Maria Cristina Trueba
@mctrueba.bsky.social
PhD at Utrecht University
Proteomics | Immuno-oncology
Proteomics | Immuno-oncology
It was a great week in Toronto attending #Hupo2025. Greateful for the opportunity of sharing our work with the world and inspired after so many scientific conversations!
#hupo2025 | María Cristina Trueba Sánchez
And with that... the week is over!
Attending #hupo2025 in Toronto has been a truly inspiring experience. This past week I had the chance to talk about the main project of my PhD thesis through both ...
www.linkedin.com
November 15, 2025 at 8:44 PM
It was a great week in Toronto attending #Hupo2025. Greateful for the opportunity of sharing our work with the world and inspired after so many scientific conversations!
Reposted by Maria Cristina Trueba
Nobody does anagrams to reveal the true nature of things anymore
August 23, 2025 at 5:09 PM
Nobody does anagrams to reveal the true nature of things anymore
Reposted by Maria Cristina Trueba
Life hack: write down stuff you’ve already done on your to-do list and slam a checkmark on it
March 18, 2025 at 2:04 PM
Life hack: write down stuff you’ve already done on your to-do list and slam a checkmark on it
Reposted by Maria Cristina Trueba
Doing this for years
Life hack: write down stuff you’ve already done on your to-do list and slam a checkmark on it
March 18, 2025 at 6:10 PM
Doing this for years
Reposted by Maria Cristina Trueba
Microplastics cross the murine intestine and induce inflammatory cell death after phagocytosis by human monocytes and neutrophils
doi.org/10.1101/2025...
doi.org/10.1101/2025...
March 17, 2025 at 6:49 PM
Microplastics cross the murine intestine and induce inflammatory cell death after phagocytosis by human monocytes and neutrophils
doi.org/10.1101/2025...
doi.org/10.1101/2025...
I recently discovered Goodreads, and I am so sad I want to read much more books than the ones I have the capacity to actually read atm. #Goodreads #books
March 3, 2025 at 11:22 AM
I recently discovered Goodreads, and I am so sad I want to read much more books than the ones I have the capacity to actually read atm. #Goodreads #books
Reposted by Maria Cristina Trueba
Absence of ICAM-1 drives tumor resistance to T and NK cell-mediated killing, with LFA-1 engager molecular potentiating anti-tumor immunity by re-engaging this synaptic interaction @cp-cellrepmed.bsky.social
www.cell.com/cell-reports...
www.cell.com/cell-reports...
February 24, 2025 at 6:43 PM
Absence of ICAM-1 drives tumor resistance to T and NK cell-mediated killing, with LFA-1 engager molecular potentiating anti-tumor immunity by re-engaging this synaptic interaction @cp-cellrepmed.bsky.social
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Reposted by Maria Cristina Trueba
T cells acquire both TCRs and CARs from other activated T cells by trogocytosis. Notably, this trogocytosis does not need a cognate receptor/ligand. Modifying CAR transmembrane domains makes trogocytosis more/less likely.
@barbera-stefano.bsky.social et al 2025
www.science.org/doi/10.1126/...
@barbera-stefano.bsky.social et al 2025
www.science.org/doi/10.1126/...
February 24, 2025 at 2:34 AM
T cells acquire both TCRs and CARs from other activated T cells by trogocytosis. Notably, this trogocytosis does not need a cognate receptor/ligand. Modifying CAR transmembrane domains makes trogocytosis more/less likely.
@barbera-stefano.bsky.social et al 2025
www.science.org/doi/10.1126/...
@barbera-stefano.bsky.social et al 2025
www.science.org/doi/10.1126/...
More of these examples are needed
Working part-time in #academia can be a means for some to enhance well-being, inclusivity, and career sustainability. Here, six researchers call for systemic changes to better support flexible working arrangements. #AcademicSky
February 21, 2025 at 9:16 PM
More of these examples are needed
February 21, 2025 at 6:20 PM
Reposted by Maria Cristina Trueba
🚨 Save the Date! NVMS Spring Meeting 2025, 26th May 🚨
Mark your calendars! 📅 The NVMS Spring Meeting is on 26th May at Sanquin, Amsterdam. Stay tuned for details on abstract submissions and the program. Let's explore the latest mass spec research in the Netherlands! 🔬⚡😀
#NVMS #MassSpec
Mark your calendars! 📅 The NVMS Spring Meeting is on 26th May at Sanquin, Amsterdam. Stay tuned for details on abstract submissions and the program. Let's explore the latest mass spec research in the Netherlands! 🔬⚡😀
#NVMS #MassSpec
February 12, 2025 at 11:38 AM
Reposted by Maria Cristina Trueba
Despair not (yet)
"If a control experiment fails, does that mean that the entire experiment is poorly designed and you must restart from scratch? Often, yes— but not always. I present five examples where failed control experiments triggered entirely new fields of research."
"If a control experiment fails, does that mean that the entire experiment is poorly designed and you must restart from scratch? Often, yes— but not always. I present five examples where failed control experiments triggered entirely new fields of research."
The controls that got out of control: How failed control experiments paved the way to transformative discoveries: EMBO reports: Vol 0, No 0
EMBO Press is an editorially independent publishing platform for the development of EMBO scientific publications.
www.embopress.org
January 27, 2025 at 6:13 AM
Despair not (yet)
"If a control experiment fails, does that mean that the entire experiment is poorly designed and you must restart from scratch? Often, yes— but not always. I present five examples where failed control experiments triggered entirely new fields of research."
"If a control experiment fails, does that mean that the entire experiment is poorly designed and you must restart from scratch? Often, yes— but not always. I present five examples where failed control experiments triggered entirely new fields of research."
Reposted by Maria Cristina Trueba
Really interesting paper 🧪 🤩
Immune evasion through mitochondrial transfer 😮
Ikeda et al find that #mitochondria from cancer cells can #transfer over to T cells - altering their #metabolism & reducing antitumour immunity
www.nature.com/articles/s41...
www.nature.com/articles/d41...
@nature.com
Immune evasion through mitochondrial transfer 😮
Ikeda et al find that #mitochondria from cancer cells can #transfer over to T cells - altering their #metabolism & reducing antitumour immunity
www.nature.com/articles/s41...
www.nature.com/articles/d41...
@nature.com
Cancer cells ‘poison’ the immune system with tainted mitochondria
Immune cells lose their cancer-fighting prowess after taking tumours’ organelles on board.
www.nature.com
January 23, 2025 at 6:41 PM
Really interesting paper 🧪 🤩
Immune evasion through mitochondrial transfer 😮
Ikeda et al find that #mitochondria from cancer cells can #transfer over to T cells - altering their #metabolism & reducing antitumour immunity
www.nature.com/articles/s41...
www.nature.com/articles/d41...
@nature.com
Immune evasion through mitochondrial transfer 😮
Ikeda et al find that #mitochondria from cancer cells can #transfer over to T cells - altering their #metabolism & reducing antitumour immunity
www.nature.com/articles/s41...
www.nature.com/articles/d41...
@nature.com
🗺 I'm deeply saddened about the recent government's decisions on science budgets. First NL and then US. Without science, there is no future.
🇪🇦 Sin palabras ante las decisiones de los gobiernos mundiales de cortar la financiacion para investigación cientifica. Sin ciencia no hay futuro.
🇪🇦 Sin palabras ante las decisiones de los gobiernos mundiales de cortar la financiacion para investigación cientifica. Sin ciencia no hay futuro.
January 23, 2025 at 11:18 AM
🗺 I'm deeply saddened about the recent government's decisions on science budgets. First NL and then US. Without science, there is no future.
🇪🇦 Sin palabras ante las decisiones de los gobiernos mundiales de cortar la financiacion para investigación cientifica. Sin ciencia no hay futuro.
🇪🇦 Sin palabras ante las decisiones de los gobiernos mundiales de cortar la financiacion para investigación cientifica. Sin ciencia no hay futuro.
Reposted by Maria Cristina Trueba
We built a rust library (rustyms) and the Annotator GUI to analyze any complex bottom-up or top-down peptidoform with any fragmentation based on ProForma 2.0.
Get it on github and read more in the preprint:
www.biorxiv.org/content/10.1...
github.com/snijderlab/a...
github.com/snijderlab/r...
Get it on github and read more in the preprint:
www.biorxiv.org/content/10.1...
github.com/snijderlab/a...
github.com/snijderlab/r...
January 22, 2025 at 8:25 PM
We built a rust library (rustyms) and the Annotator GUI to analyze any complex bottom-up or top-down peptidoform with any fragmentation based on ProForma 2.0.
Get it on github and read more in the preprint:
www.biorxiv.org/content/10.1...
github.com/snijderlab/a...
github.com/snijderlab/r...
Get it on github and read more in the preprint:
www.biorxiv.org/content/10.1...
github.com/snijderlab/a...
github.com/snijderlab/r...
Reposted by Maria Cristina Trueba
The OT-I TCR is often criticised as being very high-affinity and displaying unusual behaviour compared to other TCR transgenics. New work from @tcell.bsky.social shows this might not be the case. Will I still use OT-I and all the wonderful tools associated with it? Yes I will!
Our new work!
The 3D affinities of the OT-I TCR to foreign and self-antigens predict their 2D affinities and reveal imperfect antigen discrimination
www.biorxiv.org/content/10.1...
The 3D affinities of the OT-I TCR to foreign and self-antigens predict their 2D affinities and reveal imperfect antigen discrimination
www.biorxiv.org/content/10.1...
January 16, 2025 at 10:34 AM
The OT-I TCR is often criticised as being very high-affinity and displaying unusual behaviour compared to other TCR transgenics. New work from @tcell.bsky.social shows this might not be the case. Will I still use OT-I and all the wonderful tools associated with it? Yes I will!
Reposted by Maria Cristina Trueba
Arte (🇫🇷/🇩🇪 TV channel) just posted a documentary on proteomics on YouTube. Of course somewhat simplified but it’s nice to see our research explained in simple terms for the masses. If you have some time (or want to practice your German), it’s definitely worth watching:
m.youtube.com/watch?v=lVkb...
m.youtube.com/watch?v=lVkb...
Der Proteom-Code - Dem Geheimnis des Lebens auf der Spur | Doku HD | ARTE
YouTube video by ARTEde
m.youtube.com
December 14, 2024 at 10:32 PM
Arte (🇫🇷/🇩🇪 TV channel) just posted a documentary on proteomics on YouTube. Of course somewhat simplified but it’s nice to see our research explained in simple terms for the masses. If you have some time (or want to practice your German), it’s definitely worth watching:
m.youtube.com/watch?v=lVkb...
m.youtube.com/watch?v=lVkb...
Reposted by Maria Cristina Trueba
Could one envision a synthetic receptor technology that is fully programmable, able to detect diverse extracellular antigens – both soluble and cell-attached – and convert that recognition into a wide range of intracellular responses, from gene expression and real-time fluorescence to modulation..
December 4, 2024 at 4:05 PM
Could one envision a synthetic receptor technology that is fully programmable, able to detect diverse extracellular antigens – both soluble and cell-attached – and convert that recognition into a wide range of intracellular responses, from gene expression and real-time fluorescence to modulation..
Reposted by Maria Cristina Trueba
NKG2A-mediated immune modulation of natural killer cells by Staphylococcus aureus
Now on bioRxiv.
@biorxivpreprint.bsky.social @cusystemsimmu.bsky.social
Now on bioRxiv.
@biorxivpreprint.bsky.social @cusystemsimmu.bsky.social
NKG2A-mediated immune modulation of natural killer cells by Staphylococcus aureus
Natural killer (NK) cells are specialized lymphocytes that help protect against viruses and cancer. However, in the context of bacterial infections, NK cells can be harmful, rather than protective. Su...
www.biorxiv.org
December 4, 2024 at 10:54 AM
NKG2A-mediated immune modulation of natural killer cells by Staphylococcus aureus
Now on bioRxiv.
@biorxivpreprint.bsky.social @cusystemsimmu.bsky.social
Now on bioRxiv.
@biorxivpreprint.bsky.social @cusystemsimmu.bsky.social
Reposted by Maria Cristina Trueba
Had a great day at the 10th anniversary Science for Life meeting. My personal highlights were the incredible #cryoET talk from Julia Mahamid, and @bobcoelingh.bsky.social winning a poster prize! 🏆
December 2, 2024 at 5:58 PM
Had a great day at the 10th anniversary Science for Life meeting. My personal highlights were the incredible #cryoET talk from Julia Mahamid, and @bobcoelingh.bsky.social winning a poster prize! 🏆
🇪🇺I'm honoured to be talking about our work in immuno-oncology proteomics at RadioLibertad España with Antonio Gonzalez Armas
🇪🇦 Agradecida de poder hablar sobre nuestro trabajo en proteomica aplicada a la immunidad antitumoral en Radio Libertad con Antonio Gonzalez Armas
Let's keep sharing science!
🇪🇦 Agradecida de poder hablar sobre nuestro trabajo en proteomica aplicada a la immunidad antitumoral en Radio Libertad con Antonio Gonzalez Armas
Let's keep sharing science!
November 29, 2024 at 9:22 PM
🇪🇺I'm honoured to be talking about our work in immuno-oncology proteomics at RadioLibertad España with Antonio Gonzalez Armas
🇪🇦 Agradecida de poder hablar sobre nuestro trabajo en proteomica aplicada a la immunidad antitumoral en Radio Libertad con Antonio Gonzalez Armas
Let's keep sharing science!
🇪🇦 Agradecida de poder hablar sobre nuestro trabajo en proteomica aplicada a la immunidad antitumoral en Radio Libertad con Antonio Gonzalez Armas
Let's keep sharing science!
Reposted by Maria Cristina Trueba
REVIEW: Next-generation combination approaches for immune checkpoint therapy
www.nature.com/articles/s41...
@pamsharmamdphd.bsky.social
www.nature.com/articles/s41...
@pamsharmamdphd.bsky.social
November 25, 2024 at 7:31 PM
REVIEW: Next-generation combination approaches for immune checkpoint therapy
www.nature.com/articles/s41...
@pamsharmamdphd.bsky.social
www.nature.com/articles/s41...
@pamsharmamdphd.bsky.social
Reposted by Maria Cristina Trueba
Faculty mentoring in academic institutions, a thread.
As I advance in my academic career (read: as I keep getting more gray hair), I've come to appreciate, even more than before, the profound responsibility we (senior-ish faculty) have to support and nurture emerging talent, not diminish it.
As I advance in my academic career (read: as I keep getting more gray hair), I've come to appreciate, even more than before, the profound responsibility we (senior-ish faculty) have to support and nurture emerging talent, not diminish it.
November 21, 2024 at 12:12 AM
Faculty mentoring in academic institutions, a thread.
As I advance in my academic career (read: as I keep getting more gray hair), I've come to appreciate, even more than before, the profound responsibility we (senior-ish faculty) have to support and nurture emerging talent, not diminish it.
As I advance in my academic career (read: as I keep getting more gray hair), I've come to appreciate, even more than before, the profound responsibility we (senior-ish faculty) have to support and nurture emerging talent, not diminish it.
Reposted by Maria Cristina Trueba
There’s more to rainbows than the human eye can see: here’s how a rainbow extends into the infrared and ultraviolet.
Photos:
1. Infrared
2. Visible (obviously)
3. Ultraviolet, and
4. A composite showing how UV is beyond the violet in a rainbow, and IR beyond the red end.
🧪 #photography
Photos:
1. Infrared
2. Visible (obviously)
3. Ultraviolet, and
4. A composite showing how UV is beyond the violet in a rainbow, and IR beyond the red end.
🧪 #photography
November 21, 2024 at 10:35 AM
There’s more to rainbows than the human eye can see: here’s how a rainbow extends into the infrared and ultraviolet.
Photos:
1. Infrared
2. Visible (obviously)
3. Ultraviolet, and
4. A composite showing how UV is beyond the violet in a rainbow, and IR beyond the red end.
🧪 #photography
Photos:
1. Infrared
2. Visible (obviously)
3. Ultraviolet, and
4. A composite showing how UV is beyond the violet in a rainbow, and IR beyond the red end.
🧪 #photography
Reposted by Maria Cristina Trueba
PhosX is out! doi.org/10.1093/bioi... Leveraging the latest kinase specificity maps by the Cantley, Yaffe, and Turk labs and a rank sum statistic we created PhosX so now we can predict activities for nearly all kinases in your phosphodata, including the understudied ones. Check it out!
November 21, 2024 at 6:33 AM
PhosX is out! doi.org/10.1093/bioi... Leveraging the latest kinase specificity maps by the Cantley, Yaffe, and Turk labs and a rank sum statistic we created PhosX so now we can predict activities for nearly all kinases in your phosphodata, including the understudied ones. Check it out!