you for raising the bar for #OpenScience, Ben!
Check out the manual: bit.ly/46DuL6R
August 28, 2025 at 3:29 PM
👏 We’re recognizing Ben Johnson (CRN Team De Camilli) as this month’s Open Science Champion!
Ben developed a color-coded Open Science compliance manual that makes ASAP policies easier to navigate and apply. Thank you for raising the bar for #OpenScience, Ben!
Check out the manual: bit.ly/46DuL6R
Ben developed a color-coded Open Science compliance manual that makes ASAP policies easier to navigate and apply. Thank you for raising the bar for #OpenScience, Ben!
Check out the manual: bit.ly/46DuL6R
Reposted by Michael Hanna
Faculty opening in Cornell Chemistry at the Assistant Professor level in the area of chemical biology, broadly defined! academicjobsonline.org/ajo/jobs/30338 #chemjobs
Cornell University, Chemistry and Chemical Biology
Job #AJO30338, WDR-00054776 Assistant Professor - Chemistry and Chemical Biology, Cornell University (Ithaca, NY), Chemistry and Chemical Biology, Cornell University, Ithaca, New York, US
academicjobsonline.org
August 25, 2025 at 8:30 PM
Faculty opening in Cornell Chemistry at the Assistant Professor level in the area of chemical biology, broadly defined! academicjobsonline.org/ajo/jobs/30338 #chemjobs
Reposted by Michael Hanna
Thrilled to share that I’m starting my lab in the Department of Neuroscience at the University of Florida! We’ll study metabolism in brain aging to better understand Alzheimer’s disease. Excited to build, collab, and discover. Go Gators! 🐊
#Neuro #Aging #Alzheimers #UF
ufresearch.bsky.social
#Neuro #Aging #Alzheimers #UF
ufresearch.bsky.social
https://ufresearch.bsky.social
July 28, 2025 at 3:27 PM
Thrilled to share that I’m starting my lab in the Department of Neuroscience at the University of Florida! We’ll study metabolism in brain aging to better understand Alzheimer’s disease. Excited to build, collab, and discover. Go Gators! 🐊
#Neuro #Aging #Alzheimers #UF
ufresearch.bsky.social
#Neuro #Aging #Alzheimers #UF
ufresearch.bsky.social
Reposted by Michael Hanna
In a time as this— I am deeply thankful to be blessed with this honor. As a scientist and educator, the NSF CAREER award allows me to integrate the very core of who I am as a scientist and educator.
Forever grateful to past and present members of my lab for helping me accomplish this dream.
Forever grateful to past and present members of my lab for helping me accomplish this dream.
July 30, 2025 at 6:19 PM
In a time as this— I am deeply thankful to be blessed with this honor. As a scientist and educator, the NSF CAREER award allows me to integrate the very core of who I am as a scientist and educator.
Forever grateful to past and present members of my lab for helping me accomplish this dream.
Forever grateful to past and present members of my lab for helping me accomplish this dream.
Reposted by Michael Hanna
One for the Apicomplexa peeps:
ever wonder how does the IMC grow so fast during progeny formation? Where do all the lipids come from? In our latest work on malaria RBC stages we implicate this monster protein (~6000 residues!) and ER contact sites.
Happy+proud to share and keen to hear thoughts!
ever wonder how does the IMC grow so fast during progeny formation? Where do all the lipids come from? In our latest work on malaria RBC stages we implicate this monster protein (~6000 residues!) and ER contact sites.
Happy+proud to share and keen to hear thoughts!
July 26, 2025 at 5:16 PM
One for the Apicomplexa peeps:
ever wonder how does the IMC grow so fast during progeny formation? Where do all the lipids come from? In our latest work on malaria RBC stages we implicate this monster protein (~6000 residues!) and ER contact sites.
Happy+proud to share and keen to hear thoughts!
ever wonder how does the IMC grow so fast during progeny formation? Where do all the lipids come from? In our latest work on malaria RBC stages we implicate this monster protein (~6000 residues!) and ER contact sites.
Happy+proud to share and keen to hear thoughts!
Beautiful preprint from @aguillensamander.bsky.social who uncovered an essential role for a bridge-like lipid transfer protein (PfVPS13L1) on the growth of the inner membrane complex (IMC) in P. falciparum parasites: www.biorxiv.org/content/10.1...
A bridge-like lipid transfer protein is critical for generation of invasive stages in malaria parasites
Malaria blood stages build and maintain an intricate system of membranes during their cycle of rapid growth and schizogony (daughter-cell formation), requiring precise mechanisms of lipid synthesis an...
www.biorxiv.org
July 26, 2025 at 4:46 PM
Beautiful preprint from @aguillensamander.bsky.social who uncovered an essential role for a bridge-like lipid transfer protein (PfVPS13L1) on the growth of the inner membrane complex (IMC) in P. falciparum parasites: www.biorxiv.org/content/10.1...
Check out this great new preprint by Sam Block et al. from @mvhlab.bsky.social @korylab.bsky.social uncovering how a range of neutral amino acids are transported in mitochondria www.biorxiv.org/content/10.1...
www.biorxiv.org
June 24, 2025 at 1:39 PM
Check out this great new preprint by Sam Block et al. from @mvhlab.bsky.social @korylab.bsky.social uncovering how a range of neutral amino acids are transported in mitochondria www.biorxiv.org/content/10.1...
A very special first post on Bluesky: I’m excited to share that I’ll be starting my lab at Penn State this coming January in the Dept of Biochemistry & Molecular Biology! I’ll be hiring at all levels soon. Check out updates, thoughts, and positions on the lab account: @hanna-lab.bsky.social
May 28, 2025 at 1:25 PM
A very special first post on Bluesky: I’m excited to share that I’ll be starting my lab at Penn State this coming January in the Dept of Biochemistry & Molecular Biology! I’ll be hiring at all levels soon. Check out updates, thoughts, and positions on the lab account: @hanna-lab.bsky.social