Dr Róisín McManus
@roisinmcmanus.bsky.social
Group Leader @DZNE Bonn and @Institute of Innate Immunity 🇩🇪, PhD @TCD 🇮🇪
Neuroimmunologist, we study innate immune signalling, inflammasomes and immunometabolism in aging and dementia 🧠
https://www.iiibonn.de/roisin-mcmanus-lab/roisin-mcmanus-lab-science
Neuroimmunologist, we study innate immune signalling, inflammasomes and immunometabolism in aging and dementia 🧠
https://www.iiibonn.de/roisin-mcmanus-lab/roisin-mcmanus-lab-science
Pinned
NLRP3-mediated glutaminolysis controls microglial phagocytosis to promote Alzheimer’s disease progression
How NLRP3 impacts Alzheimer’s disease (AD) is unclear. McManus et al. find that NLRP3
is located at mitochondria where it regulates microglial metabolism. Depletion or
chronic pharmacological inhibiti...
www.cell.com
I am thrilled to share our latest article that has been published in @cp-immunity.bsky.social. We describe a new role for NLRP3 outside of its #inflammasome complex, where it can regulate microglial #metabolism & key metabolites that affect the epigenetic landscape(1)
www.cell.com/immunity/ful...
www.cell.com/immunity/ful...
🥼 We’re looking for a #MSc student to work in our lab as part of their MSc thesis or internship on an interdisciplinary project @dzne.science, in Germany!
🧠 If you’re interested in #neuroinflammation and innate immune signalling in #alzheimersdisease, check out our ad👇
jobs.dzne.de/en/jobs/1014...
🧠 If you’re interested in #neuroinflammation and innate immune signalling in #alzheimersdisease, check out our ad👇
jobs.dzne.de/en/jobs/1014...
Master student (f/m/x) in the field of Neuroimmunology 1447/2025/6
jobs.dzne.de
June 2, 2025 at 5:17 AM
🥼 We’re looking for a #MSc student to work in our lab as part of their MSc thesis or internship on an interdisciplinary project @dzne.science, in Germany!
🧠 If you’re interested in #neuroinflammation and innate immune signalling in #alzheimersdisease, check out our ad👇
jobs.dzne.de/en/jobs/1014...
🧠 If you’re interested in #neuroinflammation and innate immune signalling in #alzheimersdisease, check out our ad👇
jobs.dzne.de/en/jobs/1014...
Reposted by Dr Róisín McManus
Can AI-designed binders degrade, aggregate, stain and enrich endogenous proteins in human cells? Check out our new preprint!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Transposon-Display of AI-designed binders enables manipulation of the proteome in human cells
Transposon-Display is a highly scalable screening method that links proteins to their encoding DNA during expression in E. coli via a mutant transposase. Leveraging this system, we identified AI-desig...
www.biorxiv.org
May 16, 2025 at 7:21 PM
Can AI-designed binders degrade, aggregate, stain and enrich endogenous proteins in human cells? Check out our new preprint!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
📢 We are #hiring a #PhD student to work on an interdisciplinary, collaborative project @dzne.science in Bonn, Germany!
🧠 If you’re interested in western diet-induced #neuroinflammation and innate immune signalling in #alzheimersdisease, check out our ad below 👇
jobs.dzne.de/en/jobs/1014...
🧠 If you’re interested in western diet-induced #neuroinflammation and innate immune signalling in #alzheimersdisease, check out our ad below 👇
jobs.dzne.de/en/jobs/1014...
PhD student (f/m/x) in the field of Neuroimmunology 1439/2025/5]
jobs.dzne.de
May 14, 2025 at 5:12 AM
📢 We are #hiring a #PhD student to work on an interdisciplinary, collaborative project @dzne.science in Bonn, Germany!
🧠 If you’re interested in western diet-induced #neuroinflammation and innate immune signalling in #alzheimersdisease, check out our ad below 👇
jobs.dzne.de/en/jobs/1014...
🧠 If you’re interested in western diet-induced #neuroinflammation and innate immune signalling in #alzheimersdisease, check out our ad below 👇
jobs.dzne.de/en/jobs/1014...
Had a great time visiting @tcddublin.bsky.social last week where I got to share some of our new work from the lab! 🧠
Really enjoyed the discussions and meeting many amazing researchers, including some old friends 😊
Thanks to @David Loane and the TCD Biochemical society for the lovely invitation
Really enjoyed the discussions and meeting many amazing researchers, including some old friends 😊
Thanks to @David Loane and the TCD Biochemical society for the lovely invitation
April 25, 2025 at 5:52 AM
Had a great time visiting @tcddublin.bsky.social last week where I got to share some of our new work from the lab! 🧠
Really enjoyed the discussions and meeting many amazing researchers, including some old friends 😊
Thanks to @David Loane and the TCD Biochemical society for the lovely invitation
Really enjoyed the discussions and meeting many amazing researchers, including some old friends 😊
Thanks to @David Loane and the TCD Biochemical society for the lovely invitation
Thrilled to be at #ADPD2025 in Vienna ☀️
Thanks to everyone who came to our session on innate immunity yesterday! Really enjoyed the discussions after on our findings on #metabolism & #microglia function in #alzheimer’s disease
I’ve learned a lot at this meeting - looking forward to Copenhagen 2026 🧠
Thanks to everyone who came to our session on innate immunity yesterday! Really enjoyed the discussions after on our findings on #metabolism & #microglia function in #alzheimer’s disease
I’ve learned a lot at this meeting - looking forward to Copenhagen 2026 🧠
April 5, 2025 at 6:33 AM
Thrilled to be at #ADPD2025 in Vienna ☀️
Thanks to everyone who came to our session on innate immunity yesterday! Really enjoyed the discussions after on our findings on #metabolism & #microglia function in #alzheimer’s disease
I’ve learned a lot at this meeting - looking forward to Copenhagen 2026 🧠
Thanks to everyone who came to our session on innate immunity yesterday! Really enjoyed the discussions after on our findings on #metabolism & #microglia function in #alzheimer’s disease
I’ve learned a lot at this meeting - looking forward to Copenhagen 2026 🧠
Reposted by Dr Róisín McManus
Intermittent Fasting Increases Sex Drive in Male Mice: An Approach for Low Libido in Humans? Current findings could point the way for new therapy option / Serotonin plays key role.
Hot off the press from our Bonn based group of Dan Ehninger.
👉 www.cell.com/cell-metabol...
Hot off the press from our Bonn based group of Dan Ehninger.
👉 www.cell.com/cell-metabol...
Intermittent fasting boosts sexual behavior by limiting the central availability of tryptophan and serotonin
Xie et al. show that intermittent fasting (IF) enhances sexual behavior in male mice
by reducing serotonergic inhibition through lower brain tryptophan. While IF does
not improve endocrine function or...
www.cell.com
March 28, 2025 at 3:15 PM
Intermittent Fasting Increases Sex Drive in Male Mice: An Approach for Low Libido in Humans? Current findings could point the way for new therapy option / Serotonin plays key role.
Hot off the press from our Bonn based group of Dan Ehninger.
👉 www.cell.com/cell-metabol...
Hot off the press from our Bonn based group of Dan Ehninger.
👉 www.cell.com/cell-metabol...
This month the McManus lab turns 1! 🎉
It’s been an amazing year, from starting out with an empty lab space to having our first co-authorships, grant awards and successful student projects 📄
Delighted to work with such a wonderful team of scientists on #alzheimersdisease and #dementia research 🧠
It’s been an amazing year, from starting out with an empty lab space to having our first co-authorships, grant awards and successful student projects 📄
Delighted to work with such a wonderful team of scientists on #alzheimersdisease and #dementia research 🧠
March 28, 2025 at 5:53 AM
This month the McManus lab turns 1! 🎉
It’s been an amazing year, from starting out with an empty lab space to having our first co-authorships, grant awards and successful student projects 📄
Delighted to work with such a wonderful team of scientists on #alzheimersdisease and #dementia research 🧠
It’s been an amazing year, from starting out with an empty lab space to having our first co-authorships, grant awards and successful student projects 📄
Delighted to work with such a wonderful team of scientists on #alzheimersdisease and #dementia research 🧠
Reposted by Dr Róisín McManus
Visit the #exhibition "What the Health - One World. Your Health!" at the Museum Koenig in #Bonn.
Check out the #events surrounding the exhibition and discover how your health and the health of the planet are connected 🌍
Learn more about the program here: bonn.leibniz-lib.de/de/ausstellu...
Check out the #events surrounding the exhibition and discover how your health and the health of the planet are connected 🌍
Learn more about the program here: bonn.leibniz-lib.de/de/ausstellu...
March 27, 2025 at 8:51 AM
Visit the #exhibition "What the Health - One World. Your Health!" at the Museum Koenig in #Bonn.
Check out the #events surrounding the exhibition and discover how your health and the health of the planet are connected 🌍
Learn more about the program here: bonn.leibniz-lib.de/de/ausstellu...
Check out the #events surrounding the exhibition and discover how your health and the health of the planet are connected 🌍
Learn more about the program here: bonn.leibniz-lib.de/de/ausstellu...
Reposted by Dr Róisín McManus
🚨 Apply now! We invite you to apply for this year's International School of Advanced Immunology taking place September 14 - 19 at Maria Laach, Germany.
Visit our website for more information: www.advanced-immunology.net
#international #school #immunology
Visit our website for more information: www.advanced-immunology.net
#international #school #immunology
March 21, 2025 at 8:44 AM
🚨 Apply now! We invite you to apply for this year's International School of Advanced Immunology taking place September 14 - 19 at Maria Laach, Germany.
Visit our website for more information: www.advanced-immunology.net
#international #school #immunology
Visit our website for more information: www.advanced-immunology.net
#international #school #immunology
Happy St Patrick’s Day!
And what a lovely surprise from the lab, who all wore green this morning ☺️☘️
And what a lovely surprise from the lab, who all wore green this morning ☺️☘️
March 17, 2025 at 1:12 PM
Happy St Patrick’s Day!
And what a lovely surprise from the lab, who all wore green this morning ☺️☘️
And what a lovely surprise from the lab, who all wore green this morning ☺️☘️
Reposted by Dr Róisín McManus
I am overjoyed to present our latest paper on Autophagy in CD8 Tcells!
www.nature.com/articles/s41...
It was, as all ‘sciencing’ is, a huge team effort.
I will try to do it some justice in the following thread 😊 1/n
@cantrell-lab.bsky.social @immpres.bsky.social @ajmhowden.bsky.social
www.nature.com/articles/s41...
It was, as all ‘sciencing’ is, a huge team effort.
I will try to do it some justice in the following thread 😊 1/n
@cantrell-lab.bsky.social @immpres.bsky.social @ajmhowden.bsky.social
Autophagy repression by antigen and cytokines shapes mitochondrial, migration and effector machinery in CD8 T cells - Nature Immunology
Sinclair et al. combine quantitative proteomics and an autophagy flux reporter to map autophagy substrates and triggers during CD8 T cell differentiation. Proteins degraded and fueled by autophagy in ...
www.nature.com
March 1, 2025 at 11:18 AM
I am overjoyed to present our latest paper on Autophagy in CD8 Tcells!
www.nature.com/articles/s41...
It was, as all ‘sciencing’ is, a huge team effort.
I will try to do it some justice in the following thread 😊 1/n
@cantrell-lab.bsky.social @immpres.bsky.social @ajmhowden.bsky.social
www.nature.com/articles/s41...
It was, as all ‘sciencing’ is, a huge team effort.
I will try to do it some justice in the following thread 😊 1/n
@cantrell-lab.bsky.social @immpres.bsky.social @ajmhowden.bsky.social
Check out the latest episode from @immunosens.bsky.social where I chat about our research on #microglia, #NLRP3 and immunometabolism in #Alzheimer’s disease that was published this month in @cp-immunity.bsky.social
🎬 Episode 13 of #SpotOnScience is out!
In this episode, Dr. Róisín McManus introduces her work on the new role of NLRP3 in Alzheimer's disease.
Check out Spot on Science Episode 13: www.youtube.com/watch?v=5Hw2...
#science #research #immunology #Alzheimer
In this episode, Dr. Róisín McManus introduces her work on the new role of NLRP3 in Alzheimer's disease.
Check out Spot on Science Episode 13: www.youtube.com/watch?v=5Hw2...
#science #research #immunology #Alzheimer
Spot on Science, Episode#13, Róisín McManus / New role for NLRP3 linked to Alzheimer's disease
YouTube video by Exzellenzcluster ImmunoSensation
www.youtube.com
February 26, 2025 at 1:28 PM
Check out the latest episode from @immunosens.bsky.social where I chat about our research on #microglia, #NLRP3 and immunometabolism in #Alzheimer’s disease that was published this month in @cp-immunity.bsky.social
Reposted by Dr Róisín McManus
Five days of indulging in chocolate bars, crisps and other junk foods can lead to lingering changes in brain activity, a study shows1. The resulting brain patterns are similar to those seen in people who have obesity.
https://go.nature.com/3F61B4o
https://go.nature.com/3F61B4o
How a junk-food splurge can change your brain activity
A short bout of indulgence in fatty, sugary snacks leads to lingering brain-activity changes ― even if it does not cause weight gain.
go.nature.com
February 24, 2025 at 9:29 PM
Five days of indulging in chocolate bars, crisps and other junk foods can lead to lingering changes in brain activity, a study shows1. The resulting brain patterns are similar to those seen in people who have obesity.
https://go.nature.com/3F61B4o
https://go.nature.com/3F61B4o
Happy to share our first review from the McManus lab! 🥳
Special thanks to my PhD student & 1st author @nehalonkar.bsky.social & our co-author & collaborator Eicke Latz 📄
We summarise the key role of #metabolism on microglial function in health & #neurodegeneration 🧠
pubmed.ncbi.nlm.nih.gov/39936491/
Special thanks to my PhD student & 1st author @nehalonkar.bsky.social & our co-author & collaborator Eicke Latz 📄
We summarise the key role of #metabolism on microglial function in health & #neurodegeneration 🧠
pubmed.ncbi.nlm.nih.gov/39936491/
Neuroinflammation and immunometabolism in neurodegenerative diseases - PubMed
This review highlights the recent studies that have significantly contributed to our understanding of the metabolic dysregulation observed in activated microglia in conditions such as AD, unveiling no...
pubmed.ncbi.nlm.nih.gov
February 18, 2025 at 6:48 AM
Happy to share our first review from the McManus lab! 🥳
Special thanks to my PhD student & 1st author @nehalonkar.bsky.social & our co-author & collaborator Eicke Latz 📄
We summarise the key role of #metabolism on microglial function in health & #neurodegeneration 🧠
pubmed.ncbi.nlm.nih.gov/39936491/
Special thanks to my PhD student & 1st author @nehalonkar.bsky.social & our co-author & collaborator Eicke Latz 📄
We summarise the key role of #metabolism on microglial function in health & #neurodegeneration 🧠
pubmed.ncbi.nlm.nih.gov/39936491/
Reposted by Dr Róisín McManus
2nd Brazilian-German Immunology Workshop
Vienna, Austria
August 15-16, 2025
DEADLINE for application: March 1
Pls apply to Tim Sparwasser (sparwasser.office’at’uni-mainz.de) or Bernardo Franklin (franklin’at’uni-bonn.de) by March 1 2025, stating the title of the lecture and a half-page abstract.
Vienna, Austria
August 15-16, 2025
DEADLINE for application: March 1
Pls apply to Tim Sparwasser (sparwasser.office’at’uni-mainz.de) or Bernardo Franklin (franklin’at’uni-bonn.de) by March 1 2025, stating the title of the lecture and a half-page abstract.
February 16, 2025 at 10:16 AM
2nd Brazilian-German Immunology Workshop
Vienna, Austria
August 15-16, 2025
DEADLINE for application: March 1
Pls apply to Tim Sparwasser (sparwasser.office’at’uni-mainz.de) or Bernardo Franklin (franklin’at’uni-bonn.de) by March 1 2025, stating the title of the lecture and a half-page abstract.
Vienna, Austria
August 15-16, 2025
DEADLINE for application: March 1
Pls apply to Tim Sparwasser (sparwasser.office’at’uni-mainz.de) or Bernardo Franklin (franklin’at’uni-bonn.de) by March 1 2025, stating the title of the lecture and a half-page abstract.
Reposted by Dr Róisín McManus
*Job Opportunity*
Prof. Dominic Lemken is seeking a PhD candidate to research Consumer Behavior and Food Choices as part of our SFB!
If you are passionate about #ConsumerBehavior and #FoodEconomics find out more here:
www.uni-bonn.de/de/universit...
Prof. Dominic Lemken is seeking a PhD candidate to research Consumer Behavior and Food Choices as part of our SFB!
If you are passionate about #ConsumerBehavior and #FoodEconomics find out more here:
www.uni-bonn.de/de/universit...
www.uni-bonn.de
February 12, 2025 at 2:30 PM
*Job Opportunity*
Prof. Dominic Lemken is seeking a PhD candidate to research Consumer Behavior and Food Choices as part of our SFB!
If you are passionate about #ConsumerBehavior and #FoodEconomics find out more here:
www.uni-bonn.de/de/universit...
Prof. Dominic Lemken is seeking a PhD candidate to research Consumer Behavior and Food Choices as part of our SFB!
If you are passionate about #ConsumerBehavior and #FoodEconomics find out more here:
www.uni-bonn.de/de/universit...
Reposted by Dr Róisín McManus
Another fantastic shot from @roisinmcmanus.bsky.social at the mechanisms of activation and modulation of the #NLRP3 inflammasome! Congratulations to the McManus team at the @dzne.science and my dear friends at the iii @unibonn.bsky.social! Fantastic work!
www.cell.com/immunity/ful...
www.cell.com/immunity/ful...
NLRP3-mediated glutaminolysis controls microglial phagocytosis to promote Alzheimer’s disease progression
How NLRP3 impacts Alzheimer’s disease (AD) is unclear. McManus et al. find that NLRP3
is located at mitochondria where it regulates microglial metabolism. Depletion or
chronic pharmacological inhibiti...
www.cell.com
February 11, 2025 at 9:01 PM
Another fantastic shot from @roisinmcmanus.bsky.social at the mechanisms of activation and modulation of the #NLRP3 inflammasome! Congratulations to the McManus team at the @dzne.science and my dear friends at the iii @unibonn.bsky.social! Fantastic work!
www.cell.com/immunity/ful...
www.cell.com/immunity/ful...
Reposted by Dr Róisín McManus
Temple University @temple.edu in Philadelphia is recruiting for a Assistant or Associate Professor - Tenure Track Faculty to work on seeking Therapeutic targets for Alzheimer's Disease. Closing date: 9th March
www.dementiaresearcher.nihr.ac.uk/job/assistan...
www.dementiaresearcher.nihr.ac.uk/job/assistan...
Assistant or Associate Professor: Therapeutic targets for Alzheimer’s
Temple University in Philadelphia is recruiting for a Assistant or Associate Professor - Tenure Track Faculty to work on seeking Therapeutic targets for Alzheimer's Disease.
www.dementiaresearcher.nihr.ac.uk
February 8, 2025 at 10:30 PM
Temple University @temple.edu in Philadelphia is recruiting for a Assistant or Associate Professor - Tenure Track Faculty to work on seeking Therapeutic targets for Alzheimer's Disease. Closing date: 9th March
www.dementiaresearcher.nihr.ac.uk/job/assistan...
www.dementiaresearcher.nihr.ac.uk/job/assistan...
Reposted by Dr Róisín McManus
🎉 Huge congratulations to @roisinmcmanus.bsky.social and Michael Heneka on this exciting study uncovering a novel role for NLRP3 in regulating microglial metabolism and phagocytosis to promote Alzheimer’s disease progression www.cell.com/immunity/abs...
NLRP3-mediated glutaminolysis controls microglial phagocytosis to promote Alzheimer’s disease progression
How NLRP3 impacts Alzheimer’s disease (AD) is unclear. McManus et al. find that NLRP3
is located at mitochondria where it regulates microglial metabolism. Depletion or
chronic pharmacological inhibiti...
www.cell.com
February 6, 2025 at 8:35 PM
🎉 Huge congratulations to @roisinmcmanus.bsky.social and Michael Heneka on this exciting study uncovering a novel role for NLRP3 in regulating microglial metabolism and phagocytosis to promote Alzheimer’s disease progression www.cell.com/immunity/abs...
Reposted by Dr Róisín McManus
Join us along with The Rainwater Charitable Foundation and CurePSP for #Tau2025, Apr. 24-25 in London or online! Be a part of the conversation as leading experts work to address the future of tau research. Register now: alz.org/Tau
Tau Global Conference | Alzheimer’s Association
Leading experts from academia, industry, philanthropy and government will meet to address the future of tau research. Learn more and register.
alz.org
February 6, 2025 at 9:30 PM
Join us along with The Rainwater Charitable Foundation and CurePSP for #Tau2025, Apr. 24-25 in London or online! Be a part of the conversation as leading experts work to address the future of tau research. Register now: alz.org/Tau
Reposted by Dr Róisín McManus
Congratulations to @roisinmcmanus.bsky.social from DZNE in Bonn on her newly published paper in Immunity:
"NLRP3-mediated glutaminolysis controls microglial phagocytosis to promote Alzheimer’s disease progression"
👉 doi.org/10.1016/j.im...
👉 www.dzne.de/en/news/pres...
"NLRP3-mediated glutaminolysis controls microglial phagocytosis to promote Alzheimer’s disease progression"
👉 doi.org/10.1016/j.im...
👉 www.dzne.de/en/news/pres...
Lab Findings Support the Concept that Reducing Neuroinflammation Could Help Fight Alzheimer’s
New insights into immune cells in the context of neurodegeneration.
www.dzne.de
February 4, 2025 at 9:26 AM
Congratulations to @roisinmcmanus.bsky.social from DZNE in Bonn on her newly published paper in Immunity:
"NLRP3-mediated glutaminolysis controls microglial phagocytosis to promote Alzheimer’s disease progression"
👉 doi.org/10.1016/j.im...
👉 www.dzne.de/en/news/pres...
"NLRP3-mediated glutaminolysis controls microglial phagocytosis to promote Alzheimer’s disease progression"
👉 doi.org/10.1016/j.im...
👉 www.dzne.de/en/news/pres...
Reposted by Dr Róisín McManus
The UK Dementia Research Institute @UKDRI is seeking an outstanding established academic to take the position of Centre Director, at the level of Clinical or non-Clinical Professor at Cardiff University. Closing date: 20th March
www.dementiaresearcher.nihr.ac.uk/job/centre-d...
www.dementiaresearcher.nihr.ac.uk/job/centre-d...
Centre Director: UK Dementia Research Institute at Cardiff
The UK Dementia Research Institute are seeking an outstanding established academic to take the position of Centre Director, at the level of Clinical or non-Clinical Professor.
www.dementiaresearcher.nihr.ac.uk
February 4, 2025 at 9:58 AM
The UK Dementia Research Institute @UKDRI is seeking an outstanding established academic to take the position of Centre Director, at the level of Clinical or non-Clinical Professor at Cardiff University. Closing date: 20th March
www.dementiaresearcher.nihr.ac.uk/job/centre-d...
www.dementiaresearcher.nihr.ac.uk/job/centre-d...
Reposted by Dr Róisín McManus
Whether you feel a sudden urge to discuss your recent research findings OR have completely missed the abstract submission OR have just discovered this fabulous congress:
Submit your Late Poster and/or register here: www.nwg-goettingen.de/2025/default...
between
👉 03 – 20 February 2025 👈
Submit your Late Poster and/or register here: www.nwg-goettingen.de/2025/default...
between
👉 03 – 20 February 2025 👈
February 3, 2025 at 9:28 AM
Whether you feel a sudden urge to discuss your recent research findings OR have completely missed the abstract submission OR have just discovered this fabulous congress:
Submit your Late Poster and/or register here: www.nwg-goettingen.de/2025/default...
between
👉 03 – 20 February 2025 👈
Submit your Late Poster and/or register here: www.nwg-goettingen.de/2025/default...
between
👉 03 – 20 February 2025 👈
Reposted by Dr Róisín McManus
NLRP3-mediated glutaminolysis controls microglial phagocytosis to promote Alzheimer’s disease progression: Immunity www.cell.com/immunity/ful...
February 3, 2025 at 4:36 PM
NLRP3-mediated glutaminolysis controls microglial phagocytosis to promote Alzheimer’s disease progression: Immunity www.cell.com/immunity/ful...
Reposted by Dr Róisín McManus
NLRP3-mediated glutaminolysis controls microglial phagocytosis to promote Alzheimer’s disease progression
www.cell.com/immunity/ful...
@cp-immunity.bsky.social @roisinmcmanus.bsky.social
www.cell.com/immunity/ful...
@cp-immunity.bsky.social @roisinmcmanus.bsky.social
NLRP3-mediated glutaminolysis controls microglial phagocytosis to promote Alzheimer’s disease progression
How NLRP3 impacts Alzheimer’s disease (AD) is unclear. McManus et al. find that NLRP3
is located at mitochondria where it regulates microglial metabolism. Depletion or
chronic pharmacological inhibiti...
www.cell.com
February 3, 2025 at 5:51 PM
NLRP3-mediated glutaminolysis controls microglial phagocytosis to promote Alzheimer’s disease progression
www.cell.com/immunity/ful...
@cp-immunity.bsky.social @roisinmcmanus.bsky.social
www.cell.com/immunity/ful...
@cp-immunity.bsky.social @roisinmcmanus.bsky.social