DZNE research center
@dzne.science
Dedicated to advancing the scientific understanding of neurodegenerative diseases - from mechanisms to diagnosis, therapy, and prevention (such as AD, PD or ALS).
🔗 Imprint: https://dzne.de/en/imprint
🔗 Data Protection: https://dzne.de/en/data-protection/
🔗 Imprint: https://dzne.de/en/imprint
🔗 Data Protection: https://dzne.de/en/data-protection/
New paper out: Intranasal blood-brain barrier bypass enables sequential mitochondria-targeted bioengineered nanolamellar system for ischemic stroke therapy.: Yin, Yue; Li, Zixuan; Shu, Weijie; et al.
Nature Communications Vol. 17, no. 1, p. 760 | Thanks for sharing #dzne #papers
Nature Communications Vol. 17, no. 1, p. 760 | Thanks for sharing #dzne #papers
Intranasal blood-brain barrier bypass enables sequential mitochondria-targeted bioengineered nanolamellar system for ischemic stroke therapy.
Yin, Yue; Li, Zixuan; Shu, Weijie; et al.
Nature Communications Vol. 17, no. 1, p. 760
dlvr.it
February 5, 2026 at 1:53 PM
New paper out: Secondary obsessive-compulsive syndromes: a systematic literature review resulting in 228 suspected cases.: Runge, Kimon; Feige, Bernd; Schiele, Miriam A; et al.
Molecular psychiatry Vol. 31, no. 2, p. 1121 - 1131 | Thanks for sharing #dzne #papers
Molecular psychiatry Vol. 31, no. 2, p. 1121 - 1131 | Thanks for sharing #dzne #papers
Secondary obsessive-compulsive syndromes: a systematic literature review resulting in 228 suspected cases.
Runge, Kimon; Feige, Bernd; Schiele, Miriam A; et al.
Molecular psychiatry Vol. 31, no. 2, p. 1121 - 1131
dlvr.it
February 5, 2026 at 10:53 AM
Reposted by DZNE research center
📢 Our latest work is now in press at @natcomms.nature.com! A great collaboration with the Schultze lab @dzne.science & Denali Therapeutics, to identify molecular and functional changes associated with TREM2 signalling in microglia, with implications for TREM2 agonism.. www.nature.com/articles/s41...
TREM2 expression level is critical for microglial state, metabolic capacity and efficacy of TREM2 agonism - Nature Communications
TREM2 is an important AD risk factor playing essential roles in the microglial response to amyloid pathology. Here, authors show using a TREM2 reporter mouse that TREM2 levels are critical for efficac...
www.nature.com
February 4, 2026 at 3:41 PM
📢 Our latest work is now in press at @natcomms.nature.com! A great collaboration with the Schultze lab @dzne.science & Denali Therapeutics, to identify molecular and functional changes associated with TREM2 signalling in microglia, with implications for TREM2 agonism.. www.nature.com/articles/s41...
New paper out: Brain volume trajectories in Down syndrome and autosomal dominant Alzheimer's disease.: Kennedy, James T; Wisch, Julie K; Boerwinkle, Anna H; et al.
Alzheimer's and dementia Vol. 22, no. 1, p. e71103 | Thanks for sharing #dzne #papers
Alzheimer's and dementia Vol. 22, no. 1, p. e71103 | Thanks for sharing #dzne #papers
Brain volume trajectories in Down syndrome and autosomal dominant Alzheimer's disease.
Kennedy, James T; Wisch, Julie K; Boerwinkle, Anna H; et al.
Alzheimer's and dementia Vol. 22, no. 1, p. e71103
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February 4, 2026 at 6:14 PM
New paper out: Integrin-dependence of extramedullary erythropoiesis in the spleen of Jak2-V617F positive myeloproliferative neoplasm in mice.: Baldauf, Conny K; Poschmann, Linda; Edelmann-Stephan, Bärbel; et al.
Experimental hematology Vol. 154, p. 105340 - | Thanks for sharing #dzne #papers
Experimental hematology Vol. 154, p. 105340 - | Thanks for sharing #dzne #papers
Integrin-dependence of extramedullary erythropoiesis in the spleen of Jak2-V617F positive myeloproliferative neoplasm in mice.
Baldauf, Conny K; Poschmann, Linda; Edelmann-Stephan, Bärbel; et al.
Experimental hematology Vol. 154, p. 105340 -
dlvr.it
February 4, 2026 at 1:53 PM
New paper out: [18F]FDG-PET/CT Imaging for Response Characterisation of Experimental Melanomas to Anti-PD-L1/Anti-CTLA-4 Immunotherapy.: Antons, Melissa J; Kloiber-Langhorst, Sandra; Hirner-Eppeneder, Heidrun; et al.
Molecular imaging & biology Vol. 27, no. 6, p.… | Thanks for sharing #dzne #papers
Molecular imaging & biology Vol. 27, no. 6, p.… | Thanks for sharing #dzne #papers
[18F]FDG-PET/CT Imaging for Response Characterisation of Experimental Melanomas to Anti-PD-L1/Anti-CTLA-4 Immunotherapy.
Antons, Melissa J; Kloiber-Langhorst, Sandra; Hirner-Eppeneder, Heidrun; et al.
Molecular imaging & biology Vol. 27, no. 6, p. 1006 - 1014
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February 4, 2026 at 10:54 AM
New paper out: Association between polygenic risk for Major Depression and brain structure in a mega-analysis of 50,975 participants across 11 studies.: Shen, Xueyi; Toenders, Yara J; Han, Laura K M; et al.
Molecular psychiatry Vol. 31, no. 2, p. 611 - 621 | Thanks for sharing #dzne #papers
Molecular psychiatry Vol. 31, no. 2, p. 611 - 621 | Thanks for sharing #dzne #papers
Association between polygenic risk for Major Depression and brain structure in a mega-analysis of 50,975 participants across 11 studies.
Shen, Xueyi; Toenders, Yara J; Han, Laura K M; et al.
Molecular psychiatry Vol. 31, no. 2, p. 611 - 621
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February 3, 2026 at 6:14 PM
New paper out: Genetisch informierte Therapie in der Psychiatrie: neue Dynamik durch APOE und Antikörpertherapie der Alzheimer-Krankheit | Genetically informed treatment in psychiatry: new dynamics through APOE and antibody treatment of Alzheimer's disease:… | Thanks for sharing #dzne #papers
Genetisch informierte Therapie in der Psychiatrie: neue Dynamik durch APOE und Antikörpertherapie der Alzheimer-Krankheit | Genetically informed treatment in psychiatry: new dynamics through APOE and antibody treatment of Alzheimer's disease
Müller, Daniel J; Freitag, Christine M; Heilbronner, Urs; et al.
Der Nervenarzt Vol. 97, no. 1, p. 82 - 85
dlvr.it
February 3, 2026 at 1:53 PM
New paper out: Clinical and Genotypic Spectrum of Twinkle-Related Disorders: Insights From a Multinational Cohort Study.: Lopriore, Piervito; Ünlütürk, Zeynep; Klopstock, Thomas; et al.
Neurology Vol. 106, no. 3, p. e214401 | Thanks for sharing #dzne #papers
Neurology Vol. 106, no. 3, p. e214401 | Thanks for sharing #dzne #papers
Clinical and Genotypic Spectrum of Twinkle-Related Disorders: Insights From a Multinational Cohort Study.
Lopriore, Piervito; Ünlütürk, Zeynep; Klopstock, Thomas; et al.
Neurology Vol. 106, no. 3, p. e214401
dlvr.it
February 3, 2026 at 10:53 AM
New paper out: Multivariate associations of motor performance, sleep quality, depressive symptoms, and grey matter volume in younger and mid-to-older adults.: Küppers, Vincent; Bi, Hanwen; Nicolaisen-Sobesky, Eliana; et al.
Scientific reports Vol. 16, no. 1, p.… | Thanks for sharing #dzne #papers
Scientific reports Vol. 16, no. 1, p.… | Thanks for sharing #dzne #papers
Multivariate associations of motor performance, sleep quality, depressive symptoms, and grey matter volume in younger and mid-to-older adults.
Küppers, Vincent; Bi, Hanwen; Nicolaisen-Sobesky, Eliana; et al.
Scientific reports Vol. 16, no. 1, p. 1318
dlvr.it
February 1, 2026 at 10:53 AM
New paper out: High‐Throughput 3D Glioblastoma Model in Glycosaminoglycan Hydrogels for Personalized Therapeutic Screening: Trautmann, Rajvinder Kaur; Dennison, Nicholas; McCortney, Kathleen; et al.
Macromolecular bioscience Vol. 26, no. 1, p. e00394 | Thanks for sharing #dzne #papers
Macromolecular bioscience Vol. 26, no. 1, p. e00394 | Thanks for sharing #dzne #papers
High‐Throughput 3D Glioblastoma Model in Glycosaminoglycan Hydrogels for Personalized Therapeutic Screening
Trautmann, Rajvinder Kaur; Dennison, Nicholas; McCortney, Kathleen; et al.
Macromolecular bioscience Vol. 26, no. 1, p. e00394
dlvr.it
January 31, 2026 at 6:14 PM
New paper out: Abnormal Amplitude-Integrated Electroencephalography and Acidosis as Key Criteria Initiating Therapeutic Hypothermia in Asphyxiated Newborns - Data From the German Hypothermia Registry.: Demir, Sebiha; Groteklaes, Anne; Dresbach, Till; et al.
Acta… | Thanks for sharing #dzne #papers
Acta… | Thanks for sharing #dzne #papers
Abnormal Amplitude-Integrated Electroencephalography and Acidosis as Key Criteria Initiating Therapeutic Hypothermia in Asphyxiated Newborns - Data From the German Hypothermia Registry.
Demir, Sebiha; Groteklaes, Anne; Dresbach, Till; et al.
Acta paediatrica Vol. 115, no. 2, p. 482 - 490
dlvr.it
January 31, 2026 at 1:53 PM
New paper out: Immunotherapies in progressive multiple sclerosis.: Neziraj, Tradite; Kappos, Ludwig; Pröbstel, Anne-Katrin
| Thanks for sharing #dzne #papers
| Thanks for sharing #dzne #papers
Immunotherapies in progressive multiple sclerosis.
Neziraj, Tradite; Kappos, Ludwig; Pröbstel, Anne-Katrin
dlvr.it
January 31, 2026 at 10:53 AM
New paper out: Elenbecestat and Compound 89 Potently Inhibit BACE1 but Not BACE2 When Subchronically Dosed in Non-Human Primates.: Tschirner, Sarah K; Schmidt, Andree; Ito, Mana; et al.
Proteomics Vol. 26, no. 1, p. 100 - 107 | Thanks for sharing #dzne #papers
Proteomics Vol. 26, no. 1, p. 100 - 107 | Thanks for sharing #dzne #papers
Elenbecestat and Compound 89 Potently Inhibit BACE1 but Not BACE2 When Subchronically Dosed in Non-Human Primates.
Tschirner, Sarah K; Schmidt, Andree; Ito, Mana; et al.
Proteomics Vol. 26, no. 1, p. 100 - 107
dlvr.it
January 30, 2026 at 6:13 PM
New paper out: In-Source Fragmentation Annotation in Sterol Mass Spectrometry Imaging.: Sidorov, Iulia; Ogrinc, Nina; Spieth, Lena; et al.
Analytical chemistry Vol. 98, no. 1, p. 509 - 518 | Thanks for sharing #dzne #papers
Analytical chemistry Vol. 98, no. 1, p. 509 - 518 | Thanks for sharing #dzne #papers
In-Source Fragmentation Annotation in Sterol Mass Spectrometry Imaging.
Sidorov, Iulia; Ogrinc, Nina; Spieth, Lena; et al.
Analytical chemistry Vol. 98, no. 1, p. 509 - 518
dlvr.it
January 30, 2026 at 1:54 PM
New paper out: Bildgebung neurologischer Nebenwirkungen unter Immuntherapien : Immuncheckpoint-Inhibitoren und CAR-T-Zellen | Imaging of neurological adverse events associated with immunotherapies : Immune checkpoint inhibitors and CAR-T cells: Neumann, Timotheus… | Thanks for sharing #dzne #papers
Bildgebung neurologischer Nebenwirkungen unter Immuntherapien : Immuncheckpoint-Inhibitoren und CAR-T-Zellen | Imaging of neurological adverse events associated with immunotherapies : Immune checkpoint inhibitors and CAR-T cells
Neumann, Timotheus Josef; Baz, Anna Magdalena; Schmidt, Elena Nicola Charlotte; et al.
Die Radiologie Vol. 66, no. 1, p. 59 - 66
dlvr.it
January 30, 2026 at 10:54 AM
A DZNE-led project in Germany is testing an app for people with dementia living at home. It also supports family caregivers. The app connects users with memory-clinic professionals and practical resources. Goal is to reduce caregiver burden and stabilize home care.
👉 www.dzne.de/en/news/pres...
👉 www.dzne.de/en/news/pres...
App-supported help for people with dementia and family caregivers
DZNE leads research consortium supported by the Innovation Fund of Germany’s Federal Joint Committee.
www.dzne.de
January 30, 2026 at 10:01 AM
A DZNE-led project in Germany is testing an app for people with dementia living at home. It also supports family caregivers. The app connects users with memory-clinic professionals and practical resources. Goal is to reduce caregiver burden and stabilize home care.
👉 www.dzne.de/en/news/pres...
👉 www.dzne.de/en/news/pres...
Proud to share that PD Dr. Patrick Öckl has been awarded the Hirnliga Research Prize 2025 for pioneering work on a blood biomarker to detect Alzheimer’s-related changes early. His research on beta-synuclein offers promising insights for minimally invasive diagnosis.
👉 www.dzne.de/en/im-fokus/...
👉 www.dzne.de/en/im-fokus/...
January 30, 2026 at 9:33 AM
Proud to share that PD Dr. Patrick Öckl has been awarded the Hirnliga Research Prize 2025 for pioneering work on a blood biomarker to detect Alzheimer’s-related changes early. His research on beta-synuclein offers promising insights for minimally invasive diagnosis.
👉 www.dzne.de/en/im-fokus/...
👉 www.dzne.de/en/im-fokus/...
New paper out: Whole-brain meso-vein imaging in living humans using fast 7-T MRI.: Gulban, Omer Faruk; Stirnberg, Rüdiger; Tse, Desmond Ho Yan; et al.
Science advances Vol. 12, no. 2, p. eaea4540 | Thanks for sharing #dzne #papers
Science advances Vol. 12, no. 2, p. eaea4540 | Thanks for sharing #dzne #papers
Whole-brain meso-vein imaging in living humans using fast 7-T MRI.
Gulban, Omer Faruk; Stirnberg, Rüdiger; Tse, Desmond Ho Yan; et al.
Science advances Vol. 12, no. 2, p. eaea4540
dlvr.it
January 29, 2026 at 6:13 PM
New paper out: International consensus for the assessment of social cognition in neurocognitive disorders: framework definition and clinical recommendations of the SIGNATURE initiative.: Dodich, Alessandra; Panzavolta, Andrea; Funghi, Giulia; et al.
Alzheimer's… | Thanks for sharing #dzne #papers
Alzheimer's… | Thanks for sharing #dzne #papers
International consensus for the assessment of social cognition in neurocognitive disorders: framework definition and clinical recommendations of the SIGNATURE initiative.
Dodich, Alessandra; Panzavolta, Andrea; Funghi, Giulia; et al.
Alzheimer's research & therapy Vol. 18, no. 1, p. 6
dlvr.it
January 29, 2026 at 1:54 PM
New paper out: Fat Amount Rather Than Fatty Acid Composition Influences Postprandial Hunger, Satiety and Attention in Men and Women with a Risk Phenotype for Cardiometabolic Diseases: A Randomized Crossover Trial.: Diekmann, Christina; Schiemann, Tim B; Kienēs,… | Thanks for sharing #dzne #papers
Fat Amount Rather Than Fatty Acid Composition Influences Postprandial Hunger, Satiety and Attention in Men and Women with a Risk Phenotype for Cardiometabolic Diseases: A Randomized Crossover Trial.
Diekmann, Christina; Schiemann, Tim B; Kienēs, Hannah F; et al.
The journal of nutrition Vol. 156, no. 1, p. 101232 -
dlvr.it
January 29, 2026 at 10:53 AM
New paper out: Review: Kutzleben, Milena
Ageing and society Vol. 38, no. 1, p. 214 - 216 | Thanks for sharing #dzne #papers
Ageing and society Vol. 38, no. 1, p. 214 - 216 | Thanks for sharing #dzne #papers
Review
Kutzleben, Milena
Ageing and society Vol. 38, no. 1, p. 214 - 216
dlvr.it
January 28, 2026 at 1:54 PM
New paper out: Key components of person‐centered care for people with dementia: A systematic review of interventions to design a patient preference study: Raedke, Anika; Afi, Adel; Edvardsson, David; et al.
Alzheimer's and dementia Vol. 17, no. S7, p. e052134 | Thanks for sharing #dzne #papers
Alzheimer's and dementia Vol. 17, no. S7, p. e052134 | Thanks for sharing #dzne #papers
Key components of person‐centered care for people with dementia: A systematic review of interventions to design a patient preference study
Raedke, Anika; Afi, Adel; Edvardsson, David; et al.
Alzheimer's and dementia Vol. 17, no. S7, p. e052134
dlvr.it
January 28, 2026 at 10:53 AM
New paper out: Models in Inflammation and Immunopharmacology: Secchim Ribeiro, Lucas
| Thanks for sharing #dzne #papers
| Thanks for sharing #dzne #papers
Models in Inflammation and Immunopharmacology
Secchim Ribeiro, Lucas
dlvr.it
January 26, 2026 at 10:53 AM