Sakamoto Lab
@labsakamoto.bsky.social
Metabolic Signaling Laboratory, NNF-CBMR, University of Copenhagen
Posts by @itsmedipsikha.bsky.social
Posts by @itsmedipsikha.bsky.social
Pinned
Sakamoto Lab
@labsakamoto.bsky.social
· Sep 30
Common and distinct roles of AMPKγ isoforms in small-molecule activator-stimulated glucose uptake in mouse skeletal muscle
Objective: Small-molecule activators targeting the allosteric drug and metabolite (ADaM) site of AMPK enhance insulin-independent glucose uptake in skeletal muscle and lower glucose in preclinical mod...
www.biorxiv.org
Check out our latest preprint from the lab, spearheaded by researcher @itsmedipsikha.bsky.social , investigating the distinctive roles of regulatory gamma subunits of the AMPK protein complex in small molecule activator-stimulated skeletal muscle glucose uptake.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Sakamoto Lab
BREAKING: The Nobel Prize in Physiology or Medicine has been awarded jointly to Mary E. Brunkow, Fred Ramsdell, and Shimon Sakaguchi "for their discoveries concerning peripheral immune tolerance"
Stay tuned for more.
#NobelPrize
Stay tuned for more.
#NobelPrize
October 6, 2025 at 9:34 AM
BREAKING: The Nobel Prize in Physiology or Medicine has been awarded jointly to Mary E. Brunkow, Fred Ramsdell, and Shimon Sakaguchi "for their discoveries concerning peripheral immune tolerance"
Stay tuned for more.
#NobelPrize
Stay tuned for more.
#NobelPrize
Check out our latest preprint from the lab, spearheaded by researcher @itsmedipsikha.bsky.social , investigating the distinctive roles of regulatory gamma subunits of the AMPK protein complex in small molecule activator-stimulated skeletal muscle glucose uptake.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Common and distinct roles of AMPKγ isoforms in small-molecule activator-stimulated glucose uptake in mouse skeletal muscle
Objective: Small-molecule activators targeting the allosteric drug and metabolite (ADaM) site of AMPK enhance insulin-independent glucose uptake in skeletal muscle and lower glucose in preclinical mod...
www.biorxiv.org
September 30, 2025 at 10:42 AM
Check out our latest preprint from the lab, spearheaded by researcher @itsmedipsikha.bsky.social , investigating the distinctive roles of regulatory gamma subunits of the AMPK protein complex in small molecule activator-stimulated skeletal muscle glucose uptake.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Sakamoto Lab
#Throwback 🧪
COMMENT | From NAFLD to MASLD: implications of the new nomenclature for preclinical and clinical research
C Hsu & R Loomba
COMMENT | From NAFLD to MASLD: implications of the new nomenclature for preclinical and clinical research
C Hsu & R Loomba
From NAFLD to MASLD: implications of the new nomenclature for preclinical and clinical research - Nature Metabolism
Non-alcoholic liver disease (NAFLD) is now metabolic dysfunction-associated steatotic liver disease (MASLD), emphasizing the key metabolic factors of obesity, insulin resistance, vascular dysfunction and dyslipidaemia. Here, we discuss impacts on the existing body of clinical and preclinical liver disease research and on research moving forward.
bit.ly
September 19, 2025 at 4:01 PM
#Throwback 🧪
COMMENT | From NAFLD to MASLD: implications of the new nomenclature for preclinical and clinical research
C Hsu & R Loomba
COMMENT | From NAFLD to MASLD: implications of the new nomenclature for preclinical and clinical research
C Hsu & R Loomba
Latest publication from the lab spearheaded by @shoreseashell.bsky.social & in collaboration with @zeqiraj.bsky.social is out. Using structural, biochemical & computational tools, this work sheds light on the mechanism of action of BAY-3827 in inhibiting #AMPK 1/3
www.science.org/doi/full/10....
www.science.org/doi/full/10....
Mechanism and cellular actions of the potent AMPK inhibitor BAY-3827
The mechanism and unique molecular/cellular features of the potent and selective AMPK inhibitor BAY-3827 are unraveled.
www.science.org
September 9, 2025 at 3:17 PM
Latest publication from the lab spearheaded by @shoreseashell.bsky.social & in collaboration with @zeqiraj.bsky.social is out. Using structural, biochemical & computational tools, this work sheds light on the mechanism of action of BAY-3827 in inhibiting #AMPK 1/3
www.science.org/doi/full/10....
www.science.org/doi/full/10....
Last week @labsakamoto.bsky.social members participated in the #DHL Relay Copenhagen with one running team and one walking team! This was the lab's 5th year participating in this event and each year we get better with our performance😀
& this year was @keisakamoto.bsky.social personal best 🙌🍾
& this year was @keisakamoto.bsky.social personal best 🙌🍾
September 2, 2025 at 10:50 AM
Last week @labsakamoto.bsky.social members participated in the #DHL Relay Copenhagen with one running team and one walking team! This was the lab's 5th year participating in this event and each year we get better with our performance😀
& this year was @keisakamoto.bsky.social personal best 🙌🍾
& this year was @keisakamoto.bsky.social personal best 🙌🍾
Reposted by Sakamoto Lab
RNA droplets that grow and segregate by ribozyme catalysis. Check out our latest preprint www.biorxiv.org/content/10.1101/2025.08.29.673008v1
September 2, 2025 at 7:03 AM
RNA droplets that grow and segregate by ribozyme catalysis. Check out our latest preprint www.biorxiv.org/content/10.1101/2025.08.29.673008v1
Congratulations to Researcher @itsmedipsikha.bsky.social for being one of the recipients of the EFSD/Lilly Young Investigator Awards! We celebrated her achievement with some cakes and bubbles earlier 🥳 @easdnews.bsky.social @cbmr.science
www.europeandiabetesfoundation.org/recipients/e...
www.europeandiabetesfoundation.org/recipients/e...
August 21, 2025 at 2:28 PM
Congratulations to Researcher @itsmedipsikha.bsky.social for being one of the recipients of the EFSD/Lilly Young Investigator Awards! We celebrated her achievement with some cakes and bubbles earlier 🥳 @easdnews.bsky.social @cbmr.science
www.europeandiabetesfoundation.org/recipients/e...
www.europeandiabetesfoundation.org/recipients/e...
Reposted by Sakamoto Lab
A missing enzyme-rescue metabolite as cause of a rare skeletal dysplasia
share.google/dUNL7g7DkUle...
share.google/dUNL7g7DkUle...
A missing enzyme-rescue metabolite as cause of a rare skeletal dysplasia - Nature
In mammals, the enzyme TGDS produces UDP-4-keto-6-deoxyglucose, which binds to the catalytic pocket of UDP-xylose synthase, thereby regenerating the essential NAD+ cofactor of UDP-xylose synthase...
share.google
August 20, 2025 at 4:05 PM
A missing enzyme-rescue metabolite as cause of a rare skeletal dysplasia
share.google/dUNL7g7DkUle...
share.google/dUNL7g7DkUle...
New PTM (lactylation) linked with #TFEB stability and increased autophagy and lysosomal activity @jcb.org
Lactylation stabilizes TFEB to elevate autophagy and lysosomal activity | Journal of Cell Biology | Rockefeller University Press
Posttranslational modifications play a crucial role in regulating autophagy and lysosome–related transcription factor TFEB. Huang et al. find the increase
rupress.org
August 2, 2025 at 7:29 PM
The protein kinase, GCN2 identified as the key amino acid sensor for mTORC1. @embopress.org @embojournal.org
mTORC1 senses glutamine and other amino acids through GCN2 | The EMBO Journal
imageimageDuring starvation, individual amino acid levels are thought to be relayed via distinct
metabolic sensors, but how mTORC1 senses glutamine remains unclear. This study finds
that GCN2 kinase a...
www.embopress.org
July 23, 2025 at 11:34 AM
The protein kinase, GCN2 identified as the key amino acid sensor for mTORC1. @embopress.org @embojournal.org
Reposted by Sakamoto Lab
Commentary by Researcher @itsmedipsikha.bsky.social on the emerging role of glycogen metabolism in regulating energy homeostasis in adipose tissue is out now on @natrevendo.nature.com @cbmr.science
www.nature.com/articles/s41...
www.nature.com/articles/s41...
July 9, 2025 at 8:28 AM
Commentary by Researcher @itsmedipsikha.bsky.social on the emerging role of glycogen metabolism in regulating energy homeostasis in adipose tissue is out now on @natrevendo.nature.com @cbmr.science
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Sakamoto Lab
Unraveling Skeletal Muscle Insulin Resistance: Molecular Mechanisms and the Restorative Role of Exercise
www.ahajournals.org/doi/10.1161/...
www.ahajournals.org/doi/10.1161/...
Unraveling Skeletal Muscle Insulin Resistance: Molecular Mechanisms and the Restorative Role of Exercise | Circulation Research
Skeletal muscle is essential for movement and maintaining energy homeostasis and is
the primary tissue for insulin-stimulated glucose uptake. Skeletal muscle is composed
of various cell types that hel...
www.ahajournals.org
July 4, 2025 at 10:58 PM
Unraveling Skeletal Muscle Insulin Resistance: Molecular Mechanisms and the Restorative Role of Exercise
www.ahajournals.org/doi/10.1161/...
www.ahajournals.org/doi/10.1161/...
Reposted by Sakamoto Lab
Among the ways for next generation GLP-1 medicines to differentiate: Efficacy, safety and outcome trials in type 1 #Diabetes www.cell.com/trends/endoc...
Targeting cardiometabolic risk in type 1 diabetes through incretin physiology
People living with type 1 diabetes have significantly increased cardiovascular risk
compared with the general population. Traditional risk factors include hypertension,
dyslipidaemia, and obesity. How...
www.cell.com
July 4, 2025 at 11:06 AM
Among the ways for next generation GLP-1 medicines to differentiate: Efficacy, safety and outcome trials in type 1 #Diabetes www.cell.com/trends/endoc...
Reposted by Sakamoto Lab
Reposted by Sakamoto Lab
Studies in mice reveal that LEAP2 analogs have the potential to enhance the efficacy of glucagon-like peptide 1 receptor agonism and support durable #weightloss diabetesjournals.org/diabetes/art...
Sustained Weight Loss With Combined LEAP2 and Semaglutide Treatment in Mice
The recent identification of liver-expressed antimicrobial peptide 2 (LEAP2) as an endogenous antagonist and inverse agonist of the growth hormone secretag
diabetesjournals.org
July 2, 2025 at 10:41 AM
Studies in mice reveal that LEAP2 analogs have the potential to enhance the efficacy of glucagon-like peptide 1 receptor agonism and support durable #weightloss diabetesjournals.org/diabetes/art...
Reposted by Sakamoto Lab
Altered Relaxation and Mitochondria-Endoplasmic Reticulum Contacts Precede Major (Mal)Adaptations in Aging Skeletal Muscle and Are Prevented by Exercise
onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com/doi/10.1111/...
Altered Relaxation and Mitochondria‐Endoplasmic Reticulum Contacts Precede Major (Mal)Adaptations in Aging Skeletal Muscle and Are Prevented by Exercise
Slowed relaxation and altered MERCs embody early stages of aging in muscle, and are prevented by regular exercise.
onlinelibrary.wiley.com
July 1, 2025 at 5:55 PM
Altered Relaxation and Mitochondria-Endoplasmic Reticulum Contacts Precede Major (Mal)Adaptations in Aging Skeletal Muscle and Are Prevented by Exercise
onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com/doi/10.1111/...
Reposted by Sakamoto Lab
Innovation in the #weightloss space continues with an emerging Triple G oral peptide #obesity to enter into clinical development for obesity in 2026. www.biospace.com/drug-develop...
Protagonist Enters Obesity Fray With Triple-G Pill, Eyeing 2026 Clinical Start
With PN-477, Protagonist is directly going up against Eli Lilly, which is advancing retatrutide, also a triple-G agonist, in a Phase II trial.
www.biospace.com
July 2, 2025 at 12:03 PM
Innovation in the #weightloss space continues with an emerging Triple G oral peptide #obesity to enter into clinical development for obesity in 2026. www.biospace.com/drug-develop...
Last week we said goodbye to Florentina, who started as a postdoc with us in early 2020. We are truly privileged for her tenacity, hardwork & diligence that helped shape our group @cbmr.science & thank her for
guiding our junior colleagues. We wish her the best for her bright future!
.
guiding our junior colleagues. We wish her the best for her bright future!
.
July 1, 2025 at 8:24 PM
Last week we said goodbye to Florentina, who started as a postdoc with us in early 2020. We are truly privileged for her tenacity, hardwork & diligence that helped shape our group @cbmr.science & thank her for
guiding our junior colleagues. We wish her the best for her bright future!
.
guiding our junior colleagues. We wish her the best for her bright future!
.
Reposted by Sakamoto Lab
Happy to have contributed to this very interesting work ked/driven by Raid Nisr, Alison McNeilly and Graham Rena (University of Dundee). doi.org/10.1111/apha...
May 23, 2025 at 5:33 AM
Happy to have contributed to this very interesting work ked/driven by Raid Nisr, Alison McNeilly and Graham Rena (University of Dundee). doi.org/10.1111/apha...
Reposted by Sakamoto Lab
🔎 𝐃𝐞𝐜𝐢𝐩𝐡𝐞𝐫𝐢𝐧𝐠 𝐭𝐡𝐞 𝐆𝐈𝐏 𝐩𝐚𝐫𝐚𝐝𝐨𝐱
Why does activating the GIP receptor contribute to weight-loss, given the evidence that blocking the receptor ought to be more effective?
Prof. Jens Juul Holst outlines the evidence in Diabetes 👇
diabetesjournals.org/diabetes/art...
#GIP #GLP1 #biotech #obesity
Why does activating the GIP receptor contribute to weight-loss, given the evidence that blocking the receptor ought to be more effective?
Prof. Jens Juul Holst outlines the evidence in Diabetes 👇
diabetesjournals.org/diabetes/art...
#GIP #GLP1 #biotech #obesity
June 23, 2025 at 9:12 AM
🔎 𝐃𝐞𝐜𝐢𝐩𝐡𝐞𝐫𝐢𝐧𝐠 𝐭𝐡𝐞 𝐆𝐈𝐏 𝐩𝐚𝐫𝐚𝐝𝐨𝐱
Why does activating the GIP receptor contribute to weight-loss, given the evidence that blocking the receptor ought to be more effective?
Prof. Jens Juul Holst outlines the evidence in Diabetes 👇
diabetesjournals.org/diabetes/art...
#GIP #GLP1 #biotech #obesity
Why does activating the GIP receptor contribute to weight-loss, given the evidence that blocking the receptor ought to be more effective?
Prof. Jens Juul Holst outlines the evidence in Diabetes 👇
diabetesjournals.org/diabetes/art...
#GIP #GLP1 #biotech #obesity
Great reads if you're interested in learning more about Salt-Inducible Kinases #SIKs in metabolism.
pubmed.ncbi.nlm.nih.gov/40529046/
The Use of SIK Inhibitors as an Emerging Treatment...
pubmed.ncbi.nlm.nih.gov/40384110/
Salt-inducible Kinase Regulation of Adipose Tissue Metabolism
pubmed.ncbi.nlm.nih.gov/40529046/
The Use of SIK Inhibitors as an Emerging Treatment...
pubmed.ncbi.nlm.nih.gov/40384110/
Salt-inducible Kinase Regulation of Adipose Tissue Metabolism
The Use of Salt-Inducible Kinases (SIKs) Inhibitors as an Emerging Treatment for Inflammatory, Allergic, Autoimmune, Cancer, and Metabolic Diseases - PubMed
The invention in this patent application relates to pyrazolo-[1,5-<i>a</i>]-pyridine derivatives represented herein as formula I and formula II. These compounds are highly active SIK inhibitors and ma...
pubmed.ncbi.nlm.nih.gov
June 23, 2025 at 1:21 PM
Great reads if you're interested in learning more about Salt-Inducible Kinases #SIKs in metabolism.
pubmed.ncbi.nlm.nih.gov/40529046/
The Use of SIK Inhibitors as an Emerging Treatment...
pubmed.ncbi.nlm.nih.gov/40384110/
Salt-inducible Kinase Regulation of Adipose Tissue Metabolism
pubmed.ncbi.nlm.nih.gov/40529046/
The Use of SIK Inhibitors as an Emerging Treatment...
pubmed.ncbi.nlm.nih.gov/40384110/
Salt-inducible Kinase Regulation of Adipose Tissue Metabolism
Reposted by Sakamoto Lab
miR-30a is a critical regulator of adipose tissue fibrosis that predicts metabolically healthy #obesity in people and mice @jclinical-invest.bsky.social www.jci.org/articles/vie...
June 5, 2025 at 8:56 PM
miR-30a is a critical regulator of adipose tissue fibrosis that predicts metabolically healthy #obesity in people and mice @jclinical-invest.bsky.social www.jci.org/articles/vie...
Reposted by Sakamoto Lab
Damage to the vascular lining leads to interactions with red blood cells that hint at how to treat dangerous complications of heart attack, stroke and COVID-19
https://go.nature.com/4jyBzpe
https://go.nature.com/4jyBzpe
Sticky membranes of dead red blood cells obstruct small vessels
Damage to the vascular lining leads to interactions with red blood cells that hint at how to treat dangerous complications of heart attack, stroke and COVID-19.
go.nature.com
June 4, 2025 at 5:01 PM
Damage to the vascular lining leads to interactions with red blood cells that hint at how to treat dangerous complications of heart attack, stroke and COVID-19
https://go.nature.com/4jyBzpe
https://go.nature.com/4jyBzpe
Congratulations to all @labsakamoto.bsky.social group members for being the worthy winners of the K.I.S.S campaign! 🏆 👏 💪 Special mention to our lab manager, Marianne, for her persistence to make sure everyone gets their risk assessments done. Thanks @cbmr.science for this important initiative.
June 5, 2025 at 8:25 AM
Congratulations to all @labsakamoto.bsky.social group members for being the worthy winners of the K.I.S.S campaign! 🏆 👏 💪 Special mention to our lab manager, Marianne, for her persistence to make sure everyone gets their risk assessments done. Thanks @cbmr.science for this important initiative.