David Mick
@mick-lab.bsky.social
Biochemist studying #Cilia, Cell Signaling and Protein Trafficking via Proximity Labeling and Proteomics.
https://www.mick-lab.com
https://www.mick-lab.com
Pinned
An enzymatic cascade enables sensitive and specific proximity labeling proteomics in challenging biological systems - Nature Communications
Proximity labeling allows proteomic mapping of subcellular structures. Here, Sroka et al. develop in situ APEX activation (iAPEX) to overcome limitations of labeling specificity and H2O2 toxicity, app...
www.nature.com
Thrilled to share "in situ APEX activation" (iAPEX), a proximity labeling technology for subcellular #proteomics applied to primary #cilia. iAPEX uses an enzymatic cascade, in which a D-amino acid oxidase locally produces H2O2 to activate ascorbate peroxidase.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Thrilled to share "in situ APEX activation" (iAPEX), a proximity labeling technology for subcellular #proteomics applied to primary #cilia. iAPEX uses an enzymatic cascade, in which a D-amino acid oxidase locally produces H2O2 to activate ascorbate peroxidase.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
An enzymatic cascade enables sensitive and specific proximity labeling proteomics in challenging biological systems - Nature Communications
Proximity labeling allows proteomic mapping of subcellular structures. Here, Sroka et al. develop in situ APEX activation (iAPEX) to overcome limitations of labeling specificity and H2O2 toxicity, app...
www.nature.com
November 14, 2025 at 8:07 PM
Thrilled to share "in situ APEX activation" (iAPEX), a proximity labeling technology for subcellular #proteomics applied to primary #cilia. iAPEX uses an enzymatic cascade, in which a D-amino acid oxidase locally produces H2O2 to activate ascorbate peroxidase.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by David Mick
"... the species of trees we choose to nurture may be just as important as the number of trees we plant." Read the blog post behind the paper by Yao et al. regarding the role of #tree species in the #climate impact of European #forests. communities.springernature.com/posts/rethin...
Rethinking Europe’s Forests: Why Tree Species Matter for Climate Cooling
Yao et al. show that in Europe, forestation’s climate benefits depend on tree species. Converting conifers to broadleaves can reduce summer heat extremes and reverse warming effects of afforestation, ...
communities.springernature.com
November 11, 2025 at 10:33 AM
"... the species of trees we choose to nurture may be just as important as the number of trees we plant." Read the blog post behind the paper by Yao et al. regarding the role of #tree species in the #climate impact of European #forests. communities.springernature.com/posts/rethin...
Amazing work by the Breslow lab. Super excited to finally see this published. Unbiased CRISPRa screening reveals a novel and unexpected cilia disassembly pathway associated with neurological disease (focal cortical dysplasia). Must read for both #cilia and screening technology enthusiasts.
Excited to share our latest work on a new cilia disassembly pathway and a link between this pathway and the neurological disorder focal cortical dysplasia: www.science.org/doi/10.1126/...
Brief summary: we used a genome-wide CRISPRa GOF screen to identify negative regulators of ciliary signaling...
Brief summary: we used a genome-wide CRISPRa GOF screen to identify negative regulators of ciliary signaling...
A CRISPR activation screen reveals a cilia disassembly pathway mutated in focal cortical dysplasia
A gain-of-function screen uncovers a cilia disassembly pathway linked to genes somatically mutated in neurodevelopmental disease.
www.science.org
November 6, 2025 at 10:55 AM
Amazing work by the Breslow lab. Super excited to finally see this published. Unbiased CRISPRa screening reveals a novel and unexpected cilia disassembly pathway associated with neurological disease (focal cortical dysplasia). Must read for both #cilia and screening technology enthusiasts.
It was a lot of fun to write this review on cilia proteimics with Bernhard Schermer @cilib.social.cologne.ap.brid.gy and Ronald Ropeman, and we are excited to see it published in the @jcellsci.bsky.social special issue on Cilia and Flagella: from basic Biology to Disease.
📣 Here it is — our overview on ciliary proteomics! Great discussions and writing with @mick-lab.bsky.social and Ronald Roepman 🙏🙏
Hope we didn’t miss anything important - apologies if we did!
#cilia #ciliopathies #proteomics
@theracilproject.bsky.social @for5547.bsky.social
tinyurl.com/yc8ztn5v
Hope we didn’t miss anything important - apologies if we did!
#cilia #ciliopathies #proteomics
@theracilproject.bsky.social @for5547.bsky.social
tinyurl.com/yc8ztn5v
Advances in ciliary proteomics – towards cracking the hidden proteome code of cilia
Summary: This Review explores proteomic strategies for investigating cilia, tracing the evolution from early discoveries to recent advancements enabled by proximity labeling techniques.
journals.biologists.com
November 4, 2025 at 12:46 PM
It was a lot of fun to write this review on cilia proteimics with Bernhard Schermer @cilib.social.cologne.ap.brid.gy and Ronald Ropeman, and we are excited to see it published in the @jcellsci.bsky.social special issue on Cilia and Flagella: from basic Biology to Disease.
Interesting connection between primary #cilia and energy #metabolism in #mitochondria. www.biorxiv.org/content/10.1...
Loss of ciliary proteins IFT20 and IFT88 results in defective phagocytosis and metabolism in the RPE
A major proportion of retinal disease-causing genes are related to the primary cilium, a microtubule-based signalling organelle essential for multiple developmental pathways. Previous work has shown t...
www.biorxiv.org
October 17, 2025 at 8:47 PM
Interesting connection between primary #cilia and energy #metabolism in #mitochondria. www.biorxiv.org/content/10.1...
Very much looking forward to our next focus workshop on #cilia and #centrosomes. We'll have fantastic speakers again.
The next #DGZ Focus Workshop on #Cilia & #Centrosomes will take place November 25 (end of October is our DGZ meeting in HD). Join us for a great speaker line-up, and big thanks to David Mick @mick-lab.bsky.social & Dagmar Wachten @wachtenlab.bsky.social for organizing!
October 12, 2025 at 8:46 PM
Very much looking forward to our next focus workshop on #cilia and #centrosomes. We'll have fantastic speakers again.
Reposted by David Mick
With deep sadness, we share that Prof. Jochen Guck, Director at the Max Planck Institute for the Science of Light passed away on October 3. His visionary work bridged physics and medicine. We have lost a brilliant scientist and dear friend.
mpl.mpg.de/news/article...
@fau.de
📸 Stephan Spangenberg
mpl.mpg.de/news/article...
@fau.de
📸 Stephan Spangenberg
October 8, 2025 at 1:26 PM
With deep sadness, we share that Prof. Jochen Guck, Director at the Max Planck Institute for the Science of Light passed away on October 3. His visionary work bridged physics and medicine. We have lost a brilliant scientist and dear friend.
mpl.mpg.de/news/article...
@fau.de
📸 Stephan Spangenberg
mpl.mpg.de/news/article...
@fau.de
📸 Stephan Spangenberg
Reposted by David Mick
New findings in mice cast light on the pathways behind the growth of painful bone tumors in hereditary multiple osteochondroma and suggest that these mechanisms could be targeted to slow the disease’s progression.
Learn more in #ScienceSignaling: https://scim.ag/46VRSIp
Learn more in #ScienceSignaling: https://scim.ag/46VRSIp
An ectopic Hedgehog signaling axis drives directional tumor outgrowth in a mouse model of hereditary multiple osteochondromas
Redeployment of a developmental program drives the outgrowth of bone tumors in an inherited disease.
scim.ag
October 8, 2025 at 3:00 PM
New findings in mice cast light on the pathways behind the growth of painful bone tumors in hereditary multiple osteochondroma and suggest that these mechanisms could be targeted to slow the disease’s progression.
Learn more in #ScienceSignaling: https://scim.ag/46VRSIp
Learn more in #ScienceSignaling: https://scim.ag/46VRSIp
Reposted by David Mick
We’re renewing our collaboration with Google DeepMind!
We'll keep developing the AlphaFold Database to support protein science worldwide 🎉
To mark the moment we’ve synchronised the database with UniProtKB release 2025_03.
www.ebi.ac.uk/about/news/t...
🖥️🧬 #AlphaFold
@pdbeurope.bsky.social
We'll keep developing the AlphaFold Database to support protein science worldwide 🎉
To mark the moment we’ve synchronised the database with UniProtKB release 2025_03.
www.ebi.ac.uk/about/news/t...
🖥️🧬 #AlphaFold
@pdbeurope.bsky.social
October 7, 2025 at 2:03 PM
We’re renewing our collaboration with Google DeepMind!
We'll keep developing the AlphaFold Database to support protein science worldwide 🎉
To mark the moment we’ve synchronised the database with UniProtKB release 2025_03.
www.ebi.ac.uk/about/news/t...
🖥️🧬 #AlphaFold
@pdbeurope.bsky.social
We'll keep developing the AlphaFold Database to support protein science worldwide 🎉
To mark the moment we’ve synchronised the database with UniProtKB release 2025_03.
www.ebi.ac.uk/about/news/t...
🖥️🧬 #AlphaFold
@pdbeurope.bsky.social
Reposted by David Mick
Today is the #BBSGlobalDay — an opportunity to raise awareness of this rare condition and offer support to everyone living with BBS and their loved ones 🌍 🌎 🌏
www.img.cas.cz/2025/10/8758...
www.img.cas.cz/2025/10/8758...
October 4, 2025 at 12:33 PM
Today is the #BBSGlobalDay — an opportunity to raise awareness of this rare condition and offer support to everyone living with BBS and their loved ones 🌍 🌎 🌏
www.img.cas.cz/2025/10/8758...
www.img.cas.cz/2025/10/8758...
Reposted by David Mick
First pizza lunch after a whirlwind week moving into our brand-new research building. Exhausted, but absolutely thrilled by the incredible facilities & lab space. Can’t wait to dive back into science.
A few benches are still waiting for curious minds: PhD students and postdocs, come join us! 😉
A few benches are still waiting for curious minds: PhD students and postdocs, come join us! 😉
August 22, 2025 at 4:35 PM
First pizza lunch after a whirlwind week moving into our brand-new research building. Exhausted, but absolutely thrilled by the incredible facilities & lab space. Can’t wait to dive back into science.
A few benches are still waiting for curious minds: PhD students and postdocs, come join us! 😉
A few benches are still waiting for curious minds: PhD students and postdocs, come join us! 😉
Reposted by David Mick
'This story shows that it is possible to establish a multibillion-dollar industry purely by letting scientists communicate their research, exchange information and share materials.'
www.nature.com/articles/d41...
www.nature.com/articles/d41...
Monoclonal antibodies revolutionized biomedical science and health care
The story of the discovery of these molecules 50 years ago shows how the free exchange of ideas can lead to life-changing treatments.
www.nature.com
August 10, 2025 at 5:02 PM
'This story shows that it is possible to establish a multibillion-dollar industry purely by letting scientists communicate their research, exchange information and share materials.'
www.nature.com/articles/d41...
www.nature.com/articles/d41...
Reposted by David Mick
Science doesn’t need to be pretty and go according to plan; it just needs to lead to a discovery. If doesn’t have to be done alone or together with someone else; there just needs to be a discovery. It doesn’t need to happen fast or slow; just as long as there’s a discovery, then everybody is happy.
August 9, 2025 at 2:13 AM
Science doesn’t need to be pretty and go according to plan; it just needs to lead to a discovery. If doesn’t have to be done alone or together with someone else; there just needs to be a discovery. It doesn’t need to happen fast or slow; just as long as there’s a discovery, then everybody is happy.
Reposted by David Mick
Thrilled to see our study on how kinesin-2 motors are switched on and off published in @natsmb.nature.com ⚛️
➡️ www.nature.com/articles/s41...
Congrats to all authors from me and Anthony 🎉 @dunnschool.bsky.social Check out this animation made by talented PhD student @matthew-batisio.bsky.social 😆
➡️ www.nature.com/articles/s41...
Congrats to all authors from me and Anthony 🎉 @dunnschool.bsky.social Check out this animation made by talented PhD student @matthew-batisio.bsky.social 😆
July 29, 2025 at 9:04 AM
Thrilled to see our study on how kinesin-2 motors are switched on and off published in @natsmb.nature.com ⚛️
➡️ www.nature.com/articles/s41...
Congrats to all authors from me and Anthony 🎉 @dunnschool.bsky.social Check out this animation made by talented PhD student @matthew-batisio.bsky.social 😆
➡️ www.nature.com/articles/s41...
Congrats to all authors from me and Anthony 🎉 @dunnschool.bsky.social Check out this animation made by talented PhD student @matthew-batisio.bsky.social 😆
Reposted by David Mick
EMBL Cell Biology and Biophysics department is searching for a new director. A major position to lead this field in Europe and beyond.
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
Head of the Cell Biology and Biophysics Unit
The European Molecular Biology Laboratory (EMBL) is Europe’s flagship life sciences organisation, and one of the world’s leading research institutions. An intergovernmental organisation of 29 Member S...
embl.wd103.myworkdayjobs.com
July 29, 2025 at 7:50 AM
EMBL Cell Biology and Biophysics department is searching for a new director. A major position to lead this field in Europe and beyond.
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
Reposted by David Mick
SNAP-tag is a widespread tool for labelling protein for bioimaging. An article published in Nature Chemical Biology presents SNAP-tag2 with increased labelling kinetics and brightness, which translates into a better performance in live-cell super-resolution imaging. go.nature.com/46fMIZd 🧪
July 20, 2025 at 1:03 AM
SNAP-tag is a widespread tool for labelling protein for bioimaging. An article published in Nature Chemical Biology presents SNAP-tag2 with increased labelling kinetics and brightness, which translates into a better performance in live-cell super-resolution imaging. go.nature.com/46fMIZd 🧪
Beautiful work on the development of protein kinase reporters. Congrats all! www.nature.com/articles/s41...
Molecular recording of cellular protein kinase activity with chemical labeling - Nature Chemical Biology
Molecular recorders based on kinase activity-dependent protein labeling track specific kinase activities to understand their link to cellular phenotypes in heterogeneous cell populations and in vivo.
www.nature.com
July 13, 2025 at 9:53 AM
Beautiful work on the development of protein kinase reporters. Congrats all! www.nature.com/articles/s41...
Reposted by David Mick
Grateful to be part of such a fantastic consortium! Huge thanks to our amazing coordinator Christina and to Silke for organizing an inspiring annual meeting in Jena. Latest new: we’ve got a new rising star on the team! #cilia
May 14, 2025 at 9:09 PM
Grateful to be part of such a fantastic consortium! Huge thanks to our amazing coordinator Christina and to Silke for organizing an inspiring annual meeting in Jena. Latest new: we’ve got a new rising star on the team! #cilia
Reposted by David Mick
'Reproductive-associated changes are also known to occur at the organ level, in particular, an increase in intestinal size during pregnancy and lactation has been observed in several mammals such as mice, rats, sheep, and pigs'
thenode.biologists.com/re-growing-a...
thenode.biologists.com/re-growing-a...
Re-growing adult organs: mothers do it best - the Node
Tomotsune Ameku tells the story behind the paper "Growth of the maternal intestine during reproduction"
thenode.biologists.com
May 3, 2025 at 7:15 AM
'Reproductive-associated changes are also known to occur at the organ level, in particular, an increase in intestinal size during pregnancy and lactation has been observed in several mammals such as mice, rats, sheep, and pigs'
thenode.biologists.com/re-growing-a...
thenode.biologists.com/re-growing-a...
Reposted by David Mick
@sven-m-lange.bsky.social @alanbrownhms.bsky.social epic preprint dropped last night 🔥🔥🔥 #cilia #ift #ubiquitin #compartmentalization #signaling #GPCRs #AnticipationBuilding #SlowRead 🧪 www.biorxiv.org/content/10.1...
April 30, 2025 at 11:32 AM
@sven-m-lange.bsky.social @alanbrownhms.bsky.social epic preprint dropped last night 🔥🔥🔥 #cilia #ift #ubiquitin #compartmentalization #signaling #GPCRs #AnticipationBuilding #SlowRead 🧪 www.biorxiv.org/content/10.1...
Reposted by David Mick
Dear cilia researchers, join us in the heart of the beautiful Vosges mountains to share your latest findings! This year, partnership with @for5547.bsky.social and keynote lectures by @micromotility.bsky.social and @mick-lab.bsky.social
Registration is now open www.cfc2025.conferences-pasteur.org
Registration is now open www.cfc2025.conferences-pasteur.org
April 14, 2025 at 8:42 AM
Dear cilia researchers, join us in the heart of the beautiful Vosges mountains to share your latest findings! This year, partnership with @for5547.bsky.social and keynote lectures by @micromotility.bsky.social and @mick-lab.bsky.social
Registration is now open www.cfc2025.conferences-pasteur.org
Registration is now open www.cfc2025.conferences-pasteur.org
Reposted by David Mick
Mark your calendars & repost! Join us for the 2026 FASEB Lipid Droplets Conference!
July 26-30, 2026 in beautiful Scottsdale, Arizona.
Best of all: The FASEB Lipid Droplet meeting is co-locating with the FASEB Phospholipid meeting. Two wonderful lipid communities brought together!
July 26-30, 2026 in beautiful Scottsdale, Arizona.
Best of all: The FASEB Lipid Droplet meeting is co-locating with the FASEB Phospholipid meeting. Two wonderful lipid communities brought together!
March 27, 2025 at 1:59 PM
Mark your calendars & repost! Join us for the 2026 FASEB Lipid Droplets Conference!
July 26-30, 2026 in beautiful Scottsdale, Arizona.
Best of all: The FASEB Lipid Droplet meeting is co-locating with the FASEB Phospholipid meeting. Two wonderful lipid communities brought together!
July 26-30, 2026 in beautiful Scottsdale, Arizona.
Best of all: The FASEB Lipid Droplet meeting is co-locating with the FASEB Phospholipid meeting. Two wonderful lipid communities brought together!
Fantastic lineup again. Can't wait!
Join us next week Tuesday for the #DGZ Focus Workshop on #membrane organization and #contactsites, at noon via zoom, organized by Katja Zieske and @buttnerlab.bsky.social 👩🔬🧬
March 23, 2025 at 12:25 AM
Fantastic lineup again. Can't wait!
Reposted by David Mick
“The Trump administration has canceled funding for an ongoing 30-year, nationwide study tracking patients with prediabetes and diabetes, researchers said, at a time when top officials have emphasized their determination to curb the incidence of such chronic conditions.”
NIH cancels funding for landmark diabetes study at a time of focus on chronic disease
The Trump administration has canceled funding for an ongoing 30-year, nationwide study tracking patients with prediabetes and diabetes, researchers said.
www.statnews.com
March 18, 2025 at 12:26 AM
“The Trump administration has canceled funding for an ongoing 30-year, nationwide study tracking patients with prediabetes and diabetes, researchers said, at a time when top officials have emphasized their determination to curb the incidence of such chronic conditions.”
Reposted by David Mick
More than 2 decades ago the PINK1 protein was found to be linked to Parkinson's disease, but its structure and how it was activated was not known. Until @science.org today. A triumph for cryo-EM and structural biology, introducing new targets for drug intervention.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
March 13, 2025 at 11:19 PM
More than 2 decades ago the PINK1 protein was found to be linked to Parkinson's disease, but its structure and how it was activated was not known. Until @science.org today. A triumph for cryo-EM and structural biology, introducing new targets for drug intervention.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...