Lucas Secchim Ribeiro
@secchimribeiro.bsky.social
Platelets sequester extracellular DNA, capturing tumor-derived and free fetal DNA | Science www.science.org/doi/10.1126/...
Platelets sequester extracellular DNA, capturing tumor-derived and free fetal DNA
Platelets are anucleate blood cells vital for hemostasis and immunity. During cell death and aberrant mitosis, nucleated cells release DNA, resulting in “cell-free” DNA in plasma (cfDNA). An excess of...
www.science.org
September 1, 2025 at 2:05 PM
Platelets sequester extracellular DNA, capturing tumor-derived and free fetal DNA | Science www.science.org/doi/10.1126/...
The #IUIS2025 is on!! The @dgfi-org.bsky.social is kicking off the Satellite Symposium in great style at the Austria Center Vienna! #Immunology #Science
August 17, 2025 at 11:04 AM
The #IUIS2025 is on!! The @dgfi-org.bsky.social is kicking off the Satellite Symposium in great style at the Austria Center Vienna! #Immunology #Science
Arriving in #Vienna for the #IUIS2025! It is going to be a fantastic conference and if you are around, make sure to reach out, let's talk and build the #Immunology of the future!
August 16, 2025 at 8:07 PM
Arriving in #Vienna for the #IUIS2025! It is going to be a fantastic conference and if you are around, make sure to reach out, let's talk and build the #Immunology of the future!
Just finished reading the original #Mistborn trilogy and I am amazed with the truly engaging storytelling and character development!
I can really recommend the reading, as I am already looking very much forward to starting the next book from @brandonsanderson.bsky.social!
I can really recommend the reading, as I am already looking very much forward to starting the next book from @brandonsanderson.bsky.social!
May 28, 2025 at 4:45 PM
Just finished reading the original #Mistborn trilogy and I am amazed with the truly engaging storytelling and character development!
I can really recommend the reading, as I am already looking very much forward to starting the next book from @brandonsanderson.bsky.social!
I can really recommend the reading, as I am already looking very much forward to starting the next book from @brandonsanderson.bsky.social!
An interesting (and multi-species) short text on the immune senses of organisms! @cellpress.bsky.social
www.cell.com/trends/immun...
www.cell.com/trends/immun...
The five senses of immunity
A genealogy of immunity reveals increasingly complex systems for pathogen response,
organism homeostasis, and multispecies interaction. New studies show how the five
senses can all contribute to behav...
www.cell.com
April 21, 2025 at 6:58 PM
An interesting (and multi-species) short text on the immune senses of organisms! @cellpress.bsky.social
www.cell.com/trends/immun...
www.cell.com/trends/immun...
It was a pleasure to host the @sawitzkilab.bsky.social for the First Symposium on #SwarmLearning for Precision Medicine! Our team from the @dzne.science is always glad to engage with such outstanding researchers for important collaborations!
Really excited with our plans for the future!
Really excited with our plans for the future!
We’re excited to be a part of the Swarm Learning Initiative, working to accelerate immune response analyses in infectious diseases!
Anika, Lev, and Birgit joined the 1st Swarm Learning Symposium at @dzne.science, where Anika shared innovative concepts for ex vivo functional analyses. 📈
Anika, Lev, and Birgit joined the 1st Swarm Learning Symposium at @dzne.science, where Anika shared innovative concepts for ex vivo functional analyses. 📈
March 21, 2025 at 2:04 PM
It was a pleasure to host the @sawitzkilab.bsky.social for the First Symposium on #SwarmLearning for Precision Medicine! Our team from the @dzne.science is always glad to engage with such outstanding researchers for important collaborations!
Really excited with our plans for the future!
Really excited with our plans for the future!
Great example of how to make good use of #Olink and #SomaScan #proteomics in a population-level study!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Comparative studies of 2168 plasma proteins measured by two affinity-based platforms in 4000 Chinese adults - Nature Communications
Many recent proteomics studies use either Olink or SomaScan platforms to quantify proteins in high-throughput, but the consistency between the two is unclear. Here, the authors measure proteins in the...
www.nature.com
February 25, 2025 at 7:28 AM
Great example of how to make good use of #Olink and #SomaScan #proteomics in a population-level study!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Very interesting pre-print from the group of Vishva Dixit in California! The @genentech.bsky.social team found the small-molecule inhibitors of caspase activity can be delivered using GSDMD pores as an entry point!
#Inflammasome #Immunology
www.biorxiv.org/content/10.1...
#Inflammasome #Immunology
www.biorxiv.org/content/10.1...
Delivery of caspase inhibitors through GSDMD pores to inhibit pyroptosis
Caspase-1, -4, -5, and -11 activate Gasdermin D (GSDMD) to form pores in the plasma membrane. In addition to releasing interleukin (IL)-1β and IL-18, GSDMD pores cause a lytic, proinflammatory form of...
www.biorxiv.org
February 17, 2025 at 8:17 AM
Very interesting pre-print from the group of Vishva Dixit in California! The @genentech.bsky.social team found the small-molecule inhibitors of caspase activity can be delivered using GSDMD pores as an entry point!
#Inflammasome #Immunology
www.biorxiv.org/content/10.1...
#Inflammasome #Immunology
www.biorxiv.org/content/10.1...
Another fantastic shot from @roisinmcmanus.bsky.social at the mechanisms of activation and modulation of the #NLRP3 inflammasome! Congratulations to the McManus team at the @dzne.science and my dear friends at the iii @unibonn.bsky.social! Fantastic work!
www.cell.com/immunity/ful...
www.cell.com/immunity/ful...
NLRP3-mediated glutaminolysis controls microglial phagocytosis to promote Alzheimer’s disease progression
How NLRP3 impacts Alzheimer’s disease (AD) is unclear. McManus et al. find that NLRP3
is located at mitochondria where it regulates microglial metabolism. Depletion or
chronic pharmacological inhibiti...
www.cell.com
February 11, 2025 at 9:01 PM
Another fantastic shot from @roisinmcmanus.bsky.social at the mechanisms of activation and modulation of the #NLRP3 inflammasome! Congratulations to the McManus team at the @dzne.science and my dear friends at the iii @unibonn.bsky.social! Fantastic work!
www.cell.com/immunity/ful...
www.cell.com/immunity/ful...
As it turns out, Mars will not be kind to our immune system! Very interesting work from @dlr-spaceagency.bsky.social, @radboudumc.bsky.social and @unibonn.bsky.social!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Immune responses to human pathogens exposed to simulated Mars conditions
The identification of health risks associated with long-term crewed missions to Mars is critical for mission planning and crew safety. Human-associated pathogens can be part of the microbiome and are ...
www.biorxiv.org
February 11, 2025 at 8:35 AM
As it turns out, Mars will not be kind to our immune system! Very interesting work from @dlr-spaceagency.bsky.social, @radboudumc.bsky.social and @unibonn.bsky.social!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
It has been a while since I worked with microbiome, but it is nice to see such as amazing effort out there! Great work on @cellpress.bsky.social by the group of @blekhman.bsky.social!
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Integration of 168,000 samples reveals global patterns of the human gut microbiome
The Human Microbiome Compendium is a unified database of publicly available human
gut microbiome 16S samples, built with the integrated data from hundreds of independent
projects. The compendium is us...
www.cell.com
January 23, 2025 at 11:53 AM
It has been a while since I worked with microbiome, but it is nice to see such as amazing effort out there! Great work on @cellpress.bsky.social by the group of @blekhman.bsky.social!
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
In this very interesting publication on @cp-immunity.bsky.social, Saller and the team of Olaf Gross unveiled the complexity of #NLRP3 activators, highlighting mitochondria’s roles in switching #apoptosis to NLRP3 #inflammasome activation!
www.cell.com/immunity/ful...
www.cell.com/immunity/ful...
Acute suppression of mitochondrial ATP production prevents apoptosis and provides an essential signal for NLRP3 inflammasome activation
Mitochondria control metabolism, cell death, and innate immunity, yet their reciprocal
mechanistic connections are elusive, as is the conserved physiological function of
the NLRP3 inflammasome. Saller...
www.cell.com
January 15, 2025 at 8:31 AM
In this very interesting publication on @cp-immunity.bsky.social, Saller and the team of Olaf Gross unveiled the complexity of #NLRP3 activators, highlighting mitochondria’s roles in switching #apoptosis to NLRP3 #inflammasome activation!
www.cell.com/immunity/ful...
www.cell.com/immunity/ful...
Reposted by Lucas Secchim Ribeiro
Fernanda Torres was a surprise win, taking home her first Golden Globe for best female actor in a drama motion picture for “I’m Still Here.” She told the red carpet ahead of the awards that she was the second Brazilian to be nominated, her mother Fernanda Montenegro being the first. cnn.it/3DIPxFO
January 6, 2025 at 6:18 AM
Fernanda Torres was a surprise win, taking home her first Golden Globe for best female actor in a drama motion picture for “I’m Still Here.” She told the red carpet ahead of the awards that she was the second Brazilian to be nominated, her mother Fernanda Montenegro being the first. cnn.it/3DIPxFO
Reposted by Lucas Secchim Ribeiro
Suppression of the inflammation that occurs with aging ("inflammaging") by blocking thrombospondin-1 (Thbs1), prevented age-related blood stem cell defects and expanded lifespan in the mouse model (KO-knockout)
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
January 3, 2025 at 8:10 PM
Suppression of the inflammation that occurs with aging ("inflammaging") by blocking thrombospondin-1 (Thbs1), prevented age-related blood stem cell defects and expanded lifespan in the mouse model (KO-knockout)
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Amazing read to start the year! The team of Bali Pulendran, our #SwarmLearning partner, just published a great article, highlighting the role of #platelet factors and TPO-mediated activation as an important mechanism to enhance the durability of #vaccine responses!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
System vaccinology analysis of predictors and mechanisms of antibody response durability to multiple vaccines in humans - Nature Immunology
Pulendran and colleagues define a molecular signature that can be used to predict the durability of antibody responses to vaccination and reveal important insights into the mechanisms by which vaccine...
www.nature.com
January 3, 2025 at 8:45 AM
Amazing read to start the year! The team of Bali Pulendran, our #SwarmLearning partner, just published a great article, highlighting the role of #platelet factors and TPO-mediated activation as an important mechanism to enhance the durability of #vaccine responses!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Not only ASC specks and inflammatory cytokines, but gasdermin pores are found to be shared during pyroptosis! #Inflammasome #Immunology
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Transplantation of gasdermin pores by extracellular vesicles propagates pyroptosis to bystander cells
Expanding the consequences of pyroptosis, this study reveals that GSDMD pore-laden pyroptotic EVs transplant GSDMD pores on neighboring cell surfaces and propagate cell death to bystander cells.
www.cell.com
January 2, 2025 at 8:21 AM
Not only ASC specks and inflammatory cytokines, but gasdermin pores are found to be shared during pyroptosis! #Inflammasome #Immunology
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
The infamous article that stated the fallacious positive effect of hydroxychloroquine and azithromycin for COVID is now retracted, i.e., the results are made up and cannot be reproduced (of course).
Let's hope that good science can prevail - faster - whenever needed the most.
Let's hope that good science can prevail - faster - whenever needed the most.
December 20, 2024 at 5:09 PM
The infamous article that stated the fallacious positive effect of hydroxychloroquine and azithromycin for COVID is now retracted, i.e., the results are made up and cannot be reproduced (of course).
Let's hope that good science can prevail - faster - whenever needed the most.
Let's hope that good science can prevail - faster - whenever needed the most.