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jrjones.bsky.social
Jeff Jones, PhD
@jrjones.bsky.social
240 followers 370 following 30 posts
Molecular biologist focused on aging
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Reposted by Jeff Jones, PhD
asaflevylab.bsky.social
R.I.P Hamilton Smith, 1978 Nobel Laureate for the discovery of type II restriction-modification systems (HindII).
October 26, 2025 at 6:54 PM
Reposted by Jeff Jones, PhD
erictopol.bsky.social
Why does the naked mole rat have the longest lifespan of any rodent, nearly 40 years?
A 30-year long mystery unraveled @ScienceMagazine today!
Its cGAS enzyme in cells has 4 missense mutations that upends its function, promoting DNA repair and suppressing inflammation
www.science.org/doi/10.1126/...
October 9, 2025 at 6:06 PM
Reposted by Jeff Jones, PhD
bielleogy.bsky.social
I'm still mad someone decided to call them H2A, H2B, H3, H4.
September 29, 2025 at 9:52 PM
jrjones.bsky.social
Thrilled to share that I’m starting my lab in the Department of Neuroscience at the University of Florida! We’ll study metabolism in brain aging to better understand Alzheimer’s disease. Excited to build, collab, and discover. Go Gators! 🐊
#Neuro #Aging #Alzheimers #UF
ufresearch.bsky.social‬
https://ufresearch.bsky.social‬
July 28, 2025 at 3:27 PM
Reposted by Jeff Jones, PhD
ahellab.bsky.social
A few years back we discovered a dual hybrid protein modification composed of ADP-ribose dinucleotide and ubiquitin (ADPr-Ub). Now we reveal that ADPr-Ub can be further ubiquitinated by the E3 ubiquitin ligase RNF114!
www.nature.com/articles/s41...

www.science.org/doi/10.1126/...
Identification of RNF114 as ADPr-Ub reader through non-hydrolysable ubiquitinated ADP-ribose - Nature Communications
Deltex E3s modify ADP-ribosylated targets with ubiquitin, creating a hybrid modification whose readers remains unknown. Here, the authors synthesise a non-hydrolysable probe that mimics the modificati...
www.nature.com
July 10, 2025 at 6:11 AM
Reposted by Jeff Jones, PhD
erictopol.bsky.social
Front page, NYT today
Nothing has been proven to reverse Alzheimer’s disease, including this false claim
gift link www.nytimes.com/2025/05/21/w...
May 25, 2025 at 2:51 PM
Reposted by Jeff Jones, PhD
us.theconversation.com
The NSF helped fund the tech in your phone, the models that forecast deadly storms and 268 Nobel prize-winners.

The Trump Administration has proposed cutting its budget by 55% – and 1400+ grants are already terminated.
Unprecedented cuts to the National Science Foundation endanger research that improves economic growth, national security and your life
The Trump administration has terminated hundreds of federal grants that support engineering, biology, geology, computer science, STEM education and much more.
buff.ly
May 18, 2025 at 4:35 AM
jrjones.bsky.social
Great paper out today by my friend and colleague James Tucker! I'm hopeful that some of these scaffolds have therapeutic value.
www.sciencedirect.com/science/arti...
Scaffold hopping and sidechain modification from a flavone scaffold lead to discovery of potent, selective CK2A2 inhibitors with favorable properties for CNS activity
The human protein kinase CK2 has long been of interest as a target in oncology, but new evidence is emerging of its role in central nervous system (CN…
www.sciencedirect.com
May 13, 2025 at 4:18 PM
Reposted by Jeff Jones, PhD
erictopol.bsky.social
Good summary of this important study linking blood pressure control and reduced dementia
www.nature.com/articles/s41...
May 4, 2025 at 10:06 PM
Reposted by Jeff Jones, PhD
astronomy.bsky.social
Albert Einstein died on this day, April 18, 1955.

It is incredible to hear Albert Einstein explain his famous formula, E=mc².
April 18, 2025 at 1:12 PM
Reposted by Jeff Jones, PhD
oregonthedm.bsky.social
Biggest commitment to a 3 second joke I've ever seen
April 9, 2025 at 6:33 AM
jrjones.bsky.social
My annual post for today:
In the era of rampant misinformation, April Fools just doesn't seem appropriate or funny
April 1, 2025 at 3:38 PM
jrjones.bsky.social
Conda users will get this
Solving Environment: \
March 31, 2025 at 7:37 PM
Reposted by Jeff Jones, PhD
mcuban.bsky.social
From 2010 to 2016 (latest data I have ), NIH research contributed to EVERY drug approved by the FDA
March 22, 2025 at 10:44 AM
Reposted by Jeff Jones, PhD
sfn.org
Success often requires community support.

Discuss practical approaches to creating more accessible & inclusive research settings in this webinar w/ @umarchatterjee.bsky.social, Kimberly Fiock, PhD, Billie Goolsby, BA, @brittgratreak.bsky.social, & @dwwilliamslab.bsky.social.

#NeuroSky
SfN Neuronline Professional Development Webinar - Disabled in Neuroscience: Promoting Equitable and Accessible Research for All. March 19, noon-1:30 p.m. EDT. Colorful scientific image background.
March 18, 2025 at 5:36 PM
Reposted by Jeff Jones, PhD
erictopol.bsky.social
More than 2 decades ago the PINK1 protein was found to be linked to Parkinson's disease, but its structure and how it was activated was not known. Until @science.org today. A triumph for cryo-EM and structural biology, introducing new targets for drug intervention.
www.science.org/doi/10.1126/...
March 13, 2025 at 11:19 PM
jrjones.bsky.social
He would see the entire world burn just to be the king of ashes
March 11, 2025 at 3:30 PM
Reposted by Jeff Jones, PhD
science.org
Breaking news: Thousands of researchers and their supporters, including recently fired federal workers, have gathered across the U.S. in response to layoffs and funding cuts ordered by the Trump administration. scim.ag/41zlPv4
Thousands gather across U.S. in Stand Up for Science events
Scientists rally across the country in response to layoffs and funding cuts ordered by the Trump administration
scim.ag
March 7, 2025 at 6:27 PM
Reposted by Jeff Jones, PhD
techconnectify.bsky.social
A really clarifying question that I think should be asked of basically every politician out there is "what do you imagine power to be and why do you want it?"
March 3, 2025 at 5:04 PM
Reposted by Jeff Jones, PhD
owasow.bsky.social
Between 2010 and 2024, CDC estimates that flu resulted in an estimated 9.3 million to 41 million illnesses, 120,000 to 710,000 hospitalizations and 6,300 to 52,000 deaths annually.

That’s *with* widespread use of the flu vaccine.
www.cdc.gov/flu-burden/p...
Image shows a pyramid with three bands. At bottom CDC estimates that flu has resulted in 9.3 million to 41 million illnesses. The middle band shows an estimate of 120,000 to 710,000 hospitalizations and the peak shows an estimated 6,300 to 52,000 deaths annually between 2010 and 2024.
March 2, 2025 at 3:31 PM
Reposted by Jeff Jones, PhD
tristansnell.bsky.social
This is Winston Churchill visiting the White House during World War II.

Funny how he isn’t wearing a suit either. Almost like he was a wartime leader defending his country from being slaughtered and wiped out by an authoritarian aggressor.
March 1, 2025 at 1:59 AM
Reposted by Jeff Jones, PhD
boghuma.bsky.social
I commend every parent who is choosing to do the right thing by vaccinating their child as the measles outbreak spreads. There's no shame in changing your mind on a stance you were wrong about. Especially when it concerns protecting children from disease.
www.nbcnews.com/health/healt...
As Texas measles outbreak grows, parents are choosing to vaccinate kids
At least 124 people, mostly babies, children and teens, have been infected. Eighteen people have been hospitalized.
www.nbcnews.com
February 26, 2025 at 2:00 AM
Reposted by Jeff Jones, PhD
iwashyna.bsky.social
Over on LinkedIn, the head of the Executive Secretariat of the NIH -- a central part of NIH leadership 🧪🩺-- resigned with a lettter worth reading

www.linkedin.com/posts/nathan...
February 18, 2024 TO: Dr. Matthew Memoli, Acting Director, NIH CC: John Burklow, Chief of Staff, NIH Julie Berko, Director, OHR, NIH FROM: Nathaniel James Brought, Director, ES, NIH SUBJECT: Resignation Dear Dr. Memoli, On July 3, 2001, I stepped off a bus on Marine Corps Recruit Training Depot Perris Island. Scared out of my mind, I stood on a pair of freshly painted yellow footprints, raised my right hand, and recited the oath of enlistment: I, Nathaniel James Brought, do solemnly swear that I will support and defend the Constitution of the United States against all enemies, foreign and domestic; that I will bear true faith and allegiance to the same; and that I will obey the orders of the President of the United States and the orders of the officers appointed over me, according to regulations and the Uniform Code of Military Justice. So help me God. For the last 23 years, 7 months, and 15 days, I like to believe I have faithfully carried out the duties of each office to which I've been appointed in my military and civilian service to this nation. That Service has taken me from the Marine Corps to 3 different federal departments, spanned 3 continents, included service in one war zone, and has included: • For the Marine Corps and the National Security Agency, I worked on intelligence operations at the highest classification levels using bleeding edge intelligence tools to ensure America's special operators put boots-to-asses on America's enemies overseas (including commendations crediting my work for the kill or capture of dozens of terrorists), ensuring America's policy makers were able to track the movement of dangerous dual nuclear technology across international borders, and monitored the flow of terrorist financing across the international banking system. • Utilized information from all-source intelligence to ensure the continued security of America's homeland from international and domestic threats. • Worked with some of the finest lawyers in the world to ensure America's security operations were effective, while upholding the rights of all those who interacted with them. • Ensuring that America's rural communities had access to programs like rural development loans, farm aid, and that America's children wouldn't be hungry as they sat in their classrooms and tried to learn. • Most recently, and frankly most dear to my heart, working with each of you here at the National Institutes of Health to advance the future of science and medicine. Not for Americans. Not for any one group of people. But for ALL of humanity. I am unbelievably proud to be able to say that there are Americans who are alive, and terrorists who are not, because of the work I've done to serve this nation. I am proud to say that my service to this country has allowed me to ensure that my children have never faced the struggles of poverty that I grew up with. That service didn't begin because of some great altruistic impulse or drive. I didn't grow up saying "I want to do the great work that needs to be done to weave the fabric of America and ensure her people are not only safe, but healthy." Frankly, that service began because I was poor, and I was inspired. I grew up as a free lunch kid who lived in project housing. It was my fellow Americans who made sure I wasn't hungry in class and that I had enough food to excel academically the way I did. It was Americans who had more than we did that made sure I had good schools to attend where I could learn things that expanded my mind. As I approached the end of high school, I dreamed of going to college and figuring out how to make a living that would allow me to do more tha… to go to college. I knew my grades weren't good enough to compete for scholarships with kids who were as smart as me but also had private tutors and didn't have to work after class to be able to drive their brand-new cars to our school each day. So, I gave up. I nearly failed my senior year of high school with an attendance failure, even though I only needed two classes to graduate. I didn't see the point. What was the point of learning calculus? So it would be that much harder when my dream of being a brain surgeon died not because I was incapable, but because I didn't have the means to make it come true? I resigned myself to being one of the working poor. I resigned myself to needing a spinal fusion before I was 50, like my father, because he literally broke his back trying to make his dreams come true. The example of my father didn't inspire me at that time. It reminded me of the futility of trying to escape the rung of the social ladder I had been born onto. No matter how smart or "gifted and talented" I may have been, I saw no path that led me to a place where I could realize my potential. So, instead I accepted that it would be wasted. Ultimately, the reason I find myself here today, rather than in the place I saw as my only end, is because of another young man who committed to serving his country. Shamefully, I do not remember his name, but there was a young corporal from the United States Marine Corps who had been assigned as a recruiter in Reading, Pennsylvania at that time. This man spoke to me about my plans for my future during lunch one day at school. I told him I planned to do what my father had done. Work hard jobs until my body broke down, maybe start a struggling business, and try to do what I could to stay above the poverty line and off welfare. I told him I hoped to be successful enough that my kids never had to watch me use food stamps at the grocery store. It had been hard to watch my mom go through that. How sad is that? I was a smart young 18-…
February 20, 2025 at 6:43 PM
jrjones.bsky.social
This is not the increased brain plasticity I had hoped for...
edition.cnn.com/2025/02/03/h...
Human brain samples contain an entire spoon’s worth of nanoplastics, study says | CNN
Human brains today contain 50% more plastic than in 2016, a new study found. Brain of people diagnosed with dementia had the most.
edition.cnn.com
February 5, 2025 at 11:17 PM
jrjones.bsky.social
TO-DO lists will grow if left unchecked
February 5, 2025 at 11:01 PM