@nunoraimundo.bsky.social
New roles for lysosomes... and maybe new targets for Batten disease?
Loss of the lysosomal protein CLN3 triggers c-Abl-dependent YAP1 pro-apoptotic signaling | EMBO reports www.embopress.org/doi/full/10....
Loss of the lysosomal protein CLN3 triggers c-Abl-dependent YAP1 pro-apoptotic signaling | EMBO reports www.embopress.org/doi/full/10....
Loss of the lysosomal protein CLN3 triggers c-Abl-dependent YAP1 pro-apoptotic signaling | EMBO reports
imageimageLoss of Batten disease-associated lysosomal protein CLN3 leads to DNA damage and activation
of c-Abl-YAP1-dependent pro-apoptotic signaling which underlies increased apoptosis
susceptibility...
www.embopress.org
November 7, 2025 at 12:03 PM
New roles for lysosomes... and maybe new targets for Batten disease?
Loss of the lysosomal protein CLN3 triggers c-Abl-dependent YAP1 pro-apoptotic signaling | EMBO reports www.embopress.org/doi/full/10....
Loss of the lysosomal protein CLN3 triggers c-Abl-dependent YAP1 pro-apoptotic signaling | EMBO reports www.embopress.org/doi/full/10....
The 2025 @embo.org Contact Sites meeting was extraordinary. Congratulations to
Michelangelo Campanella and
Mélanie Paillard
meetings.embo.org/event/25-mem...
Marta Giacomello and I are already working to make the 2027 meeting memorable.
Keep in touch (like a contact site). It will be 🔥 🔥 🔥
Michelangelo Campanella and
Mélanie Paillard
meetings.embo.org/event/25-mem...
Marta Giacomello and I are already working to make the 2027 meeting memorable.
Keep in touch (like a contact site). It will be 🔥 🔥 🔥
Membrane Contact Sites: Methodology, Biology & Pathology
Intracellular organelles are connected through regions of close apposition known as membrane contact sites (MCS). The growing understanding of MCS’ biology and function has dramatically changed the t…
meetings.embo.org
October 7, 2025 at 6:47 PM
The 2025 @embo.org Contact Sites meeting was extraordinary. Congratulations to
Michelangelo Campanella and
Mélanie Paillard
meetings.embo.org/event/25-mem...
Marta Giacomello and I are already working to make the 2027 meeting memorable.
Keep in touch (like a contact site). It will be 🔥 🔥 🔥
Michelangelo Campanella and
Mélanie Paillard
meetings.embo.org/event/25-mem...
Marta Giacomello and I are already working to make the 2027 meeting memorable.
Keep in touch (like a contact site). It will be 🔥 🔥 🔥
Reposted
The future is visiting again! We are seeking applicants for the 7th season of MITOchats. Deadline for submission is October 17th. Visit www.mitotalks.org for details or submit your application at forms.gle/5D6vWE92yYCi...
September 25, 2025 at 9:59 PM
The future is visiting again! We are seeking applicants for the 7th season of MITOchats. Deadline for submission is October 17th. Visit www.mitotalks.org for details or submit your application at forms.gle/5D6vWE92yYCi...
Reposted
(2/2) And from January 2026 onwards:
Jan 08 Peter Kim
Feb 05 Robin Klemm
March 05 Natalie Niemi
April 02 Henry Higgs
May 07 Eija Pirinen
June 04 Heidi McBride
usual time and place. See you there?
Jan 08 Peter Kim
Feb 05 Robin Klemm
March 05 Natalie Niemi
April 02 Henry Higgs
May 07 Eija Pirinen
June 04 Heidi McBride
usual time and place. See you there?
September 9, 2025 at 5:07 PM
(2/2) And from January 2026 onwards:
Jan 08 Peter Kim
Feb 05 Robin Klemm
March 05 Natalie Niemi
April 02 Henry Higgs
May 07 Eija Pirinen
June 04 Heidi McBride
usual time and place. See you there?
Jan 08 Peter Kim
Feb 05 Robin Klemm
March 05 Natalie Niemi
April 02 Henry Higgs
May 07 Eija Pirinen
June 04 Heidi McBride
usual time and place. See you there?
Reposted
Now that the summer season is over, it's time for some MITObusiness. (1/2)
Oct 02 Kostas Tokatlidis
Nov 06 Hiromi Sesaki
Dec 04 Ewa Bomba-Warczak
Oct 02 Kostas Tokatlidis
Nov 06 Hiromi Sesaki
Dec 04 Ewa Bomba-Warczak
September 9, 2025 at 5:07 PM
Now that the summer season is over, it's time for some MITObusiness. (1/2)
Oct 02 Kostas Tokatlidis
Nov 06 Hiromi Sesaki
Dec 04 Ewa Bomba-Warczak
Oct 02 Kostas Tokatlidis
Nov 06 Hiromi Sesaki
Dec 04 Ewa Bomba-Warczak
Happy 4th! 🇺🇸
July 4, 2025 at 12:56 PM
Happy 4th! 🇺🇸
Reposted
Sign up for midwest metabolism & Trimad joint meeting! Abstracts are due 9/2/25. The vast majority of talks will come from the abstracts - great opportunity for trainees! www.vai.org/event/2025-m...
2025 Midwest Metabolism Meeting
Join us for 2025 Midwest Metabolism Meeting at Van Andel Institute Stay informed about exciting upcoming events and activities.
www.vai.org
June 4, 2025 at 6:21 PM
Sign up for midwest metabolism & Trimad joint meeting! Abstracts are due 9/2/25. The vast majority of talks will come from the abstracts - great opportunity for trainees! www.vai.org/event/2025-m...
Reposted
MITOtalks and especially MITOchats have been playing with time travel. This week, instead of bringing the future over, we will get there faster: our speaker will tell us all about a mitochondrial progeria syndrome. Usual time and place.
June 4, 2025 at 2:38 PM
MITOtalks and especially MITOchats have been playing with time travel. This week, instead of bringing the future over, we will get there faster: our speaker will tell us all about a mitochondrial progeria syndrome. Usual time and place.
Reposted
Two mtDNA papers of ours in one PNAS issue:
#1 on the Y951N patient mutation of PolG, heroically spear-headed by Josefin Forslund
#2 revealing surprising dNTP imbalance & subsequent mtDNA depletion in RRM2B-deficient mice, a great collaboration with the Chabes lab
www.pnas.org/toc/pnas/122...
#1 on the Y951N patient mutation of PolG, heroically spear-headed by Josefin Forslund
#2 revealing surprising dNTP imbalance & subsequent mtDNA depletion in RRM2B-deficient mice, a great collaboration with the Chabes lab
www.pnas.org/toc/pnas/122...
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
www.pnas.org
April 22, 2025 at 6:41 PM
Two mtDNA papers of ours in one PNAS issue:
#1 on the Y951N patient mutation of PolG, heroically spear-headed by Josefin Forslund
#2 revealing surprising dNTP imbalance & subsequent mtDNA depletion in RRM2B-deficient mice, a great collaboration with the Chabes lab
www.pnas.org/toc/pnas/122...
#1 on the Y951N patient mutation of PolG, heroically spear-headed by Josefin Forslund
#2 revealing surprising dNTP imbalance & subsequent mtDNA depletion in RRM2B-deficient mice, a great collaboration with the Chabes lab
www.pnas.org/toc/pnas/122...
Reposted
Excited to share our latest paper in Science Advances! We finally dissected a new pathway for mitochondrial quality control upon mtDNA replication stress! Let’s start a short thread! 🧵
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Retromer promotes the lysosomal turnover of mtDNA
Lysosomal uptake of mtDNA controls mitochondrial quality.
www.science.org
April 4, 2025 at 6:42 PM
Excited to share our latest paper in Science Advances! We finally dissected a new pathway for mitochondrial quality control upon mtDNA replication stress! Let’s start a short thread! 🧵
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted
Great chance for Canadian researchers to attend a great scientific meeting in Canada!
Missed the deadline for the abstract submission for the CSMB meeting on Protein Homeostasis – From Basic Science to Human Health?
Well the deadline was extended until April 15th!
event.fourwaves.com/csmb-prince-...
Well the deadline was extended until April 15th!
event.fourwaves.com/csmb-prince-...
2025 CSMB-PRinCE Joint Conference
Fourwaves - 2025 CSMB-PRinCE Joint Conference
event.fourwaves.com
April 1, 2025 at 3:48 PM
Great chance for Canadian researchers to attend a great scientific meeting in Canada!
Reposted
MITOtalks this week
April 1, 2025 at 4:10 PM
MITOtalks this week
A reliable and selective AMPK inhibitor - really important tool for AMPK research, congratulations to the team
Pleased to share our new preprint describing mechanistic insights and cellular selectivity of the AMPK inhibitor.
March 7, 2025 at 7:35 AM
A reliable and selective AMPK inhibitor - really important tool for AMPK research, congratulations to the team
Reposted
It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS or other (non-LCH) dendritic or histiocytic sarcomas cases.
February 8, 2025 at 9:21 PM
It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS or other (non-LCH) dendritic or histiocytic sarcomas cases.
Reposted
Time for some mito-business. Or should we say methyl-business?? Let's ask our speaker Thomas MacVicar.
This thursday, usual time and place.
This thursday, usual time and place.
February 3, 2025 at 6:55 PM
Time for some mito-business. Or should we say methyl-business?? Let's ask our speaker Thomas MacVicar.
This thursday, usual time and place.
This thursday, usual time and place.
Reposted
This the season... for the last MITOtalk in 2024.
When translation is no longer enough to understand what is going on, our speaker will tell us what happens after.
When translation is no longer enough to understand what is going on, our speaker will tell us what happens after.
December 2, 2024 at 9:19 AM
This the season... for the last MITOtalk in 2024.
When translation is no longer enough to understand what is going on, our speaker will tell us what happens after.
When translation is no longer enough to understand what is going on, our speaker will tell us what happens after.