PaquetLab
@paquetlab.bsky.social
3D iPSC models and CRISPR to investigate mechanisms of neurodegenerative and neurovascular disorders | Professor of Neurobiology at LMU Munich | https://isd-research.de/paquetlab
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PaquetLab
@paquetlab.bsky.social
· Mar 12
Open #Postdoc position @isd-research.bsky.social @lmumuenchen.bsky.social to develop an #iPSC-derived #BBB model. Fully funded and embedded in our international Foundation Leducq Network of Excellence www.brenda-leducq.de Experience in vascular biology or related field required. Please RP and apply
Big congrats to Mila @milaborri.bsky.social from the lab for obtaining a EU-funded #MCSA postdoc fellowship!! We look forward to working with you on developing #iPSC based vascularized human brain tissue models to study major #brain diseases, such as #Alzheimer's and #stroke!
October 9, 2025 at 6:58 AM
Big congrats to Mila @milaborri.bsky.social from the lab for obtaining a EU-funded #MCSA postdoc fellowship!! We look forward to working with you on developing #iPSC based vascularized human brain tissue models to study major #brain diseases, such as #Alzheimer's and #stroke!
Great conference! Very happy to join again.
Join us for 𝗦𝘁𝗲𝗺 𝗖𝗲𝗹𝗹𝘀 𝗶𝗻 𝗡𝗲𝘂𝗿𝗼𝘀𝗰𝗶𝗲𝗻𝗰𝗲, 𝟮𝟱𝘁𝗵-𝟮𝟳𝘁𝗵 𝗼𝗳 𝗙𝗲𝗯𝗿𝘂𝗮𝗿𝘆, 𝟮𝟬𝟮𝟲 in Tübingen, Germany.
Register here until 30th of November:
👉 stemcelltuebingen.com
Speaker slots and stipends available
Please repost and spread the news!
@dzne.science
@hih-tuebingen.bsky.social
@tueneurocampus.bsky.social
Register here until 30th of November:
👉 stemcelltuebingen.com
Speaker slots and stipends available
Please repost and spread the news!
@dzne.science
@hih-tuebingen.bsky.social
@tueneurocampus.bsky.social
October 3, 2025 at 6:33 AM
Great conference! Very happy to join again.
Very happy to be at the Barcelona #B4event blood-brain-barrier meeting and present our work this afternoon on a novel fully #iPSC based model of the #BBB that allows investigating neurovascular diseases! premc.org/blood-brain-...
October 1, 2025 at 1:50 PM
Very happy to be at the Barcelona #B4event blood-brain-barrier meeting and present our work this afternoon on a novel fully #iPSC based model of the #BBB that allows investigating neurovascular diseases! premc.org/blood-brain-...
Reposted by PaquetLab
What makes Bluesky different: it’s open source, so anyone can contribute to building the experience they want. And even if you build a whole new app, the protocol means you can migrate with your data, identity, and relationships intact.
The eternally-great thing about open source: if something doesn't exist, and the devs don't have time to work on it themselves, you can just implement it for them!
If they decide not to take it as-is, you've still helped explore the design space.
And if they don't accept it, but you need it, fork!
If they decide not to take it as-is, you've still helped explore the design space.
And if they don't accept it, but you need it, fork!
Figured out enough of the rsky-relay internals to implement this myself (reporting the data that it currently records):
September 17, 2025 at 6:10 PM
What makes Bluesky different: it’s open source, so anyone can contribute to building the experience they want. And even if you build a whole new app, the protocol means you can migrate with your data, identity, and relationships intact.
Great #BBB Model to study malaria! Congrats Maria and Team!
We are happy to show one ourt first exciting papers. We have developed a blood-brain barrier model to study the disruptive effects caused by the malaria parasite, Plasmodium falciparum.
First, congratulations to the fearless @liviapiatti.bsky.social and @alinabatzi.bsky.social
rdcu.be/ezBl7
First, congratulations to the fearless @liviapiatti.bsky.social and @alinabatzi.bsky.social
rdcu.be/ezBl7
Plasmodium falciparum egress disrupts endothelial junctions and activates JAK-STAT signaling in a microvascular 3D blood-brain barrier model
Nature Communications - Here the authors show that Plasmodium falciparum egress products disrupt endothelial barrier and activate JAK-STAT and interferon type response in a 3D blood-brain barrier...
rdcu.be
August 7, 2025 at 1:13 PM
Great #BBB Model to study malaria! Congrats Maria and Team!
Reposted by PaquetLab
Primary paper: www.cell.com/cell-reports...
July 29, 2025 at 3:00 PM
Primary paper: www.cell.com/cell-reports...
Reposted by PaquetLab
🎓🇩🇪 Over 500 LMU students will get the Germany Scholarship in 2025 – a record! 💡 It provides €300/month, funded half by the government, half by private sponsors. Supporting talent and social engagement, no matter their background. #LMU #Scholarship #Education 👉 Read more: www.lmu.de/en/newsroom/....
July 16, 2025 at 9:30 AM
🎓🇩🇪 Over 500 LMU students will get the Germany Scholarship in 2025 – a record! 💡 It provides €300/month, funded half by the government, half by private sponsors. Supporting talent and social engagement, no matter their background. #LMU #Scholarship #Education 👉 Read more: www.lmu.de/en/newsroom/....
Reposted by PaquetLab
'Stem Cells in Neuroscience' is returning to Tübingen, Germany.
SAVE THE DATE: February 25-27, 2026.
More info: stemcelltuebingen.com
Please share
#stemcelltuebingen2026
@dzne.science
@hih-tuebingen.bsky.social
@unituebingen.bsky.social
@tueneurocampus.bsky.social
SAVE THE DATE: February 25-27, 2026.
More info: stemcelltuebingen.com
Please share
#stemcelltuebingen2026
@dzne.science
@hih-tuebingen.bsky.social
@unituebingen.bsky.social
@tueneurocampus.bsky.social
July 1, 2025 at 7:07 AM
'Stem Cells in Neuroscience' is returning to Tübingen, Germany.
SAVE THE DATE: February 25-27, 2026.
More info: stemcelltuebingen.com
Please share
#stemcelltuebingen2026
@dzne.science
@hih-tuebingen.bsky.social
@unituebingen.bsky.social
@tueneurocampus.bsky.social
SAVE THE DATE: February 25-27, 2026.
More info: stemcelltuebingen.com
Please share
#stemcelltuebingen2026
@dzne.science
@hih-tuebingen.bsky.social
@unituebingen.bsky.social
@tueneurocampus.bsky.social
Reposted by PaquetLab
The #ClustersOfExcellence have been selected: today, the Excellence Commission approved 70 projects for funding. 45 clusters will continue and 25 will be newly established. Funding starts on 1 Jan 2026 for 7 years, with €539 million per year. The full list: www.dfg.de/resource/blo... 1/3
May 22, 2025 at 6:10 PM
The #ClustersOfExcellence have been selected: today, the Excellence Commission approved 70 projects for funding. 45 clusters will continue and 25 will be newly established. Funding starts on 1 Jan 2026 for 7 years, with €539 million per year. The full list: www.dfg.de/resource/blo... 1/3
Reposted by PaquetLab
🎉 Major achievement for #LMU in the Excellence Strategy: All seven proposed Clusters of Excellence have successfully passed the review process and will be funded for seven years as of 2026. An outstanding result! 🎉 #ExcellenceCluster #LMUMunich #research Read more here: www.lmu.de/en/newsroom/...
May 22, 2025 at 4:25 PM
🎉 Major achievement for #LMU in the Excellence Strategy: All seven proposed Clusters of Excellence have successfully passed the review process and will be funded for seven years as of 2026. An outstanding result! 🎉 #ExcellenceCluster #LMUMunich #research Read more here: www.lmu.de/en/newsroom/...
…and our research cluster @synergy-munich.bsky.social is one of the funded ones! Big congratulations to all involved!
Die #Exzellenzcluster stehen fest: Heute hat die Exzellenzkommission 70 Projekte zur Förderung ausgewählt. 45 Cluster werden fortgesetzt, 25 neu eingerichtet. Die Förderung beginnt ab 1. Jan. 2026 für 7 Jahre, die Fördersumme beträgt insg. 539 Mio. €/Jahr. Die Liste: www.dfg.de/resource/blo... 1/3
May 22, 2025 at 3:32 PM
…and our research cluster @synergy-munich.bsky.social is one of the funded ones! Big congratulations to all involved!
Important engagement by our Master student Stella:
🔬🌱 Master’s student Stella Chroni promotes #sustainability in science at LMU’s Martinsried Campus. Through the #GreenOffice, she supports research labs in reducing resource consumption & helps implementing more sustainable practices. More about Stella an her work for the Green Office at #LMU here:
The Sustainability of Science
Molecular Biology student Stella Chroni supports the Green Office on Martinsried Campus, promoting sustainable lab practices and raising awareness among scientists and peers.
www.lmu.de
May 7, 2025 at 6:37 PM
Important engagement by our Master student Stella:
Reposted by PaquetLab
Europe’s choice is clear.
To put science at the heart of its economy.
To become the home of scientific freedom and collaboration.
And to welcome talent from all over the world.
I’m glad to present the first elements of our Choose Europe Initiative.
→ europa.eu/!TTbWbJ
To put science at the heart of its economy.
To become the home of scientific freedom and collaboration.
And to welcome talent from all over the world.
I’m glad to present the first elements of our Choose Europe Initiative.
→ europa.eu/!TTbWbJ
May 5, 2025 at 10:00 AM
Europe’s choice is clear.
To put science at the heart of its economy.
To become the home of scientific freedom and collaboration.
And to welcome talent from all over the world.
I’m glad to present the first elements of our Choose Europe Initiative.
→ europa.eu/!TTbWbJ
To put science at the heart of its economy.
To become the home of scientific freedom and collaboration.
And to welcome talent from all over the world.
I’m glad to present the first elements of our Choose Europe Initiative.
→ europa.eu/!TTbWbJ
Reposted by PaquetLab
Excited to be at #Tau2025 in London! I really enjoy the great and inspiring discussions with all the fellow Tau enthusiasts! 🔬👩🔬
Great to be at #Tau2025 in London, where @angelikadannert.bsky.social from the lab presents our human #iPSC model of Tauopathies in a packed poster session
April 24, 2025 at 3:23 PM
Excited to be at #Tau2025 in London! I really enjoy the great and inspiring discussions with all the fellow Tau enthusiasts! 🔬👩🔬
Great to be at #Tau2025 in London, where @angelikadannert.bsky.social from the lab presents our human #iPSC model of Tauopathies in a packed poster session
April 24, 2025 at 3:11 PM
Great to be at #Tau2025 in London, where @angelikadannert.bsky.social from the lab presents our human #iPSC model of Tauopathies in a packed poster session
Great starter pack for Tau aficionados! Thanks Melissa
Love seeing the beautiful butterfly at #Tau2025 where 1000+ scientists and clinicians are gathering to share ideas to accelerate biomedical discoveries.
Here is a starter pack to quickly follow TAUrrific researchers. Let me know if I need to add anybody
go.bsky.app/KHno2VG
@millermb.bsky.social
Here is a starter pack to quickly follow TAUrrific researchers. Let me know if I need to add anybody
go.bsky.app/KHno2VG
@millermb.bsky.social
April 24, 2025 at 3:08 PM
Great starter pack for Tau aficionados! Thanks Melissa
Reposted by PaquetLab
🚀 New study reveals how four different anti-amyloid drugs interact with amyloid beta protein. They found that lecanemab performed best in binding to small oligomeric forms of the amyloid protein, suggesting a working model for treating people in the earlier stages of Alzheimer’s (1/4)
April 18, 2025 at 10:01 AM
🚀 New study reveals how four different anti-amyloid drugs interact with amyloid beta protein. They found that lecanemab performed best in binding to small oligomeric forms of the amyloid protein, suggesting a working model for treating people in the earlier stages of Alzheimer’s (1/4)
Reposted by PaquetLab
Congratulations to
Dr. Jean Paul Chadarevian and the entire @blurtonjoneslab.bsky.social team for this beautiful piece of work: Harnessing human iPSC-microglia for CNS-wide delivery of disease modifying proteins." 👍👍👍
www.sciencedirect.com/science/arti...
Dr. Jean Paul Chadarevian and the entire @blurtonjoneslab.bsky.social team for this beautiful piece of work: Harnessing human iPSC-microglia for CNS-wide delivery of disease modifying proteins." 👍👍👍
www.sciencedirect.com/science/arti...
Harnessing human iPSC-microglia for CNS-wide delivery of disease-modifying proteins
Widespread delivery of therapeutic proteins to the brain remains challenging. To determine whether human induced pluripotent stem cell (iPSC)-microgli…
www.sciencedirect.com
April 14, 2025 at 6:54 PM
Congratulations to
Dr. Jean Paul Chadarevian and the entire @blurtonjoneslab.bsky.social team for this beautiful piece of work: Harnessing human iPSC-microglia for CNS-wide delivery of disease modifying proteins." 👍👍👍
www.sciencedirect.com/science/arti...
Dr. Jean Paul Chadarevian and the entire @blurtonjoneslab.bsky.social team for this beautiful piece of work: Harnessing human iPSC-microglia for CNS-wide delivery of disease modifying proteins." 👍👍👍
www.sciencedirect.com/science/arti...
Reposted by PaquetLab
Losing sleep over #iPSC transgene silencing after differentiation?
Same here — too many times😭
So we built a PiggyBac construct that resists silencing.
Expression stays ON, even after differentiation.
Our #preprint is out👇
🔗 www.biorxiv.org/content/10.1...
Supported by @cziscience.bsky.social
Same here — too many times😭
So we built a PiggyBac construct that resists silencing.
Expression stays ON, even after differentiation.
Our #preprint is out👇
🔗 www.biorxiv.org/content/10.1...
Supported by @cziscience.bsky.social
Prevention of Transgene Silencing During Human Pluripotent Stem Cell Differentiation
While high and stable transgene expression can be achieved in undifferentiated pluripotent stem cells, conventional transgene expression systems are often silenced upon differentiation. Silencing occu...
www.biorxiv.org
April 15, 2025 at 3:37 PM
Losing sleep over #iPSC transgene silencing after differentiation?
Same here — too many times😭
So we built a PiggyBac construct that resists silencing.
Expression stays ON, even after differentiation.
Our #preprint is out👇
🔗 www.biorxiv.org/content/10.1...
Supported by @cziscience.bsky.social
Same here — too many times😭
So we built a PiggyBac construct that resists silencing.
Expression stays ON, even after differentiation.
Our #preprint is out👇
🔗 www.biorxiv.org/content/10.1...
Supported by @cziscience.bsky.social
Reposted by PaquetLab
It has taken decades to get to this point, but stem cells for Parkinson's disease showing promise in 2 clinical trials
nature.com/articles/d41...
nature.com/articles/s41...
nature.com/articles/s41...
nature.com/articles/d41...
nature.com/articles/s41...
nature.com/articles/s41...
Clinical trials test the safety of stem-cell therapy for Parkinson’s disease
Transplanting dopamine-releasing neurons into the brain is a promising regenerative therapy for Parkinson’s disease. Two clinical trials show that it is safe, but more evidence is needed to prove its ...
nature.com
April 16, 2025 at 3:35 PM
It has taken decades to get to this point, but stem cells for Parkinson's disease showing promise in 2 clinical trials
nature.com/articles/d41...
nature.com/articles/s41...
nature.com/articles/s41...
nature.com/articles/d41...
nature.com/articles/s41...
nature.com/articles/s41...
Reposted by PaquetLab
We are excited to announce Prof Malin Parmar, Ph.D. as our next webinar speaker!
Title: Developing a Stem Cell Based Therapy for #Parkinsons Disease
April 16 2025
9-10am (ET) 3-4pm (CET)
Host: Henrietta Nielsen, Ph.D.
Register: bit.ly/4jmX0d3
Title: Developing a Stem Cell Based Therapy for #Parkinsons Disease
April 16 2025
9-10am (ET) 3-4pm (CET)
Host: Henrietta Nielsen, Ph.D.
Register: bit.ly/4jmX0d3
April 9, 2025 at 2:12 PM
We are excited to announce Prof Malin Parmar, Ph.D. as our next webinar speaker!
Title: Developing a Stem Cell Based Therapy for #Parkinsons Disease
April 16 2025
9-10am (ET) 3-4pm (CET)
Host: Henrietta Nielsen, Ph.D.
Register: bit.ly/4jmX0d3
Title: Developing a Stem Cell Based Therapy for #Parkinsons Disease
April 16 2025
9-10am (ET) 3-4pm (CET)
Host: Henrietta Nielsen, Ph.D.
Register: bit.ly/4jmX0d3
Welcome @ismnd.bsky.social to #Bluesky!
April 9, 2025 at 2:20 PM
Welcome @ismnd.bsky.social to #Bluesky!
Reposted by PaquetLab
The telling is not only that scientists are avoiding trips to the 🇺🇸 It is the fact that most interviewed for this piece asked to remain anonymous with (very real) fear of retaliation. by @klangin.bsky.social www.science.org/content/arti...
International scientists rethink U.S. conference attendance
Opposition to Trump administration and fears of customs run-ins are shifting travel plans
www.science.org
March 31, 2025 at 10:24 PM
The telling is not only that scientists are avoiding trips to the 🇺🇸 It is the fact that most interviewed for this piece asked to remain anonymous with (very real) fear of retaliation. by @klangin.bsky.social www.science.org/content/arti...
If you are at #ADPD2025 in Vienna, please join us now in hall F1 to get an update about our human 3D #iPSC model of #Alzheimer disease!
April 2, 2025 at 2:36 PM
If you are at #ADPD2025 in Vienna, please join us now in hall F1 to get an update about our human 3D #iPSC model of #Alzheimer disease!