Max Schelski
@maxschelski.bsky.social
Neuroscientist. Developing mathematical models of cell biology underlying synaptic plasticity. Coding Python.
PhD done @ Bradke lab #NeuroDev #Microtubules
PostDoc in Tchumatchenko group. #SynapticPlasticity #Dendrites
https://github.com/maxschelski/
PhD done @ Bradke lab #NeuroDev #Microtubules
PostDoc in Tchumatchenko group. #SynapticPlasticity #Dendrites
https://github.com/maxschelski/
Pinned
Max Schelski
@maxschelski.bsky.social
· Nov 20
Hi! I'm Max. I'm developing a #biophysical model of #microtubules in #neurons during #development. The model is based on my surprising experimental finding (lots of live-cell imaging) that the entire microtubule array in neurites flows retrogradely into the soma: www.science.org/doi/10.1126/... 🧪 🧠📈
Reposted by Max Schelski
🚨Big news!🚨
The lab is relocating to Lisbon, joining a great team of experimental and theoretical neuroscientists, and the Neurotechnology Warehouse, a new initiative to bridge basic and translational research.
I'll be sharing postdoc openings soon. Come join us in this new incarnation of the lab!
The lab is relocating to Lisbon, joining a great team of experimental and theoretical neuroscientists, and the Neurotechnology Warehouse, a new initiative to bridge basic and translational research.
I'll be sharing postdoc openings soon. Come join us in this new incarnation of the lab!
🧠🎼 What does it take to restore movement? Neuroscientist and engineer, @juangallego.bsky.social, joins the new Centre for Restorative Neurotechnology at the Champalimaud Foundation.
🔗 Find out more in this interview: www.fchampalimaud.org/news/juan-al...
🔗 Find out more in this interview: www.fchampalimaud.org/news/juan-al...
October 7, 2025 at 4:37 PM
🚨Big news!🚨
The lab is relocating to Lisbon, joining a great team of experimental and theoretical neuroscientists, and the Neurotechnology Warehouse, a new initiative to bridge basic and translational research.
I'll be sharing postdoc openings soon. Come join us in this new incarnation of the lab!
The lab is relocating to Lisbon, joining a great team of experimental and theoretical neuroscientists, and the Neurotechnology Warehouse, a new initiative to bridge basic and translational research.
I'll be sharing postdoc openings soon. Come join us in this new incarnation of the lab!
Reposted by Max Schelski
Maybe check out the associated website. icg-explorer.org. I know I know, it's not fully integrated with ICG1, but these things are difficult.
October 7, 2025 at 10:12 PM
Maybe check out the associated website. icg-explorer.org. I know I know, it's not fully integrated with ICG1, but these things are difficult.
Reposted by Max Schelski
“Mapping ion channel function” doi.org/10.7554/eLif... isn’t exactly a citation slayer, but it’s still one of my favourites (& my first independent project). Today we push pt 2, where we trace code origin & unite almost all channel models in a common expression. Boom! www.biorxiv.org/content/10.1...
An ion channel omnimodel for standardized biophysical neuron modelling
Biophysical neuron modeling is an indispensable tool in neuroscience research, with the combination of diverse ion channel kinetics and morphologies being used to explain various single-neuron propert...
www.biorxiv.org
October 6, 2025 at 6:25 PM
“Mapping ion channel function” doi.org/10.7554/eLif... isn’t exactly a citation slayer, but it’s still one of my favourites (& my first independent project). Today we push pt 2, where we trace code origin & unite almost all channel models in a common expression. Boom! www.biorxiv.org/content/10.1...
Reposted by Max Schelski
Excited to share our new preprint in which we propose a biologically plausible mechanistic solution to the problem of how the brain can flexibly learn and store new representations without forgetting previously learned information.
www.biorxiv.org/content/10.1...
Detailed 🧵 below 👇 1/12
www.biorxiv.org/content/10.1...
Detailed 🧵 below 👇 1/12
Assembly-based computations through contextual dendritic gating of plasticity
Neuronal assemblies — groups of strongly connected neurons — are considered the basic building blocks of perception and memory in the brain by encoding representations of specific concepts. Despite re...
www.biorxiv.org
July 25, 2025 at 10:53 AM
Excited to share our new preprint in which we propose a biologically plausible mechanistic solution to the problem of how the brain can flexibly learn and store new representations without forgetting previously learned information.
www.biorxiv.org/content/10.1...
Detailed 🧵 below 👇 1/12
www.biorxiv.org/content/10.1...
Detailed 🧵 below 👇 1/12
Reposted by Max Schelski
Very happy to share this preprint from the lab led by @cmiehl.bsky.social, Sebastian and Maurycy on how to flexibly learn with nonlinear dendrites and inhibitory context-dependent gating, putting biological detail in ANNs. Check out Christoph's post below for a preview or the paper for more details!
Excited to share our new preprint in which we propose a biologically plausible mechanistic solution to the problem of how the brain can flexibly learn and store new representations without forgetting previously learned information.
www.biorxiv.org/content/10.1...
Detailed 🧵 below 👇 1/12
www.biorxiv.org/content/10.1...
Detailed 🧵 below 👇 1/12
Assembly-based computations through contextual dendritic gating of plasticity
Neuronal assemblies — groups of strongly connected neurons — are considered the basic building blocks of perception and memory in the brain by encoding representations of specific concepts. Despite re...
www.biorxiv.org
July 25, 2025 at 1:21 PM
Very happy to share this preprint from the lab led by @cmiehl.bsky.social, Sebastian and Maurycy on how to flexibly learn with nonlinear dendrites and inhibitory context-dependent gating, putting biological detail in ANNs. Check out Christoph's post below for a preview or the paper for more details!
Reposted by Max Schelski
Very happy our cautionary tale of GECI expression in the hippocampus is out in @eLife.
https://elifesciences.org/articles/93804
We describe Ca2+ waves though the hippocampus. Mesmerising but artefact of GECI expression.
Also a tweet print https://x.com/tonykellyEU/status/1723654794626154891. 1/3
https://elifesciences.org/articles/93804
We describe Ca2+ waves though the hippocampus. Mesmerising but artefact of GECI expression.
Also a tweet print https://x.com/tonykellyEU/status/1723654794626154891. 1/3
August 30, 2025 at 8:14 PM
Very happy our cautionary tale of GECI expression in the hippocampus is out in @eLife.
https://elifesciences.org/articles/93804
We describe Ca2+ waves though the hippocampus. Mesmerising but artefact of GECI expression.
Also a tweet print https://x.com/tonykellyEU/status/1723654794626154891. 1/3
https://elifesciences.org/articles/93804
We describe Ca2+ waves though the hippocampus. Mesmerising but artefact of GECI expression.
Also a tweet print https://x.com/tonykellyEU/status/1723654794626154891. 1/3
Reposted by Max Schelski
Dendrites have been under the microscope, since 1888. We took it further and put dendrites under 3 different microscopes (ExM, STED, EM) and reconstructed entire branches to reveal fine nanoscale details. #SuperResolution #ElectronMicroscopy #Morphology
https://doi.org/10.1101/2025.07.18.664460
https://doi.org/10.1101/2025.07.18.664460
August 30, 2025 at 8:14 PM
Dendrites have been under the microscope, since 1888. We took it further and put dendrites under 3 different microscopes (ExM, STED, EM) and reconstructed entire branches to reveal fine nanoscale details. #SuperResolution #ElectronMicroscopy #Morphology
https://doi.org/10.1101/2025.07.18.664460
https://doi.org/10.1101/2025.07.18.664460
Reposted by Max Schelski
Recently I referred to how dendritic compartmentalisation increases computation.
What is a computational unit. How has the view evolved from point neuron (basis for ANNs). How a neuroscience view may increase AI efficiency.
buff.ly/zoF1rJz
preprint on compartmentalisation buff.ly/TAsJuVr
What is a computational unit. How has the view evolved from point neuron (basis for ANNs). How a neuroscience view may increase AI efficiency.
buff.ly/zoF1rJz
preprint on compartmentalisation buff.ly/TAsJuVr
September 2, 2025 at 3:33 PM
Recently I referred to how dendritic compartmentalisation increases computation.
What is a computational unit. How has the view evolved from point neuron (basis for ANNs). How a neuroscience view may increase AI efficiency.
buff.ly/zoF1rJz
preprint on compartmentalisation buff.ly/TAsJuVr
What is a computational unit. How has the view evolved from point neuron (basis for ANNs). How a neuroscience view may increase AI efficiency.
buff.ly/zoF1rJz
preprint on compartmentalisation buff.ly/TAsJuVr
Reposted by Max Schelski
New group leader position in computational neuroscience @ Neurocentre Magendie, INSERM, Bordeaux! More info here: www.bordeaux-neurocampus.fr/group-leader...
⚠️ Application deadline: end of September 2025
@neurobordeaux.bsky.social @neuromagendie.bsky.social
⚠️ Application deadline: end of September 2025
@neurobordeaux.bsky.social @neuromagendie.bsky.social
Group leader tenured-track position in Computational Neuroscience - Bordeaux Neurocampus
Neurocentre Magendie
www.bordeaux-neurocampus.fr
July 4, 2025 at 12:26 PM
New group leader position in computational neuroscience @ Neurocentre Magendie, INSERM, Bordeaux! More info here: www.bordeaux-neurocampus.fr/group-leader...
⚠️ Application deadline: end of September 2025
@neurobordeaux.bsky.social @neuromagendie.bsky.social
⚠️ Application deadline: end of September 2025
@neurobordeaux.bsky.social @neuromagendie.bsky.social
Reposted by Max Schelski
We just pushed “Memory by a 1000 rules” onto bioRxiv, where we use clever #ML to find #plasticity quadruplets (EE, EI, IE, II) that learn basic stability in spiking nets. Why is it cool? We find 1000s!! of solutions, and they don’t just stabilise. They #memorise! www.biorxiv.org/content/10.1...
Memory by a thousand rules: Automated discovery of functional multi-type plasticity rules reveals variety & degeneracy at the heart of learning
Synaptic plasticity is the basis of learning and memory, but the link between synaptic changes and neural function remains elusive. Here, we used automated search algorithms to obtain thousands of str...
www.biorxiv.org
June 2, 2025 at 6:50 PM
We just pushed “Memory by a 1000 rules” onto bioRxiv, where we use clever #ML to find #plasticity quadruplets (EE, EI, IE, II) that learn basic stability in spiking nets. Why is it cool? We find 1000s!! of solutions, and they don’t just stabilise. They #memorise! www.biorxiv.org/content/10.1...
Reposted by Max Schelski
Here is your last reminder that the application deadline for Imbizo.Africa is nearing quickly, the 1st of July, in fact tomorrow. Still the place where diversity is at its best in the world! Tell all who need to hear. #africa #neuro
#Imbizo - Simons Computational Neuroscience Imbizo - #Imbizo
Simons Computational Neuroscience Imbizo summer school in Cape Town, South Africa
Imbizo.Africa
June 30, 2025 at 7:53 PM
Here is your last reminder that the application deadline for Imbizo.Africa is nearing quickly, the 1st of July, in fact tomorrow. Still the place where diversity is at its best in the world! Tell all who need to hear. #africa #neuro
Reposted by Max Schelski
First Bluesky post! I'm excited to share a preprint from my postdoctoral work where we 1) define the developmental mechanisms guiding formation of a vagal gut-brain circuit and 2) discover that this circuit regulates much more than just appetite. www.biorxiv.org/content/10.1...
Ontogeny of the vagal gut-brain axis
Gut-brain communication is a key component of homeostasis which regulates behaviors such as appetite and reward. Intestinal entero-endocrine cells (EECs) translate nutrient intake into signals which a...
www.biorxiv.org
May 8, 2025 at 8:18 PM
First Bluesky post! I'm excited to share a preprint from my postdoctoral work where we 1) define the developmental mechanisms guiding formation of a vagal gut-brain circuit and 2) discover that this circuit regulates much more than just appetite. www.biorxiv.org/content/10.1...
Reposted by Max Schelski
PhD/Postdoc position in Computational Neuroscience at the Institute of Neuroinformatics (UZH and ETH Zürich): we are investigating the neural circuits underlying perception and learning in uncertain environments: www.ini.uzh.ch/en/research/... #PhD #ComputationalNeuroscience #UZHZurich #ETHZurich
Open positions
www.ini.uzh.ch
June 11, 2025 at 8:54 AM
PhD/Postdoc position in Computational Neuroscience at the Institute of Neuroinformatics (UZH and ETH Zürich): we are investigating the neural circuits underlying perception and learning in uncertain environments: www.ini.uzh.ch/en/research/... #PhD #ComputationalNeuroscience #UZHZurich #ETHZurich
Reposted by Max Schelski
Our work, out at Cell, shows that the brain’s dopamine signals teach each individual a unique learning trajectory. Collaborative experiment-theory effort, led by Sam Liebana in the lab. The first experiment my lab started just shy of 6y ago & v excited to see it out: www.cell.com/cell/fulltex...
June 11, 2025 at 3:18 PM
Our work, out at Cell, shows that the brain’s dopamine signals teach each individual a unique learning trajectory. Collaborative experiment-theory effort, led by Sam Liebana in the lab. The first experiment my lab started just shy of 6y ago & v excited to see it out: www.cell.com/cell/fulltex...
Reposted by Max Schelski
My latest Aronov lab paper is now published @Nature!
When a chickadee looks at a distant location, the same place cells activate as if it were actually there 👁️
The hippocampus encodes where the bird is looking, AND what it expects to see next -- enabling spatial reasoning from afar
bit.ly/3HvWSum
When a chickadee looks at a distant location, the same place cells activate as if it were actually there 👁️
The hippocampus encodes where the bird is looking, AND what it expects to see next -- enabling spatial reasoning from afar
bit.ly/3HvWSum
June 11, 2025 at 10:24 PM
My latest Aronov lab paper is now published @Nature!
When a chickadee looks at a distant location, the same place cells activate as if it were actually there 👁️
The hippocampus encodes where the bird is looking, AND what it expects to see next -- enabling spatial reasoning from afar
bit.ly/3HvWSum
When a chickadee looks at a distant location, the same place cells activate as if it were actually there 👁️
The hippocampus encodes where the bird is looking, AND what it expects to see next -- enabling spatial reasoning from afar
bit.ly/3HvWSum
Reposted by Max Schelski
Preprint Alert 🚀
Multi-agent reinforcement learning (MARL) often assumes that agents know when other agents cooperate with them. But for humans, this isn’t always the case. For example, plains indigenous groups used to leave resources for others to use at effigies called Manitokan.
1/8
Multi-agent reinforcement learning (MARL) often assumes that agents know when other agents cooperate with them. But for humans, this isn’t always the case. For example, plains indigenous groups used to leave resources for others to use at effigies called Manitokan.
1/8
June 9, 2025 at 6:16 AM
Reposted by Max Schelski
Planning to apply for #research #funding from the ERC?
From the next application rounds, expect changes to the:
• proposal structure
• evaluation process
• extra funding you can request
• eligibility for Starting & Consolidator #Grants (from 2027)
More 👇 europa.eu/!RPHWvv
From the next application rounds, expect changes to the:
• proposal structure
• evaluation process
• extra funding you can request
• eligibility for Starting & Consolidator #Grants (from 2027)
More 👇 europa.eu/!RPHWvv
Changes to the 2026 and 2027 Work Programmes
With the launch of the competitions for grants under ERC Work Programme 2026 in July of this year, several changes to the submission of applications and the evaluation of proposals will apply. The mai...
europa.eu
June 2, 2025 at 10:02 AM
Planning to apply for #research #funding from the ERC?
From the next application rounds, expect changes to the:
• proposal structure
• evaluation process
• extra funding you can request
• eligibility for Starting & Consolidator #Grants (from 2027)
More 👇 europa.eu/!RPHWvv
From the next application rounds, expect changes to the:
• proposal structure
• evaluation process
• extra funding you can request
• eligibility for Starting & Consolidator #Grants (from 2027)
More 👇 europa.eu/!RPHWvv
Reposted by Max Schelski
the magic growing/shrinking GTP/GDP switch lies in the differential ability to bend out of plane and hold on neighbours.
Alone you go faster, together we go further.
Alone you go faster, together we go further.
Happy to contribute to this fantastic work by @maksimkalutskii.bsky.social and @maxotubule.bsky.social!
www.pnas.org/doi/abs/10.1...
www.pnas.org/doi/abs/10.1...
June 4, 2025 at 10:50 AM
the magic growing/shrinking GTP/GDP switch lies in the differential ability to bend out of plane and hold on neighbours.
Alone you go faster, together we go further.
Alone you go faster, together we go further.
Reposted by Max Schelski
Happy to contribute to this fantastic work by @maksimkalutskii.bsky.social and @maxotubule.bsky.social!
www.pnas.org/doi/abs/10.1...
www.pnas.org/doi/abs/10.1...
June 3, 2025 at 11:14 AM
Happy to contribute to this fantastic work by @maksimkalutskii.bsky.social and @maxotubule.bsky.social!
www.pnas.org/doi/abs/10.1...
www.pnas.org/doi/abs/10.1...
Reposted by Max Schelski
New from the Baas lab: Regulation of axonal microtubule orientation by protein motors and TRIM46/augmin in hippocampal vs SCG neurons
faseb.onlinelibrary.wiley.com/doi/abs/10.1...
faseb.onlinelibrary.wiley.com/doi/abs/10.1...
June 3, 2025 at 4:40 PM
New from the Baas lab: Regulation of axonal microtubule orientation by protein motors and TRIM46/augmin in hippocampal vs SCG neurons
faseb.onlinelibrary.wiley.com/doi/abs/10.1...
faseb.onlinelibrary.wiley.com/doi/abs/10.1...
Reposted by Max Schelski
The @viennabiocenter.bsky.social PostDoc Program call is now open! We have 16 fully-funded positions for scientists with a PhD in biology, chemistry, physics, bioinformatics etc.
Apply here: training.vbc.ac.at/post-docs/vi...
#VBCPostDoc
Apply here: training.vbc.ac.at/post-docs/vi...
#VBCPostDoc
June 2, 2025 at 11:28 AM
The @viennabiocenter.bsky.social PostDoc Program call is now open! We have 16 fully-funded positions for scientists with a PhD in biology, chemistry, physics, bioinformatics etc.
Apply here: training.vbc.ac.at/post-docs/vi...
#VBCPostDoc
Apply here: training.vbc.ac.at/post-docs/vi...
#VBCPostDoc
Reposted by Max Schelski
🥼 We’re looking for a #MSc student to work in our lab as part of their MSc thesis or internship on an interdisciplinary project @dzne.science, in Germany!
🧠 If you’re interested in #neuroinflammation and innate immune signalling in #alzheimersdisease, check out our ad👇
jobs.dzne.de/en/jobs/1014...
🧠 If you’re interested in #neuroinflammation and innate immune signalling in #alzheimersdisease, check out our ad👇
jobs.dzne.de/en/jobs/1014...
Master student (f/m/x) in the field of Neuroimmunology 1447/2025/6
jobs.dzne.de
June 2, 2025 at 5:17 AM
🥼 We’re looking for a #MSc student to work in our lab as part of their MSc thesis or internship on an interdisciplinary project @dzne.science, in Germany!
🧠 If you’re interested in #neuroinflammation and innate immune signalling in #alzheimersdisease, check out our ad👇
jobs.dzne.de/en/jobs/1014...
🧠 If you’re interested in #neuroinflammation and innate immune signalling in #alzheimersdisease, check out our ad👇
jobs.dzne.de/en/jobs/1014...
Reposted by Max Schelski
1/6 Why does the brain maintain such precise excitatory-inhibitory balance?
Our new preprint explores a provocative idea: Small, targeted deviations from this balance may serve a purpose: to encode local error signals for learning.
www.biorxiv.org/content/10.1...
led by @jrbch.bsky.social
Our new preprint explores a provocative idea: Small, targeted deviations from this balance may serve a purpose: to encode local error signals for learning.
www.biorxiv.org/content/10.1...
led by @jrbch.bsky.social
May 27, 2025 at 7:49 AM
1/6 Why does the brain maintain such precise excitatory-inhibitory balance?
Our new preprint explores a provocative idea: Small, targeted deviations from this balance may serve a purpose: to encode local error signals for learning.
www.biorxiv.org/content/10.1...
led by @jrbch.bsky.social
Our new preprint explores a provocative idea: Small, targeted deviations from this balance may serve a purpose: to encode local error signals for learning.
www.biorxiv.org/content/10.1...
led by @jrbch.bsky.social
Reposted by Max Schelski
Big if true in nature:
"Strikingly, this phenomenon does not require additional mechanisms like intransitive or higher-order interactions; rather, coexistence arises from dense networks of indirect effects."
🧪 #EvoBio #Complexity #Macroecology
"Strikingly, this phenomenon does not require additional mechanisms like intransitive or higher-order interactions; rather, coexistence arises from dense networks of indirect effects."
🧪 #EvoBio #Complexity #Macroecology
Microbial communities can harbor many species that do not coexist in pairs, yet can coexist in the full community. Here we provide the mathematical foundations of emergent coexistence, and explain why it can't be predicted from pairwise tests www.biorxiv.org/content/10.1...
May 21, 2025 at 9:53 AM
Big if true in nature:
"Strikingly, this phenomenon does not require additional mechanisms like intransitive or higher-order interactions; rather, coexistence arises from dense networks of indirect effects."
🧪 #EvoBio #Complexity #Macroecology
"Strikingly, this phenomenon does not require additional mechanisms like intransitive or higher-order interactions; rather, coexistence arises from dense networks of indirect effects."
🧪 #EvoBio #Complexity #Macroecology