Kei Sakamoto
@keisakamoto.bsky.social
Professor Univ. of Copenhagen, Vice Director Novo Nordisk Foundation Center for Basic Metabolic Research, Metabolic Signaling, glucose metabolism, AMPK
Pinned
Kei Sakamoto
@keisakamoto.bsky.social
· Mar 6
Pleased to share our new preprint describing mechanistic insights and cellular selectivity of the AMPK inhibitor.
Reposted by Kei Sakamoto
The structure of BAY-3827 with wild-type AMPK α2 kinase domain by @zeqiraj.bsky.social & postdoc Mohd. Syed Ayengar helped determine the mechanism of action of this compound and the limitations for its use, addressing a long-standing challenge in the field: the absence of specific AMPK inhibitors.
September 9, 2025 at 3:17 PM
The structure of BAY-3827 with wild-type AMPK α2 kinase domain by @zeqiraj.bsky.social & postdoc Mohd. Syed Ayengar helped determine the mechanism of action of this compound and the limitations for its use, addressing a long-standing challenge in the field: the absence of specific AMPK inhibitors.
Reposted by Kei Sakamoto
Latest publication from the lab spearheaded by @shoreseashell.bsky.social & in collaboration with @zeqiraj.bsky.social is out. Using structural, biochemical & computational tools, this work sheds light on the mechanism of action of BAY-3827 in inhibiting #AMPK 1/3
www.science.org/doi/full/10....
www.science.org/doi/full/10....
Mechanism and cellular actions of the potent AMPK inhibitor BAY-3827
The mechanism and unique molecular/cellular features of the potent and selective AMPK inhibitor BAY-3827 are unraveled.
www.science.org
September 9, 2025 at 3:17 PM
Latest publication from the lab spearheaded by @shoreseashell.bsky.social & in collaboration with @zeqiraj.bsky.social is out. Using structural, biochemical & computational tools, this work sheds light on the mechanism of action of BAY-3827 in inhibiting #AMPK 1/3
www.science.org/doi/full/10....
www.science.org/doi/full/10....
Reposted by Kei Sakamoto
The gut hormone mimetic era in medicine is just getting started
www.nature.com/articles/s42...
erictopol.substack.com/p/the-gut-br...
www.nature.com/articles/s42...
erictopol.substack.com/p/the-gut-br...
Shaping the future of cardiometabolic innovation: advances and opportunities - Nature Metabolism
Obesity is a global public health concern closely linked to cardiometabolic complications. This Comment provides our views on recent breakthroughs, emerging innovations and future needs of therapeutic...
www.nature.com
July 11, 2025 at 2:22 PM
The gut hormone mimetic era in medicine is just getting started
www.nature.com/articles/s42...
erictopol.substack.com/p/the-gut-br...
www.nature.com/articles/s42...
erictopol.substack.com/p/the-gut-br...
Reposted by Kei Sakamoto
Obesity is a global public health concern closely linked to cardiometabolic complications. This Comment provides views on recent breakthroughs, emerging innovations and future needs of therapeutic interventions to counteract obesity and its associated health risks. www.nature.com/articles/s42...
Shaping the future of cardiometabolic innovation: advances and opportunities - Nature Metabolism
Obesity is a global public health concern closely linked to cardiometabolic complications. This Comment provides our views on recent breakthroughs, emerging innovations and future needs of therapeutic...
www.nature.com
July 11, 2025 at 1:25 PM
Obesity is a global public health concern closely linked to cardiometabolic complications. This Comment provides views on recent breakthroughs, emerging innovations and future needs of therapeutic interventions to counteract obesity and its associated health risks. www.nature.com/articles/s42...
Happy to have contributed to this very interesting work ked/driven by Raid Nisr, Alison McNeilly and Graham Rena (University of Dundee). doi.org/10.1111/apha...
May 23, 2025 at 5:33 AM
Happy to have contributed to this very interesting work ked/driven by Raid Nisr, Alison McNeilly and Graham Rena (University of Dundee). doi.org/10.1111/apha...
Reposted by Kei Sakamoto
Special day for our group @cbmr.science as we celebrate the successful defense of our (first) freshly minted PhD, Dr. Conchita Bringas 🥳 Her thesis was based on characterizing novel #AMPK inhibitors. Special thanks to the great committee @rbdamgaard.bsky.social ,Dave Carling & Lykke Sylow.
May 16, 2025 at 6:35 PM
Special day for our group @cbmr.science as we celebrate the successful defense of our (first) freshly minted PhD, Dr. Conchita Bringas 🥳 Her thesis was based on characterizing novel #AMPK inhibitors. Special thanks to the great committee @rbdamgaard.bsky.social ,Dave Carling & Lykke Sylow.
Reposted by Kei Sakamoto
The surprising result for a GLP-1 pill (orforglipron) is the magnitude of weight loss in a Phase 3 trial of participants with Type 2 diabetes. For still unexplained reasons, people with diabetes lose much less weight on GLP-1 drugs than those with obesity, w/o diabetes.
April 20, 2025 at 3:58 PM
The surprising result for a GLP-1 pill (orforglipron) is the magnitude of weight loss in a Phase 3 trial of participants with Type 2 diabetes. For still unexplained reasons, people with diabetes lose much less weight on GLP-1 drugs than those with obesity, w/o diabetes.
Th most-cited research papers of all time. A 1951 publication by US biochemist Oliver Lowry in the Journal of Biological Chemistry describing an assay to determine the amount of protein in a solution has been cited more than 350,000 times.
April 21, 2025 at 11:00 AM
Th most-cited research papers of all time. A 1951 publication by US biochemist Oliver Lowry in the Journal of Biological Chemistry describing an assay to determine the amount of protein in a solution has been cited more than 350,000 times.
Eli Lilly announced positive results from a large clinical trial of its once-daily pill orforglipron in people with type 2 diabetes, while Pfizer announced last week it was halting development of its candidate after signs of liver injury in a trial participant.
April 21, 2025 at 7:45 AM
Eli Lilly announced positive results from a large clinical trial of its once-daily pill orforglipron in people with type 2 diabetes, while Pfizer announced last week it was halting development of its candidate after signs of liver injury in a trial participant.
Joan was a visionary and inspirational leader, researcher and generous mentor and friend. His legacy will stay forever.
@irbbarcelona.org
@irbbarcelona.org
Online now - a tribute to the memory of Prof. Joan J. Guinovart from Jordi Duran and Matthew Gentry.
Prof. Guinovart was a renowned biochemist in the field of glycogen metabolism and known for his leadership in science.
(1/4)
Prof. Guinovart was a renowned biochemist in the field of glycogen metabolism and known for his leadership in science.
(1/4)
April 18, 2025 at 2:50 PM
Joan was a visionary and inspirational leader, researcher and generous mentor and friend. His legacy will stay forever.
@irbbarcelona.org
@irbbarcelona.org
Reposted by Kei Sakamoto
President Donald Trump has nominated Susan Monarez, an infectious disease researcher and current acting director of the Centers for Disease Control and Prevention, to become the agency’s permanent leader. scim.ag/425J0xs
Trump’s new CDC pick ‘has her work cut out for her’
Susan Monarez, an expert in biosecurity and infectious disease, strikes some as a sensible choice to head the health agency—but some staffers there have raised concerns
scim.ag
March 26, 2025 at 5:12 PM
President Donald Trump has nominated Susan Monarez, an infectious disease researcher and current acting director of the Centers for Disease Control and Prevention, to become the agency’s permanent leader. scim.ag/425J0xs
Reposted by Kei Sakamoto
From 2010 to 2016 (latest data I have ), NIH research contributed to EVERY drug approved by the FDA
March 22, 2025 at 10:44 AM
From 2010 to 2016 (latest data I have ), NIH research contributed to EVERY drug approved by the FDA
Reposted by Kei Sakamoto
Interested in aging?
Super excited about this upcoming Keystone meeting!! 🧪🌲🌲
Aging: Immune Function and Organ Health -- Banff, Canada in 2026!!! ✨✨
Joint meeting with the Keystone Innate Immunity meeting!
#aging #immunity @keystonesymposia.bsky.social
www.keystonesymposia.org/conferences/...
Super excited about this upcoming Keystone meeting!! 🧪🌲🌲
Aging: Immune Function and Organ Health -- Banff, Canada in 2026!!! ✨✨
Joint meeting with the Keystone Innate Immunity meeting!
#aging #immunity @keystonesymposia.bsky.social
www.keystonesymposia.org/conferences/...
Aging: Immune Function and Organ Health | Keystone Symposia
Join us at the Keystone Symposia on Aging: Immune Function and Organ Health, March 2026, in Banff, with field leaders!
www.keystonesymposia.org
March 22, 2025 at 12:55 AM
Interested in aging?
Super excited about this upcoming Keystone meeting!! 🧪🌲🌲
Aging: Immune Function and Organ Health -- Banff, Canada in 2026!!! ✨✨
Joint meeting with the Keystone Innate Immunity meeting!
#aging #immunity @keystonesymposia.bsky.social
www.keystonesymposia.org/conferences/...
Super excited about this upcoming Keystone meeting!! 🧪🌲🌲
Aging: Immune Function and Organ Health -- Banff, Canada in 2026!!! ✨✨
Joint meeting with the Keystone Innate Immunity meeting!
#aging #immunity @keystonesymposia.bsky.social
www.keystonesymposia.org/conferences/...
Reposted by Kei Sakamoto
The Strategic Research Programme in Diabetes at Karolinska Institutet and Umeå Univeristy is seeking a Programme Manager (based in Stockholm).
More information about the programme is here ki.se/en/srp-diabe...
and the link to the position is here ki.varbi.com/en/what:job/...
Please repost!
More information about the programme is here ki.se/en/srp-diabe...
and the link to the position is here ki.varbi.com/en/what:job/...
Please repost!
March 21, 2025 at 3:23 PM
The Strategic Research Programme in Diabetes at Karolinska Institutet and Umeå Univeristy is seeking a Programme Manager (based in Stockholm).
More information about the programme is here ki.se/en/srp-diabe...
and the link to the position is here ki.varbi.com/en/what:job/...
Please repost!
More information about the programme is here ki.se/en/srp-diabe...
and the link to the position is here ki.varbi.com/en/what:job/...
Please repost!
Thank you very much for this initiative and providing us with the opportunity to share our memories and stories. His legacy will stay forever. Visionary and inspirational leader, researcher and generous mentor and friend.
Honoring Dr. Joan Guinovart—a visionary in science and an inspiration to many. Share your memories, stories, and gratitude to celebrate his remarkable legacy.
Let’s keep his spirit alive:
➡️ www.irbbarcelona.org/en/guinovart
Let’s keep his spirit alive:
➡️ www.irbbarcelona.org/en/guinovart
March 21, 2025 at 9:05 PM
Thank you very much for this initiative and providing us with the opportunity to share our memories and stories. His legacy will stay forever. Visionary and inspirational leader, researcher and generous mentor and friend.
Reposted by Kei Sakamoto
More than 2 decades ago the PINK1 protein was found to be linked to Parkinson's disease, but its structure and how it was activated was not known. Until @science.org today. A triumph for cryo-EM and structural biology, introducing new targets for drug intervention.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
March 13, 2025 at 11:19 PM
More than 2 decades ago the PINK1 protein was found to be linked to Parkinson's disease, but its structure and how it was activated was not known. Until @science.org today. A triumph for cryo-EM and structural biology, introducing new targets for drug intervention.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Kei Sakamoto
A partner for Petrelintide #obesity www.globenewswire.com/news-release...
Zealand Pharma and Roche enter collaboration and license agreement to co-develop and co-commercialize petrelintide as a future foundational therapy for people with overweight and obesity
Company announcement – No. 4 / 2025 Zealand Pharma and Roche enter collaboration and license agreement to co-develop and co-commercialize petrelintide as...
www.globenewswire.com
March 12, 2025 at 9:40 AM
A partner for Petrelintide #obesity www.globenewswire.com/news-release...
"Glycogen drives tumour initiation and progression in lung adenocarcinoma"
March 12, 2025 at 6:55 AM
"Glycogen drives tumour initiation and progression in lung adenocarcinoma"
Reposted by Kei Sakamoto
Strong presence of the @labsakamoto.bsky.social group members at the Metabolism Day #MD25 @cbmr.science Posters were presented by postdocs Joy & Jordana and by PhD students Maria, Hongling, Conchita & Costanza. #AMPK #TFEB #SIK
March 11, 2025 at 4:10 PM
Strong presence of the @labsakamoto.bsky.social group members at the Metabolism Day #MD25 @cbmr.science Posters were presented by postdocs Joy & Jordana and by PhD students Maria, Hongling, Conchita & Costanza. #AMPK #TFEB #SIK
Reposted by Kei Sakamoto
A special issue on #WomensHealth in #ScienceAdvances highlights a growing wave of research focusing on women’s unique biological and psychological experiences.
Learn more: scim.ag/3R59fPe (THREAD 🧵)
Learn more: scim.ag/3R59fPe (THREAD 🧵)
March 11, 2025 at 7:46 PM
A special issue on #WomensHealth in #ScienceAdvances highlights a growing wave of research focusing on women’s unique biological and psychological experiences.
Learn more: scim.ag/3R59fPe (THREAD 🧵)
Learn more: scim.ag/3R59fPe (THREAD 🧵)
Reposted by Kei Sakamoto
Our group @cbmr.science is now driven by an all women workforce (barring Kei), & we are incredibly fortunate to have these (multi)talented, hard working & generous women who support & elevate each other every day!
Happy International Women's Day!
#WomensDay2025 #LatePost
Happy International Women's Day!
#WomensDay2025 #LatePost
March 10, 2025 at 2:56 PM
Our group @cbmr.science is now driven by an all women workforce (barring Kei), & we are incredibly fortunate to have these (multi)talented, hard working & generous women who support & elevate each other every day!
Happy International Women's Day!
#WomensDay2025 #LatePost
Happy International Women's Day!
#WomensDay2025 #LatePost
Reposted by Kei Sakamoto
Currently, NIH's Center for Scientific Review reviews 66,000 grant applications a year, with panels run by NIH’s separate institutes reviewing the rest.
Under a new plan, the institute-run panels will be eliminated, and many of the scientists overseeing them will be laid off. scim.ag/3QP0FUG
Under a new plan, the institute-run panels will be eliminated, and many of the scientists overseeing them will be laid off. scim.ag/3QP0FUG
NIH will eliminate many peer review panels and lay off some scientists overseeing them
scim.ag
March 8, 2025 at 1:08 AM
Currently, NIH's Center for Scientific Review reviews 66,000 grant applications a year, with panels run by NIH’s separate institutes reviewing the rest.
Under a new plan, the institute-run panels will be eliminated, and many of the scientists overseeing them will be laid off. scim.ag/3QP0FUG
Under a new plan, the institute-run panels will be eliminated, and many of the scientists overseeing them will be laid off. scim.ag/3QP0FUG
Reposted by Kei Sakamoto
"The academic structure … makes planning for a family feel like an impossible luxury."
In this #ScienceWorkingLife, two postdocs share how, as women in academia, having children can feel impossible—and how talking about it makes them feel less alone. scim.ag/3F60VMt #InternationalWomensDay
In this #ScienceWorkingLife, two postdocs share how, as women in academia, having children can feel impossible—and how talking about it makes them feel less alone. scim.ag/3F60VMt #InternationalWomensDay
As women in academia, having children can feel impossible. Talking about it makes us feel less alone
The struggle is “balancing their careers not just with motherhood, but with what comes before: relationships and planning for a family,” these postdocs write
scim.ag
March 8, 2025 at 3:07 PM
"The academic structure … makes planning for a family feel like an impossible luxury."
In this #ScienceWorkingLife, two postdocs share how, as women in academia, having children can feel impossible—and how talking about it makes them feel less alone. scim.ag/3F60VMt #InternationalWomensDay
In this #ScienceWorkingLife, two postdocs share how, as women in academia, having children can feel impossible—and how talking about it makes them feel less alone. scim.ag/3F60VMt #InternationalWomensDay
Pleased to share our new preprint describing mechanistic insights and cellular selectivity of the AMPK inhibitor.
March 6, 2025 at 12:40 PM
Pleased to share our new preprint describing mechanistic insights and cellular selectivity of the AMPK inhibitor.
Reposted by Kei Sakamoto
Out now: Our method article describing large scale production & enzyme activity measurements of human glycogen synthase-glycogenin (GS-GN) complex published in the MIMB book series. Lead by researcher, Dipsikha Biswas & in collaboration with @zeqiraj.bsky.social @universityofleeds.bsky.social
Large-Scale Protein Production and Activity Assay Protocols for Human Glycogen Synthase-Glycogenin Complex
Glycogen synthase (GS) is the rate-limiting enzyme for glycogen production and together with glycogenin (GN) and glycogen branching enzyme (GBE), can generate glycogen particles containing up to 50,00...
link.springer.com
February 27, 2025 at 10:16 AM
Out now: Our method article describing large scale production & enzyme activity measurements of human glycogen synthase-glycogenin (GS-GN) complex published in the MIMB book series. Lead by researcher, Dipsikha Biswas & in collaboration with @zeqiraj.bsky.social @universityofleeds.bsky.social