Haass Lab
LightNews LightNews
banner
haasslab.bsky.social
Haass Lab
@haasslab.bsky.social
250 followers 130 following 10 posts
The Haass lab account | πŸ‡©πŸ‡ͺ @DZNE_de @SyNergy_Cluster Munich | πŸ”¬AD, FTLD & microglia research | πŸ•΅οΈ PI Christian Haass (signed -CH) | πŸ’¬ Posts by @lisdeweerd.bsky.social
Posts Replies Media Videos
Pinned
haasslab.bsky.social
Haass Lab @haasslab.bsky.social Β· 6d
πŸ“’ Our latest work is now in press at @natcomms.nature.com! A great collaboration with the Schultze lab @dzne.science & Denali Therapeutics, to identify molecular and functional changes associated with TREM2 signalling in microglia, with implications for TREM2 agonism.. www.nature.com/articles/s41...
TREM2 expression level is critical for microglial state, metabolic capacity and efficacy of TREM2 agonism - Nature Communications
TREM2 is an important AD risk factor playing essential roles in the microglial response to amyloid pathology. Here, authors show using a TREM2 reporter mouse that TREM2 levels are critical for efficac...
www.nature.com
Reposted by Haass Lab
synergy-munich.bsky.social
🧠 TREM2 Levels Shape Microglial Metabolic Fitness. This study shows that microglial #TREM2 is not an on/off signal but a graded axis that tracks with microglial state and function.

πŸ”—Read a summary of the study on our website: www.synergy-munich.de/news-events/...
February 9, 2026 at 3:06 PM
haasslab.bsky.social
πŸ“’ Our latest work is now in press at @natcomms.nature.com! A great collaboration with the Schultze lab @dzne.science & Denali Therapeutics, to identify molecular and functional changes associated with TREM2 signalling in microglia, with implications for TREM2 agonism.. www.nature.com/articles/s41...
TREM2 expression level is critical for microglial state, metabolic capacity and efficacy of TREM2 agonism - Nature Communications
TREM2 is an important AD risk factor playing essential roles in the microglial response to amyloid pathology. Here, authors show using a TREM2 reporter mouse that TREM2 levels are critical for efficac...
www.nature.com
February 4, 2026 at 3:41 PM
Reposted by Haass Lab
nomascus.bsky.social
Birds have a thick retina devoid of blood vessels - so how do they ensure sufficient oxygen availability?
They don't - neurons rely on glycolysis, metabolizing glucose released from the pecten.

Insane new study that includes comparative data on lizards and crocs.πŸ§ͺ

www.nature.com/articles/s41...
Oxygen-free metabolism in the bird inner retina supported by the pecten - Nature
While the photoreceptor outer segments in the bird outer retina have access to oxygen, the inner retina operates under chronic anoxia, supported by anaerobic glycolysis in the retinal neurons.
www.nature.com
January 22, 2026 at 2:14 PM
Reposted by Haass Lab
lukensjohnr.bsky.social
Ageing promotes microglial accumulation of slow-degrading synaptic proteins @nature.com
www.nature.com/articles/s41...
January 21, 2026 at 4:32 PM
Reposted by Haass Lab
science.org
Monitoring markers of tau protein in the blood can predict functional outcomes in patients recovering from ischemic stroke better than MRI, according to a comprehensive study of more than 1200 patients in #ScienceTranslationalMedicine. https://scim.ag/49TTWTQ
Brain-derived tau for monitoring brain injury in acute ischemic stroke
Brain-derived tau in plasma reflects the extent of brain injury in acute ischemic stroke, predicts functional outcomes, and detects treatment effects.
scim.ag
January 15, 2026 at 4:07 PM
Reposted by Haass Lab
labwaggoner.bsky.social
A minimally invasive dried blood spot biomarker test for the detection of Alzheimer’s disease pathology
www.nature.com/articles/s41... @natmed.nature.com @nicholasashton.bsky.social @bannerhealth.bsky.social @wagnersbrum.bsky.social
January 6, 2026 at 4:33 AM
Reposted by Haass Lab
sjorsscheres.bsky.social
Oh wow: Cryo-EM structure of #TAF15 filaments from postmortem #FTLD brains by the group of Ben Ryskeldi-Falcon at the @mrclmb.bsky.social. What an amazing tour-de-force!! 🀯

www.biorxiv.org/content/10.6...
January 13, 2026 at 6:48 PM
Reposted by Haass Lab
molneurodegen.bsky.social
Neuronal subtype governs #amyloid structure, cellular response, and cognitive outcome in genetically targeted APP mouse models

Gabriella A. Perez, Zoe Lai...Joanna L. Jankowsky
@bcmhouston.bsky.social @washumedicine.bsky.social #AlzheimersDisease #GABAergic

link.springer.com/article/10.1...
January 6, 2026 at 9:34 PM
Reposted by Haass Lab
cp-immunity.bsky.social
Online now: State-specific enhancer landscapes govern microglial plasticity
State-specific enhancer landscapes govern microglial plasticity
Microglia adopt diverse states throughout life. Whether these represent fixed lineages or reversible plasticity remains unclear. Hamagami and Kapadia et al. show that reactive microglia switch states through reprogramming of histone modifications at state-specific enhancers and associated transcription factors, linking developmental, aging, and disease phenotypes within a unified dynamic framework.
dlvr.it
January 7, 2026 at 3:48 PM
Reposted by Haass Lab
dementiaresearcher.bsky.social
Postdoc opportunity in the Holstege lab in Leuven analysing multi omics brain data to uncover protective mechanisms against ageing and neurodegeneration. Closing date: 4th March

www.dementiaresearcher.nihr.ac.uk/job/postdoc-...
Postdoc: Genomic resilience against neurodegeneration
Postdoctoral role in Leuven studying resilience to neurodegeneration using multi omics data from cognitively healthy centenarian brain samples.
www.dementiaresearcher.nihr.ac.uk
January 7, 2026 at 9:56 AM
Reposted by Haass Lab
mrclmb.bsky.social
Excellent opportunity for a #postdoc to join Michel Goedert’s group, investigating the mechanisms which cause the formation of amyloid filaments in neurodegenerative diseases, in collaboration with @sjorsscheres.bsky.social’s group.
More details: www.nature.com/naturecareer...
Closes 04 JAN
Michel Goedert, sat in front of a computer screen which displays filament fold structures
December 16, 2025 at 10:18 AM
Reposted by Haass Lab
javierolivares.bsky.social
Research icebreaker Polarstern sets sail for the Antarctic Weddell Sea.
An international research team led by the University of Rostock is investigating the impact of climate change on biodiversity in Antarctica. @awi.de @helmholtz.de
www.uni-rostock.de/en/
Marine benthos in the Eastern Weddell Sea (Photo: Alfred-Wegener-Institut / Tomas Lundalv) The aim of the expedition is to lay the foundation for long-term observations of biodiversity in a possible future marine protected area. The research voyage will take place from December 15, 2025, to February 2, 2026, and marks the fieldwork phase of the EU joint project β€œWeddell Sea Observatory of Biodiversity and Ecosystem Change” (WOBEC), which is supported by eleven partner institutions and national funders from Europe and the USA under the umbrella of the European Partnership for Biodiversity Biodiversa+. The expedition will also supply the German Antarctic station Neumayer III, which is maintained by the Alfred Wegener Institute (AWI). Marine Benthos in eastern Weddell Sea (Photo: Alfred-Wegener-Institut / Tomas Lundalv) The EU project WOBEC is coordinated by the AWI and investigates how biodiversity and ecosystem functions are changing in this ice-rich region. The Weddell Sea is a biodiversity hotspot: it is home to sponge and coral gardens, as well as huge swarms of krill. The area is also a habitat for bottom-dwelling fish, whales, and ice-dependent organisms, including Weddell seals and emperor penguins. β€œThe Weddell Sea is one of the last largely untouched marine areas on our planet. It serves as a refuge for many cold-loving species in times of man-made climate change,” explains Dr. Hauke Flores, marine biologist at the AWI and coordinator of WOBEC. β€œWith WOBEC, we are laying the foundation for early detection of changes and the development of effective protection strategies for a potential marine protected area.” Crabeater Seal (Photo: Alfred-Wegener-Institut / Tim Kalvelage) Setting off for one of the last largely untouched ecosystems on Eart. Under the scientific direction of Dr. Heike Link from the University of Rostock, the 46-member team will carry out research along the Prime Meridian and in the eastern Weddell Sea over the coming weeks. On board the research vessel operated by the Alfred Wegener Institute, Helmholtz Centre for Polar and Marine Research (AWI), the researchers plan to conduct investigations around the seamount Maud Rise where unique current conditions result in a highly productive and biodiverse community, and continue earlier work on the species-rich communities on the shelf region off Kapp Norvegia, west of the German Antarctic station Neumayer III. Both modern autonomous observation systems and classic oceanographic measurement methods will be used. β€œWe want to understand how this unique ecosystem is developing and what effects the decline in Antarctic sea ice is having on the communities,” says expedition leader and marine ecologist at the University of Rostock, Heike Link. β€œThe expedition is a crucial test for our joint observation concept, which we are setting up for the coming years.” Emperor penguins on the sea ice of the Weddell Sea (Photo: Alfred-Wegener-Institut / Mario Hoppmann) Data for tomorrow – knowledge for protecting the Southern Ocean During the expedition, scientists will collect new biological, chemical, and physical data and also make historical data sets available to the general public. This is based on close cooperation with international partners and the Commission for the Conservation of Antarctic Marine Living Resources (CCAMLR). With the Polarstern setting sail today, WOBEC's fieldwork begins – an important step towards a better understanding of one of the most sensitive and valuable ecosystems on Earth. This news item was first published by the University of Rostock.
December 15, 2025 at 5:16 PM
Reposted by Haass Lab
paquetlab.bsky.social
New paper out today at @natneuro.nature.com in collab. with DichgansLab @isd-research.bsky.social @lmumuenchen.bsky.social: We developed a fully #iPSC-derived human model of the #BBB #blood-brain-barrier and applied it to study neurovascular disease (NVD)! #OA PDF here: rdcu.be/eUIl3 ThreadπŸ‘‡ 1/10
December 15, 2025 at 2:25 PM
Reposted by Haass Lab
mathiasjucker.bsky.social
Human – mouse chimeric cultures to study microglia and amyloid pathology; This is a very exciting approach with lots of potential. Congratulations to Vasiliki Panagiotakopoulou! Cell Reports www.cell.com/cell-reports...
Chimeric human organoid and mouse brain slice co-cultures to study microglial function
Panagiotakopoulou et al. developed a co-culture system combining human cerebral organoids and mouse brain slices. The model supports long-term study of human microglia, enhances cortical marker expres...
www.cell.com
December 14, 2025 at 3:56 PM
Reposted by Haass Lab
ukdri.ac.uk
That’s a wrap on Connectome 2025! πŸ‘

Today has been another fantastic day, with special thanks to our keynote Prof Christian Haas, and Charles Sabine OBE who gave a powerful talk about his lived experience of Huntington's disease.

Thank you to everyone who made it such a great event!
December 10, 2025 at 4:32 PM
Reposted by Haass Lab
bmc-lmu.bsky.social
🧬 Researchers at the #BMC #Munich have developed an in vivo #CRISPR screening method to study how #macrophages are regulated during #neuroinflammation.

➑️ www.med.lmu.de/bmc/en/news/...

#multiplesclerosis #MS #biomedical #research #Munich #Germany
In vivo CRISPR screen reveals regulation of macrophage states in neuroinflammation
A research team led by Martin Kerschensteiner has developed an experimental platform that helps uncover the signals that instruct immune cells in neuroinflammatory disease.
www.med.lmu.de
December 8, 2025 at 9:26 AM
haasslab.bsky.social
Check out our latest publication! πŸ‘‡
molneurodegen.bsky.social Molecular Neurodegeneration @molneurodegen.bsky.social Β· Aug 20
'Early intervention anti-AΞ² #immunotherapy attenuates #microglial activation without inducing exhaustion at residual plaques'

Lis de Weerd @lisdeweerd.bsky.social Selina Hummel, Stephan A. MΓΌller...Christian Haass @haasslab.bsky.social #AlzheimersDisease #amyloid

bit.ly/3V8PDMa
August 25, 2025 at 1:20 PM
Reposted by Haass Lab
lukensjohnr.bsky.social
Microglia replacement halts the progression of microgliopathy in mice and humans @science.org www.science.org/doi/10.1126/...
Microglia replacement halts the progression of microgliopathy in mice and humans
Colony-stimulating factor 1 receptor (CSF1R) is primarily expressed in microglia. Its monoallelic mutation causes CSF1R-associated microgliopathy (CAMP), a major form of adult-onset leukoencephalopath...
www.science.org
July 10, 2025 at 7:01 PM
Reposted by Haass Lab
lmu-osc.bsky.social
​Hackathon: Data Under Threat/Data Rescuing in #MΓΌnchen

The LMU OSC runs a hackathon to support the #SciOp #SafeguardingResearch initiative: Rescuing research data that is deleted by the Trump administration.
πŸ“… 07/08/25 from 16 – 19 (only in-person)
πŸ‘‰ Details and signup: github.com/lmu-osc/safe...
GitHub - lmu-osc/safeguar.de-hackathon
Contribute to lmu-osc/safeguar.de-hackathon development by creating an account on GitHub.
github.com
July 11, 2025 at 12:37 PM
Reposted by Haass Lab
dzne.science
Congratulations to Christian Haass (@haasslab.bsky.social)! He receives an honorary doctorate from the University of Eastern Finland for 30+ years of groundbreaking Alzheimer’s research on beta-amyloid proteins and new therapeutic approaches. πŸ“Έ: UFE/Raija TΓΆrrΓΆnen & UFE/Niko Jouhkimainen
Photo of ceremony. Photo of ceremony.
June 16, 2025 at 1:17 PM
Reposted by Haass Lab
standupforscience.bsky.social
HAPPY PRIDE πŸ³οΈβ€πŸŒˆ

Under Trump, research using terms like β€œTrans,” β€œLGBTQ,” & β€œGender identity” is being defunded. These terms reflect real people who deserve science that includes them.

Stand with us to protect LGBTQ+ science from political erasure.
grant-watch.us/nih-data.html
@rcmedphys.bsky.social
A word cloud made from flagged terms in terminated NIH grant proposals. The most prominent words in large font include β€œtrans,” β€œdiverse,” β€œdiversity,” β€œminority,” β€œsex,” β€œexpression,” β€œmental health,” β€œgender,” and β€œwomen.” Other visible terms include β€œLGBTQ,” β€œracial,” β€œunderrepresented,” β€œdisability,” β€œbarriers,” β€œblack,” β€œequity,” β€œhealth equity,” β€œvaccine,” β€œbias,” and β€œintersectionality.” The word cloud highlights terms related to identity, inclusion, and marginalized communities.
June 1, 2025 at 3:22 PM
Reposted by Haass Lab
sj-marzi.bsky.social
How does APOE change your risk of developing Alzheimer's disease? At least partially by changing the function of immune cells in your brain 🧠🧬

New paper out in @natcomms.nature.com today: www.nature.com/articles/s41...

@ukdri.ac.uk @kingsioppn.bsky.social @imperialbrains.bsky.social
https://nature.com/articles/s4146…
May 27, 2025 at 8:33 AM
Reposted by Haass Lab
dfg.de
The #ClustersOfExcellence have been selected: today, the Excellence Commission approved 70 projects for funding. 45 clusters will continue and 25 will be newly established. Funding starts on 1 Jan 2026 for 7 years, with €539 million per year. The full list: www.dfg.de/resource/blo... 1/3
Map of Germany with the Clusters of Excellence
May 22, 2025 at 6:10 PM
Reposted by Haass Lab
lmu.de
πŸŽ‰ Major achievement for #LMU in the Excellence Strategy: All seven proposed Clusters of Excellence have successfully passed the review process and will be funded for seven years as of 2026. An outstanding result! πŸŽ‰ #ExcellenceCluster #LMUMunich #research Read more here: www.lmu.de/en/newsroom/...
May 22, 2025 at 4:25 PM
Reposted by Haass Lab
synergy-munich.bsky.social
πŸ’­ Our PhD & Postdoc reps initiated visits to our Technology Hubs for our researchers and kicked off with a visit to our Single-Cell and Spatial Transcriptome Hubs last week.

πŸ‘‹ Thanks Arek Kendirli, Janos Groh, Clara de la Rosa del Val, and Simon Frerich for hosting the first event of the series!
March 6, 2025 at 12:50 PM