Haass Lab
@haasslab.bsky.social
The Haass lab account | 🇩🇪 @DZNE_de @SyNergy_Cluster Munich | 🔬AD, FTLD & microglia research | 🕵️ PI Christian Haass (signed -CH) | 💬 Posts by @lisdeweerd.bsky.social
Check out our latest publication! 👇
'Early intervention anti-Aβ #immunotherapy attenuates #microglial activation without inducing exhaustion at residual plaques'
Lis de Weerd @lisdeweerd.bsky.social Selina Hummel, Stephan A. Müller...Christian Haass @haasslab.bsky.social #AlzheimersDisease #amyloid
bit.ly/3V8PDMa
Lis de Weerd @lisdeweerd.bsky.social Selina Hummel, Stephan A. Müller...Christian Haass @haasslab.bsky.social #AlzheimersDisease #amyloid
bit.ly/3V8PDMa
August 25, 2025 at 1:20 PM
Check out our latest publication! 👇
Reposted by Haass Lab
Microglia replacement halts the progression of microgliopathy in mice and humans @science.org www.science.org/doi/10.1126/...
Microglia replacement halts the progression of microgliopathy in mice and humans
Colony-stimulating factor 1 receptor (CSF1R) is primarily expressed in microglia. Its monoallelic mutation causes CSF1R-associated microgliopathy (CAMP), a major form of adult-onset leukoencephalopath...
www.science.org
July 10, 2025 at 7:01 PM
Microglia replacement halts the progression of microgliopathy in mice and humans @science.org www.science.org/doi/10.1126/...
Reposted by Haass Lab
Hackathon: Data Under Threat/Data Rescuing in #München
The LMU OSC runs a hackathon to support the #SciOp #SafeguardingResearch initiative: Rescuing research data that is deleted by the Trump administration.
📅 07/08/25 from 16 – 19 (only in-person)
👉 Details and signup: github.com/lmu-osc/safe...
The LMU OSC runs a hackathon to support the #SciOp #SafeguardingResearch initiative: Rescuing research data that is deleted by the Trump administration.
📅 07/08/25 from 16 – 19 (only in-person)
👉 Details and signup: github.com/lmu-osc/safe...
GitHub - lmu-osc/safeguar.de-hackathon
Contribute to lmu-osc/safeguar.de-hackathon development by creating an account on GitHub.
github.com
July 11, 2025 at 12:37 PM
Hackathon: Data Under Threat/Data Rescuing in #München
The LMU OSC runs a hackathon to support the #SciOp #SafeguardingResearch initiative: Rescuing research data that is deleted by the Trump administration.
📅 07/08/25 from 16 – 19 (only in-person)
👉 Details and signup: github.com/lmu-osc/safe...
The LMU OSC runs a hackathon to support the #SciOp #SafeguardingResearch initiative: Rescuing research data that is deleted by the Trump administration.
📅 07/08/25 from 16 – 19 (only in-person)
👉 Details and signup: github.com/lmu-osc/safe...
Reposted by Haass Lab
Congratulations to Christian Haass (@haasslab.bsky.social)! He receives an honorary doctorate from the University of Eastern Finland for 30+ years of groundbreaking Alzheimer’s research on beta-amyloid proteins and new therapeutic approaches. 📸: UFE/Raija Törrönen & UFE/Niko Jouhkimainen
June 16, 2025 at 1:17 PM
Congratulations to Christian Haass (@haasslab.bsky.social)! He receives an honorary doctorate from the University of Eastern Finland for 30+ years of groundbreaking Alzheimer’s research on beta-amyloid proteins and new therapeutic approaches. 📸: UFE/Raija Törrönen & UFE/Niko Jouhkimainen
Reposted by Haass Lab
HAPPY PRIDE 🏳️🌈
Under Trump, research using terms like “Trans,” “LGBTQ,” & “Gender identity” is being defunded. These terms reflect real people who deserve science that includes them.
Stand with us to protect LGBTQ+ science from political erasure.
grant-watch.us/nih-data.html
@rcmedphys.bsky.social
Under Trump, research using terms like “Trans,” “LGBTQ,” & “Gender identity” is being defunded. These terms reflect real people who deserve science that includes them.
Stand with us to protect LGBTQ+ science from political erasure.
grant-watch.us/nih-data.html
@rcmedphys.bsky.social
June 1, 2025 at 3:22 PM
HAPPY PRIDE 🏳️🌈
Under Trump, research using terms like “Trans,” “LGBTQ,” & “Gender identity” is being defunded. These terms reflect real people who deserve science that includes them.
Stand with us to protect LGBTQ+ science from political erasure.
grant-watch.us/nih-data.html
@rcmedphys.bsky.social
Under Trump, research using terms like “Trans,” “LGBTQ,” & “Gender identity” is being defunded. These terms reflect real people who deserve science that includes them.
Stand with us to protect LGBTQ+ science from political erasure.
grant-watch.us/nih-data.html
@rcmedphys.bsky.social
Reposted by Haass Lab
How does APOE change your risk of developing Alzheimer's disease? At least partially by changing the function of immune cells in your brain 🧠🧬
New paper out in @natcomms.nature.com today: www.nature.com/articles/s41...
@ukdri.ac.uk @kingsioppn.bsky.social @imperialbrains.bsky.social
New paper out in @natcomms.nature.com today: www.nature.com/articles/s41...
@ukdri.ac.uk @kingsioppn.bsky.social @imperialbrains.bsky.social
https://nature.com/articles/s4146…
May 27, 2025 at 8:33 AM
How does APOE change your risk of developing Alzheimer's disease? At least partially by changing the function of immune cells in your brain 🧠🧬
New paper out in @natcomms.nature.com today: www.nature.com/articles/s41...
@ukdri.ac.uk @kingsioppn.bsky.social @imperialbrains.bsky.social
New paper out in @natcomms.nature.com today: www.nature.com/articles/s41...
@ukdri.ac.uk @kingsioppn.bsky.social @imperialbrains.bsky.social
Reposted by Haass Lab
The #ClustersOfExcellence have been selected: today, the Excellence Commission approved 70 projects for funding. 45 clusters will continue and 25 will be newly established. Funding starts on 1 Jan 2026 for 7 years, with €539 million per year. The full list: www.dfg.de/resource/blo... 1/3
May 22, 2025 at 6:10 PM
The #ClustersOfExcellence have been selected: today, the Excellence Commission approved 70 projects for funding. 45 clusters will continue and 25 will be newly established. Funding starts on 1 Jan 2026 for 7 years, with €539 million per year. The full list: www.dfg.de/resource/blo... 1/3
Reposted by Haass Lab
🎉 Major achievement for #LMU in the Excellence Strategy: All seven proposed Clusters of Excellence have successfully passed the review process and will be funded for seven years as of 2026. An outstanding result! 🎉 #ExcellenceCluster #LMUMunich #research Read more here: www.lmu.de/en/newsroom/...
May 22, 2025 at 4:25 PM
🎉 Major achievement for #LMU in the Excellence Strategy: All seven proposed Clusters of Excellence have successfully passed the review process and will be funded for seven years as of 2026. An outstanding result! 🎉 #ExcellenceCluster #LMUMunich #research Read more here: www.lmu.de/en/newsroom/...
Reposted by Haass Lab
💭 Our PhD & Postdoc reps initiated visits to our Technology Hubs for our researchers and kicked off with a visit to our Single-Cell and Spatial Transcriptome Hubs last week.
👋 Thanks Arek Kendirli, Janos Groh, Clara de la Rosa del Val, and Simon Frerich for hosting the first event of the series!
👋 Thanks Arek Kendirli, Janos Groh, Clara de la Rosa del Val, and Simon Frerich for hosting the first event of the series!
March 6, 2025 at 12:50 PM
💭 Our PhD & Postdoc reps initiated visits to our Technology Hubs for our researchers and kicked off with a visit to our Single-Cell and Spatial Transcriptome Hubs last week.
👋 Thanks Arek Kendirli, Janos Groh, Clara de la Rosa del Val, and Simon Frerich for hosting the first event of the series!
👋 Thanks Arek Kendirli, Janos Groh, Clara de la Rosa del Val, and Simon Frerich for hosting the first event of the series!
Reposted by Haass Lab
We've been studying mechanisms of resilience that protect lysosomes from damage and wrote a review on the topic. We consider lysosomal stress and damage on a spectrum. Please help me share as this is my first post 😀 and I don't have many followers! 🙏 Open Access: www.embopress.org/doi/full/10....
February 27, 2025 at 3:54 PM
We've been studying mechanisms of resilience that protect lysosomes from damage and wrote a review on the topic. We consider lysosomal stress and damage on a spectrum. Please help me share as this is my first post 😀 and I don't have many followers! 🙏 Open Access: www.embopress.org/doi/full/10....
Reposted by Haass Lab
Excited to share our latest work with Denali Therapeutics as Deep Piction. Using our proprietary clearing & imaging, we’ve mapped the full targeting profile of brain-penetrating transport vehicles (ATVs) in both whole mouse bodies and monkey brains. nature.com/articles/s41...
February 26, 2025 at 8:33 AM
Excited to share our latest work with Denali Therapeutics as Deep Piction. Using our proprietary clearing & imaging, we’ve mapped the full targeting profile of brain-penetrating transport vehicles (ATVs) in both whole mouse bodies and monkey brains. nature.com/articles/s41...
Reposted by Haass Lab
Our new paper on the proteolytic processing of TMEM106B is out in @cp-cellreports.bsky.social! TMEM106B undergoesphysiological shedding and additional C-terminal trimming. The new luminal-domain antibody is commercially available!
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Physiological shedding and C-terminal proteolytic processing of TMEM106B
Genetic variants in TMEM106B, coding for a transmembrane protein of unknown function, have been identified as critical genetic modulators in various n…
www.sciencedirect.com
December 26, 2024 at 10:14 AM
Our new paper on the proteolytic processing of TMEM106B is out in @cp-cellreports.bsky.social! TMEM106B undergoesphysiological shedding and additional C-terminal trimming. The new luminal-domain antibody is commercially available!
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Haass Lab
We did it and now it is published: A highly Lewy-fold selective and quantitative Synuclein Aggregate Amplification Assay (SAA). Huge thanks to the amazing teams at MODAG GmbH, LMU Munich, and Bologna University!
rdcu.be/eaISM
rdcu.be/eaISM
A quantitative Lewy-fold-specific alpha-synuclein seed amplification assay as a progression marker for Parkinson’s disease
rdcu.be
February 21, 2025 at 5:23 PM
We did it and now it is published: A highly Lewy-fold selective and quantitative Synuclein Aggregate Amplification Assay (SAA). Huge thanks to the amazing teams at MODAG GmbH, LMU Munich, and Bologna University!
rdcu.be/eaISM
rdcu.be/eaISM
Reposted by Haass Lab
👋 Meet our PhD and Postdoc Representatives
💭 The voice of our PhD students and Postdocs. A point of contact for feedback, questions, criticism, and improvements. And they organize extracurricular activities! Meet @angelikadannert.bsky.social, Clara, Lis and Nathalie.
🔗 Read more: lnkd.in/dKtzshqr
💭 The voice of our PhD students and Postdocs. A point of contact for feedback, questions, criticism, and improvements. And they organize extracurricular activities! Meet @angelikadannert.bsky.social, Clara, Lis and Nathalie.
🔗 Read more: lnkd.in/dKtzshqr
February 18, 2025 at 1:25 PM
👋 Meet our PhD and Postdoc Representatives
💭 The voice of our PhD students and Postdocs. A point of contact for feedback, questions, criticism, and improvements. And they organize extracurricular activities! Meet @angelikadannert.bsky.social, Clara, Lis and Nathalie.
🔗 Read more: lnkd.in/dKtzshqr
💭 The voice of our PhD students and Postdocs. A point of contact for feedback, questions, criticism, and improvements. And they organize extracurricular activities! Meet @angelikadannert.bsky.social, Clara, Lis and Nathalie.
🔗 Read more: lnkd.in/dKtzshqr
Reposted by Haass Lab
This is really interesting. Known for a long time lysosomal enzymes are secreted- it’s the principle of cross correction for lysosomal
Storage diseases. However the idea lysosomes are released or degrading plaques extracellularly is 🤯. Do they differ from EVs/EPs?
www.cell.com/cell-reports...
Storage diseases. However the idea lysosomes are released or degrading plaques extracellularly is 🤯. Do they differ from EVs/EPs?
www.cell.com/cell-reports...
Microglia degrade Alzheimer’s amyloid-beta deposits extracellularly via digestive exophagy
Jacquet et al. shows that microglia use digestive exophagy to engage large Aβ deposits
that cannot be phagocytosed, forming acidic extracellular compartments on the aggregates
into which lysosomal enz...
www.cell.com
February 14, 2025 at 11:54 AM
This is really interesting. Known for a long time lysosomal enzymes are secreted- it’s the principle of cross correction for lysosomal
Storage diseases. However the idea lysosomes are released or degrading plaques extracellularly is 🤯. Do they differ from EVs/EPs?
www.cell.com/cell-reports...
Storage diseases. However the idea lysosomes are released or degrading plaques extracellularly is 🤯. Do they differ from EVs/EPs?
www.cell.com/cell-reports...
Reposted by Haass Lab
Big congrats to the winners, including Marvin Reich, PhD student co-supervised by our lab in a nice collab with @haasslab.bsky.social
Congrats to these two first authors from DZNE Munich on receiving the "Best Paper Award" from the DZNE foundation! @shreeyakedia.bsky.social was honored for her paper published in “Nature Neuroscience”. Marvin Reich, received the award for his paper published in “Science Translational Medicine”.
February 6, 2025 at 6:48 AM
Big congrats to the winners, including Marvin Reich, PhD student co-supervised by our lab in a nice collab with @haasslab.bsky.social
Reposted by Haass Lab
I am thrilled to share our latest article that has been published in @cp-immunity.bsky.social. We describe a new role for NLRP3 outside of its #inflammasome complex, where it can regulate microglial #metabolism & key metabolites that affect the epigenetic landscape(1)
www.cell.com/immunity/ful...
www.cell.com/immunity/ful...
NLRP3-mediated glutaminolysis controls microglial phagocytosis to promote Alzheimer’s disease progression
How NLRP3 impacts Alzheimer’s disease (AD) is unclear. McManus et al. find that NLRP3
is located at mitochondria where it regulates microglial metabolism. Depletion or
chronic pharmacological inhibiti...
www.cell.com
February 3, 2025 at 4:18 PM
I am thrilled to share our latest article that has been published in @cp-immunity.bsky.social. We describe a new role for NLRP3 outside of its #inflammasome complex, where it can regulate microglial #metabolism & key metabolites that affect the epigenetic landscape(1)
www.cell.com/immunity/ful...
www.cell.com/immunity/ful...
Reposted by Haass Lab
Multimodal synapse analysis reveals restricted integration of transplanted neurons remodeled by TREM2 https://www.biorxiv.org/content/10.1101/2025.01.31.635250v1
January 31, 2025 at 3:15 PM
Multimodal synapse analysis reveals restricted integration of transplanted neurons remodeled by TREM2 https://www.biorxiv.org/content/10.1101/2025.01.31.635250v1
Reposted by Haass Lab
Alpha-Synuclein co-pathology in Alzheimer's Disease drives tau accumulation https://www.biorxiv.org/content/10.1101/2025.01.24.634706v1
January 27, 2025 at 3:20 PM
Alpha-Synuclein co-pathology in Alzheimer's Disease drives tau accumulation https://www.biorxiv.org/content/10.1101/2025.01.24.634706v1
Reposted by Haass Lab
Very happy to announce that the PaquetLab is now on Bluesky. We are excited to connect with everyone interested in our research and present updates on our work and lab activities! Our lab engineers 3-dimensional models of #human-brain-tissue and the #BBB and applies them to investigate ...
January 12, 2025 at 3:15 PM
Very happy to announce that the PaquetLab is now on Bluesky. We are excited to connect with everyone interested in our research and present updates on our work and lab activities! Our lab engineers 3-dimensional models of #human-brain-tissue and the #BBB and applies them to investigate ...
(REPOST) Can we achieve protein replacement in the brain using a single dose gene therapy approach, without infecting the brain? Yes we can! Read it here in our latest paper by @marvin_reich in collaboration with Denali Therapeutics science.org/doi/10.1126/... (1/8)
Peripheral expression of brain-penetrant progranulin rescues pathologies in mouse models of frontotemporal lobar degeneration
Peripheral AAV-mediated delivery of brain-penetrant PGRN rescues TDP-43 pathology, neurodegeneration, and motor phenotypes in FTLD-GRN models.
science.org
December 10, 2024 at 10:54 AM
(REPOST) Can we achieve protein replacement in the brain using a single dose gene therapy approach, without infecting the brain? Yes we can! Read it here in our latest paper by @marvin_reich in collaboration with Denali Therapeutics science.org/doi/10.1126/... (1/8)