Mathias Jucker
@mathiasjucker.bsky.social
Biomedical Researcher
Professor @dzne.science @hih-tuebingen.bsky.social
Tübingen 🇩🇪 & Zürich 🇨🇭
Professor @dzne.science @hih-tuebingen.bsky.social
Tübingen 🇩🇪 & Zürich 🇨🇭
An excellent review of Abeta seeds by my current and former students and postdocs. Abeta seeds are becoming increasingly important as immunotherapy moves towards presymptomatic stages. doi.org/10.1111/jnc....
Amyloid‐β Seeds in Alzheimer's Disease: Research Challenges and Implications
The amyloid cascade hypothesis places amyloid-β (Aβ) at the center of Alzheimer's disease (AD) pathogenesis. Evidence suggests that AD progresses in two phases: an early phase driven by Aβ aggregatio...
doi.org
November 7, 2025 at 8:27 PM
An excellent review of Abeta seeds by my current and former students and postdocs. Abeta seeds are becoming increasingly important as immunotherapy moves towards presymptomatic stages. doi.org/10.1111/jnc....
Reposted by Mathias Jucker
November 7, 2025 at 11:37 AM
I'm curious to know if the microglia repopulation would also work via blood. - Brain-wide microglia replacement using a nonconditioning strategy ameliorates pathology in mouse models of neurological disorders | Science Translational Medicine www.science.org/doi/10.1126/...
Brain-wide microglia replacement using a nonconditioning strategy ameliorates pathology in mouse models of neurological disorders
A tricyclic depletion protocol allows for microglia replacement without preconditioning and mitigates pathology in mouse models of neurodegeneration.
www.science.org
May 16, 2025 at 10:12 AM
I'm curious to know if the microglia repopulation would also work via blood. - Brain-wide microglia replacement using a nonconditioning strategy ameliorates pathology in mouse models of neurological disorders | Science Translational Medicine www.science.org/doi/10.1126/...
Long-term full amyloid removal potentially delayed symptom onset and dementia progression! Findings from the DIAN study. sciencedirect.com/science/arti...
Safety and efficacy of long-term gantenerumab treatment in dominantly inherited Alzheimer's disease: an open-label extension of the phase 2/3 multicentre, randomised, double-blind, placebo-controlled ...
Amyloid plaque removal by monoclonal antibody therapies slows clinical progression in symptomatic Alzheimer's disease; however, the potential for dela…
sciencedirect.com
March 20, 2025 at 6:30 AM
Long-term full amyloid removal potentially delayed symptom onset and dementia progression! Findings from the DIAN study. sciencedirect.com/science/arti...
Join us for a Master's in Neuroscience in Tübingen, Germany. www.neuroschool-tuebingen.de/application/...
March 9, 2025 at 9:33 AM
Join us for a Master's in Neuroscience in Tübingen, Germany. www.neuroschool-tuebingen.de/application/...
Great summary of the history of early growth hormone preparations and their link to iatrogenic CJD and Alzheimer. Unfolding story of protein mis-folding causing Alzheimer’s disease in recipients of human pituitary growth hormone. , doi.org/10.1210/jend...
The unfolding story of protein mis-folding causing Alzheimer’s disease in recipients of human pituitary growth hormone
Abstract. Human growth hormone (hGH) has been in clinical use for children with GH deficiency (GHD) since the late 1950s. The original formulations were co
doi.org
February 22, 2025 at 9:08 AM
Great summary of the history of early growth hormone preparations and their link to iatrogenic CJD and Alzheimer. Unfolding story of protein mis-folding causing Alzheimer’s disease in recipients of human pituitary growth hormone. , doi.org/10.1210/jend...
One more day to apply for these neurodegeneration professorships!
Two flagship chair professorships for neurodgenerative diseases in Tübingen, Germany. Both affiliated with our university @hih-tuebingen.bsky.social and the German Center for Neurodegenerative diseases @dzne.science. Apply and join us!
www.nature.com/naturecareer...
www.nature.com/naturecareer...
www.nature.com/naturecareer...
www.nature.com/naturecareer...
Nature Careers | Science jobs | Choose from 1,225 live vacancies
Search for your next job from 1,225 live vacancies, or upload your CV now and let recruiters find you
nature.com
January 22, 2025 at 3:53 PM
One more day to apply for these neurodegeneration professorships!
Reposted by Mathias Jucker
Dear Donald Trump: A letter from Nature on how to make science thrive and why it matters for the health, prosperity and safety of people of America and the world
🧪
www.nature.com/articles/d41...
🧪
www.nature.com/articles/d41...
Dear Donald Trump: A letter from Nature on how to make science thrive
The US federal government can harness science to secure the health, prosperity and safety of Americans and the world.
www.nature.com
January 15, 2025 at 5:31 PM
Dear Donald Trump: A letter from Nature on how to make science thrive and why it matters for the health, prosperity and safety of people of America and the world
🧪
www.nature.com/articles/d41...
🧪
www.nature.com/articles/d41...
amazing! doi.org/10.1038/s415...
In vivo base editing extends lifespan of a humanized mouse model of prion disease - Nature Medicine
An in vivo base editing approach targeting the PRNP gene led to a 52% increase in the lifespan of mouse models inoculated with the most common sporadic and genetic types of human pathogenic prion isol...
doi.org
January 14, 2025 at 7:36 PM
amazing! doi.org/10.1038/s415...
Reposted by Mathias Jucker
Two flagship chair professorships for neurodgenerative diseases in Tübingen, Germany. Both affiliated with our university @hih-tuebingen.bsky.social and the German Center for Neurodegenerative diseases @dzne.science. Apply and join us!
www.nature.com/naturecareer...
www.nature.com/naturecareer...
www.nature.com/naturecareer...
www.nature.com/naturecareer...
Nature Careers | Science jobs | Choose from 1,225 live vacancies
Search for your next job from 1,225 live vacancies, or upload your CV now and let recruiters find you
nature.com
December 16, 2024 at 4:14 PM
Two flagship chair professorships for neurodgenerative diseases in Tübingen, Germany. Both affiliated with our university @hih-tuebingen.bsky.social and the German Center for Neurodegenerative diseases @dzne.science. Apply and join us!
www.nature.com/naturecareer...
www.nature.com/naturecareer...
www.nature.com/naturecareer...
www.nature.com/naturecareer...
What a cool read and quiz about confidence! Why probability probably doesn’t exist (but it is useful to act like it does)https://www.nature.com/articles/d41586-024-04096-5
Why probability probably doesn’t exist (but it is useful to act like it does)
All of statistics and much of science depends on probability — an astonishing achievement, considering no one’s really sure what it is.
www.nature.com
December 31, 2024 at 1:30 PM
What a cool read and quiz about confidence! Why probability probably doesn’t exist (but it is useful to act like it does)https://www.nature.com/articles/d41586-024-04096-5
Two flagship chair professorships for neurodgenerative diseases in Tübingen, Germany. Both affiliated with our university @hih-tuebingen.bsky.social and the German Center for Neurodegenerative diseases @dzne.science. Apply and join us!
www.nature.com/naturecareer...
www.nature.com/naturecareer...
www.nature.com/naturecareer...
www.nature.com/naturecareer...
Nature Careers | Science jobs | Choose from 1,225 live vacancies
Search for your next job from 1,225 live vacancies, or upload your CV now and let recruiters find you
nature.com
December 16, 2024 at 4:14 PM
Two flagship chair professorships for neurodgenerative diseases in Tübingen, Germany. Both affiliated with our university @hih-tuebingen.bsky.social and the German Center for Neurodegenerative diseases @dzne.science. Apply and join us!
www.nature.com/naturecareer...
www.nature.com/naturecareer...
www.nature.com/naturecareer...
www.nature.com/naturecareer...
Now that #lecanemab (#Leqembi) has been approved in Europe, we have updated our #Alzheimer game! Play and find out when is the best time to start immunotherapy. Play at --> hih-tuebingen.de/alzheimer/game
December 11, 2024 at 7:01 PM
Now that #lecanemab (#Leqembi) has been approved in Europe, we have updated our #Alzheimer game! Play and find out when is the best time to start immunotherapy. Play at --> hih-tuebingen.de/alzheimer/game
Trajectories of neurofilament light chain (a presumed marker of neurodegeneration) in CSF and blood over the entire course of (autosomal dominant) #Alzheimer's. doi.org/10.1038/s414.... Great collaboration with Dominantly Inherited Alzheimer Network (DIAN) @dzne.science @hih-tuebingen.bsky.social
Comparative neurofilament light chain trajectories in CSF and plasma in autosomal dominant Alzheimer’s disease - Nature Communications
This study supports neurofilament light chain protein (NfL) in both cerebrospinal fluid (CSF) and blood as an early marker of neurodegeneration in Alzheimer’s disease but suggests that NfL in CSF may ...
doi.org
December 11, 2024 at 6:56 PM
Trajectories of neurofilament light chain (a presumed marker of neurodegeneration) in CSF and blood over the entire course of (autosomal dominant) #Alzheimer's. doi.org/10.1038/s414.... Great collaboration with Dominantly Inherited Alzheimer Network (DIAN) @dzne.science @hih-tuebingen.bsky.social
