Michael Fischbach
@mfgrp.bsky.social
Liu (Liao) Family Professor of Bioengineering, ChEM-H @Stanford.
Reposted by Michael Fischbach
Reposted by Michael Fischbach
This pair of papers demonstrating strong and systemic immune responses to skin commensals applied topically to unbroken skin, including induction of B cells for vaccination.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Skin autonomous antibody production regulates host-microbiota interactions - Nature
Nature - Skin autonomous antibody production regulates host-microbiota interactions
www.nature.com
December 26, 2024 at 5:14 PM
This pair of papers demonstrating strong and systemic immune responses to skin commensals applied topically to unbroken skin, including induction of B cells for vaccination.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Michael Fischbach
These are my favorites too! 🤯
December 26, 2024 at 5:22 PM
These are my favorites too! 🤯
Reposted by Michael Fischbach
What an amazing story that was such a blast to collaborate on with @mfgrp.bsky.social lab!!! Phenomenal work led by @djenetbousbaine.bsky.social and all co-authors!! Unroll this thread and be amazed 🤯👇🏾
Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55
December 24, 2024 at 2:25 AM
What an amazing story that was such a blast to collaborate on with @mfgrp.bsky.social lab!!! Phenomenal work led by @djenetbousbaine.bsky.social and all co-authors!! Unroll this thread and be amazed 🤯👇🏾
Reposted by Michael Fischbach
Scientists turned a harmless skin bacterium into a powerful vaccine delivery tool, boosting immunity in the lungs and nose.
@mfgrp.bsky.social @djenetbousbaine.bsky.social @nature.com
t.co/xXXCJx5VYm
#ImmunoSky 🧪
@mfgrp.bsky.social @djenetbousbaine.bsky.social @nature.com
t.co/xXXCJx5VYm
#ImmunoSky 🧪
December 21, 2024 at 4:32 PM
Scientists turned a harmless skin bacterium into a powerful vaccine delivery tool, boosting immunity in the lungs and nose.
@mfgrp.bsky.social @djenetbousbaine.bsky.social @nature.com
t.co/xXXCJx5VYm
#ImmunoSky 🧪
@mfgrp.bsky.social @djenetbousbaine.bsky.social @nature.com
t.co/xXXCJx5VYm
#ImmunoSky 🧪
Reposted by Michael Fischbach
A typical project for an incoming graduate student might involve 1–2 weeks of planning and 2–5 years of execution, [yet] the problem you choose will influence the impact of your work just as much as the quality of your execution. @mfgrp.bsky.social
open.spotify.com/episode/6KMh...
open.spotify.com/episode/6KMh...
December 20, 2024 at 2:55 PM
A typical project for an incoming graduate student might involve 1–2 weeks of planning and 2–5 years of execution, [yet] the problem you choose will influence the impact of your work just as much as the quality of your execution. @mfgrp.bsky.social
open.spotify.com/episode/6KMh...
open.spotify.com/episode/6KMh...
Reposted by Michael Fischbach
Insanely creative and original immunology and bioengineering work from the Fischbach Lab at Stanford with high translational potential
Full article in NATURE: www.nature.com/articles/s41...
Follow the scientists:
@mfgrp.bsky.social
@djenetbousbaine.bsky.social
@katebauman.bsky.social
Full article in NATURE: www.nature.com/articles/s41...
Follow the scientists:
@mfgrp.bsky.social
@djenetbousbaine.bsky.social
@katebauman.bsky.social
Stanford Scientists Transform Ubiquitous Skin Bacterium into a Topical Vaccine Against Tetanus
Even better, it’s cheap, entirely pain-free, no need to stand in a line, and not followed by fever, swelling, redness, or a sore arm.
www.goodnewsnetwork.org
December 16, 2024 at 12:58 PM
Insanely creative and original immunology and bioengineering work from the Fischbach Lab at Stanford with high translational potential
Full article in NATURE: www.nature.com/articles/s41...
Follow the scientists:
@mfgrp.bsky.social
@djenetbousbaine.bsky.social
@katebauman.bsky.social
Full article in NATURE: www.nature.com/articles/s41...
Follow the scientists:
@mfgrp.bsky.social
@djenetbousbaine.bsky.social
@katebauman.bsky.social
Reposted by Michael Fischbach
Beautiful work with exciting implications for topical vaccination by @mfgrp.bsky.social ✨
Give this a read 👇
Give this a read 👇
Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55
December 13, 2024 at 11:05 PM
Beautiful work with exciting implications for topical vaccination by @mfgrp.bsky.social ✨
Give this a read 👇
Give this a read 👇
Reposted by Michael Fischbach
Vaccines, but make it skincare!🧴🧬 Congratulations to Stanford BioE Professor Michael Fischbach @mfgrp.bsky.social & @djenetbousbaine.bsky.social for engineering a skin bacterium that could lead to needle-free vaccines.
Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55
December 13, 2024 at 1:00 AM
Vaccines, but make it skincare!🧴🧬 Congratulations to Stanford BioE Professor Michael Fischbach @mfgrp.bsky.social & @djenetbousbaine.bsky.social for engineering a skin bacterium that could lead to needle-free vaccines.
Reposted by Michael Fischbach
Check out our last pub. from @mfgrp.bsky.social al lab! We discovered that skin commensal microbes induce systemic and local B cell responses upon colonization and took advantage of this knowledge to create topical vaccines using engineered skin microbes. Please read the thread for details.
Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55
December 12, 2024 at 12:33 AM
Check out our last pub. from @mfgrp.bsky.social al lab! We discovered that skin commensal microbes induce systemic and local B cell responses upon colonization and took advantage of this knowledge to create topical vaccines using engineered skin microbes. Please read the thread for details.
Reposted by Michael Fischbach
Your hand lotion is now also a vaccine. Hot damn
Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55
December 12, 2024 at 3:10 PM
Your hand lotion is now also a vaccine. Hot damn
Reposted by Michael Fischbach
Two fascinating papers just out in Nature @natureportfolio.bsky.social:
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Skin autonomous antibody production regulates host-microbiota interactions - Nature
Nature - Skin autonomous antibody production regulates host-microbiota interactions
www.nature.com
December 12, 2024 at 2:05 PM
Two fascinating papers just out in Nature @natureportfolio.bsky.social:
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Michael Fischbach
Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55
December 12, 2024 at 2:07 PM
Reposted by Michael Fischbach
Brilliant work congrats to the authors!
Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55
December 12, 2024 at 9:29 AM
Brilliant work congrats to the authors!
Reposted by Michael Fischbach
Awesome thread from @mfgrp.bsky.social about what might be the most amazing result you'll hear about in 2024: antigens stuck on the surface of the skin bacterium S. epidermidis generate a strong immune response in mouse.
Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55
December 11, 2024 at 8:17 PM
Awesome thread from @mfgrp.bsky.social about what might be the most amazing result you'll hear about in 2024: antigens stuck on the surface of the skin bacterium S. epidermidis generate a strong immune response in mouse.
Reposted by Michael Fischbach
A remarkable story from @mfgrp.bsky.social and colleagues: immunization via skin S. epidermidis generates systemic and mucosal antibody responses.
Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55
December 12, 2024 at 5:12 AM
A remarkable story from @mfgrp.bsky.social and colleagues: immunization via skin S. epidermidis generates systemic and mucosal antibody responses.
Reposted by Michael Fischbach
And in a Nature publication double-header, @mfgrp.bsky.social @stanford-chemh.bsky.social collaborates with Yasmine Belkaid and workers in this study reporting on local immune response including antibody generation in response to skin commensals:
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Skin autonomous antibody production regulates host-microbiota interactions - Nature
Nature - Skin autonomous antibody production regulates host-microbiota interactions
www.nature.com
December 11, 2024 at 11:23 PM
And in a Nature publication double-header, @mfgrp.bsky.social @stanford-chemh.bsky.social collaborates with Yasmine Belkaid and workers in this study reporting on local immune response including antibody generation in response to skin commensals:
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Michael Fischbach
This is the most amazing thread since they did a similar thing to cure a cancer
Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55
December 11, 2024 at 6:54 PM
This is the most amazing thread since they did a similar thing to cure a cancer
Reposted by Michael Fischbach
Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55
December 11, 2024 at 7:10 PM
Reposted by Michael Fischbach
Holy shit this is amazing!!! 🤯
Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55
December 11, 2024 at 7:19 PM
Holy shit this is amazing!!! 🤯
Reposted by Michael Fischbach
discovery that a skin microbe can, without inflammation, induce a systemic B-cell response... and then engineering that microbe into a potent vaccine platform that can be applied as a topical cream. amazing work from @djenetbousbaine.bsky.social and @mfgrp.bsky.social! www.nature.com/articles/s41...
December 11, 2024 at 7:23 PM
discovery that a skin microbe can, without inflammation, induce a systemic B-cell response... and then engineering that microbe into a potent vaccine platform that can be applied as a topical cream. amazing work from @djenetbousbaine.bsky.social and @mfgrp.bsky.social! www.nature.com/articles/s41...
Reposted by Michael Fischbach
An amazing discovery, and a very informative and engaging thread. Could develop into a transformative new mode for efficient vaccination
Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55
December 11, 2024 at 7:23 PM
An amazing discovery, and a very informative and engaging thread. Could develop into a transformative new mode for efficient vaccination
Reposted by Michael Fischbach
one to savor over the holidays. also so cool to see how the directions of the work between @mfgrp.bsky.social and Belkaid labs diverged.
Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55
December 11, 2024 at 7:35 PM
one to savor over the holidays. also so cool to see how the directions of the work between @mfgrp.bsky.social and Belkaid labs diverged.
Reposted by Michael Fischbach
Brilliant 🧵on a fascinating study demonstrating potent systemic and mucosal antibody responses to the common skin commensal Staph. epidermidis. Engineered S. epi expressing or displaying unrelated antigens elicited protective immunity,suggesting it could serve as topical vaccines. 💉
Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55
December 11, 2024 at 7:39 PM
Brilliant 🧵on a fascinating study demonstrating potent systemic and mucosal antibody responses to the common skin commensal Staph. epidermidis. Engineered S. epi expressing or displaying unrelated antigens elicited protective immunity,suggesting it could serve as topical vaccines. 💉
Reposted by Michael Fischbach
Co-opting a skin commensal to design new vaccines! An amazingly creative and thoughtful new approach that integrates our knowledge of immune system responses. #ImmunoSky
Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55
December 11, 2024 at 7:58 PM
Co-opting a skin commensal to design new vaccines! An amazingly creative and thoughtful new approach that integrates our knowledge of immune system responses. #ImmunoSky